WO2010002955A3 - Biomarqueurs de souchitude et procédés d’utilisation - Google Patents

Biomarqueurs de souchitude et procédés d’utilisation Download PDF

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Publication number
WO2010002955A3
WO2010002955A3 PCT/US2009/049343 US2009049343W WO2010002955A3 WO 2010002955 A3 WO2010002955 A3 WO 2010002955A3 US 2009049343 W US2009049343 W US 2009049343W WO 2010002955 A3 WO2010002955 A3 WO 2010002955A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
biomarkers
stemness
another aspect
agent
Prior art date
Application number
PCT/US2009/049343
Other languages
English (en)
Other versions
WO2010002955A2 (fr
Inventor
Xudong Dai
Christopher G. Winter
Hongyue Dai
Original Assignee
Merck Sharp & Dohme Corp.
Rosetta Inpharmatics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Corp., Rosetta Inpharmatics Llc filed Critical Merck Sharp & Dohme Corp.
Publication of WO2010002955A2 publication Critical patent/WO2010002955A2/fr
Publication of WO2010002955A3 publication Critical patent/WO2010002955A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L’invention concerne, selon un aspect, des procédés, des biomarqueurs et des signatures d’expression destinés à évaluer le degré auquel un échantillon cellulaire présente des propriétés de cellules souches. Selon un autre aspect, l’invention concerne des procédés de comparaison d’agents qui modulent la fonction de gènes en fonction du degré auquel l’agent module l’expression génique des biomarqueurs de souchitude. Selon un autre aspect, l’invention concerne des procédés de prévision de la réponse d’un sujet atteint d’un cancer à un traitement par un agent, fondés sur des modifications des niveaux d’expression génique de biomarqueurs de souchitude. Selon un autre aspect, l’invention concerne des procédés de prévision de l’efficacité thérapeutique d’un agent thérapeutique anticancéreux.
PCT/US2009/049343 2008-07-03 2009-07-01 Biomarqueurs de souchitude et procédés d’utilisation WO2010002955A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13397608P 2008-07-03 2008-07-03
US61/133,976 2008-07-03

Publications (2)

Publication Number Publication Date
WO2010002955A2 WO2010002955A2 (fr) 2010-01-07
WO2010002955A3 true WO2010002955A3 (fr) 2010-03-11

Family

ID=41466588

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/049343 WO2010002955A2 (fr) 2008-07-03 2009-07-01 Biomarqueurs de souchitude et procédés d’utilisation

Country Status (1)

Country Link
WO (1) WO2010002955A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"SUPERARRAY. RT2 Profiler PCR Array Human Stem Cell", 2 June 2007 (2007-06-02), pages 1, Retrieved from the Internet <URL:http://web.archive.org/web/20070602160551/www.superarray.com/rt_pcr_product/HTML/APHS-405A.html> [retrieved on 20091110] *
BHATTACHARYA ET AL.: "Gene expression in human embryonic stem cell lines: unique molecular signature.", BLOOD, vol. 103, no. 8, 15 April 2004 (2004-04-15), pages 2956 - 2964 *
GUPTA ET AL.: "Identification of selective inhibitors of cancer stem cells by high-throughput screening.", CELL, vol. 138, no. 4, 21 August 2009 (2009-08-21), pages 645 - 659 *
LU ET AL.: "Common Human Cancer Genes Discovered by Integrated Gene-Expression Analysis.", PLOS ONE., vol. 2, no. 11, November 2007 (2007-11-01), pages E1149 1 - 13 *

Also Published As

Publication number Publication date
WO2010002955A2 (fr) 2010-01-07

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