WO2009132014A3 - Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates - Google Patents

Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates Download PDF

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Publication number
WO2009132014A3
WO2009132014A3 PCT/US2009/041269 US2009041269W WO2009132014A3 WO 2009132014 A3 WO2009132014 A3 WO 2009132014A3 US 2009041269 W US2009041269 W US 2009041269W WO 2009132014 A3 WO2009132014 A3 WO 2009132014A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioabsorbable polymer
molecular weight
polymer compositions
exhibiting enhanced
compositions exhibiting
Prior art date
Application number
PCT/US2009/041269
Other languages
French (fr)
Other versions
WO2009132014A2 (en
Inventor
Sasa Andjelic
Benjamin D. Fitz
Jianguo Jack Zhou
Original Assignee
Ethicon, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethicon, Inc. filed Critical Ethicon, Inc.
Priority to EP17196383.8A priority Critical patent/EP3293228B1/en
Priority to EP09735198.5A priority patent/EP2283077B1/en
Publication of WO2009132014A2 publication Critical patent/WO2009132014A2/en
Publication of WO2009132014A3 publication Critical patent/WO2009132014A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C71/00—After-treatment of articles without altering their shape; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D7/00—Producing flat articles, e.g. films or sheets
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/16—Compositions of unspecified macromolecular compounds the macromolecular compounds being biodegradable
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L69/00—Compositions of polycarbonates; Compositions of derivatives of polycarbonates
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/08—Melt spinning methods
    • D01D5/098—Melt spinning methods with simultaneous stretching
    • D01D5/0985—Melt spinning methods with simultaneous stretching by means of a flowing gas (e.g. melt-blowing)
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/58—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products
    • D01F6/62—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters
    • D01F6/625—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters derived from hydroxy-carboxylic acids, e.g. lactones
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/58—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products
    • D01F6/68—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyaminoacids or polypeptides
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/78—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from copolycondensation products
    • D01F6/86—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from copolycondensation products from polyetheresters
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
    • D04H1/54—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving
    • D04H1/56—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving in association with fibre formation, e.g. immediately following extrusion of staple fibres
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/60—Nonwoven fabric [i.e., nonwoven strand or fiber material]
    • Y10T442/608—Including strand or fiber material which is of specific structural definition
    • Y10T442/609—Cross-sectional configuration of strand or fiber material is specified

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Textile Engineering (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend.
PCT/US2009/041269 2008-04-22 2009-04-21 Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates WO2009132014A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP17196383.8A EP3293228B1 (en) 2008-04-22 2009-04-21 Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates
EP09735198.5A EP2283077B1 (en) 2008-04-22 2009-04-21 Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/107,569 US8236904B2 (en) 2005-12-28 2008-04-22 Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates
US12/107,569 2008-04-22

Publications (2)

Publication Number Publication Date
WO2009132014A2 WO2009132014A2 (en) 2009-10-29
WO2009132014A3 true WO2009132014A3 (en) 2009-12-30

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Family Applications (1)

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PCT/US2009/041269 WO2009132014A2 (en) 2008-04-22 2009-04-21 Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates

Country Status (3)

