WO2009153806A3 - Process for preparing memantine hydrochloride substantially free of impurities - Google Patents

Process for preparing memantine hydrochloride substantially free of impurities Download PDF

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Publication number
WO2009153806A3
WO2009153806A3 PCT/IN2009/000274 IN2009000274W WO2009153806A3 WO 2009153806 A3 WO2009153806 A3 WO 2009153806A3 IN 2009000274 W IN2009000274 W IN 2009000274W WO 2009153806 A3 WO2009153806 A3 WO 2009153806A3
Authority
WO
WIPO (PCT)
Prior art keywords
memantine hydrochloride
impurities
substantially free
memantine
produce
Prior art date
Application number
PCT/IN2009/000274
Other languages
French (fr)
Other versions
WO2009153806A2 (en
Inventor
Pradeep Kumar Jauhari
Original Assignee
Sairam Organics Pvt. Ltd.
Pharmaceutical Solutions Fzco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sairam Organics Pvt. Ltd., Pharmaceutical Solutions Fzco filed Critical Sairam Organics Pvt. Ltd.
Publication of WO2009153806A2 publication Critical patent/WO2009153806A2/en
Publication of WO2009153806A3 publication Critical patent/WO2009153806A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for preparing memantine hydrochloride free from impurities comprises (a) reacting 1,3-dimethyladamantane with acetonitrile and sulphuric acid to produce 1 - acetamido-3,5- dimethyl adamantane; (b) treating 1-acetamido-3,5-dimethyl adamantane with base in the presence of solvent to produce memantine; (c) reacting memantine with alcoholic HCI in the presence of solvents to produce memantine hydrochloride; and purification of memantine hydrochloride using aliphatic solvents.
PCT/IN2009/000274 2008-05-09 2009-05-08 Process for preparing memantine hydrochloride substantially free of !mpurities WO2009153806A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1143/CHE/2008 2008-05-09
IN1143CH2008 2008-05-09

Publications (2)

Publication Number Publication Date
WO2009153806A2 WO2009153806A2 (en) 2009-12-23
WO2009153806A3 true WO2009153806A3 (en) 2010-12-23

Family

ID=41434514

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000274 WO2009153806A2 (en) 2008-05-09 2009-05-08 Process for preparing memantine hydrochloride substantially free of !mpurities

Country Status (1)

Country Link
WO (1) WO2009153806A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102531919A (en) * 2011-11-09 2012-07-04 广东肇庆星湖生物科技股份有限公司 Preparation method of memantinehydrochloride
CN106946713A (en) * 2017-03-13 2017-07-14 张家港九力新材料科技有限公司 A kind of preparation method of memantine
CN111233670A (en) * 2020-03-09 2020-06-05 四川尚锐生物医药有限公司 Memantine hydrochloride impurity compound and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009057140A2 (en) * 2007-10-30 2009-05-07 Msn Laboratories Limited Improved process for memantine hydrochloride

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009057140A2 (en) * 2007-10-30 2009-05-07 Msn Laboratories Limited Improved process for memantine hydrochloride

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Disclosed Anonymously: Novel Polymorphic Form of Memantine Hydrochloride, Process for Preparation and Pharmaceutical Compositions thereof", IP.COM ELECTRONIC PUBLICATION IPCOM00159896D, 2 November 2007 (2007-11-02) *
REDDY ET AL: "An Improved Synthesis of Memantine Hydroyhloride: Anti-Alzheimer's Drug", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 11, 15 February 2007 (2007-02-15), pages 268 - 269 *

Also Published As

Publication number Publication date
WO2009153806A2 (en) 2009-12-23

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