WO2009136651A1 - Topical composition for external use and process for producing the same - Google Patents
Topical composition for external use and process for producing the same Download PDFInfo
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- WO2009136651A1 WO2009136651A1 PCT/JP2009/058792 JP2009058792W WO2009136651A1 WO 2009136651 A1 WO2009136651 A1 WO 2009136651A1 JP 2009058792 W JP2009058792 W JP 2009058792W WO 2009136651 A1 WO2009136651 A1 WO 2009136651A1
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- external use
- ceramide
- topical composition
- acid
- water
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- AERBNCYCJBRYDG-UHFFFAOYSA-N CCCCCCCCCCCCCCC(C(C(CO)N)O)O Chemical compound CCCCCCCCCCCCCCC(C(C(CO)N)O)O AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/61—Surface treated
- A61K2800/62—Coated
- A61K2800/624—Coated by macromolecular compounds
Definitions
- the present invention relates to a topical composition for external use containing a ceramide analogue-containing particle, and a process for producing a topical composition for external use.
- Ceramide is present in a stratum corneum of a skin, and plays an important role for constructing a necessary lipid barrier for retaining a moisture, and maintaining a moisture. Ceramide present in a stratum conrneum is produced by degradation of cerebroside with an enzyme called cerebrosidase. It is known that a part of ceramide is changed into phytosphingosine and sphingosine with an enzyme called ceramidase, and they are important as an agent of regulating proliferation and differentiation of cells. In a human skin, six kinds of different types of ceramides are present, and have different functions, respectively.
- ceramide is a substance having high crystallizability, has low solubility in other oil solution, and precipitates a crystal at a low temperature, it was difficult to maintain stability when incorporated into cosmetics.
- an emulsion composition including specified sphingoglycolipids having the moisturizing activity, the skin roughness preventing activity and the emulsifying activity is disclosed (see e.g. Japanese Patent Application Laid-Open (JP-A) No. 2000-51676).
- ceramide-incorporated cosmetic additive containing cholesterol, fatty acid, and a water-soluble polymer see e.g. JP-ANo. 7-187987
- a water-in-oil emulsion composition in which a salt formed of sphingosines and a specified fatty acid is used as an emulsifying agent, and an oil-soluble antioxidant is added at a specified ratio as a topical composition for external use, which is excellent in stability also in the case of severe temperature change, and is good in a use feeling (see e.g. JP-ANo. 2006-335692) are disclosed.
- An object of the present invention is to provide a topical composition for external use containing a ceramide analogue-containing particle of a minute particle diameter uniformly and stably, and a process for producing a topical composition for external use in which dispersion stability of a ceramide analogue-containing particle is good.
- a topical composition for external use comprising: a ceramide analogue-containing particle having a particle diameter of 0.001 ⁇ m to 0.2 ⁇ m; and a water-soluble polymer.
- ⁇ 2> The topical composition for external use of ⁇ 1>, further comprising an oil component different from the ceramide analogue in an amount of 20 parts by mass or less relative to 1 part by mass of the ceramide analogue-containing particle.
- ⁇ 5> The topical composition for external use of any one of ⁇ 1> to ⁇ 3>, wherein the water-soluble polymer is a collagen derivative.
- ⁇ 6> The topical composition for external use of ⁇ 5>, wherein the weight-average molecular weight of the collagen derivative is 5000 or less.
- ⁇ 7> The topical composition for external use of any one of ⁇ 1> to ⁇ 3>, wherein the water-soluble polymer is a polysaccharide.
- ⁇ 8> The topical composition for external use of ⁇ 7>, wherein the weight-average molecular weight of the polysaccharide is 100,000 or less.
- ⁇ 9> The topical composition for external use of any one of ⁇ 1> to ⁇ 3>, wherein the water-soluble polymer is hyaluronic acid.
- ⁇ 10> The topical composition for external use of ⁇ 9>, wherein the weight-average molecular weight of the hyaluronic acid is 300,000 or less.
- a process for producing a topical composition for external use containing a ceramide analogue-containing particle and a water-soluble polymer comprising forming a ceramide analogue-containing particle in an aqueous phase containing a water-soluble polymer.
- ⁇ 13> The process for producing a topical composition for external use of ⁇ 12>, wherein a viscosity of the aqueous phase is 30 mPa-s or less.
- Fig. 1 is an exploded perspective of a microdevice as one example of a micromixer.
- Fig. 2 is a schematic cross-sectional view of a T-type microreactor showing one example of a mixing mechanism with a T-type microreactor.
- the topical composition for external use of the invention contains a ceramide analogue-containing particle of a particle diameter of 0.001 ⁇ m to 0.2 ⁇ m, and a water-soluble polymer.
- the invention has the great characteristic that the ceramide analogue is contained at a shape of a fine dispersed particle.
- Such the ceramide analogue-containing particle may be dispersed as it is in an aqueous phase component containing a water-soluble polymer, or may form an oily phase as a dispersed particle with an oil component different from the ceramide analogue, and take a form of an emulsion.
- Such the oil component is contained preferably in an amount of 20 parts by mass or less, further preferably 10 parts by mass or less relative to 1 part by mass of the ceramide analogue-containing particle.
- any water-soluble polymer may be used as far as it is a polymer which is dissolved in water (25°C) in an amount of at least around 0.001% by mass.
- water-soluble polymer examples include: polysaccharides such as pectin, kappa carrageenan, locust bean gum, guar gum, hydroxypropylguar gum, xanthan gum, karaya gum, tamarind seed polysaccharide, arabic gum, tragacanth gum, sodium hyaluronate, sodium chondroitin sulfate, sodium alginate etc.; proteins such as casein, albumin, methylated collagen, hydrolyzed collagen, water-soluble collagen etc.; synthetic polymers such as carboxyvinyl polymer, poly(sodium acrylate), polyvinyl alcohol, polyethylene glycol, ethylene oxide/propylene oxide block copolymer etc.; water-soluble cellulose derivatives such as hydroxyethylcellulose, hydroxymethylcellulose etc.
- polysaccharides such as pectin, kappa carrageenan, locust bean gum, guar gum, hydroxypropylguar gum, xant
- the water-soluble polymer which may be used in the invention may be synthetic or natural and, among the water-soluble polymer, a natural polymer is preferable and polysaccharides and proteins which are naturally occurring polymers are preferably used.
- More preferable examples include collagen derivatives, polysaccharides, and hyaluronic acids and, from a viewpoint of stabilization of the ceramide analogue particle and step suitability described later, as the collagen derivatives, the weight-average molecular weight of 5,000 or less is preferable, and the range of 200 to 3,000 is more preferable.
- preferable examples of the polysaccharides include specifically xanthan gum, kappa carrageenan, and dextran, and the weight-average molecular weight of 3,000,000 or less is preferable, and the more preferable molecular weight is in the range of 10,000 to 2,000,000.
- the hyaluronic acids the weight-average molecular weight of 300,000 or less is preferably used, and the more preferable molecular weight is in the rage of 5,000 to 200,000.
- weight-average molecular weight of these polymers a value measured by gel permeation chromatography is used.
- the water-soluble polymer only one kind may be used, or two or more kinds may be used together depending on the purpose.
- the content of the water-soluble polymer in the topical composition for external use is preferably in the range of 0.001 to 5% by mass, more preferably in the rage of 0.01 to 1% by mass.
- the composition has an advantage that the composition is not sticky, and a good feeling is obtained.
- composition of external use of the invention has a feature that the ceramide analogue-containing particle detailed below is dispersed in an aqueous phase containing the water-soluble polymer.
- an aqueous solution containing water as a main component, which contains the water-soluble polymer may be used.
- a water-soluble functional component such as a water-soluble antioxidant, and a plant extract may be further added to the aqueous phase in such the range that the effect of the invention is not deteriorated.
- the ceramide analogue in the invention includes ceramide and a derivative thereof, and may be any of ceramide such as natural ceramide regardless of their origin such as synthetic and extract, and glycosylated ceramide such as sphingoglycolipid, and an analogue thereof.
- examples of the ceramide which may be used in the invention include compounds which are generally known as ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, sphingosine, phytosphingosine, or glycosylated ceramide.
- the invention has a feature that the ceramide analogue is contained in the topical composition for external use in the shape of a particle containing the ceramid analogue.
- Such the ceramide analogue-containing particle may be dispersed as it is in an aqueous phase component containing the water-soluble polymer, or may form an oily phase as a dispersed particle with an oil component different from the ceramide analogue, and may be dispersed as an oily phase particle in the aqueous phase.
- a method of forming the ceramide analogue-containing particle will be described later.
