WO2009138985A3 - Agents de couplage pour la synthèse de polypeptides et de polynucléotides - Google Patents

Agents de couplage pour la synthèse de polypeptides et de polynucléotides Download PDF

Info

Publication number
WO2009138985A3
WO2009138985A3 PCT/IL2009/000486 IL2009000486W WO2009138985A3 WO 2009138985 A3 WO2009138985 A3 WO 2009138985A3 IL 2009000486 W IL2009000486 W IL 2009000486W WO 2009138985 A3 WO2009138985 A3 WO 2009138985A3
Authority
WO
WIPO (PCT)
Prior art keywords
coupling agents
polynucleotides
polypeptides
synthesis
disclosed
Prior art date
Application number
PCT/IL2009/000486
Other languages
English (en)
Other versions
WO2009138985A2 (fr
Inventor
Fernando Albericio
Ayman El-Faham
Yoav Luxembourg
Ariel Ewenson
Original Assignee
Luxembourg Bio Technologies Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luxembourg Bio Technologies Ltd. filed Critical Luxembourg Bio Technologies Ltd.
Publication of WO2009138985A2 publication Critical patent/WO2009138985A2/fr
Publication of WO2009138985A3 publication Critical patent/WO2009138985A3/fr
Priority to IL209300A priority Critical patent/IL209300A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/22—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne de nouveaux agents de couplage contenant une partie groupe partant unique, lesquels peuvent être utilisés avantageusement et de façon sûre comme agents de couplage dans diverses synthèses chimiques de polypeptides et/ou de polynucléotides et sont particulièrement utiles comme agents de couplage ayant une action de renforcement de rendement et de suppression de racémisation pour une utilisation dans les synthèses de peptides. L'invention concerne également des procédés de préparation de tels agents de couplage et leur utilisation dans la préparation de polypeptides et/ou de polynucléotides.
PCT/IL2009/000486 2008-05-15 2009-05-14 Agents de couplage pour la synthèse de polypeptides et de polynucléotides WO2009138985A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL209300A IL209300A0 (en) 2008-05-15 2010-11-14 Coupling agents for the synthesis of polypeptides and polynucleotides

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7175308P 2008-05-15 2008-05-15
US61/071,753 2008-05-15
US7181608P 2008-05-19 2008-05-19
US61/071,816 2008-05-19

Publications (2)

Publication Number Publication Date
WO2009138985A2 WO2009138985A2 (fr) 2009-11-19
WO2009138985A3 true WO2009138985A3 (fr) 2010-03-18

Family

ID=41319128

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2009/000486 WO2009138985A2 (fr) 2008-05-15 2009-05-14 Agents de couplage pour la synthèse de polypeptides et de polynucléotides

Country Status (1)

Country Link
WO (1) WO2009138985A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2170822A2 (fr) 2007-05-16 2010-04-07 Luxembourg Bio Technologies Ltd. Agents de couplage de type iminium/carbocation accepteurs de protons coupling agents
CN107311961A (zh) * 2016-04-26 2017-11-03 成都巴赛泰德生物科技有限公司 一种多肽缩合试剂comu的合成工艺
WO2018086993A1 (fr) 2016-11-14 2018-05-17 Synthon Biopharmaceuticals B.V. Procédé de préparation d'alpha, oméga-diamino alcanes mono-protégés

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070043207A1 (en) * 2005-08-16 2007-02-22 Luxembourg Industries Ltd. Novel coupling agent and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070043207A1 (en) * 2005-08-16 2007-02-22 Luxembourg Industries Ltd. Novel coupling agent and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EL-FAHAM ET AL.: "Morpholine-Based Immonium and Halogenamidinium Salts as Coupling Reagents in Peptide Synthesis", TETRAHEDRON, vol. 60, 2004, pages 2447 - 2467 *
HAN ET AL.: "Recent Development of Peptide Coupling Reagents in Organic Synthesis", JOURNAL OF ORGANIC CHEMISTRY, vol. 73, 6 March 2008 (2008-03-06), pages 2731 - 2737 *

Also Published As

Publication number Publication date
WO2009138985A2 (fr) 2009-11-19

Similar Documents

Publication Publication Date Title
WO2007062160A3 (fr) Procedes et compositions de sequençage d'un acide nucleique
HK1211280A1 (en) Process for the praparation of 2,3,3,3-tetrafluoropropene 2333-
WO2006007207A3 (fr) Procedes et dispositifs pour la determination de sequence d'acides nucleiques
WO2007010263A3 (fr) Procedes permettant de sequencer un modele de polynucleotide
WO2009022236A8 (fr) Plate-forme immunogène
DK2506868T3 (da) Kimæriske og hybride faktor viii-fc-polypeptider og fremgangsmåder til anvendelse deraf
WO2008119567A8 (fr) Domaine de liaison spécifique d'espèces croisées
HK1102800A1 (en) Cap for vessel for performing multi-stage process
UA110599C2 (uk) Пептид для імунотерапії пухлин, включаючи нейрональні пухлини та пухлини мозку
IL172297A0 (en) Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis iii
WO2005047523A3 (fr) Procedes courts de sequençage de polynucleotides
IL225739A0 (en) A preparation comprising a polypeptide comprising non-naturally encoded amino acids attached to nucleic acid molecules
PL1794292T3 (pl) Warianty alfa-amylazy stabilizowane względem di- i/lub multimeryzacji, sposób ich wytwarzania oraz środki piorące i czyszczące zawierające te warianty alfa-amylazy
WO2009067686A8 (fr) Hémi-l-malate de sunitinib, polymorphes et leur préparation, polymorphes de malate de sunitinib racémique, compositions contenant une base de sunitinib et de l'acide malique et leur préparation
WO2006133312A3 (fr) Synthese en plusieurs etapes ordonnees par chimie induite par acides nucleiques
WO2011061625A3 (fr) Compositions pour augmenter la stabilité et l'activité d'un polypeptide, et procédés apparentés
EP1922345A4 (fr) Procede destine a la preparation d'un copolymere-1
WO2008140641A3 (fr) Palipéridone pure et ses procédés de préparation
WO2008137881A3 (fr) Protéines d'ehrlichia ewingii, acides nucléiques, et procédés pour leur utilisation
WO2008021346A3 (fr) Palipéridone pure et ses procédés d'obtention
WO2007088099A3 (fr) Composes servant à traiter une ischémie et une neurodégénération
WO2010028066A3 (fr) Épitopes cd133
WO2010111622A3 (fr) Amidases et procédés pour leur utilisation
WO2005065339A3 (fr) Genes de cycles cellulaires et leurs procedes d'utilisation associes
WO2009138985A3 (fr) Agents de couplage pour la synthèse de polypeptides et de polynucléotides

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09746279

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09746279

Country of ref document: EP

Kind code of ref document: A2