WO2009137598A3 - Methods and composition for modulating hematopoietic stem cell migration - Google Patents

Methods and composition for modulating hematopoietic stem cell migration Download PDF

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Publication number
WO2009137598A3
WO2009137598A3 PCT/US2009/043010 US2009043010W WO2009137598A3 WO 2009137598 A3 WO2009137598 A3 WO 2009137598A3 US 2009043010 W US2009043010 W US 2009043010W WO 2009137598 A3 WO2009137598 A3 WO 2009137598A3
Authority
WO
WIPO (PCT)
Prior art keywords
stem cell
methods
composition
hematopoietic stem
cell migration
Prior art date
Application number
PCT/US2009/043010
Other languages
French (fr)
Other versions
WO2009137598A2 (en
Inventor
Dorothy A. Sipkins
Angela Colmone
Original Assignee
University Of Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Chicago filed Critical University Of Chicago
Publication of WO2009137598A2 publication Critical patent/WO2009137598A2/en
Publication of WO2009137598A3 publication Critical patent/WO2009137598A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Abstract

Embodiments of the invention include methods and compositions for inhibiting or reducing the sequestration, the aberrant migration, and/or the suppression of stem cell function in an atypical location or atypical microenvironment.
PCT/US2009/043010 2008-05-06 2009-05-06 Methods and composition for modulating hematopoietic stem cell migration WO2009137598A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US5092608P 2008-05-06 2008-05-06
US61/050,926 2008-05-06
US5200108P 2008-05-09 2008-05-09
US61/052,001 2008-05-09
US6192808P 2008-06-16 2008-06-16
US61/061,928 2008-06-16

Publications (2)

Publication Number Publication Date
WO2009137598A2 WO2009137598A2 (en) 2009-11-12
WO2009137598A3 true WO2009137598A3 (en) 2009-12-30

Family

ID=41265376

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/043010 WO2009137598A2 (en) 2008-05-06 2009-05-06 Methods and composition for modulating hematopoietic stem cell migration

Country Status (1)

Country Link
WO (1) WO2009137598A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060286117A1 (en) * 2003-11-26 2006-12-21 Fine Howard A Neuronally expressed stem cell factor modulates angiogenesis and neural stem cell migration to areas of brain injury
US20070190023A1 (en) * 2006-01-25 2007-08-16 Michela Battista Methods and compositions for modulating the mobilization of stem cells
US20070196922A1 (en) * 2001-10-02 2007-08-23 Didier Trono Methods and Compositions Relating to Restricted Expression Lentiviral Vectors and Their Applications

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070196922A1 (en) * 2001-10-02 2007-08-23 Didier Trono Methods and Compositions Relating to Restricted Expression Lentiviral Vectors and Their Applications
US20060286117A1 (en) * 2003-11-26 2006-12-21 Fine Howard A Neuronally expressed stem cell factor modulates angiogenesis and neural stem cell migration to areas of brain injury
US20070190023A1 (en) * 2006-01-25 2007-08-16 Michela Battista Methods and compositions for modulating the mobilization of stem cells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CZECHOWICZ ET AL.: "Efficient Transplantation via Antibody-Based Clearance of Hematopoietic Stem Cell Niches.", SCIENCE, vol. 318, no. 5854, 23 November 2007 (2007-11-23), pages 1296 - 1299 *
KRUIJF ET AL.: "Repeated Hematopoietic Stem and Progenitor Cell Mobilization Without Depletion of the Bone Marrow Stem and Progenitor Cell Pool in Mice After Repeated Administration of Recombinant Murine G-CSF.", HUM IMMUNOL., vol. 68, no. 5, May 2007 (2007-05-01), pages 368 - 374 *

Also Published As

Publication number Publication date
WO2009137598A2 (en) 2009-11-12

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