- (1-1) is a compound known as ceramide 1
- (1-2) is a compound known as ceramide 9
- (1-3) is a compound known as ceramide 4
- (1-4) is a compound known as ceramide 2
- (1-5) is a compound known as ceramide 3
- (1-6) is a compound known as ceramide 5
- (1-7) is a compound known as ceramide 6
- (1-8) is a compound known as ceramide 7
- (1-9) is a compound known as ceramide 8
- (1-10) is a compound known as ceramide 3B.
- ceramide is a natural substance, in ceramides actually derived from a human or an animal, there are various variation examples in the length of the alkyl chain, and ceramide having the above skeleton may have any structure in the alkyl chain length.
- ceramides modified depending on the purpose such as ceramide in which a double bond is introduced in the molecule in order to impart solubility for the purpose of formulation into preparations, and ceramide in which a hydrophobic group is introduced to impart permeability, may be used.
- ceramides having the general structure named natural type may be a natural product (extract) or a synthetic substance, or commercially available ceramide may be used depending on the purpose.
- ceramides As these ceramides, a natural (D(-) body) optically active body may be used, or a non-natural (L(+) body) optically active body may be used, or further, a mixture of a natural type and a non-natural type may be used.
- a relative configuration of the above compounds may be natural configuration, or other non-natural configuration, or a mixture thereof.
- topical composition for external use is used for the purpose of an emollient of a skin, from a viewpoint of the barrier effect, it is preferable to use the natural optically active body.
- Such the natural ceramides are also available as a sold product, and examples include Ceramide I, Ceramide III, Ceramide IIIA, Ceramide IIIB, Ceramide IIIC, and Ceramide VI (all manufactured by Cosmofarm), Ceramide TIC-OOl (manufactured by Takasago International Corporation), CERAMIDE II (manufactured by Quest International), DS-Ceramide VI, DS-CLA-Phytoceramide, C6-Phytoceramide, and DS-ceramide Y3S (manufactured by DOOSAN), and CERAMIDE2 (manufactured by Sedama), and the exemplified compound (1-5) is available as trade name: CERAMIDE 3, manufactured by Evonik (formerly Deggusa), and the exemplified compound (1-7) is available as trade name: CERAMIDE 6, manufactured by Evonik (formerly Deggusa). [0025] (Glycosylated ceramide)
- ceramide analogue in the invention examples include glycosylated ceramide compound (hereinafter, also referred to as "sugar ceramide compound”) containing sugars in the molecule.
- glycosylated ceramide may be a sugar derivative in which a hydroxyl group in a unit of sugar is replaced with other group.
- the sugar derivative includes glucosamine, glucuronic acid, and N-acetylglucosamine.
- sugars having the number of sugar units of 1 to 5 is preferable, and specifically, glucose and lactose are preferable, and glucose is more preferable.
- ceramide analogue represented by the following structural formula may be also used.
- a natural (D(-) body) optically active body may be used, or a non-natural (L(+) body) optically active body may be used, or further, a mixture of a natural type and a non-natural type may be used.
- Relative configuration of the above compound may be natural configuration, may be other non-natural configuration, or may be configuration of a mixture thereof.
- examples of phytosphingosine which may be preferably used in the invention include PHYTOSPHINGOSINE (INCI name; 8 th Edition) and exemplified compounds described below.
- phytosphingosine either of a natural extract or a synthetic product may be used. And, phytosphingosine is available by synthesis, or as a sold product. Examples of commercially available natural spbingosines include D-Sphingosine (4-Sphingenine) (SIGMA-ALDRICH), DSphytosphingosine (DOOSAN), and phytosphingosine (Cosmofarm) and, further, the exemplified compound (5-5) is available as trade name: PHYTOSPHINGOSINE, manufactured by Evonik (formerly Deggusa). [0034] (Acid)
- ceramide analogue sphingosines are used in the topical composition for external use of the invention, it is preferable to use jointly a compound having an acidic residue capable of forming a salt with the compound.
- a compound having an acidic residue an inorganic acid, or an organic acid of a carbon number of 5 or less is preferable.
- Examples of the inorganic acid include phosphoric acid, hydrochloric acid, nitric acid, sulfuric acid, perchloric acid, and carbonic acid, and phosphoric acid, and hydrochloric acid are preferable.
- organic acid examples include monocarboxylic acids such as formic acid, acetic acid, propionic acid, butyric acid, isobutyric acid, and valeric acid; dicarboxylic acids such as succinic acid, phthalic acid, fumaric acid, oxalic acid, malonic acid, and glutaric acid; oxycarboxylic acids such as glycolic acid, citric acid, lactic acid, pyruvic acid, malic acid, and tartaric acid; amino acids such as glutamic acid, and aspartic acid.
- phosphoric acid, hydrochloric acid, succinic acid, citric acid, lactic acid, glutamic acid, and aspartic acid are preferable, and lactic acid, glutamic acid, and aspartic acid are particularly preferable.
- a jointly used acid may be used by pre-mixing with phytosphingosine, may be added at the time of formation of the ceramide analogue-containing particle, or may be used by adding as a pH adjusting agent after particle formation.
- the addition amount is around 1 to 50 parts by mass relative to 100 parts by mass of phytosphingosine used.
- the addition amount is around 1 to 50 parts by mass relative to 100 parts by mass of phytosphingosine used.
- the topical composition for external use of the invention only one kind ceramide analogue may be used, or two or more kinds may be used jointly, and since ceramides have generally a high melting point, and high crystallizability, it is preferable to use two or more kinds jointly from a viewpoint of emulsification stability/handling property.
- natural ceramides it is most preferable to combine two or more kinds of natural ceramides. And, it is preferable to use by combining natural ceramides, and one or more kinds selected from sugar ceramide compounds, or natural ceramides, and one or more kinds selected from phytosphingosines, from a viewpoint of finely-dividing of a particle, and improvement in dispersion stability of an emulsion.
- sphingosines are added preferably at 0.005 to 1000 parts by weight, further preferably 0.05 to 500 parts by weight, particularly preferably 0.5 to 200 parts by weight relative to 100 parts by weight of natural ceramides.
- sphingosines are added preferably at 0.005 to 1000 parts by weight, further preferably 0.05 to 500 parts by weight, particularly preferably 0.5 to 200 parts by weight relative to 100 parts by weight of natural ceramides.
- the ceramide analogue which may be used in the invention is contained in the topical composition for external use with a shape of a particle having a particle diameter of 1 nm to 0.2 ⁇ m, preferably 1 nm to 75 nm, more preferably 1 nm to 50 nm, most preferably 1 nm to 13 nm.
- a particle diameter of 1 nm to 0.2 ⁇ m preferably 1 nm to 75 nm, more preferably 1 nm to 50 nm, most preferably 1 nm to 13 nm.
- Such the particle is referred to as "ceramide analogue-containing particle" in the invention.
- warming is performed preferably to the range of 30 to 6O 0 C and, as described below, it is more preferable to prepare a particle by compatibilizing with other oil component, or dissolving in an organic solvent.
- a particle diameter of the ceramide analogue-containing particle in the topical composition for external use of 0.2 ⁇ m or less when the topical composition for external use of the invention is used in medicaments, or cosmetics, transparency of the composition is maintained, and skin absorbability becomes good.
- the known method may be applied and, in the invention, from a viewpoint of finely-dividing, for example, it is preferable to prepare a particle using a high pressure emulsifying method of applying a high shearing force of 100 Mpa or more, or a precipitation method, or take a method using a micromixer by passing an oily phase and an aqueous phase independently through a micropath having a cross section area at a narrowest part of 1 ⁇ m 2 to 1 mm 2 , and combining respective phases to mix them.
- a high pressure emulsifying method of applying a high shearing force of 100 Mpa or more, or a precipitation method
- take a method using a micromixer by passing an oily phase and an aqueous phase independently through a micropath having a cross section area at a narrowest part of 1 ⁇ m 2 to 1 mm 2 , and combining respective phases to mix them.
- the particle diameter of the ceramide analogue-containing particle in the invention may be measured with a commercially available particle size distribution meter.
- the topical composition for external use of the invention is, for example, an emulsion, as a method of measuring a particle size distribution of an emulsion, an optical microscope method, a cofocal laser microscope method, an electron microscope method, an atomic force microscope method, a static light scattering method, a laser diffraction method, a dynamic light scattering method, a centrifugation settling method, an electric pulse measuring method, a chromatography method, an ultrasound damping method are known, and apparatuses corresponding to each principle are commercially available.
- a dynamic light scattering method is preferable in measurement of the particle diameter of the dispersed particle.
