WO2009150526A3 - Photothermal detection system - Google Patents

Photothermal detection system Download PDF

Info

Publication number
WO2009150526A3
WO2009150526A3 PCT/IB2009/005935 IB2009005935W WO2009150526A3 WO 2009150526 A3 WO2009150526 A3 WO 2009150526A3 IB 2009005935 W IB2009005935 W IB 2009005935W WO 2009150526 A3 WO2009150526 A3 WO 2009150526A3
Authority
WO
WIPO (PCT)
Prior art keywords
optical path
laser beam
sample
heating
photothermal
Prior art date
Application number
PCT/IB2009/005935
Other languages
French (fr)
Other versions
WO2009150526A2 (en
Inventor
Herman Pieter Spaink
Thomas Schmidt
Michel Alain Gaston Julien Orrit
Florian Markus Kulzer
Original Assignee
Universiteit Leiden
Stichting Voor De Technische Wetenschappen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universiteit Leiden, Stichting Voor De Technische Wetenschappen filed Critical Universiteit Leiden
Publication of WO2009150526A2 publication Critical patent/WO2009150526A2/en
Publication of WO2009150526A3 publication Critical patent/WO2009150526A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/171—Systems in which incident light is modified in accordance with the properties of the material investigated with calorimetric detection, e.g. with thermal lens detection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/1452—Adjustment of focus; Alignment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/171—Systems in which incident light is modified in accordance with the properties of the material investigated with calorimetric detection, e.g. with thermal lens detection
    • G01N2021/1712—Thermal lens, mirage effect

Abstract

A photothermal system for performing high throughput single particle detection, the system comprising: a first optical path for directing a probe laser beam (PB) and a heating laser beam (MHB) towards a target or sample area (62); and a second optical path for directing the probe laser beam from the sample to a detector for detecting phase changes (ΔΦ) induced in the probe beam (PB) by the photothermal effect due to local heating of the sample by the heating beam (MHB), wherein the first optical path includes one or more optical elements (60a, 60b) arranged to define a detection volume of more than 10 femtolitres.
PCT/IB2009/005935 2008-06-13 2009-06-15 Photothermal detection system WO2009150526A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0810893A GB0810893D0 (en) 2008-06-13 2008-06-13 Photothermal detection system
GB0810893.8 2008-06-13

Publications (2)

Publication Number Publication Date
WO2009150526A2 WO2009150526A2 (en) 2009-12-17
WO2009150526A3 true WO2009150526A3 (en) 2010-02-25

Family

ID=39672272

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/005935 WO2009150526A2 (en) 2008-06-13 2009-06-15 Photothermal detection system

Country Status (2)

Country Link
GB (1) GB0810893D0 (en)
WO (1) WO2009150526A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2732263A1 (en) * 2011-07-13 2014-05-21 Universität Leipzig Twin-focus photothermal correlation spectroscopy method and device for the characterization of dynamical processes in liquids and biomaterials with the help of absorbing markers

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004025278A1 (en) * 2002-09-13 2004-03-25 Centre National De La Recherche Scientifique (C.N.R.S) Photothermal imaging of immersed tiny metal particles
WO2006013272A2 (en) * 2004-07-07 2006-02-09 Centre National De La Recherche Scientifique (C.N.R.S.) Method and system for optical detection of nano-objects in a light refracting medium

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004025278A1 (en) * 2002-09-13 2004-03-25 Centre National De La Recherche Scientifique (C.N.R.S) Photothermal imaging of immersed tiny metal particles
WO2006013272A2 (en) * 2004-07-07 2006-02-09 Centre National De La Recherche Scientifique (C.N.R.S.) Method and system for optical detection of nano-objects in a light refracting medium

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BELENKII ET AL: "Use of laser detectors in capillary liquid chromatography", JOURNAL OF CHROMATOGRAPHY B : BIOMEDICAL APPLICATIONS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 434, no. 2, 30 December 1988 (1988-12-30), pages 337 - 361, XP026213152, ISSN: 0378-4347, [retrieved on 19881230] *
BRUSNISCHKIN ET AL.: "photothermal lens detection of gold nanoparticles", APPLIED SPECTROSCOPY, vol. 61, no. 11, 2007, pages 1191 - 1201, XP002549323 *
CARTER C A ET AL: "Thermal lens absorption measurements on small volume samples", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 56, no. 6, 1 May 1984 (1984-05-01), pages 922 - 925, XP008113055, ISSN: 0003-2700 *
GHALEB K A ET AL: "Photothermal spectrometry for detection in miniaturized systems: relevant features, strategies and recent applications", SPECTROCHIMICA ACTA. PART A: MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, ELSEVIER, AMSTERDAM, NL, vol. 60, no. 12, 1 October 2004 (2004-10-01), pages 2793 - 2801, XP004553512, ISSN: 1386-1425 *
KULZER ET AL: "Photothermal detection of individual gold nanoparticles", CHEMPHYSCHEM, no. 9, 2008 - 30 July 2008 (2008-07-30), pages 1761 - 1766, XP002549325 *
MAWATARI ET AL.: "Functional thermal lens microscopes for ultrasensitive analysis of non fluorescent molecules and microchip chemistry", PROC OF SPIE, vol. 6343, 2006, pages 63430C-1 - 63430C-7, XP002549324 *
PROSKURNIN ET AL.: "optimisation of thermal lens microscopic measurements in a microchip", ANALYTICA CHIMICA ACTA, no. 480, 2003, pages 79 - 95, XP002549322 *
TAMAKI E ET AL: "Microchannel-assisted thermal-lens spectrometry for microchip analysis", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 987, no. 1-2, 14 February 2003 (2003-02-14), pages 197 - 204, XP004405820, ISSN: 0021-9673 *

Also Published As

Publication number Publication date
WO2009150526A2 (en) 2009-12-17
GB0810893D0 (en) 2008-07-23

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