WO2009141090A1 - {f-19} -labeled l-glutamic acid and l-glutamine derivative (iii), use thereof and method for obtaining them - Google Patents
{f-19} -labeled l-glutamic acid and l-glutamine derivative (iii), use thereof and method for obtaining them Download PDFInfo
- Publication number
- WO2009141090A1 WO2009141090A1 PCT/EP2009/003419 EP2009003419W WO2009141090A1 WO 2009141090 A1 WO2009141090 A1 WO 2009141090A1 EP 2009003419 W EP2009003419 W EP 2009003419W WO 2009141090 A1 WO2009141090 A1 WO 2009141090A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- branched
- unbranched
- alkyl
- compound
- general formula
- Prior art date
Links
- IOGDZLCPHHWGSJ-UHFFFAOYSA-N NC(CC(CF)C(N)=O)C(O)=O Chemical compound NC(CC(CF)C(N)=O)C(O)=O IOGDZLCPHHWGSJ-UHFFFAOYSA-N 0.000 description 1
- GYXWJFPCEJLQTR-UHFFFAOYSA-N NC(CC(CF)C(O)=O)C(O)=O Chemical compound NC(CC(CF)C(O)=O)C(O)=O GYXWJFPCEJLQTR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/992,956 US20110064673A1 (en) | 2008-05-20 | 2009-05-14 | New L-Glutamic acid and L-Glutamine derivative (III), use thereof and method for obtaining them |
CA2723594A CA2723594A1 (en) | 2008-05-20 | 2009-05-14 | {f-19}-labeled l-glutamic acid and l-glutamine derivative (iii), use thereof and method for obtaining them |
CN2009801185407A CN102083773A (en) | 2008-05-20 | 2009-05-14 | {F-19} -labeled L-glutamic acid and L-glutamine derivative (III), use thereof and method for obtaining them |
JP2011509883A JP2011520931A (en) | 2008-05-20 | 2009-05-14 | {F-19} -labeled L-glutamic acid and L-glutamine derivative (III), their use and method for obtaining them |
EP09749580A EP2282981A1 (en) | 2008-05-20 | 2009-05-14 | {f-19} -labeled l-glutamic acid and l-glutamine derivative (iii), use thereof and method for obtaining them |
US14/257,431 US20140227191A1 (en) | 2008-05-20 | 2014-04-21 | L-glutamic acid and l-glutamine derivative (iii), use thereof and method for obtaining them |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08075509A EP2123620A1 (en) | 2008-05-20 | 2008-05-20 | {F-19}-labeled L-Glutamic acid and L-Glutamine derivative (III), use thereof and method for obtaining them |
EP08075509.3 | 2008-05-20 | ||
DE08075509.3 | 2008-05-20 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/992,956 A-371-Of-International US20110064673A1 (en) | 2008-05-20 | 2009-05-14 | New L-Glutamic acid and L-Glutamine derivative (III), use thereof and method for obtaining them |
US14/257,431 Continuation US20140227191A1 (en) | 2008-05-20 | 2014-04-21 | L-glutamic acid and l-glutamine derivative (iii), use thereof and method for obtaining them |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2009141090A1 true WO2009141090A1 (en) | 2009-11-26 |
WO2009141090A9 WO2009141090A9 (en) | 2010-03-25 |
WO2009141090A8 WO2009141090A8 (en) | 2010-10-28 |
Family
ID=39967400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2009/003419 WO2009141090A1 (en) | 2008-05-20 | 2009-05-14 | {f-19} -labeled l-glutamic acid and l-glutamine derivative (iii), use thereof and method for obtaining them |
Country Status (11)
Country | Link |
---|---|
US (2) | US20110064673A1 (en) |
EP (2) | EP2123620A1 (en) |
JP (1) | JP2011520931A (en) |
KR (1) | KR20110013411A (en) |
CN (1) | CN102083773A (en) |
AR (1) | AR073844A1 (en) |