- a commercially available measuring apparatus using dynamic light scattering include nanotrack UPA (Nikkiso Co., Ltd.), dynamic light scattering-type particle diameter distribution measuring apparatus (trade name: LB-550, manufactured by Horiba Ltd.), and a concentrated system particle diameter analyzer (trade name: FPAR-1000, manufactured by Otsuka Electronics Co., Ltd.).
- the particle diameter in the invention is a value measured using the dynamic light scattering-type particle diameter distribution measuring apparatus (trade name: LB-550, manufactured by Horiba Ltd.) and, specifically, a value measured as described below is adopted.
- the particle diameter may be obtained as the median diameter letting a sample refractive index to be 1.600, letting a dispersing medium refractive index to be 1.333 (pure water), and letting a viscosity of a dispersing solvent to be a viscosity of pure water.
- the content of the ceramide analogue in the topical composition for external use of the invention is preferably in the range of 0.01% by mass to 5% by mass from a viewpoint of a feeling of a user, and is more preferably in the range of 0.1% by mass to 3% by mass.
- the external use agent of the invention is such that the ceramide analogue-containing particle is dispersed in an aqueous phase containing the water-soluble polymer and, further, may take a form in which an oil component different from the ceramide analogue (in the present specification, arbitrarily referred to as other oil component) is contained, and the ceramide analogue is contained in the oil component.
- an oil component different from the ceramide analogue in the present specification, arbitrarily referred to as other oil component
- the oil component in the invention refers to an oil component which is not separable from the ceramide analogue.
- the oil component different from the ceramide analogue which is jointly used herein is not particularly limited, but may be an oil component as an active ingredient which is added depending on the use purpose of the topical composition for external use, or may be an oil component which is used for improving dispersion stability and a use feeling on a skin, or controlling physical properties of the composition.
- the topical composition for external use of the invention may contain at least one of stenone and sterol as other oil component. This component is useful for improving dispersion stability of the ceramide analogue-containing particle.
- stenone which may be used as other oil component in the invention include the following.
- Examples of sterol include the following. [0045]
- Brassicasterol [0046] The stenone compound and the sterol compound are available by synthesis, or as a sold product.
- phytostenone is available as trade name: UNIFETH 5 manufactured by Toyohakko Co., Ltd.
- PEO-STEROL is available as trade name: NIKKOL BPS-20, manufactured by Nikko Chemicals Co., Ltd.
- the stenone compound, and the sterol compound may be used alone, respectively or a plurality of kinds thereof may be used.
- the content relative to the total mass of an oily phase component contained in the topical composition for external use is preferably 30% by mass to 70% by mass, more preferably 40% by mass to 60% by mass, from a viewpoint of dispersion stability of the dispersed particle.
- Insoluble in an aqueous medium refers to that solubility in 100 mL of an aqueous medium is 0.001 g or less at 25°C, and hardly soluble in an aqueous medium refers to that solubility in 100 mL of an aqueous medium is more than 0.01 g and 0.1 g or less.
- carotenoids examples include hydrocarbons (carotenes) and oxidized alcohol derivatives thereof (xanthophylls).
- carotenoids examples include actinioerythrol, astaxanthin, bixin, canthaxanthin, capsanthin, capsorubin, ⁇ -8'-apo-carotenal (apocarotenal), ⁇ -12'-apo-carotenal, ⁇ -carotene, ⁇ -carotene, "carotene” (mixture of ⁇ - and ⁇ - carotenes), ⁇ -carotene, ⁇ -cryptoxanthin, lutein, lycopene, biorelithrin, and zeaxanthin, and esters of carotenoids containing hydroxyl or carboxyl among them.
- Carotenoids particularly preferably used in the invention is at least one of astaxanthin and a derivative such as an ester of astaxanthin which have the oxidation preventing effect, the anti-inflammatory effect, the skin aging preventing effect, and the whitening effect, and are known as a coloring material in the range of yellow to red (hereinafter, collectively referred to as "astaxanthins").
- Examples of the natural material include red yeast phaffia, green alga haematococcus, marine bacteria, and britt.
- Other examples include an extract such as an extract from cultures thereof.
- the astaxanthins may be contained in an emulsion composition of the invention, as an astaxanthin-containing oil separated/extracted (further, if necessary, arbitrarily purified) from other natural substance containing astaxanthins.
- haematococcus alga also referred to as haematococcus alga extract
- haematococcus alga extract At least one of the astaxanthin and an ester thereof (astaxanthins) may be contained in the topical composition for external use of the invention, as an astaxanthin-containing oil separated/extracted from natural substances containing at least one of the astaxanthin and an ester thereof.
- astaxanthin-containing oil include extracts obtained by culturing red yeast phaffia, green alga haematococcus, or marine bacteria, and extracting from cultures thereof, and an extract from Euphausia superb.
- haematococcus alga extract haematococcus alga-derived coloring matter
- britt-derived from coloring matter and synthesized astaxanthin in the kind and the content of an ester.
- haematococcus alga extract which may be used in the invention is derived include Haematococcus pluvialis, Haematococcus lacustris, Haematococcus capensis, Haematococcus droebakensis, and Haematococcus zimbabwiensis.
- haematococcus alga extracts which are widely sold may be used, and the haematococcus alga extract may be obtained as ASTOTS-S ASTOTS-2.5 O, ASTOTS-50, and ASTOTS-100 manufactured by Takeda Shiki Co., Ltd. AstaReal Oil 5OF, and AstaReal Oil 5F manufactured by Fuji Chemical Industry Co., Ltd. or BioAstin SCE7 manufactured by Toyokagaku Co., Ltd.
- the content of astaxanthins in the haematococcus alga extract which may be used in the invention as a pure coloring matter is preferably 0.001 to 50% by mass, more preferably 0.01 to 25% by mass from a viewpoint of handling at production of the topical composition for external use.
- fats or oils used as other oil component include fats or oils which are liquid at a normal temperature (fats or oils) and fats or oils which are solid at a normal temperature (fats).
- a coconut oil which is a medium chain fatty acid triglyceride is preferably used from a viewpoint of the dispersed particle diameter and stability of the topical composition for external use.
- the fats or oils commercially available products may be used. And, in the invention, the fats or oils may be used alone, or may be used by mixing them.
- a compound having a phenolic hydroxyl group which is other oil component which may be used in the invention include polyphenols (e.g. catechin), guaiac butter, nordihydroguaretic acid (NDGA), gallic acid esters, BHT (butylhydroxytoluene), BHA (butylhydroxyanisole), vitamin Es and bisphenols.
- examples of gallic acid esters include propyl gallate, butyl gallate and octyl gallate.
- Examples of the amine-based compound include phenylenediamine, diphenyl-p-phenylenediamine and 4-amino-p-diphenylamine, and diphenyl- ⁇ -phenylenediamine and 4-amino-p-diphenylamine are more preferable.
- Examples of an oil-solubilized derivative of ascorbic acid and erythorbic acid include stearic acid L-ascorbyl ester, tetraisopalmitic acid L-ascorbyl ester, palmitic acid L-ascorbyl ester, palmitic acid erythorbyl ester, and tetraisopalmitic acid erythorbyl ester.
- vitamin Es are particularly preferably used from a viewpoint of the excellence of stability and the function of oxidation prevention.
- Vitamin Es are not particularly limited, but examples include vitamin Es selected from a compound group consisting of tocopherol and derivatives thereof, as well as a compound group consisting of tocotrienol and derivatives thereof. These may be used alone, or a plurality of them may be used together. Alternatively, vitamin E selected from a compound group consisting of tocopherol and derivatives thereof, and vitamin E selected from a compound group consisting of tocotrienol and derivatives thereof may be used by combining them.
- the compound group consisting of tocopherol and derivatives thereof includes dl- ⁇ -tocopherol, dl- ⁇ -tocopherol, dl- ⁇ -tocopherol, dl- ⁇ -tocopherol, dl- ⁇ -tocopherol acetate, nicotinic acid-dl- ⁇ -tocopherol, linoleic acid-dl- ⁇ -tocopherol, and dl- ⁇ -tocopherol succinate.
- dl- ⁇ -tocopherol, dl- ⁇ -tocopherol, dl- ⁇ -tocopherol, dl- ⁇ -tocopherol, and a mixture thereof (mix tocopherol) are more preferable.
- acetic acid esters of them are preferably used as the tocopherol derivatives.
- the compound group consisting of tocotrienol and derivative thereof includes ⁇ -tocotrienol, ⁇ -tocotrienol, ⁇ -tocotrienol, and ⁇ -tocotrienol. And, the tocotrienol derivative, acetic acid esters of them are preferably used.
- Tocotrienol is a compound similar to tocopherol contained in wheat varieties, rice bran, and palm oil, has three double bonds contained in a side chain part of tocopherol, and has the excellent oxidation preventing performance.
