WO2009145874A1 - Container having vortex breaker and system - Google Patents
Container having vortex breaker and system Download PDFInfo
- Publication number
- WO2009145874A1 WO2009145874A1 PCT/US2009/003075 US2009003075W WO2009145874A1 WO 2009145874 A1 WO2009145874 A1 WO 2009145874A1 US 2009003075 W US2009003075 W US 2009003075W WO 2009145874 A1 WO2009145874 A1 WO 2009145874A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- container
- outlet
- vortex breaker
- fluid
- walls
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/26—Constructional details, e.g. recesses, hinges flexible
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/02—Means for regulation, monitoring, measurement or control, e.g. flow regulation of foam
Definitions
- This invention relates to a disposable container having a vortex breaker at its outlet and to a system utilizing the container.
- a disposable container for a fluid having an inlet and an outlet having a device for minimizing or preventing foaming of fluid at the outlet.
- a system is also provided that utilizes the container with a unit operation down stream of the container such as a normal flow filtration (NFF) unit or the like whereby treated fluid is recovered.
- the effluent from the container can be directed through clarification depth filters, pre- filters or microporous membrane filters. Examples of specific unit operations include clarification, buffer and media preparation and virus removal.
- the outlet is provided with a vortex breaker comprising a solid surface that initially directs fluid away from the outlet. Openings are provided adjacent the solid surface which permits fluid to enter the outlet. The initial direction of fluid away from the outlet minimizes or prevents the formation of one or more vortices at the outlet.
- Figure 1 is a schematic view of a system of this invention.
- Figure 2 is a perspective view of a vortex breaker positioned adjacent an outlet of the container of this invention.
- the disposable container of this invention is formed of monolayer or multilayer flexible walls formed of a polymeric composition such as polyethylene, including ultrahigh molecular weight polyethylene, linear low density polyethylene, low density or medium density polyethylene; polypropylene; ethylene vinyl acetate (EVOH); polyvinyl chloride (PVC); polyvinyl acetate (PVA); ethylene vinyl acetate copolymers (EVA copolymers); blends of various thermoplastics; coextrusions of different thermoplastics; multilayered laminates of different thermoplastics; or the like.
- polyethylene including ultrahigh molecular weight polyethylene, linear low density polyethylene, low density or medium density polyethylene; polypropylene; ethylene vinyl acetate (EVOH); polyvinyl chloride (PVC); polyvinyl acetate (PVA); ethylene vinyl acetate copolymers (EVA copolymers); blends of various thermoplastics; coextrusions of different thermoplastics; multilayered laminates of different thermoplastics; or the like.
- the container is provided with an inlet, and an outlet.
- the outlet is provided with a vortex breaker positioned adjacent the outlet and secured to the inside surface of the container such as by heat sealing or with an adhesive.
- the vortex breaker can be molded into the outlet structure.
- the disposable container is positioned within a solid support container for ease of filling and emptying the container of fluid.
- the container of this invention 10 having inlet 9 and containing fluid 12 includes a vortex breaker 14 secured to the inner surface 16 of the container 10 at outlet 11.
- a pump 18 is provided to direct the fluid 12 through the outlet 11 to a downstream unit operation such as a filtration unit 20 as shown.
- An example of a process utilized with the system of this invention is the production of proteins derived from growing cells which are lysed to release cellular protein. The protein then is isolated by filtration to separate cell debris from the protein. The filtrate is directed through conduit 22 to a point of use or to be further treated.
- a vortex breaker 30 of this invention is shown.
- the vortex breaker comprises a solid surface 32 that can be any shape including circular, as shown or polygonal.
- the base 34 is sealed to the inner wall 16 of container 10.
- the vortex breaker 30 is positioned adjacent outlet 11.
- the solid surface 32 is supported by supports 36 attached to solid surface 32 and base 34.
- the vortex breaker 30 initially causes fluid to be directed away from outlet 11 as indicated by arrows 38 and 40 and then is directed to outlet 11 through the spaces between supports 36 as indicated by arrows 37 and 39. By operating with this vortex breaker, formation of vortices is minimized or prevented.