CA (1) | CA2723594A1 (en) |
PE (1) | PE20091926A1 (en) |
TW (1) | TW201010733A (en) |
UY (1) | UY31834A (en) |
WO (1) | WO2009141090A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011060887A3 (en) * | 2009-11-17 | 2012-04-12 | Bayer Pharma Aktiengesellschaft | Method for production of f-18 labeled glutamic acid derivatives |
EP2520557A1 (en) * | 2011-05-03 | 2012-11-07 | Bayer Pharma Aktiengesellschaft | Novel precursors of glutamate derivatives |
EP2520556A1 (en) | 2011-05-03 | 2012-11-07 | Bayer Pharma Aktiengesellschaft | Radiolabeled amino acids for diagnostic imaging |
US8747809B2 (en) | 2009-08-14 | 2014-06-10 | The Trustees Of The University Of Pennsylvania | Single diastereomers of 4-fluoroglutamine and methods of their preparation and use |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA017713B1 (en) | 2006-11-01 | 2013-02-28 | Байер Шеринг Фарма Акциенгезельшафт | [f-18]-labeled l-glutamic acid, [f-18]-labeled l-glutamine, derivatives thereof and use thereof and processes for their preparation |
EP2123621A1 (en) | 2008-05-20 | 2009-11-25 | Bayer Schering Pharma Aktiengesellschaft | New [F-18]-marked L-glutamic acids and L-glutamic acid derivatives (1), application thereof and method for their manufacture |
EP2322171A3 (en) * | 2009-11-17 | 2011-06-01 | Bayer Schering Pharma Aktiengesellschaft | Fluorine labeled L-glutamic acid derivatives |
CN103333079B (en) * | 2013-07-03 | 2016-08-17 | 广东回旋医药科技股份有限公司 | Imino group acids PET developer and preparation method and application |
CN109467514B (en) * | 2018-11-15 | 2020-11-24 | 西北师范大学 | Synthetic method of alpha-amino-gamma-carbonyl pimelate compound |
CN109369445B (en) * | 2018-11-20 | 2021-10-15 | 首都医科大学 | Radioactive glutamine derivatives for diagnosis and treatment and process for preparing the same |
EP3888471A4 (en) * | 2018-12-18 | 2021-12-22 | Peng, Xianfeng | Application of glutamine derivative in preparation of animal feed additive |
WO2021011492A1 (en) * | 2019-07-12 | 2021-01-21 | University Of Mississippi | L-y-methyleneglutamine compounds and methods of use |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008052788A1 (en) * | 2006-11-01 | 2008-05-08 | Bayer Schering Pharma Aktiengesellschaft | [f-18]-labeled l-glutamic acid, [f-18]-labeled l-glutamine, derivatives thereof and use thereof and processes for their preparation |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9324872D0 (en) * | 1993-12-03 | 1994-01-19 | Univ Pasteur | Pharmaceutical compounds |
US5721265A (en) * | 1994-08-05 | 1998-02-24 | Sri International | Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells |
AU2001278945A1 (en) * | 2000-08-10 | 2002-02-25 | Eli Lilly And Company | 4-substituted d-glutamic acid derivatives for use as antibiotic |
AU2001288658A1 (en) * | 2000-09-01 | 2002-03-13 | Annovis, Inc. | Screen for glutamate reuptake inhibitors, stimulators, and modulators |
KR20050033067A (en) * | 2002-08-02 | 2005-04-08 | 말린크로트, 인코포레이티드 | Radioactively labelled amino acid analogues, their preparation and use |
US7483732B2 (en) * | 2004-04-15 | 2009-01-27 | Boston Scientific Scimed, Inc. | Magnetic resonance imaging of a medical device and proximate body tissue |
WO2007001940A2 (en) * | 2005-06-23 | 2007-01-04 | Emory University | Imaging agents |
-
2008