- These vitamin Es are preferably contained in, particularly, an oily phase of the present topical composition for external use as an oil-soluble antioxidant because they can effectively exert the oxidation preventing function of an oil component. It is further preferable that, among the vitamin Es, at least one kind selected from the compound group consisting of tocotrienol and derivatives thereof is contained from a viewpoint of the oxidation preventing effect.
- the content when such the other oil component is used is preferably 0.1% by mass to 50% by mass, more preferably 0.2% by mass to 25% by mass, further preferably 0.5% by mass, 10% by mass from a viewpoint of a dispersed particle diameter/emulsion stability in view of application of the topical composition for external use to medicaments and cosmetics.
- the topical composition for external use of the invention may contain a surfactant in an oily phase.
- emulsion stability of an oily phase-dispersed particle may be improved.
- other oily component is not necessarily required, and only the ceramide analogue-containing particle is used as a component constituting an oily phase in some cases.
- use of a surfactant is useful for improving emulsion stability and dispersion stability of the dispersed particle. Even when the surfactant is used, it goes without saying that the specified stenone compound or the specified sterol compound may be used.
- the surfactant in the invention is preferable in that the interface tension of oily phase/aqueous phase in the topical composition for external use may be extremely reduced and, as a result, the particle diameter may be reduced.
- HLB of 8 or more is preferable, HLB of 10 or more is more preferable, and HLB of 12 or more is particularly preferable.
- An upper limit of a HLB value is not particularly limited, but is generally 20 or less, preferably 18 or less.
- M w is the molecular weight of a hydrophilic group
- M 0 is the molecular weight of a hydrophobic group
- Examples of the surfactant which may be used in the invention are not limited to, but include cationic, anionic, amphoteric, and nonionic surfactants, and nonionic surfactants are preferable.
- Examples of the nonionic surfactant include glycerin fatty acid ester, organic acid monoglyceride, polyglycerin fatty acid ester, propylene glycol fatty acid ester, polyglycerin condensed ricinoleic acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, and polyoxyethylene sorbitan fatty acid ester.
- the surfactant is not necessarily required to be highly purified by distillation, and may be a reaction mixture.
- Polyglycerin fatty acid ester used in the invention is an ester of polyglycerin of the average polymerization degree of 2 or more, preferably 6 to 15, more preferably 8 to 10, and fatty acid of a carbon number of 8 to 18 such as caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, and linoleic acid.
- polyglycerin fatty acid ester examples include hexaglycerin monooleic acid ester, hexaglycerin monostearic acid ester, hexaglycerin monopalmitic acid ester, hexaglycerin monomyristic acid ester, hexaglycerin monolauric acid ester, decaglycerin monooleic acid ester, decaglycerin monostearic acid ester, decaglycerin monopalmitic acid ester, decaglycerin monomyristic acid ester, and decaglycerin monolauric acid ester.
- polyglycerin fatty acid esters may be used alone, or may be used by mixing them.
- Examples of the commercially available product include NIKKOL DGMS, NIKKOL DGMO-CV, NIKKOL DGMO-90V, NIKKOL DGDO, NIKKOL DGMIS, NIKKOL DGTIS, NIKKOL Tetraglyn 1-SV, NIKKOL Tetraglyn 1-0, NIKKOL Tetraglyn 3-S, NIKKOL Tetraglyn 5-S, NIKKOL Tetraglyn 5-O, NIKKOL Hexaglyn 1-L, NIKKOL Hexaglyn 1-M, NIKKOL Hexaglyn 1-SV, NIKKOL Hexaglyn 1-0, KIKKOL Hexaglyn 3-S, NIKKOL Hexaglyn 4-B, NIKKOL Hexaglyn 5-S, NIKKOL Hexaglyn 5-0, NIKKOL Hexaglyn PR- 15, NIKKOL Decaglyn 1-L, NIKKOL Deca
- NIKKOL Decaglyn 1-L NIKKOL Decaglyn 1-M
- NIKKOL Decaglyn 1-SV NIKKOL Decaglyn 1-50SV
- NIKKOL Decaglyn 1-ISV 5 NIKKOL Decaglyn 1-0
- NIKKOL Decaglyn 1-OV 5 NIKKOL Decaglyn 1-LN Ryoto-Polyglyester L-7D, L-IOD, M-IOD, P-8D, SWA-IOD, SWA- 15D 5 SWA-20D, S-24D, S-28D, 0-15D 5 0-5OD 5 B-70D, B-IOOD 5 ER-60D, and LOP-120DP.
- Sorbitan fatty acid ester used in the invention has a carbon number of fatty acid of preferably 8 or more, more preferably 12 or more.
- sorbitan fatty acid ester include monocaprylic acid sorbitan, monolauric acid sorbitan, monostearic acid sorbitan, sesquistearic acid sorbitan, tristearic acid sorbitan, isostearic acid sorbitan, sesquisostearic acid sorbitan, oleic acid sorbitan, sesquioleic acid sorbitan, and trioleic acid sorbitan.
- Examples of the commercially available product include NIKKOL SL-IO, SP-IOV 5 SS-IOV 5 SS-IOMV, SS-15V, SS-30V, SI-IORV, SI-15RV, SO-IOV, SO-15MV, SO-15V, SO-30V, SO-IOR, SO-15R, SO-30R, and SO-15EX manufactured by Nikko Chemicals Co., - Ltd., Solgen 30V, 40V, 50V, 90, and 110 manufactured by Dai-ich Kogyo Seiyaku Co., Ltd., and Leodor AS-IOV, AO-IOV, AO- 15 V, SP-LlO, SP-PlO, SP-SlOV, SP-S30V, SP-OlOV, and SP-O30V manufactured by Kao Corporation.
- sucrose fatty acid esters may be used alone, or may be used by mixing them.
- Examples of the commercially available product include Ryoto-Sugar Ester S-070, S-170, S-270, S-370, S-370F, S-570, S-770, S-970, S-1170, S-1170F, S-1570, S-1670, P-070, P- 170, P- 1570, P- 1670, M- 1695, 0- 170, O- 1570, OWA- 1570, L- 195, L-595, L- 1695, LWA-1570, B-370, B-370F, ER-190, ER-290, and POS-135 manufactured by Mitsubishi-Kagaku Foods Corporation, and DK Ester SS 5 F160, F140, FIlO, F90, F70, F50, F-A50, F-20W, F-IO, F-AlOE, Cosmelike B-30, S-10, S-50, S-70
- Examples of the commercially available products include NIKKOL TL-10, NIKKOL TP-IOV, NIKKOL TS-IOV, NIKKOL TS-10MV, NIKKOL TS-106V, NIKKOL TS-30V, NIKKOL TI-IOV, NIKKOL TO-IOV, NIKKOL TO-IOMV, NIKKOL TO-106V, and NIKKOL TO-30V manufactured by Nikko Chemicals Co., Ltd., Leodor TW-L106, TW-L120, TW-P120, TW-S106V, TW-S120V, TW-S320V, TW-O106V, TW-O120V, TW-O320V, TW-IS399C, Leodor Super SP-LlO, and TW-L 120 manufactured by Kao Corporation, and Solgen TW-20, TW-60V, and TW-80V manufactured by Dai-ich Kogyo Seiyaku Co., Ltd..
- lecithin may be used together with the water-soluble nonionic surfactant.
- Lecithin used in the invention has an essential constituent component of a glycerin skeleton, a fatty acid residue and a phosphoric acid residue, to which a base and a polyhydric alcohol are bound, and is also called phospholipid.
- lecithin Since lecithin has a hydrophilic group and a hydrophobic group in the molecule, it has been previously used widely as an emulsifier in the fields of foods, medicaments and cosmetics.
- lecithin is utilized as lecithin, and may be utilized in the invention and, from a viewpoint of formation of the fine oil droplet particle diameter and stability of a functional oil component, lecithin is preferably named generally as high purity lecithin, and this has the lecithin purity of 80% or more, more preferably 90% or more.
- lecithin may include previously known various lecithins extracted and separated from living bodies of plants, animals and microorganisms.
- lecithin examples include various lecithins derived from plants such as soybean, corn, peanut, rapeseed, wheat variety, animals such as yolk, and cow, and microorganisms such as Escherichia coli.
- Examples of a chemical name of such the lecithin include glycerolecithin such as phosphatidic acid, phosphatidylglycerin, phosphatidylinositol, phosphatidylethanolamine, phosphatidylmethylethanolamine, phosphatidylcholine, phosphatidylserine, bisphosphatidic acid, and diphosphatidylglycerin (cardiolipin); sphingolecithin such as sphingomyelin.
