WO2009140743A3 - Blood imaging - Google Patents

Blood imaging Download PDF

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Publication number
WO2009140743A3
WO2009140743A3 PCT/BE2009/000027 BE2009000027W WO2009140743A3 WO 2009140743 A3 WO2009140743 A3 WO 2009140743A3 BE 2009000027 W BE2009000027 W BE 2009000027W WO 2009140743 A3 WO2009140743 A3 WO 2009140743A3
Authority
WO
WIPO (PCT)
Prior art keywords
assessment
physiological parameters
emission tomography
imaging techniques
present
Prior art date
Application number
PCT/BE2009/000027
Other languages
French (fr)
Other versions
WO2009140743A2 (en
Inventor
Guy Bormans
Alfons Verbruggen
Original Assignee
Katholieke Universiteit Leuven
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Katholieke Universiteit Leuven filed Critical Katholieke Universiteit Leuven
Publication of WO2009140743A2 publication Critical patent/WO2009140743A2/en
Publication of WO2009140743A3 publication Critical patent/WO2009140743A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Abstract

The invention generally relates to the application of imaging techniques, in particular positron emission tomography (PET) or single photon emission tomography (SPECT), in the assessment of physiological parameters in a subject. The compounds of the present invention were shown to be cell membrane permeant and to have a specific binding affinity (or substrate affinity) for the carbonic anhydrases type I and II, and are accordingly useful for the in vivo and in vitro labeling of erythrocytes (RBC). It is accordingly an object of the present invention to provide said novel compounds, in particular the radio labeled variants thereof, and their use in imaging techniques to perform the assessment of physiological parameters, such as blood volume measurements, or blood flow measurements.
PCT/BE2009/000027 2008-05-23 2009-05-25 Blood imaging WO2009140743A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12862408P 2008-05-23 2008-05-23
US61/128624 2008-05-23

Publications (2)

Publication Number Publication Date
WO2009140743A2 WO2009140743A2 (en) 2009-11-26
WO2009140743A3 true WO2009140743A3 (en) 2010-06-24

Family

ID=41340594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BE2009/000027 WO2009140743A2 (en) 2008-05-23 2009-05-25 Blood imaging

Country Status (1)

Country Link
WO (1) WO2009140743A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106278963B (en) * 2015-05-14 2017-10-17 上海原子科兴药业有限公司 Target sulfonamides compound, intermediate and the preparation and application of carbonic anhydrase Ⅸ
CN106822099A (en) * 2015-11-27 2017-06-13 王子厚 The medicinal composition for injections that vitamin C acts synergistically with benzenesulfonamide compounds
EP3249409A1 (en) * 2016-05-25 2017-11-29 CNIC Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III Fdg (fluorodeoxyglucose (18f))-labeled red blood cells as diagnostic radiopharmaceuticals
KR102359439B1 (en) 2017-03-31 2022-02-09 (주)아모레퍼시픽 A composition comprising benzoic acid amide compound and cyclodextrin solubilizer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003089013A1 (en) * 2002-04-15 2003-10-30 The Regents Of The University Of California Cyclooxygenase-2 selective agents useful as imaging probes and related methods

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003089013A1 (en) * 2002-04-15 2003-10-30 The Regents Of The University Of California Cyclooxygenase-2 selective agents useful as imaging probes and related methods

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HUSIC H DAVID ET AL: "Identification of intracellular carbonic anhydrase in Chlamydomonas reinhardtii with a carbonic anhydrase-directed photoaffinity label", PLANT PHYSIOLOGY (ROCKVILLE), vol. 105, no. 1, 1994, pages 133 - 139, XP002579112, ISSN: 0032-0889 *
SCOZZAFAVA A ET AL: "Carbonic anhydrase inhibitors and activators and their use in therapy", EXPERT OPINION ON THERAPEUTIC PATENTS 200612 GB LNKD- DOI:10.1517/13543776.16.12.1627, vol. 16, no. 12, December 2006 (2006-12-01), pages 1627 - 1664, XP002579113, ISSN: 1354-3776 *
ZHANG J Y ET AL: "Pharmacokinetics and metabolism of a COX-2 inhibitor, valdecoxib, in mice", DRUG METABOLISM AND DISPOSITION, WILLIAMS AND WILKINS, BALTIMORE, MD, US LNKD- DOI:10.1124/DMD.31.4.491, vol. 31, no. 4, 1 April 2003 (2003-04-01), pages 491 - 501, XP002311622, ISSN: 0090-9556 *

Also Published As

Publication number Publication date
WO2009140743A2 (en) 2009-11-26

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