- 2008-05-20 EP EP08075509A patent/EP2123620A1/en not_active Withdrawn
-
2009
- 2009-05-14 US US12/992,956 patent/US20110064673A1/en not_active Abandoned
- 2009-05-14 EP EP09749580A patent/EP2282981A1/en not_active Withdrawn
- 2009-05-14 CA CA2723594A patent/CA2723594A1/en not_active Abandoned
- 2009-05-14 CN CN2009801185407A patent/CN102083773A/en active Pending
- 2009-05-14 JP JP2011509883A patent/JP2011520931A/en active Pending
- 2009-05-14 WO PCT/EP2009/003419 patent/WO2009141090A1/en active Application Filing
- 2009-05-14 KR KR1020107025996A patent/KR20110013411A/en not_active Application Discontinuation
- 2009-05-20 UY UY0001031834A patent/UY31834A/en not_active Application Discontinuation
- 2009-05-20 AR ARP090101804A patent/AR073844A1/en unknown
- 2009-05-20 PE PE2009000708A patent/PE20091926A1/en not_active Application Discontinuation
- 2009-05-20 TW TW098116728A patent/TW201010733A/en unknown
-
2014
- 2014-04-21 US US14/257,431 patent/US20140227191A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008052788A1 (en) * | 2006-11-01 | 2008-05-08 | Bayer Schering Pharma Aktiengesellschaft | [f-18]-labeled l-glutamic acid, [f-18]-labeled l-glutamine, derivatives thereof and use thereof and processes for their preparation |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8747809B2 (en) | 2009-08-14 | 2014-06-10 | The Trustees Of The University Of Pennsylvania | Single diastereomers of 4-fluoroglutamine and methods of their preparation and use |
WO2011060887A3 (en) * | 2009-11-17 | 2012-04-12 | Bayer Pharma Aktiengesellschaft | Method for production of f-18 labeled glutamic acid derivatives |
EP2520557A1 (en) * | 2011-05-03 | 2012-11-07 | Bayer Pharma Aktiengesellschaft | Novel precursors of glutamate derivatives |
EP2520556A1 (en) | 2011-05-03 | 2012-11-07 | Bayer Pharma Aktiengesellschaft | Radiolabeled amino acids for diagnostic imaging |
WO2012150204A1 (en) * | 2011-05-03 | 2012-11-08 | Bayer Pharma Aktiengesellschaft | Novel precursors of glutamate derivatives |
WO2012150220A1 (en) | 2011-05-03 | 2012-11-08 | Bayer Pharma Aktiengesellschaft | Radiolabeled amino acids for diagnostic imaging |
CN103827057A (en) * | 2011-05-03 | 2014-05-28 | 皮拉莫尔影像股份公司 | Radiolabeled amino acids for diagnostic imaging |
JP2014519489A (en) * | 2011-05-03 | 2014-08-14 | ピラマル イメージング ソシエテ アノニム | Radiolabeled amino acids for diagnostic imaging |
US9000037B2 (en) | 2011-05-03 | 2015-04-07 | Piramal Imaging Sa | Precursors of glutamate derivatives |
US9238631B2 (en) | 2011-05-03 | 2016-01-19 | Piramal Imaging Sa | Radiolabeled amino acids for diagnostic imaging |
RU2600981C2 (en) * | 2011-05-03 | 2016-10-27 | Пирамаль Имэджинг Са | Novel precursors of glutamate derivatives |
Also Published As
Publication number | Publication date |
---|---|
UY31834A (en) | 2010-01-05 |
EP2123620A1 (en) | 2009-11-25 |
AR073844A1 (en) | 2010-12-09 |
PE20091926A1 (en) | 2010-01-24 |
TW201010733A (en) | 2010-03-16 |
US20140227191A1 (en) | 2014-08-14 |
JP2011520931A (en) | 2011-07-21 |
KR20110013411A (en) | 2011-02-09 |
CA2723594A1 (en) | 2009-11-26 |
CN102083773A (en) | 2011-06-01 |
EP2282981A1 (en) | 2011-02-16 |
WO2009141090A8 (en) | 2010-10-28 |
WO2009141090A9 (en) | 2010-03-25 |
US20110064673A1 (en) | 2011-03-17 |
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