- glycerolecithin such as phosphatidic acid, phosphatidylglycerin, phosphatidylinositol, phosphatidylethanolamine, phosphatidylmethylethanolamine, phosphatidylcholine, phosphatidylserine, bisphosphatidic acid, and diphosphatidylglycerin (cardiolipin); sphingolecithin such as sphingomyelin.
- lecithin in addition to the high purity lecithin, hydrogenated lecithin, enzyme-degraded lecithin, enzyme-degraded hydrogenated lecithin, and hydroxylecithin may be used.
- lecithins which may be used in the invention may be used alone, or in the form of a mixture of plural of them.
- the amount of the surfactant in the topical composition for external use of the invention is the amount more than 0.5 -fold amount based on mass relative to the total mass of oily phase components other than the surfactant (the sum of ceramide analogue-containing particle and other oil component), and more than 5 -fold amount based on mass relative to the phospholipid amount.
- the amount of the surfactant being 0.5-fold amount or more relative to the total mass of oily phase components other than the surfactant, an emulsion of the finer particle diameter may be obtained and, by adopting the amount being 5 -fold or more relative to the amount of phospholipid, it becomes difficult to deteriorate emulsion stability.
- the amount of the surfactant can make emulsion stability remarkably good, particularly when ascorbic acid, citric acid, or a salt thereof is present in the present composition.
- the amount of the surfactant relative to the total mass of oily phase components other than the surfactant is preferably more than 0.5 -fold amount, more preferably 2-fold amount or less, further preferably 1.5-fold amount of less, particularly preferably 1-fold amount or less, in order to obtain the fine particle diameter.
- the amount of the surfactant relative to the amount of phospholipid is preferably more than 5 -fold amount, more preferably 50-fold amount or less, further preferably 30-fold amount or less, particularly preferably 15-fold amount or less based on a mass, in order to make emulsion stability good.
- the addition amount of the surfactant is preferably 0.5 to 30% by mass, more preferably 1 to 20% by mass, further preferably 2 to 15% by mass relative to the topical composition for external use.
- the addition amount of the surfactant within the above range is preferable in that the interface tension between oily phase/aqueous phase is easily decreased, stability is improved, and foaming due to addition of the surfactant may be suppressed.
- the water-soluble organic solvent in the invention is used as an oily phase containing a natural component for mixing with an aqueous solution described later.
- This aqueous organic solvent is a main component of an extracting liquid which extracts a natural component, at the same time. That is, in the invention, the natural component is used for mixing with an aqueous solution, in the state where extracted into an extracting liquid containing the water-soluble organic solvent as a main component.
- the water-soluble organic solvent used in the invention refers to an organic solvent having solubility in water at 25°C of 10% by mass or more. Solubility in water is preferably 30% by mass or more, further preferably 50% by mass or more from a viewpoint of stability of a finished emulsion or dispersion.
- the water-soluble organic solvent may be used alone, or may be a mixed solvent of a plurality of water-soluble organic solvents. Alternatively, the solvent may be used as a mixture with water. When the mixture with water is used, the water-soluble organic solvent is contained preferably in an amount of at least 50% by volume or more, more preferably 70% by volume or more.
- water-soluble organic solvent examples include methanol, ethanol, 1-propanol, 2-propanol, 2-butanol, acetone, tetrahydrofuran, acetonitrile, methyl ethyl ketone, dipropylene glycol monomethyl ether, methyl acetate, methyl acetoacetate, N-methylpyrrolidone, dimethyl sulfoxide, ethylene glycol, 1,3-butanediol, 1,4-butandiol, propylene glycol, diethylene glycol, and triethylene glycol, and a mixture thereof.
- ethanol, propylene glycol or acetone is preferable, and ethanol, or a mixed solution of ethanol and water is particularly preferable.
- the polyhydric alcohol has the moisturizing function and the viscosity adjusting function.
- the polyhydric alcohol also has the function of reducing the interface tension between water and a fat or oil component, making an interface easily spread, and making easier to form a fine and stable particle.
- the polyhydric alcohol which may be used in the invention may be used without any limitation, as far as it is a di- or more hydric alcohol.
- a polyhydric alcohol having the number of hydroxyl groups in one molecule of 3 or more is preferable to use.
- the interface tension between an aqueous solvent and a fat or oil component may be more effectively reduced, and a finer, and stable particle may be formed.
- intestinal tract absorbability may be enhanced and, in the case of transdermal medicament utility and cosmetic utility, skin absorbability may be enhanced.
- the content of the polyhydric alcohol is preferably 10 to 60% by mass, more preferably 20 to 55% by mass, further preferably 30 to 50% by mass relative to the topical composition for external use, from a viewpoint of the viscosity of the topical composition for external use in addition to the particle diameter, the stability and the acepticus.
- the content of the polyhydric alcohol is 10% by mass or more, this is preferable in that sufficient storage stability is easily obtained depending on the kind and the content of the fat or oil component.
- the content of the polyhydric alcohol is 60% by mass or less, this is preferable in that the maximum effect is obtained, and increase in the viscosity of the topical composition for external use is easily suppressed.
- components used in the topical composition for external use such as a skin external use agent may be arbitrarily used depending on the purpose.
- a finely-divided oily phase particle (containing ceramide analogue-containing particle) having the particle diameter of an oily phase of objective 0.2 ⁇ m or less depending on the stirring condition (shearing force, temperature, pressure), the condition of using a micromixer, and a ratio of an oily phase and an aqueous phase in a process for producing a topical composition for external use described later, in addition to factors due to the aforementioned components of the topical composition for external use, may be obtained.
- a process for producing such the dispersion comprises preparing an oily phase containing the ceramide analogue, or an oily phase containing the ceramide analogue and other oil component, and an aqueous phase containing the water-soluble polymer separately, and emulsifying prepared oily phase and aqueous phase to form the ceramide analogue-containing particle in an aqueous phase containing the water-soluble polymer.
- the viscosity of an aqueous phase containing the water-soluble polymer is 30 mPa-s or less, from a viewpoint of finely-dividing of the ceramide analogue-containing particle.
- the separately prepared oily phase and aqueous phase are each independently passed through a micropath having the cross-sectional area of a narrowest part of 1 ⁇ m 2 to 1 mm 2 and, thereafter, respective phases are combined and mixed, from a viewpoint of fine dividing.
- the preparation temperature may be changed depending on a boiling point of a solvent used and, usually, preparation is implemented at preferably 2O 0 C to 8O 0 C, more preferably 20°C to 6O 0 C.
- a method of mixing separately prepared oily phase and aqueous phase as described above, and applying a high pressure emulsifying method of adding a high shearing force such as 100 MPa or more is preferably exemplified.
- ceramide analogue-containing particles having the volume average particle diameter of 1 run to 200 run are dispersed may be obtained.
- Examples of the process for producing the topical composition for external use of the invention include a) preparing an aqueous phase containing a water-soluble polymer using an aqueous medium (water etc.), b) mixing the ceramide analogue in at least 1% by mass relative to the total mass of an oily phase and, optionally, a water-soluble organic solvent, the specified stenone compound and other oil component (carotenoid etc.) to prepare an oily phase, and c) mixing the oily phase and the aqueous phase using a micromixer by a method detailed later to perform emulsification and dispersing, to obtain a topical composition for external use (emulsion) containing a dispersed particle having the volume average particle diameter of 1 nm to 200 nm.
- a topical composition for external use emulsion
- the topical composition for external use in the powder state may be obtained by adding a step of drying a ceramide dispersion in the emulsion state obtained above by spray drying, and the like.
- the mixing of the oily phase and the aqueous phase is preferably mixing by countercurrent collision from a viewpoint of obtaining the finer dispersed particle.
- the most suitable device for mixing by countercurrent collision is a countercurrent collision-type micromixer.
- the micromixer mixes mainly two different liquids in a fine space, one of liquids is an organic solvent phase containing a functional oil component, and the other is an aqueous phase which is an aqueous solution.
- micromixer When the micromixer is applied to preparation of an emulsion having the small particle diameter which is one of microchemistry processes, a good emulsion or dispersion having relatively low energy and small heat production, having the more uniform particle diameter as compared with a normal stirring emulsification dispersing system or high pressure homogenizer emulsification dispersing, and also having the excellent storage stability is easily obtained.
- This is an optimal method for emulsifying a natural component which is easily thermally degraded.
- a summary of a method of emulsification or dispersing using the micromixer include dividing the aqueous phase and the oily phase into fine spaces, respectively, and contacting or colliding respective fine spaces. This method is clearly different from a membrane emulsification method or a microchannel emulsification method which is a method in which only one is divided into a fine space, and the other is a bulk and, even when only one is actually divided into a fine space, the effect as in the invention is not obtained.