Country Link
US (4) US8236904B2 (en)
EP (2) EP3293228B1 (en)
WO (1) WO2009132014A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8236904B2 (en) 2005-12-28 2012-08-07 Ethicon, Inc. Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates
US8802126B2 (en) * 2008-06-30 2014-08-12 Abbott Cardiovascular Systems Inc. Polyester implantable medical device with controlled in vivo biodegradability
US9492587B2 (en) * 2009-04-13 2016-11-15 Abbott Cardiovascular Systems Inc. Stent made from an ultra high molecular weight bioabsorbable polymer with high fatigue and fracture resistance
MY156526A (en) * 2009-06-17 2016-02-26 Toray Industries Method for producing crystallized polyester
US8349354B2 (en) * 2009-09-22 2013-01-08 Ethicon, Inc. Composite layered hemostasis device
US9173978B2 (en) 2010-09-22 2015-11-03 Ethicon, Inc. Bioabsorbable polymeric compositions, processing methods, and medical devices therefrom
JP2015502542A (en) * 2011-12-01 2015-01-22 エシコン・インコーポレイテッドＥｔｈｉｃｏｎ， Ｉｎｃｏｒｐｏｒａｔｅｄ In vitro method for predicting in vivo absorption time of implants and devices made of bioabsorbable polymers
US10675376B2 (en) 2012-05-24 2020-06-09 Ethicon Llc Mechanically strong absorbable polymeric blend compositions of precisely controllable absorption rates, processing methods, and products therefrom
CN105705511A (en) 2013-04-12 2016-06-22 艾其林医药公司 Deuterated nucleoside prodrugs useful for treating HCV
AU2014355033B2 (en) 2013-11-27 2018-05-24 Ethicon Llc Absorbable polymeric blend compositions with precisely controllable absorption rates, processing methods, and dimensionally stable medical devices therefrom
US9181427B2 (en) * 2013-12-11 2015-11-10 Ethicon, Inc. Absorbable bimodal polymeric blend compositions, processing methods, and medical devices
US10086109B2 (en) 2015-06-02 2018-10-02 Ethicon, Inc. Absorbable medical devices based on novel films and foams made from semi-crystalline, segmented copolymers of lactide and epsilon-caprolactone exhibiting long term absorption characteristics
DK3384079T3 (en) * 2015-12-03 2020-07-20 Dupont Us Holding Llc FIBRØS CONSTRUCTION AND RELATED PROCEDURES
CN105839291B (en) * 2016-04-25 2019-04-12 江苏盛纺纳米材料科技股份有限公司 A kind of nanofiber antibacterial nonwoven material and preparation method
US9873790B1 (en) * 2016-11-07 2018-01-23 Ethicon, Inc. Absorbable polymer blend compositions having enhanced nucleation rates
US11578204B2 (en) * 2017-09-01 2023-02-14 Poly-Med, Inc. Polymers for additive manufacturing
CN108659472B (en) * 2018-05-07 2020-08-14 浙江大学 Method for regulating PPDO mechanical property and degradation rate based on crystallization temperature
US11235332B2 (en) 2018-06-14 2022-02-01 Ethicon, Inc. Accelerated hydrolysis system
EP3822402A4 (en) * 2018-07-09 2022-07-27 National Institute for Materials Science Nonwoven fabric, method for manufacturing same, and composition for electrospinning
US11028222B2 (en) 2018-11-28 2021-06-08 Ethicon, Inc. Advanced processing of absorbable poly(p-dioxanone) containing high level of p-dioxanone monomer
DE102020110089A1 (en) * 2020-04-09 2021-10-14 Karl-Franzens-Universität Graz Process for the production of a porous active substance carrier by means of hot melt extrusion

