WO2009145434A3 - Cd70-expressing neural stem cells capable of inhibiting transplant immune responses and use thereof - Google Patents

Cd70-expressing neural stem cells capable of inhibiting transplant immune responses and use thereof Download PDF

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Publication number
WO2009145434A3
WO2009145434A3 PCT/KR2009/001600 KR2009001600W WO2009145434A3 WO 2009145434 A3 WO2009145434 A3 WO 2009145434A3 KR 2009001600 W KR2009001600 W KR 2009001600W WO 2009145434 A3 WO2009145434 A3 WO 2009145434A3
Authority
WO
WIPO (PCT)
Prior art keywords
immune responses
stem cells
neural stem
cells capable
expressing neural
Prior art date
Application number
PCT/KR2009/001600
Other languages
French (fr)
Korean (ko)
Other versions
WO2009145434A2 (en
Inventor
안규리
이은미
김재영
Original Assignee
한화석유화학 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한화석유화학 주식회사 filed Critical 한화석유화학 주식회사
Publication of WO2009145434A2 publication Critical patent/WO2009145434A2/en
Publication of WO2009145434A3 publication Critical patent/WO2009145434A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Abstract

The present invention relates to a composition for inhibiting immune responses to transplanted internal organs, tissues or cells including CD70-expressing neural stem cells, and a method for inhibiting immune responses of individuals using the composition.
PCT/KR2009/001600 2008-03-31 2009-03-30 Cd70-expressing neural stem cells capable of inhibiting transplant immune responses and use thereof WO2009145434A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0029700 2008-03-31
KR1020080029700A KR100963030B1 (en) 2008-03-31 2008-03-31 Cd70 expressing neuronal stem cells and their use for prevention of immune responses in transplantation

Publications (2)

Publication Number Publication Date
WO2009145434A2 WO2009145434A2 (en) 2009-12-03
WO2009145434A3 true WO2009145434A3 (en) 2010-02-18

Family

ID=41377703

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/001600 WO2009145434A2 (en) 2008-03-31 2009-03-30 Cd70-expressing neural stem cells capable of inhibiting transplant immune responses and use thereof

Country Status (2)

Country Link
KR (1) KR100963030B1 (en)
WO (1) WO2009145434A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106062196B (en) 2013-04-30 2020-01-21 建国大学校产业学校协力团 CMP-acetylneuraminic acid hydroxylase targeting vector, vector-transduced transgenic animal for xenotransplantation, and method for producing same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050082389A (en) * 2004-02-18 2005-08-23 메덱스젠 주식회사 Pharmaceutical composition for treatment of transplantation rejection comprising concatameric immunoadhesin
US20050191299A1 (en) * 2004-02-09 2005-09-01 The Cbr Institute For Biomedical Research, Inc. CD70 inhibition for the treatment and prevention of inflammatory bowel disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050191299A1 (en) * 2004-02-09 2005-09-01 The Cbr Institute For Biomedical Research, Inc. CD70 inhibition for the treatment and prevention of inflammatory bowel disease
KR20050082389A (en) * 2004-02-18 2005-08-23 메덱스젠 주식회사 Pharmaceutical composition for treatment of transplantation rejection comprising concatameric immunoadhesin

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BORST J. ET AL.: "CD27 and CD70 in T cell and B cell activation.", CURR OPIN IMMUNOL., vol. 17, no. 3, June 2005 (2005-06-01), pages 275 - 281 *
BOWMAN MR ET AL.: "The cloning of CD70 and its identification as the ligand for CD27.", J IMMUNOL., vol. 152, no. 4, 15 February 1994 (1994-02-15), pages 1756 - 1761 *
KOBATA T. ET AL.: "CD27-CD70 interactions regulate B-cell activation by T cells.", PROC NATL ACAD SCI U S A., vol. 92, no. 24, 21 November 1995 (1995-11-21), pages 11249 - 11253 *
VAN OOSTERWIJK MF ET AL.: "CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12- induced Th1 cell development.", INT IMMUNOL., vol. 19, no. 6, June 2007 (2007-06-01), pages 713 - 718 *
WENNERSTEN A ET AL.: "Sustained survival ofxenografted human neural stem/progenitor cells in experimental brain trauma despite discontinuation of immunosuppression.", EXP NEUROL., vol. 199, no. 2, June 2006 (2006-06-01), pages 339 - 347 *
WONG AM ET AL.: "Neural stem cell grafts reduce the extent of neuronal damage in a mouse model of global ischaemia.", BRAIN RES., vol. 1063, no. 2, 30 November 2005 (2005-11-30), pages 140 - 150 *

Also Published As

Publication number Publication date
KR100963030B1 (en) 2010-06-10
WO2009145434A2 (en) 2009-12-03
KR20090104328A (en) 2009-10-06

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