- the known micromixer there are a variety of structures.
- the comb tooth type micromixer has a structure in which two comb tooth-like paths are faced, and arranged so that one path enters between two the other paths, alternately a representative of which is a mixer manufactured by IMM.
- the micromixer shown in JP-ANo.2004-33901 may be also preferably used.
- Fig. 2 is a schematic cross-sectional view of T-type microreactor, showing one example of a mixing mechanism with a T-type microreactor.
- Fig. 3 is a conceptional view of a T-type microreactor, showing one example of a mixing mechanism with a T-type microreactor.
- a cross-section of a T-type path 200 of a T-type microreactor is shown.
- a fluid which has been flown therein in a direction of an arrow D through an inlet 202a, and a fluid which has been flown therein in a direction of an arrow E through an inlet 202b are collided at a central part in a path of the T-type path 200, and mixed to become a fine fluid particle.
- the fine fluid particle is flown out in a direction of an arrow F through an outlet 204.
- This T-type microreactor is useful for mixing when the volume of a path is small.
- a fluid mixing mechanism (concept) 300 of other T-type microreactor is shown.
- fluids which have been flown therein through two paths 302a and 302b are mutually collided and mixed to become a fine fluid particle. That is, the fluid, on one hand, is flown in a path 302a in a direction of an arrow G, and is flown out in a direction of an arrow H.
- the fluid is flown in a path 302b in a direction of an arrow I, and is flown out in a direction of an arrow J.
- Fluids which have been flown out through paths 302a and 302b, respectively, are collided, are mixed, and are flied approximately orthogonal with a direction of an arrow G to J.
- the fluid mixing mechanism described in the path figure, Fig. 3 collides and mixes fluids diffused by a procedure of misting. By this collision and mixing, the fluid becomes finer, and a great contact surface may be obtained.
- the collision-type micromixer a representative which is the KM mixer, has a structure in which forcible contact is tried utilizing the kinetic energy. Specifically, there is a central collision-type micromixer disclosed by Nagasawa et al. ("H.Nagasawa et al., Chem.Eng.Technol.,28,No.3,324-330 (2005)", JP-ANo.2005-288254). In the method of countercurrently colliding an aqueous phase and an organic solvent phase, since a mixing time is extremely short, and an oily phase droplet is instantly formed, an extremely fine emulsion or dispersion is easily formed.
- a temperature at emulsification is such that micro-mixing is performed at a temperature of the aforementioned separate fine space of the micromixer (temperature at micro-mixing part of micromixer) at preferably 8O 0 C or lower, more preferably 0°C to 80°C, particularly preferably 5 0 C to 75°C, from a viewpoint of particle diameter uniformity of the resulting emulsion.
- a retained temperature of the fine space of the micromixer is preferably 100 0 C or lower.
- the retained temperature is controlled at a temperature of 80 0 C or lower.
- Retained temperatures of the oily phase and the aqueous phase divided into the fine space of the micromixer, and of the fine space of the micromixer are different depending on components contained in the aqueous phase and the oily phase, and are each independently preferably 0 0 C to 5O 0 C, particularly preferably 5°C to 25°C.
- the retained temperature of the fine space of the micromixer, the retained temperatures of the oily phase and aqueous phase divided into the fine space of the micromixer, and the retained temperatures of the oily phase and the aqueous phase before division into the fine space of the micromixer i.e. retained temperatures of oily phase and aqueous phase supplying tanks) may be different, respectively, but the same temperature is preferable in stability of mixing.
- the cross-sectional area of a narrowest part of the fine space (path) of the micromixer in the invention is 1 ⁇ m 2 to 1 mm 2 and, from a viewpoint of miniaturization of the emulsion particle diameter and sharpness of the particle diameter distribution, preferably 500 ⁇ m 2 to 50,000 ⁇ m 2 .
- the cross-sectional area of a narrowest part of the fine space (path) of the micromixer used in the aqueous phase in the invention is particularly preferably 1,000 ⁇ m to 50,000 ⁇ m 2 from a viewpoint of mixing stability.
- the cross-sectional area of a narrowest part of the fine space (path) of the micromixer used in the oily phase is particularly preferably 500 ⁇ m 2 to 20,000 ⁇ m 2 from a viewpoint of miniaturization of the emulsion particle diameter and sharpness of the particle diameter distribution.
- the flow rate of the oily phase and the aqueous phase at emulsification and dispersing are different depending on the micromixer used and, from a viewpoint of miniaturization of the emulsion particle diameter and sharpness of the particle diameter distribution, the flow rate of the aqueous phase is preferably 10 ml/min to 500 ml/min, more preferably 20 ml/min to 350 ml/min, particularly preferably 50 ml/min to 200 ml/min.
- the flow rate of the oily phase is preferably 1 ml/min to 100 ml/min, more preferably 3 ml/min to 50 ml/min, particularly preferably 5 ml/min to 50 ml/min.
- the value obtained by dividing flow rates of both phases by the cross-sectional area of a microchannel, that is, the flow speed ratio (Vo/Vw) of both phases is preferably in the range of 0.05 or more and 5 or less from a viewpoint of miniaturization of a particle and design of the micromixer, wherein Vo is the flow speed of an organic solvent phase containing a water-insoluble natural component, and Vw is the flow speed of an aqueous phase. And, the flow speed ratio (Vo/Vw) of 0.1 or more and 3 or less is the most preferable range from a viewpoint of further miniaturization of a particle.
- solution sending pressures of the aqueous phase and the oily phase are preferably 0.030 MPa to 5 MPa and 0.010 MPa to 1 MPa 5 more preferably 0.1 MPa to 2 MPa and 0.02 MPa to 0.5 MPa, particularly preferably 0.2 MPa to 1 MPa and 0.04 MPa to 0.2 MPa, respectively.
- solution sending pressure of the aqueous phase of 0.030 MPa to 5 MPa the stable solution sending flow rate tends to be maintained and, by adopting the solution sending pressure of the oily phase of 0.010 MPa to 1 MPa, uniform mixing property tends to be obtained, being preferable.
- the flow rate, the solution sending pressure and the retained temperature are more preferably a combination of respective preferably examples.
- a route from introduction of the aqueous phase and the oily phase into the mixromixer to discharge as a oil-in- water droplet emulsion will be explained using an example of a microdevice (Fig. 1) as one example of the mixromixer in the invention.
- a cross-section as a path for the oily phase or the aqueous phase in the invention is such that rectangular annular channels 108 and 110 are concentrically formed.
- bores 112 and 114 leading to each annular channel are formed, penetrating in a direction of its thickness (or height) direction.
- a bore 116 penetrating in its thickness direction is formed in the confluence element 104.
- this bore 116 when an element is secured thereto in order to construct the microdevice 100, an end 120 of the bore 116 situated on a surface of the confluence element 104 opposite to the supply element 102 is opened in the annular channel 108.
- four bores 116 are formed, and they are arranged at an equal interval in a circumferential direction of the annular channel 108.
- a bore 118 is formed, penetrating therethrough, like the bore 116.
- the bore 118 is formed so as to be opened in the annular channel 110, like the bore 116.
- Bores 118 are arranged at an equal interval in a circumferential direction of the annular channel 110, and the bore 116 and the bore 118 are arranged so as to be positioned alternately.
- microchannels 124 and 126 are formed on a surface 122 opposite to the discharge element 106 of the confluent element 104.
- One end of this microchannel 124 or 126 is an opening part of the bore 116 or 118, the other end is a center 128 of the surface 122, and all microchannels extend from bores towards this center 128, and are converged at a center.
- a cross-section of the microchannel may be, for example, rectangular.
- a bore 130 passing a center thereof and penetrating in a thickness direction is formed. Therefore, this bore is opened in the center 128 of the confluence element 104 at one end, and is opened in the outside of the microdevice at the other end.
- fluids A and B supplied from the outside of the microdevice 100 at ends of bores 112 and 114 are flown into annular channels 108 and 110 via bores 112 and 114, respectively.
- the annular channel 108 and the bore 116 are communicated, and the fluid A which has flown into the annular channel 108 enters a microchannel 124 via the bore 116.
- the annular channel 110 and the bore 118 are communicated, and the fluid B which has flown into the annular channel 110 enters a microchannel 126 via the bore 118.
- Fluids A and B are flown into microchannels 124 and 126, respectively, and are flown towards a center 128, and are converged.
- the converged fluids are discharged as a stream C to the outside of the microdevice via the bore 130.
- microdevice 100 may have the following spec.
