WO2009153569A3 - Cb1 receptor modulators - Google Patents

Cb1 receptor modulators Download PDF

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Publication number
WO2009153569A3
WO2009153569A3 PCT/GB2009/001539 GB2009001539W WO2009153569A3 WO 2009153569 A3 WO2009153569 A3 WO 2009153569A3 GB 2009001539 W GB2009001539 W GB 2009001539W WO 2009153569 A3 WO2009153569 A3 WO 2009153569A3
Authority
WO
WIPO (PCT)
Prior art keywords
ring
alkyl
hydrogen
specified
cycloalkyl
Prior art date
Application number
PCT/GB2009/001539
Other languages
French (fr)
Other versions
WO2009153569A2 (en
Inventor
Anthony Murray
Thomas Hoegberg
Martin Cooper
Emelie Bjurling
Jean-Marie Receveur
Pia Karina Noerregaard
Original Assignee
7Tm Pharma A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 7Tm Pharma A/S filed Critical 7Tm Pharma A/S
Publication of WO2009153569A2 publication Critical patent/WO2009153569A2/en
Publication of WO2009153569A3 publication Critical patent/WO2009153569A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compounds of formula (I) suppress the normal signalling activity of cannabinoid receptor CB1 and are therefore useful inter alia in the treatment of conditions directly or indirectly associated with obesity and overweight, Wherein A1 is -COOH or tetrazolyl; R2, R3, R'2 and R'3 are independently selected from -R9, - CN, -F1 -Cl, -Br, -OR9, or -SR9; R9 is hydrogen, C1-C3 alkyl, cycloalkyl, or fully or partially fluorinated C1-C3 alkyl; R1 is (i) a bond, or (H) -C(R10)(R11)-*. -C(R10)(R11)-O-*. -C(R10)(R11)CH2*, or -CH2C(R10)(R11)-*, wherein the bond indicated by an asterisk is attached to Ring A ring; R10 is hydrogen and R11 is hydrogen, (C1-C3)alkyl or -OH; or R10 and R11 are both (C1-C3)alkyl; or R10 and R11 taken together with the carbon atom to which they are attached form a (C3-C5)cycloalkyl ring; Ring A is an aromatic ring as specified in the claims; Z1 is a moncyclic group as specified in the claims.
PCT/GB2009/001539 2008-06-18 2009-06-18 Cb1 receptor modulators WO2009153569A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0811212.0 2008-06-18
GBGB0811212.0A GB0811212D0 (en) 2008-06-18 2008-06-18 CB1 Receptor Modulators

Publications (2)

Publication Number Publication Date
WO2009153569A2 WO2009153569A2 (en) 2009-12-23
WO2009153569A3 true WO2009153569A3 (en) 2010-02-04

Family

ID=39672526

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/001539 WO2009153569A2 (en) 2008-06-18 2009-06-18 Cb1 receptor modulators

Country Status (2)

Country Link
GB (1) GB0811212D0 (en)
WO (1) WO2009153569A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3206683A4 (en) 2014-10-16 2018-06-13 The Board of Trustees of the Leland Stanford Junior University Novel methods, compounds, and compositions for anesthesia
EP3456716A4 (en) * 2016-05-09 2019-11-06 Nippon Soda Co., Ltd. Ring-shaped amine compound and pest control agent

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006133926A1 (en) * 2005-06-17 2006-12-21 Carex Sa Pyrazole derivates as cannabinoid receptor modulators

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006133926A1 (en) * 2005-06-17 2006-12-21 Carex Sa Pyrazole derivates as cannabinoid receptor modulators

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HOGENAUER E K: "Latest advances in the cannabinoids", EXPERT OPINION ON THERAPEUTIC PATENTS, INFORMA HEALTHCARE, GB, vol. 17, no. 12, 1 December 2007 (2007-12-01), pages 1457 - 1476, XP002517654, ISSN: 1354-3776 *

Also Published As

Publication number Publication date
GB0811212D0 (en) 2008-07-23
WO2009153569A2 (en) 2009-12-23

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