WO2009134725A3 - Monomethylamine progesteron antagonists such as cdb-4453 in the treatment of endometriosis, uterine fibroids, dysmenorrhea, breast cancer etc - Google Patents
Monomethylamine progesteron antagonists such as cdb-4453 in the treatment of endometriosis, uterine fibroids, dysmenorrhea, breast cancer etc Download PDFInfo
- Publication number
- WO2009134725A3 WO2009134725A3 PCT/US2009/041841 US2009041841W WO2009134725A3 WO 2009134725 A3 WO2009134725 A3 WO 2009134725A3 US 2009041841 W US2009041841 W US 2009041841W WO 2009134725 A3 WO2009134725 A3 WO 2009134725A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- monomethylamine
- dysmenorrhea
- treatment
- breast cancer
- endometriosis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
Abstract
The subject matter of the instant invention is pertinent to the field of treatment of progesterone-dependent conditions. Compositions for practicing the methods, comprising one or more 19-norsteroid progesterone receptor modulators having a monomethylamine-substituted phenyl ring at the 11 β-position of carbon 11 and exhibiting low antiglucocorticoid activity, are also disclosed. Embodiments of the instant invention disclose methods for treating endometriosis, dysmenorrhea, breast cancer, uterine fibroids and endometrial hyperproliferation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4845908P | 2008-04-28 | 2008-04-28 | |
US61/048,459 | 2008-04-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009134725A2 WO2009134725A2 (en) | 2009-11-05 |
WO2009134725A3 true WO2009134725A3 (en) | 2009-12-23 |
Family
ID=40756776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/041841 WO2009134725A2 (en) | 2008-04-28 | 2009-04-27 | Compositions and methods for treating progesterone-dependent conditions |
Country Status (3)
Country | Link |
---|---|
CL (1) | CL2009001012A1 (en) |
TW (1) | TW201002736A (en) |
WO (1) | WO2009134725A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0900171A2 (en) * | 2009-03-20 | 2010-12-28 | Richter Gedeon Nyrt | Novel crystal form of 17-acetoxy-11-[4-(dimethyl-amino)-phenyl]-21-metoxy-19-norpregna-4,9-dien-3,20-dione and process for it's preparation |
HUP0900487A2 (en) * | 2009-08-05 | 2011-03-28 | Richter Gedeon Nyrt | Novel crystal polymorphic form of 17-acetoxy-11 -[4-(dimethylamino)phenyl]-21-methoxy-4,9-diene-3,20-dione and process for it's preparation |
US9603856B2 (en) * | 2013-11-03 | 2017-03-28 | Flamina Holding Ag | Pharmaceutical composition or group of compositions for inhibiting autocrine HCG production in adult human cells |
WO2016081383A1 (en) | 2014-11-17 | 2016-05-26 | Arno Therapeutics, Inc. | Onapristone extended-release compositions and methods |
US10308676B2 (en) | 2015-09-25 | 2019-06-04 | Context Biopharma Inc. | Methods of making onapristone intermediates |
US10548905B2 (en) | 2015-12-15 | 2020-02-04 | Context Biopharma Inc. | Amorphous onapristone compositions and methods of making the same |
JP2019513706A (en) * | 2016-03-21 | 2019-05-30 | コンテキスト・バイオファーマ・インコーポレイテッド | Onapristone metabolite composition and method |
US20180148471A1 (en) | 2016-11-30 | 2018-05-31 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997041145A1 (en) * | 1996-05-01 | 1997-11-06 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | 21-substituted progesterone derivatives as new antiprogestational agents |
WO2001074840A2 (en) * | 2000-03-17 | 2001-10-11 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregna 21-substituted 19-norpregnadienedione as antiprogestational agents |
US6900193B1 (en) * | 1996-05-01 | 2005-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
WO2007103510A2 (en) * | 2006-03-08 | 2007-09-13 | Danco Laboratories Llc | Methods, dosing regimens & medications using anti-progestational agents for the treatment of disorders |
WO2008067086A2 (en) * | 2006-10-24 | 2008-06-05 | Repros Therapeutics Inc. | Compositions and methods for suppressing endometrial proliferation |
WO2008129396A2 (en) * | 2007-04-20 | 2008-10-30 | Preglem S.A. | Progesterone antagonist and selective progesterone modulator in the treatment of uterine bleeding |
-
2009
- 2009-04-14 TW TW098112266A patent/TW201002736A/en unknown
- 2009-04-27 WO PCT/US2009/041841 patent/WO2009134725A2/en active Application Filing
- 2009-04-28 CL CL2009001012A patent/CL2009001012A1/en unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997041145A1 (en) * | 1996-05-01 | 1997-11-06 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | 21-substituted progesterone derivatives as new antiprogestational agents |
US6900193B1 (en) * | 1996-05-01 | 2005-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
WO2001074840A2 (en) * | 2000-03-17 | 2001-10-11 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregna 21-substituted 19-norpregnadienedione as antiprogestational agents |
WO2007103510A2 (en) * | 2006-03-08 | 2007-09-13 | Danco Laboratories Llc | Methods, dosing regimens & medications using anti-progestational agents for the treatment of disorders |
WO2008067086A2 (en) * | 2006-10-24 | 2008-06-05 | Repros Therapeutics Inc. | Compositions and methods for suppressing endometrial proliferation |
WO2008129396A2 (en) * | 2007-04-20 | 2008-10-30 | Preglem S.A. | Progesterone antagonist and selective progesterone modulator in the treatment of uterine bleeding |
Non-Patent Citations (2)
Title |
---|
ATTARDI BARBARA J ET AL: "CDB-4124 and its putative monodemethylated metabolite, CDB-4453, are potent antiprogestins with reduced antiglucocorticoid activity: In vitro comparison to mifepristone and CDB-2914", MOLECULAR AND CELLULAR ENDOCRINOLOGY, ELSEVIER IRELAND LTD, IE, vol. 188, no. 1-2, 25 February 2002 (2002-02-25), pages 111 - 123, XP002496575, ISSN: 0303-7207 * |
MEALY N E ET AL: "CDB-4124", DRUGS OF THE FUTURE 200411 ES, vol. 29, no. 11, November 2004 (2004-11-01), pages 1133, XP009118559, ISSN: 0377-8282 * |
Also Published As
Publication number | Publication date |
---|---|
TW201002736A (en) | 2010-01-16 |
CL2009001012A1 (en) | 2009-09-25 |
WO2009134725A2 (en) | 2009-11-05 |
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