- Diameter and length of bore 112 1.5/10 mm (circular cross-section)
- Diameter and length of bore 114 1.5/10 mm (circular cross-section)
- Diameter and length of bore 116 0.5/4 mm (circular cross-section)
- Diameter and length of bore 118 0.5/4 mm (circular cross-section)
- Cross-sectional shape of microchannel 124, width, depth, length rectangular, cross-sectional area, 350 ⁇ m/100 ⁇ m/12.5 mm/35000 ⁇ m 2
- Cross-sectional shape of microchannel 126, width, depth, length rectangular, cross-sectional area, 50 ⁇ m/100 ⁇ m/10 mm/5000 ⁇ m 2
- Diameter and length of bore 130 500 ⁇ m, 10 mm (circular cross-section) [0118]
- the size of the microchannel (in Fig. 1 , 124 and 126) in which the aqueous phase and the oily phase are collided is defined in the preferable range in context with flow rates of the aqueous phase and the oily phase.
- a water-soluble organic solvent which has been used is removed after emulsification and dispersing through the micropath.
- a method of removing a solvent an evaporation method using a rotary evaporator, a flash evaporator, or an ultrasound atomizer, and a membrane separating method such as an ultrafiltration membrane and a reverse osmosis membrane are known, and an ultrafiltration membrane method is particularly preferable.
- An ultra filter (abbreviated as UF) is an apparatus by which a stock solution (water, mixed aqueous solution of high-molecular substance, low-molecular substance, and colloidal substance) is pressurized, and water is poured into a UF apparatus, thereby, the stock solution may be separated into two-system solutions of a permeated solution (low-molecular substance) and a concentrated solution (high-molecular substance, colloidal substance), and taken out.
- a stock solution water, mixed aqueous solution of high-molecular substance, low-molecular substance, and colloidal substance
- the ultrafiltration membrane is a typical asymmetric membrane made by the Leob-Sourirajan method.
- a polymer material used includes polyacrylonitrile, polyvinyl chloride-polyacrylonitrile copolymer, polysulfone, polyether sulfone, vinylidene fluoride, aromatic polyamide, and cellulose acetate.
- a ceramic membrane has become to be used.
- fouling occurs, in which a polymer is deposited on a membrane surface. For this reason, it is normal to wash the membrane with a chemical or warm water periodically. For this reason, a membrane material is required to have resistance to a chemical and heat resistance.
- a membrane module of an ultrafiltration membrane there are various kinds such as flat membrane type, tubular type, hollow thread type, and spiral type.
- An index for performance of an ultrafiltration membrane is a fractionation molecular weight, and various membranes having a fractionation molecular weight of 1,000 to 300,000 are commercially available.
- the commercially available membrane module there are Microsa UF (Asahi Kasei Chemicals Corporation), and capillary-type element (trade name: NTU-3306, manufactured by Nitto Denko Corporation), being not limiting.
- a material of a membrane is particularly preferably polysulfone, polyether sulfone, and aromatic polyamide are particularly preferable from a viewpoint of solvent resistance.
- a membrane module a flat membrane is mainly used at a laboratory scale, and a hollow shred type and spiral type are industrially used, and a hollow shred type is particularly preferable.
- a fraction molecular weight is different depending on a kind of an active ingredient and, usually, the range of 5,000 to 100,000 is used.
- An operation temperature may be 0°C to 80 0 C and, in view of degradation of an active ingredient, the range of 10 0 C to 40°C is particularly preferable.
- an ultrafiltration membrane method is a preferable method.
- this is preferable and, if necessary, ultrafiltration membranes having different fractionation molecular weights may be also used.
- a concentration efficacy may be enhanced by operating at a temperature different from that of solvent removal.
- the topical composition for external use (emulsion) obtained by mixing with the micromixer is a oil-in- water droplet emulsion.
- the volume average particle diameter (median diameter) of the dispersed particle of the emulsion is 1 nm to 100 nm. From a viewpoint of transparency of the resulting emulsion, the diameter is more preferably 1 nm to 50 nm.
- the particle diameter of the dispersed particle obtained by the process for producing the topical composition for external use of the invention may be measured with a commercially available particle size distribution meter, and details thereof are as described above. [0126] ⁇ Utility>
- the topical composition for external use of the invention is a fine emulsion composition excellent in the emollient effect due to the ceramide compound. For this reason, the composition is preferably used in a variety of utilities depending on the function of the ceramide compound.
- the composition may be widely used, for example, in medicaments (external use preparations, skin preparations), or cosmetics.
- medicaments include parenteral preparations such as suppositories, and coating preparations (skin external use preparations)
- cosmetic include skin care cosmetics (lotions, beauty essences, emulsions, creams, etc.), sun-screen cosmetics, and makeup cosmetics such as lip rouges and foundations, being not limiting.
- topical composition for external use of the invention is used in beauty washes, beauty essences, emulsions, cream packs/masks, packs, hair washing cosmetics, fragrance cosmetics, liquid body cleansing preparations, UV care cosmetics, deodorant cosmetics, oral care cosmetics, analgesics or antiphlogstic-containing gels, and aqueous products such as drug efficacy ingredient-containing layer of antiphlogistic-containing patch, products having a transparency feeling are obtained, and occurrence of inconvenient phenomenon such as settlement, precipitation or neckling of insolubles under the severe conditions such as long term storage and sterilization treatment may be suppressed.
- Ceramide 3 [Ceramide compound, embodiment 1-5] 0.1 part Ceramide 6 [Ceramide compound, embodiment 1-7] 0.1 part Phytosphingosine 0.07 part
- micromixer The condition for using the micromixer are as follows. -Microchannel- OiIy phase side microchannel
- An aqueous phase was introduced into an external annulus at the flow rate of 21.0 ml/min, an oil phase was introduced into an internal annulus at the flow rate of 3.0 ml/min, and these were micro-mixed.
- the resulting emulsion (ceramide-dispersed composition) was desolvated to the ethanol concentration of 0.1% or less using Evapor (CEP-lab) manufactured by Ogawara Corporation, and this was concentrated and adjusted to the emulsion concentration of 2.0% to obtain an emulsion A.
- Evapor CEP-lab
- the emulsion concentration referred herein is the concentration based on the sum of a solid matter added to an oily phase.
- Each of the resulting addition liquids 1-Ato 1-F at 50 parts was taken, and added to 50 parts of the emulsion (ceramide-dispersed composition) 1 obtained from the oily phase liquid 1, and the mixture was stirred with a magnetic stirrer at 300 rpm for 30 minutes to obtain topical compositions for external use 1-Ato 1-F having the final emulsion concentration of 1.0%.
- Ceramide 3 [Ceramide compound, embodiment 1-5] 0.1 part Ceramide 6 [Ceramide compound, embodiment 1-7] 0.1 part Phytosphingosine 0.03 part
- the resulting oily phase liquid 2 (oily phase) and each of addition liquids 2-A to 2-F as an aqueous phase were micro-mixed at the ratio (mass ratio) of 1 :7 using a KM-type micromixer 100/100 which is a collision type, to obtain compositions for external use 2-A to 2-F.
- the aqueous phase was introduced into an external annulus at the flow rate of 21.0 ml/min, the oily phase was introduced into an internal annulus at the flow rate of 3.0 ml/min, and this was micro-mixed.
- Example compositions for external use 2-A to 2-F and a comparative topical composition for external use 2-G were desolvated to the ethanol concentration of 0.1% or less using Evapor (CEP-lab) manufactured by Okawara Corporation, and this was concentrated and adjusted to the emulsion concentration of 1.0% to obtain Example compositions for external use 2-A to 2-F and a comparative topical composition for external use 2-G.
- the emulsion concentration referred herein is the concentration based on the sum of a solid matter added to the oily phase. [0135] [Table 2]
- the particle diameter of the ceramide analogus-containing particle in the crude topical composition for external use immediately after preparation, or an oily phase particle containing the ceramide analogus-containing particle was measured using a dynamic light scattering-type particle diameter distribution measuring apparatus (trade name: LB-550, manufactured by Horiba Ltd.).
- the topical composition for external use of the invention has the small particle diameter of the ceramide analogue-containing particle, and is excellent in dispersibility and dispersing stability of such the particle.
- topical compositions for external use 1-A 1 to 1-F' and a comparative topical composition for external use 1-G' were prepared in the same manner as Examples 1-A to 1-F and Comparative Example 1-G except that ceramide 3 was changed to ceramide 3B.
- topical compositions for external use 2-A' to 2-F' and a comparative topical composition for external use 2-G' were prepared in the same manner as Examples 2-A to 2-F and Comparative Example 2-G except that ceramide 3 was changed to ceramide 3B.
