WO2009143495A3 - Saccharomyces cerevisiae strains for the overproduction of formate - Google Patents

Saccharomyces cerevisiae strains for the overproduction of formate Download PDF

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Publication number
WO2009143495A3
WO2009143495A3 PCT/US2009/045087 US2009045087W WO2009143495A3 WO 2009143495 A3 WO2009143495 A3 WO 2009143495A3 US 2009045087 W US2009045087 W US 2009045087W WO 2009143495 A3 WO2009143495 A3 WO 2009143495A3
Authority
WO
WIPO (PCT)
Prior art keywords
formate
overproduction
saccharomyces cerevisiae
cerevisiae strains
engineered yeast
Prior art date
Application number
PCT/US2009/045087
Other languages
French (fr)
Other versions
WO2009143495A2 (en
WO2009143495A8 (en
Inventor
Zeev Waks
Pamela Silver
Original Assignee
President And Fellows Of Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by President And Fellows Of Harvard College filed Critical President And Fellows Of Harvard College
Publication of WO2009143495A2 publication Critical patent/WO2009143495A2/en
Publication of WO2009143495A3 publication Critical patent/WO2009143495A3/en
Publication of WO2009143495A8 publication Critical patent/WO2009143495A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides engineered yeast and methods for increasing production of formate, a hydrogen precursor. Moreover, the engineered yeast and methods provided herein produce another valuable compound, ethanol, as a byproduct.
PCT/US2009/045087 2008-05-22 2009-05-22 Fast-growing yeast WO2009143495A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12850008P 2008-05-22 2008-05-22
US61/128,500 2008-05-22

Publications (3)

Publication Number Publication Date
WO2009143495A2 WO2009143495A2 (en) 2009-11-26
WO2009143495A3 true WO2009143495A3 (en) 2010-01-21
WO2009143495A8 WO2009143495A8 (en) 2010-03-18

Family

ID=41211207

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/045087 WO2009143495A2 (en) 2008-05-22 2009-05-22 Fast-growing yeast

Country Status (1)

Country Link
WO (1) WO2009143495A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8999683B2 (en) 2010-06-18 2015-04-07 Technical University Of Denmark Production of biodiesel by yeast from lignocellulose and glycerol
BR112012032279A2 (en) * 2010-06-18 2018-08-28 Univ Denmark Tech Dtu biodiesel production by yeast from lignocellulose and glycerol
ES2532508T3 (en) * 2010-11-18 2015-03-27 Dsm Ip Assets B.V. Yeast strains manipulated to produce ethanol from glycerol
EP2532733B1 (en) * 2011-06-06 2015-01-14 Commissariat à l'Énergie Atomique et aux Énergies Alternatives A method for enhancing the fermentative poteltial and growth rate of microorganisms under anaerobiosis
WO2013033097A1 (en) * 2011-08-29 2013-03-07 Gevo, Inc. Alteration of the nadh/nad+ ratio to increase flux through nadh-dependent pathways
WO2014057008A1 (en) 2012-10-09 2014-04-17 Chalmers Intellectual Property Rights Ab Engineering of acetyl-coenzyme a metabolism in yeast
CA2920114A1 (en) * 2013-08-15 2015-02-19 Lallemand Hungary Liquidity Management Llc Methods for the improvement of product yield and production in a microorganism through glycerol recycling

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008063650A2 (en) * 2006-11-20 2008-05-29 President And Fellows Of Harvard College Systems of hydrogen and formic acid production in yeast

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008063650A2 (en) * 2006-11-20 2008-05-29 President And Fellows Of Harvard College Systems of hydrogen and formic acid production in yeast

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JENS RUPPRECHT ET AL: "Perspectives and advances of biological H2 production in microorganisms", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 72, no. 3, 5 August 2006 (2006-08-05), pages 442 - 449, XP019422082, ISSN: 1432-0614 *
NATH K ET AL: "Improvement of fermentative hydrogen production: Various approaches", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY OCTOBER 2004 SPRINGER VERLAG DE, vol. 65, no. 5, October 2004 (2004-10-01), pages 520 - 529, XP002553358 *
WAKS ZEEV ET AL: "Engineering a Synthetic Dual-Organism System for Hydrogen Production", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 75, no. 7, April 2009 (2009-04-01), pages 1867 - 1875, XP002553357, ISSN: 0099-2240 *

Also Published As

Publication number Publication date
WO2009143495A2 (en) 2009-11-26
WO2009143495A8 (en) 2010-03-18

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