WO2009152340A3 - Use of 2,3-substituted thiophenes for the treatment of lung inflammation - Google Patents

Use of 2,3-substituted thiophenes for the treatment of lung inflammation Download PDF

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Publication number
WO2009152340A3
WO2009152340A3 PCT/US2009/047051 US2009047051W WO2009152340A3 WO 2009152340 A3 WO2009152340 A3 WO 2009152340A3 US 2009047051 W US2009047051 W US 2009047051W WO 2009152340 A3 WO2009152340 A3 WO 2009152340A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
substituted thiophenes
lung inflammation
thiophenes
substituted
Prior art date
Application number
PCT/US2009/047051
Other languages
French (fr)
Other versions
WO2009152340A2 (en
Inventor
Andrew Garton
Neil Gibson
Graeme Griffin
Original Assignee
Osi Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osi Pharmaceuticals, Inc. filed Critical Osi Pharmaceuticals, Inc.
Publication of WO2009152340A2 publication Critical patent/WO2009152340A2/en
Publication of WO2009152340A3 publication Critical patent/WO2009152340A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methods of treating inflammatory lung conditions comprising administering 2,3- substituted thiophenes of the formula (I).
PCT/US2009/047051 2008-06-12 2009-06-11 2,3-substituted thiophenes in lung inflammation therapies WO2009152340A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6088808P 2008-06-12 2008-06-12
US61/060,888 2008-06-12

Publications (2)

Publication Number Publication Date
WO2009152340A2 WO2009152340A2 (en) 2009-12-17
WO2009152340A3 true WO2009152340A3 (en) 2011-04-28

Family

ID=40887204

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/047051 WO2009152340A2 (en) 2008-06-12 2009-06-11 2,3-substituted thiophenes in lung inflammation therapies

Country Status (1)

Country Link
WO (1) WO2009152340A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000067794A1 (en) * 1999-05-06 2000-11-16 The Trustees Of Columbia University In The City Of New York Methods for inhibiting cutaneous inflammation and hyperpigmentation
US20050154014A1 (en) * 2003-01-06 2005-07-14 Jason Bloxham (2-carboxamido)(3-amino) thiophene compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000067794A1 (en) * 1999-05-06 2000-11-16 The Trustees Of Columbia University In The City Of New York Methods for inhibiting cutaneous inflammation and hyperpigmentation
US20050154014A1 (en) * 2003-01-06 2005-07-14 Jason Bloxham (2-carboxamido)(3-amino) thiophene compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GARTON ANDREW J ET AL: "OSI-930: a novel selective inhibitor of Kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models", CANCER RESEARCH 15 JAN 2006,, vol. 66, no. 2, 15 January 2006 (2006-01-15), pages 1015 - 1024, XP002530042 *
REBER L ET AL: "Stem cell factor and its receptor c-Kit as targets for inflammatory diseases", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER BV, NL, vol. 533, no. 1-3, 8 March 2006 (2006-03-08), pages 327 - 340, XP025169607, ISSN: 0014-2999, [retrieved on 20060308] *

Also Published As

Publication number Publication date
WO2009152340A2 (en) 2009-12-17

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