WO2009132209A3 - Methods and compounds for mitigating pathogenic outbreaks using replikin count cycles - Google Patents

Methods and compounds for mitigating pathogenic outbreaks using replikin count cycles Download PDF

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Publication number
WO2009132209A3
WO2009132209A3 PCT/US2009/041565 US2009041565W WO2009132209A3 WO 2009132209 A3 WO2009132209 A3 WO 2009132209A3 US 2009041565 W US2009041565 W US 2009041565W WO 2009132209 A3 WO2009132209 A3 WO 2009132209A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
methods
mitigating
pathogenic
replikin count
Prior art date
Application number
PCT/US2009/041565
Other languages
French (fr)
Other versions
WO2009132209A2 (en
Inventor
Samuel Bogoch
Elenore S . Bogoch
Samuel Winston Bogoch
Anne Elenore Borsanyi
Original Assignee
Samuel Bogoch
Bogoch Elenore S
Samuel Winston Bogoch
Anne Elenore Borsanyi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2008/061336 external-priority patent/WO2008156914A2/en
Application filed by Samuel Bogoch, Bogoch Elenore S, Samuel Winston Bogoch, Anne Elenore Borsanyi filed Critical Samuel Bogoch
Priority to JP2011506455A priority Critical patent/JP2011519837A/en
Priority to EP20090734389 priority patent/EP2300493A2/en
Priority to AU2009240587A priority patent/AU2009240587A1/en
Priority to CA2720465A priority patent/CA2720465A1/en
Priority to US12/538,027 priority patent/US20100144589A1/en
Priority to SG2013059449A priority patent/SG193783A1/en
Priority to AU2009279428A priority patent/AU2009279428A1/en
Priority to PCT/US2009/053208 priority patent/WO2010017514A2/en
Priority to CA2733461A priority patent/CA2733461A1/en
Priority to EP09791315.6A priority patent/EP2320932B1/en
Priority to SG2011076536A priority patent/SG175275A1/en
Priority to SG10201401532PA priority patent/SG10201401532PA/en
Priority to CA2759325A priority patent/CA2759325A1/en
Priority to US12/581,112 priority patent/US9233148B2/en
Priority to NZ595812A priority patent/NZ595812A/en
Priority to AU2009344843A priority patent/AU2009344843A1/en
Priority to PCT/US2009/061108 priority patent/WO2010123519A1/en
Priority to EP20090743995 priority patent/EP2421546A1/en
Publication of WO2009132209A2 publication Critical patent/WO2009132209A2/en
Publication of WO2009132209A3 publication Critical patent/WO2009132209A3/en
Priority to IL208765A priority patent/IL208765A0/en
Priority to IL210745A priority patent/IL210745A0/en
Priority to IL215770A priority patent/IL215770A0/en
Priority to US14/957,465 priority patent/US20160122397A1/en
Priority to US15/159,603 priority patent/US20160267244A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56905—Protozoa
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention provides methods of predicting increases in pathogenic virulence, morbidity, and/or mortality or expansion in pathogen populations within regions or into new regions by identifying cycles or ratios of increasing concentrations of a family of small peptides expressed in pathogens and provides compounds comprising the small peptides for treatment and prevention of pathogenic outbreaks.
PCT/US2009/041565 2008-04-23 2009-04-23 Methods and compounds for mitigating pathogenic outbreaks using replikin count cycles WO2009132209A2 (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
JP2011506455A JP2011519837A (en) 2008-04-23 2009-04-23 Methods and compounds for mitigating pathogen outbreaks using Replikin Count Cycle
EP20090734389 EP2300493A2 (en) 2008-04-23 2009-04-23 Methods and compounds for mitigating pathogenic outbreaks using replikin count cycles
AU2009240587A AU2009240587A1 (en) 2008-04-23 2009-04-23 Methods and compounds for mitigating pathogenic outbreaks using replikin count cycles
CA2720465A CA2720465A1 (en) 2008-04-23 2009-04-23 Methods and compounds for mitigating pathogenic outbreaks using replikin count cycles
US12/538,027 US20100144589A1 (en) 2008-08-08 2009-08-07 Methods of predicting cancer lethality using replikin counts
SG2013059449A SG193783A1 (en) 2008-08-08 2009-08-07 Methods of predicting cancer lethality using replikin counts
AU2009279428A AU2009279428A1 (en) 2008-08-08 2009-08-07 Methods of predicting cancer lethality using Replikin counts
PCT/US2009/053208 WO2010017514A2 (en) 2008-08-08 2009-08-07 Methods of predicting cancer lethality using replikin counts
CA2733461A CA2733461A1 (en) 2008-08-08 2009-08-07 Methods of predicting cancer lethality using replikin counts
EP09791315.6A EP2320932B1 (en) 2008-08-08 2009-08-07 Methods of predicting cancer lethality using replikin counts
EP20090743995 EP2421546A1 (en) 2009-04-23 2009-10-16 Replikin-sequences for preventing/treating influenza and determining infectivity/lethality
SG2011076536A SG175275A1 (en) 2009-04-23 2009-10-16 Replikin-sequences for preventing/treating influenza and determining infectivity/lethality
PCT/US2009/061108 WO2010123519A1 (en) 2009-04-23 2009-10-16 Replikin-sequences for preventing/treating influenza and determining infectivity/lethality
SG10201401532PA SG10201401532PA (en) 2009-04-23 2009-10-16 Replikin-sequences for preventing/treating influenza and determining infectivity/lethality
CA2759325A CA2759325A1 (en) 2009-04-23 2009-10-16 Replikin-sequences for preventing/treating influenza and determining infectivity/lethality
US12/581,112 US9233148B2 (en) 2009-01-09 2009-10-16 Replikin-based compounds for prevention and treatment of influenza and methods of differentiating infectivity and lethality in influenza
NZ595812A NZ595812A (en) 2009-04-23 2009-10-16 Replikin-sequences for preventing/treating influenza and determining infectivity/lethality
AU2009344843A AU2009344843A1 (en) 2009-04-23 2009-10-16 Replikin-sequences for preventing/treating influenza and determining infectivity/lethality
IL208765A IL208765A0 (en) 2008-04-23 2010-10-17 Methods and compounds for mitigating pathogenic outbreaks using replikin count cycles
IL210745A IL210745A0 (en) 2008-08-08 2011-01-19 Methods of predicting cancer lethality using replikin counts
IL215770A IL215770A0 (en) 2009-04-23 2011-10-23 Replikin-sequences for preventing/treating influenza and determining infectivity/ lethality
US14/957,465 US20160122397A1 (en) 2009-01-09 2015-12-02 Replikin-based compounds for prevention and treatment of influenza and methods of differentiating infectivity and lethality in influenza
US15/159,603 US20160267244A1 (en) 2008-08-08 2016-05-19 Methods of predicting cancer lethality using replikin counts