- the vortex breaker may also be formed as part of the outlet 11.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Closures For Containers (AREA)
- Details Of Rigid Or Semi-Rigid Containers (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009801199363A CN102046772A (en) | 2008-05-30 | 2009-05-18 | Container having vortex breaker and system |
JP2011511606A JP2011521857A (en) | 2008-05-30 | 2009-05-18 | Vessel and system with vortex breaker |
ES09755237.6T ES2532631T3 (en) | 2008-05-30 | 2009-05-18 | Container that has a vortex breaker and system |
EP09755237.6A EP2279239B1 (en) | 2008-05-30 | 2009-05-18 | Container having vortex breaker and system |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13034908P | 2008-05-30 | 2008-05-30 | |
US61/130,349 | 2008-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009145874A1 true WO2009145874A1 (en) | 2009-12-03 |
Family
ID=40756493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/003075 WO2009145874A1 (en) | 2008-05-30 | 2009-05-18 | Container having vortex breaker and system |
Country Status (6)
Country | Link |
---|---|
US (1) | US9290729B2 (en) |
EP (1) | EP2279239B1 (en) |
JP (2) | JP2011521857A (en) |
CN (1) | CN102046772A (en) |
ES (1) | ES2532631T3 (en) |
WO (1) | WO2009145874A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014072010A1 (en) * | 2012-11-12 | 2014-05-15 | Sartorius Stedim Biotech Gmbh | Container with a device for preventing foam formation and method for producing said device |
US11952207B2 (en) | 2020-12-02 | 2024-04-09 | Krones Ag | Product tank and device for filling a container with a filling product |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8376608B2 (en) * | 2011-04-11 | 2013-02-19 | Israel Harry Zimmerman | Energy-saving static stirring apparatus for automatically stirring a fluid |
CN103318864A (en) * | 2013-06-21 | 2013-09-25 | 江苏绿陵润发化工有限公司 | Ammonium phosphate flash evaporation chamber improved structure |
CN104014148B (en) * | 2014-05-09 | 2016-05-11 | 江苏嘉泰蒸发结晶设备有限公司 | The anti-whirlpool device of separator |
BR112018014583A2 (en) | 2016-01-22 | 2018-12-11 | Saint Gobain Performance Plastics Corp | fluid mixing system |
FR3081167B1 (en) * | 2018-05-17 | 2020-06-12 | IFP Energies Nouvelles | DEVICE FOR LIMITING VORTEX AND SOLID DEPOSITS |
KR102236208B1 (en) * | 2020-11-24 | 2021-04-05 | 주식회사 위드앤티 | Vortex breaker and reactor using this |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0460804A1 (en) | 1990-06-06 | 1991-12-11 | United Kingdom Atomic Energy Authority | A method of mixing a liquid and solids and apparatus therefor |
US20010051371A1 (en) | 1998-02-27 | 2001-12-13 | Dale Vilmer Kiplinger | Automated biogenerator |
US20040062140A1 (en) * | 2002-09-27 | 2004-04-01 | Cadogan David Phillip | Bioprocess container, bioprocess container mixing device and method of use thereof |
Family Cites Families (27)
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US969997A (en) | 1909-11-08 | 1910-09-13 | Louis Thiem | Automatic cistern-cleaner. |
US2917131A (en) | 1955-04-11 | 1959-12-15 | Shell Dev | Cyclone separator |
FR2213904B2 (en) | 1973-01-15 | 1978-02-24 | Muller Jacques | |
JPS5715192Y2 (en) * | 1973-12-03 | 1982-03-29 | ||
JPS51145646U (en) * | 1975-05-17 | 1976-11-22 | ||
JPS52149270A (en) | 1976-06-07 | 1977-12-12 | Nippon Zeon Co Ltd | Equipment for mass transfer of hollow fiber type |
US4394966A (en) * | 1978-05-09 | 1983-07-26 | Snyder Industries, Inc. | Spraying apparatus having a fluid storage tank with agitator and anti-vortex tank fittings |