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011054A2 (en) * 2002-07-31 2004-02-05 Alza Corporation Injectable multimodal polymer depot compositions and uses thereof
WO2007078718A1 (en) * 2005-12-28 2007-07-12 Ethicon, Inc. Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551361A (en) 1967-10-13 1970-12-29 Phillips Petroleum Co Method of foaming an olefin polymer using starch as a nucleating agent
US3978185A (en) 1968-12-23 1976-08-31 Exxon Research And Engineering Company Melt blowing process
US4208215A (en) 1974-11-22 1980-06-17 Gte Service Corporation Method for enhancing the crystallization rate of high purity amorphous Si3 N2 powder by intimate contact with a titanium containing material
US4052988A (en) * 1976-01-12 1977-10-11 Ethicon, Inc. Synthetic absorbable surgical devices of poly-dioxanone
US4098845A (en) 1976-03-11 1978-07-04 The Goodyear Tire & Rubber Company Method for accelerating the crystallization rate of crystallizable polyester resin
US4163100A (en) 1976-09-02 1979-07-31 Bayer Aktiengesellschaft Rapidly crystallizing polyester compositions
JPS57198745A (en) 1981-06-01 1982-12-06 Asahi Chem Ind Co Ltd Crystallization accelerator for polyester
US4490326A (en) * 1981-07-30 1984-12-25 Ethicon, Inc. Molding process for polydioxanone polymers
US4400328A (en) 1981-10-19 1983-08-23 Yoshinobu Takegami Crystalline aluminosilicate zeolite catalyst and the method for manufacturing thereof
US4495166A (en) 1982-07-19 1985-01-22 Mobil Oil Corporation Synthesis of ZSM-5 utilizing a mixture of quaternary ammonium ions and amines
US4444927A (en) 1982-09-13 1984-04-24 Ethicon, Inc. Sucrose and/or lactose nucleating agents for the crystallization of polydioxanone
US4720570A (en) 1986-03-14 1988-01-19 Celanese Corporation Rate of crystallizing diphenylisophthalate/diphenylterephthalate monomer
JPH0696668B2 (en) 1988-01-29 1994-11-30 出光興産株式会社 Resin composition
IT1216472B (en) 1988-02-29 1990-03-08 Montefibre Spa QUICK CRYSTALLIZATION POLYESTER COMPOSITIONS.
US4906730A (en) 1988-05-06 1990-03-06 General Electric Company Polyetherimide blends, and molding method
JP2700482B2 (en) 1988-12-08 1998-01-21 チッソ株式会社 Method for producing polypropylene
AU9121991A (en) 1990-11-05 1992-05-26 Dow Chemical Company, The Controlled nucleation of semi-crystalline polymers
US5359013A (en) 1990-11-06 1994-10-25 Alliedsignal Inc. Polymer nylon compositions featuring improved rates of crystallization and method for forming the same
US5414051A (en) 1991-02-19 1995-05-09 Alliedsignal Inc. Nylon compositions featuring improved rates of crystallization and methods for forming the same
US5155183A (en) 1991-04-16 1992-10-13 Eastman Kodak Company Process for the preparation of copoly(arylene sulfide) having an enhanced rate of crystallization
US5281643A (en) 1991-05-28 1994-01-25 Istituto Guido Donegani S.P.A. Thermoplastic polyester molding compositions containing quaternary ammonium compounds
US5496918A (en) 1991-09-23 1996-03-05 Alliedsignal Inc. Process for improving the properties of polymers
US5266629A (en) 1992-11-20 1993-11-30 Shell Oil Company Polyketone containing graphite nucleating agent
US5707643A (en) * 1993-02-26 1998-01-13 Santen Pharmaceutical Co., Ltd. Biodegradable scleral plug
US5344982A (en) 1993-04-02 1994-09-06 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Diamines and polyimides containing pendent ethynyl groups
US5414036A (en) 1993-04-12 1995-05-09 Enichem S.P.A. Rapidly crystallizing polyester molding compositions
US5344892A (en) 1993-07-02 1994-09-06 Enichem S.P.A. Polyester compositions with improved crystallization rate
EP0724604B2 (en) 1993-10-21 2005-12-14 Exxonmobil Oil Corporation Polyolefin blends of bimodal molecular weight distribution
US5431972A (en) 1993-10-22 1995-07-11 Shell Oil Company Nucleation of crystallization in polyesters
JPH07196675A (en) 1993-11-24 1995-08-01 Tokuyama Corp Nucleation agent for crystallization
JP3144972B2 (en) 1993-12-16 2001-03-12 ポリプラスチックス株式会社 Polyester resin composition
MY112911A (en) 1994-06-09 2001-10-31 Arakawa Chem Ind Process for crystal nucleation of crystalline thermoplastic resin and crystalline thermoplastic resin composition
JP3334338B2 (en) 1994-06-21 2002-10-15 三菱化学株式会社 Polylactic acid based resin composition