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
PCT/US2008/061336 WO2008156914A2 (en) 2007-05-30 2008-04-23 Synthetic replikin peptides against pathogenic infection of invertebrates in aquaculture
US12/108,458 2008-04-23
US12/108,458 US9408902B2 (en) 2007-05-30 2008-04-23 Synthetic replikin peptides against pathogenic infection of invertebrates in aquaculture
USPCT/US2008/061336 2008-04-23
US5401008P 2008-05-16 2008-05-16
US61/054,010 2008-05-16
US8735408P 2008-08-08 2008-08-08
US61/087,354 2008-08-08
US14361809P 2009-01-09 2009-01-09
US61/143,618 2009-01-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/429,044 Continuation-In-Part US20090269367A1 (en) 2008-04-23 2009-04-23 Methods and compounds for mitigating pathogenic outbreaks using replikin count cycles

Publications (2)

Publication Number Publication Date
WO2009132209A2 WO2009132209A2 (en) 2009-10-29
WO2009132209A3 true WO2009132209A3 (en) 2010-03-18

Family

ID=41066049

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/041565 WO2009132209A2 (en) 2008-04-23 2009-04-23 Methods and compounds for mitigating pathogenic outbreaks using replikin count cycles

Country Status (6)

Country Link
EP (1) EP2300493A2 (en)
JP (1) JP2011519837A (en)
AU (1) AU2009240587A1 (en)
CA (1) CA2720465A1 (en)
IL (1) IL208765A0 (en)
WO (1) WO2009132209A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9233148B2 (en) 2009-01-09 2016-01-12 Samuel Bogoch Replikin-based compounds for prevention and treatment of influenza and methods of differentiating infectivity and lethality in influenza
US9320784B2 (en) 2009-08-07 2016-04-26 Samuel Bogoch Peptides shared among lethal cancers and therapeutic compositions comprising said peptides
SG11201405447QA (en) 2012-03-09 2014-10-30 Samuel Bogoch Therapies, vaccines, and predictive methods for infectious salmon anemia virus

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002085093A2 (en) * 2001-03-27 2002-10-31 Samuel Bogoch Replikin peptides and uses thereof
WO2003083058A2 (en) * 2002-03-26 2003-10-09 Samuel Bogoch Replikin peptides in rapid replication of glioma cells and in influenza epidemics
WO2005104754A2 (en) * 2004-04-28 2005-11-10 Samuel Bogoch System and method for identifying complex patterns of amino acids
WO2006088962A2 (en) * 2005-02-16 2006-08-24 Samuel Bogoch Replikin peptides and uses thereof
WO2007022151A2 (en) * 2005-08-15 2007-02-22 Vaxin, Inc. Immunization of avians by administration of non-replicating vectored vaccines
WO2007149715A2 (en) * 2006-06-16 2007-12-27 Dow Agrosciences Llc Novel dna sequences, vectors and proteins of avian influenza hemagglutinin

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002085093A2 (en) * 2001-03-27 2002-10-31 Samuel Bogoch Replikin peptides and uses thereof
WO2003083058A2 (en) * 2002-03-26 2003-10-09 Samuel Bogoch Replikin peptides in rapid replication of glioma cells and in influenza epidemics
WO2005104754A2 (en) * 2004-04-28 2005-11-10 Samuel Bogoch System and method for identifying complex patterns of amino acids
WO2006088962A2 (en) * 2005-02-16 2006-08-24 Samuel Bogoch Replikin peptides and uses thereof
WO2007022151A2 (en) * 2005-08-15 2007-02-22 Vaxin, Inc. Immunization of avians by administration of non-replicating vectored vaccines
WO2007149715A2 (en) * 2006-06-16 2007-12-27 Dow Agrosciences Llc Novel dna sequences, vectors and proteins of avian influenza hemagglutinin

Also Published As

Publication number Publication date
JP2011519837A (en) 2011-07-14
CA2720465A1 (en) 2009-10-29
AU2009240587A1 (en) 2009-10-29
IL208765A0 (en) 2010-12-30
EP2300493A2 (en) 2011-03-30
WO2009132209A2 (en) 2009-10-29

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