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Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
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EP09742775.1A EP2273969B1 (en) | 2008-05-09 | 2009-04-30 | Topical composition for external use and process for producing the same |
CN2009801136928A CN102006853A (en) | 2008-05-09 | 2009-04-30 | Topical composition for external use and process for producing the same |
US12/991,036 US20110059145A1 (en) | 2008-05-09 | 2009-04-30 | Topical composition for external use and process for producing the same |
Applications Claiming Priority (2)
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JP2008123688A JP4879934B2 (en) | 2008-05-09 | 2008-05-09 | Composition for external use and method for producing the same |
JP2008-123688 | 2008-05-09 |
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WO2009136651A1 true WO2009136651A1 (en) | 2009-11-12 |
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PCT/JP2009/058792 WO2009136651A1 (en) | 2008-05-09 | 2009-04-30 | Topical composition for external use and process for producing the same |
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US (1) | US20110059145A1 (en) |
EP (1) | EP2273969B1 (en) |
JP (1) | JP4879934B2 (en) |
KR (1) | KR101603809B1 (en) |
CN (1) | CN102006853A (en) |
TW (1) | TW200948390A (en) |
WO (1) | WO2009136651A1 (en) |
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US9492492B2 (en) * | 2010-12-17 | 2016-11-15 | Johnson & Johnson Consumer Inc. | Compositions comprising Lilium martagon extracts and uses thereof |
US8293293B2 (en) | 2010-12-17 | 2012-10-23 | Johnson & Johnson Consumer Companies, Inc. | Compositions comprising Lilium martagon extracts and uses thereof |
KR101433913B1 (en) | 2011-04-28 | 2014-09-01 | 주식회사 진영바이오 | Glycosyl ceramide compound, and composition comprising the compound |
TWI414362B (en) | 2011-05-18 | 2013-11-11 | Ind Tech Res Inst | Extraction apparatus |
DE102011109546A1 (en) * | 2011-08-03 | 2013-02-07 | Evonik Goldschmidt Gmbh | Use of sphinganine to improve the visual appearance of the skin and hair |
JP6010307B2 (en) * | 2012-02-14 | 2016-10-19 | アサヌマ コーポレーション株式会社 | Aqueous cosmetics |
CN103385806B (en) * | 2013-08-08 | 2015-08-12 | 珀莱雅化妆品股份有限公司 | A kind of method suppressing skin-lightening cosmetic to turn yellow |
KR102211958B1 (en) * | 2020-02-10 | 2021-02-04 | 코스맥스 주식회사 | Manufacturing method of powder composition dispersed by particulate process and a powder composition manufactured thereby |
WO2022163336A1 (en) * | 2021-01-29 | 2022-08-04 | 株式会社コーセー | Ceramide-containing composition |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0249091A (en) | 1988-08-11 | 1990-02-19 | Suntory Ltd | Astaxanthin-containing composition |
JPH07187987A (en) | 1993-12-24 | 1995-07-25 | Kanebo Ltd | Skin cosmetic |
JPH11310512A (en) | 1998-04-30 | 1999-11-09 | Q P Corp | Preparation of additive for cosmetic and cosmetic compounded with the same |
JP2000051676A (en) | 1998-08-07 | 2000-02-22 | Kibun Food Chemifa Co Ltd | Emulsifier and emulsion composition |
JP2001139796A (en) | 1999-11-12 | 2001-05-22 | Pigeon Corp | Transparent dispersion containing ceramides and method for producing the same |
JP2001316217A (en) | 2000-05-11 | 2001-11-13 | Takasago Internatl Corp | Aqueous transparent composition |
JP2002317124A (en) * | 2001-04-18 | 2002-10-31 | Kao Corp | Dilatancy composition |
JP2003113393A (en) * | 2001-10-03 | 2003-04-18 | Nof Corp | Ceramide dispersion, method for producing the same, and application of the same |
JP2004033901A (en) | 2002-07-03 | 2004-02-05 | Nippon Paint Co Ltd | Production method for metal colloidal solution |
JP2005288254A (en) | 2004-03-31 | 2005-10-20 | Ube Ind Ltd | Micro-device and method for confluence of fluids |
JP2006335692A (en) | 2005-06-02 | 2006-12-14 | Kao Corp | Water-in-oil type emulsion composition |
WO2007004300A1 (en) * | 2005-07-06 | 2007-01-11 | Dr.Ci:Labo Co., Ltd. | Cosmetic product |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR920010246B1 (en) * | 1990-07-20 | 1992-11-21 | 한국화장품주식회사 | Cosmetic composition |
FR2673179B1 (en) * | 1991-02-21 | 1993-06-11 | Oreal | CERAMIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS IN COSMETICS AND DERMOPHARMACY. |
JP2001342113A (en) * | 2000-06-02 | 2001-12-11 | Kao Corp | Solution for beauty |
JP2002338459A (en) * | 2001-05-16 | 2002-11-27 | Nikko Chemical Co Ltd | Method for solubilizing ceramide and ceramide- formulated skin care preparation obtained by using the method |
WO2004045566A1 (en) * | 2002-11-15 | 2004-06-03 | Kose Corporation | Semitransparent cosmetics |
KR100715464B1 (en) * | 2005-05-25 | 2007-05-07 | 김쌍규 | Remote Dialing System By Speech Recognition |
KR100693292B1 (en) * | 2005-10-06 | 2007-03-13 | 주식회사 바이오랜드 | Novel pseudoceramides and the composition comprising the same |
-
2008
- 2008-05-09 JP JP2008123688A patent/JP4879934B2/en active Active
-
2009
- 2009-04-30 US US12/991,036 patent/US20110059145A1/en not_active Abandoned
- 2009-04-30 KR KR1020107027110A patent/KR101603809B1/en active IP Right Grant
- 2009-04-30 WO PCT/JP2009/058792 patent/WO2009136651A1/en active Application Filing
- 2009-04-30 CN CN2009801136928A patent/CN102006853A/en active Pending
- 2009-04-30 EP EP09742775.1A patent/EP2273969B1/en active Active
- 2009-05-05 TW TW098114832A patent/TW200948390A/en unknown
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0249091A (en) | 1988-08-11 | 1990-02-19 | Suntory Ltd | Astaxanthin-containing composition |
JPH07187987A (en) | 1993-12-24 | 1995-07-25 | Kanebo Ltd | Skin cosmetic |
JPH11310512A (en) | 1998-04-30 | 1999-11-09 | Q P Corp | Preparation of additive for cosmetic and cosmetic compounded with the same |
JP2000051676A (en) | 1998-08-07 | 2000-02-22 | Kibun Food Chemifa Co Ltd | Emulsifier and emulsion composition |
JP2001139796A (en) | 1999-11-12 | 2001-05-22 | Pigeon Corp | Transparent dispersion containing ceramides and method for producing the same |
JP2001316217A (en) | 2000-05-11 | 2001-11-13 | Takasago Internatl Corp | Aqueous transparent composition |
JP2002317124A (en) * | 2001-04-18 | 2002-10-31 | Kao Corp | Dilatancy composition |
JP2003113393A (en) * | 2001-10-03 | 2003-04-18 | Nof Corp | Ceramide dispersion, method for producing the same, and application of the same |
JP2004033901A (en) | 2002-07-03 | 2004-02-05 | Nippon Paint Co Ltd | Production method for metal colloidal solution |
JP2005288254A (en) | 2004-03-31 | 2005-10-20 | Ube Ind Ltd | Micro-device and method for confluence of fluids |
JP2006335692A (en) | 2005-06-02 | 2006-12-14 | Kao Corp | Water-in-oil type emulsion composition |
WO2007004300A1 (en) * | 2005-07-06 | 2007-01-11 | Dr.Ci:Labo Co., Ltd. | Cosmetic product |
Non-Patent Citations (2)
Title |
---|
CHEMISTRY OF ASTAXANTHIN, 2005, Retrieved from the Internet <URL:URL:http://www.astaxanthin.co.jp/chemical/basic.htm> |
H.NAGASAWA ET AL., CHEM.ENG.TECHNOL., vol. 28, no. 3, 2005, pages 324 - 330 |
Also Published As
Publication number | Publication date |
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CN102006853A (en) | 2011-04-06 |
TW200948390A (en) | 2009-12-01 |
KR20110010754A (en) | 2011-02-07 |
EP2273969A1 (en) | 2011-01-19 |
JP4879934B2 (en) | 2012-02-22 |
EP2273969B1 (en) | 2019-12-25 |
KR101603809B1 (en) | 2016-03-16 |
US20110059145A1 (en) | 2011-03-10 |
JP2009269882A (en) | 2009-11-19 |
EP2273969A4 (en) | 2014-01-01 |
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