TW369414B (en) 1994-09-30 1999-09-11 Yamanouchi Pharma Co Ltd Bone formation transplant
US5641501A (en) * 1994-10-11 1997-06-24 Ethicon, Inc. Absorbable polymer blends
FR2725732B1 (en) * 1994-10-12 1996-12-13 Fiberweb Sodoca Sarl COMPOSITE STRUCTURE FORMED FROM LACTIC ACID DERIVATIVES AND PROCESS FOR PRODUCING THE SAME
AU714545B2 (en) 1995-04-26 2000-01-06 Honeywell International, Inc. Polyester molding compositions
CA2294714A1 (en) * 1997-07-02 1999-01-14 Santen Pharmaceutical Co., Ltd. Polylactic acid scleral plugs
US5969021A (en) 1997-08-07 1999-10-19 Fina Technology, Inc. Method of improving crystallization rate and temperature of syndiotactic polypropylene and compositions and products made therefrom
GB9719601D0 (en) 1997-09-15 1997-11-19 Univ West London The Crystallisation of sugars
JP2000045164A (en) 1998-07-23 2000-02-15 Unitika Ltd Biodegradable mulching sheet
US6080798A (en) 1998-09-28 2000-06-27 Handa; Paul Manufacturing foams by stress-induced nucleation
EP1173265B1 (en) 1999-01-29 2005-12-21 Bristol-Myers Squibb Company Sonic impinging jet crystallization apparatus and process
US6159406A (en) 1999-05-25 2000-12-12 Eastman Kodak Company Process for rapid crystallization of polyesters and co-polyesters via in-line drafting and flow-induced crystallization
DE60029289T2 (en) 1999-10-05 2007-07-26 Nippon Shokubai Co., Ltd. Biodegradable polyester resin composition and its use
WO2001061345A1 (en) 2000-02-17 2001-08-23 Myerson Allan S Nucleation and crystallization of polymers
JP2001288154A (en) 2000-03-31 2001-10-16 Arakawa Chem Ind Co Ltd New amide compound, nucleating agent for crystallizing thermoplastic resin and crystallizing thermoplastic resin composition
US6395795B1 (en) 2000-09-29 2002-05-28 Ausimont Usa, Inc. Titanium dioxide nucleating agent systems for foamable polymer compositions
US6319576B1 (en) 2000-11-20 2001-11-20 The Coca-Cola Company Method to increase the crystallization rate of polyesters
US6521685B1 (en) 2001-07-03 2003-02-18 Milliken & Company Clarifying agent formulations for thermoplastics exhibiting very high nucleation efficacy
US6534623B1 (en) 2001-07-25 2003-03-18 E.I. Du Pont De Nemours And Company Process for the preparation of crystalline polycarbonate oligomers
EP1344538A1 (en) 2002-03-14 2003-09-17 Degradable Solutions AG Porous biodegradable implant material and method for its fabrication
US6831149B2 (en) 2002-06-28 2004-12-14 Ethicon, Inc. Polymerization process using mono-and di-functional initiators to prepare fast crystallizing polylactone copolymers
US6794484B2 (en) 2002-06-28 2004-09-21 Ethicon, Inc. Crystallizable polylactone copolymers prepared from mono- and di-functional polymerization initiators
US7066260B2 (en) * 2002-08-26 2006-06-27 Schlumberger Technology Corporation Dissolving filter cake
RU2355385C2 (en) 2002-11-06 2009-05-20 Алза Корпорейшн Compositions of prolongedaction with controlled release
US20050048099A1 (en) * 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
US20080051866A1 (en) * 2003-02-26 2008-02-28 Chao Chin Chen Drug delivery devices and methods
JP4040567B2 (en) * 2003-11-11 2008-01-30 クラシエホールディングス株式会社 Polylactic acid fiber and woven or knitted fabric comprising the same
EP1689469A2 (en) 2003-11-14 2006-08-16 Alza Corporation Package for pharmaceutical formulation
ES2354617T3 (en) * 2004-04-19 2011-03-16 The Procter And Gamble Company FIBERS, NON-FABRICED MATERIALS AND ITEMS CONTAINING NANOFIBERS PRODUCED FROM POLYMERS WITH HIGH TEMPERATURE OF GLASS TRANSITION.
JP5008015B2 (en) * 2004-12-27 2012-08-22 株式会社豊田中央研究所 Aliphatic polyester composition and molded article thereof
US8236904B2 (en) * 2005-12-28 2012-08-07 Ethicon, Inc. Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011054A2 (en) * 2002-07-31 2004-02-05 Alza Corporation Injectable multimodal polymer depot compositions and uses thereof
WO2007078718A1 (en) * 2005-12-28 2007-07-12 Ethicon, Inc. Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VON RECUM H A ET AL: "Degradation of polydispersed poly(l-lactic acid) to modulate lactic acid release", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 16, no. 6, 1 January 1995 (1995-01-01), pages 441 - 447, XP004032951, ISSN: 0142-9612 *

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