FI64295C (en) * | 1982-04-28 | 1983-11-10 | Santasalo Sohlberg Ab Oy | FOERVARINGSTANK FOER DESTILLERAT VATTEN |
US4696741A (en) | 1986-04-18 | 1987-09-29 | Phillips Petroleum Company | Vortex breaker for use in a liquid-liquid separator or the like |
US5229292A (en) * | 1986-07-28 | 1993-07-20 | Stine Seed Farm, Inc. | Biological control of insects using pseudomonas strains transformed with bacillus thuringiensis insect toxingene |
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US5096578A (en) | 1990-08-15 | 1992-03-17 | Texaco Inc. | Vortex breaker for horizontal liquid draw off tray sump |
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JP2540442B2 (en) * | 1993-10-21 | 1996-10-02 | 旭エンジニアリング株式会社 | Gas replacement device |
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DE19832823C1 (en) | 1998-07-21 | 1999-08-26 | Aesculap Ag & Co Kg | Filter holder for sterilizer container |
MY132497A (en) | 1999-03-26 | 2007-10-31 | Carlsberg Tetley Brewing Ltd | Beer dispenser |
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DE10221429A1 (en) | 2002-05-14 | 2003-12-04 | Siemens Ag | Intake pipe for an air intake system of an internal combustion engine |
US6739456B2 (en) | 2002-06-03 | 2004-05-25 | University Of Florida Research Foundation, Inc. | Apparatus and methods for separating particles |
US6983899B2 (en) * | 2002-12-31 | 2006-01-10 | Melendez Henry D | Handheld paint spraying apparatus with anti-sputter spray nozzle |
US6849182B2 (en) | 2003-05-14 | 2005-02-01 | Heron Innovators Inc. | Hydrocyclone having unconstrained vortex breaker |
US7157007B2 (en) * | 2003-06-20 | 2007-01-02 | National Tank Company | Vertical gas induced flotation cell |
-
2009
- 2009-05-18 US US12/454,461 patent/US9290729B2/en active Active
- 2009-05-18 CN CN2009801199363A patent/CN102046772A/en active Pending
- 2009-05-18 ES ES09755237.6T patent/ES2532631T3/en active Active
- 2009-05-18 EP EP09755237.6A patent/EP2279239B1/en active Active
- 2009-05-18 JP JP2011511606A patent/JP2011521857A/en not_active Abandoned
- 2009-05-18 WO PCT/US2009/003075 patent/WO2009145874A1/en active Application Filing
-
2015
- 2015-05-29 JP JP2015110494A patent/JP5876958B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0460804A1 (en) | 1990-06-06 | 1991-12-11 | United Kingdom Atomic Energy Authority | A method of mixing a liquid and solids and apparatus therefor |
US20010051371A1 (en) | 1998-02-27 | 2001-12-13 | Dale Vilmer Kiplinger | Automated biogenerator |
US20040062140A1 (en) * | 2002-09-27 | 2004-04-01 | Cadogan David Phillip | Bioprocess container, bioprocess container mixing device and method of use thereof |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014072010A1 (en) * | 2012-11-12 | 2014-05-15 | Sartorius Stedim Biotech Gmbh | Container with a device for preventing foam formation and method for producing said device |
US9493334B2 (en) | 2012-11-12 | 2016-11-15 | Sartorius Stedim Biotech Gmbh | Container having device for preventing foaming and method for producing the device |
US11952207B2 (en) | 2020-12-02 | 2024-04-09 | Krones Ag | Product tank and device for filling a container with a filling product |
Also Published As
Publication number | Publication date |
---|---|
JP5876958B2 (en) | 2016-03-02 |
EP2279239A1 (en) | 2011-02-02 |
CN102046772A (en) | 2011-05-04 |
JP2015163534A (en) | 2015-09-10 |
US20100012666A1 (en) | 2010-01-21 |
JP2011521857A (en) | 2011-07-28 |
ES2532631T3 (en) | 2015-03-30 |
US9290729B2 (en) | 2016-03-22 |
EP2279239B1 (en) | 2015-01-28 |
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