WO2009131423A3 - Novel hepatitis a virus antigen gene and transformed plants with the gene - Google Patents

Novel hepatitis a virus antigen gene and transformed plants with the gene Download PDF

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Publication number
WO2009131423A3
WO2009131423A3 PCT/KR2009/002173 KR2009002173W WO2009131423A3 WO 2009131423 A3 WO2009131423 A3 WO 2009131423A3 KR 2009002173 W KR2009002173 W KR 2009002173W WO 2009131423 A3 WO2009131423 A3 WO 2009131423A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
hepatitis
virus antigen
transformed plants
virus
Prior art date
Application number
PCT/KR2009/002173
Other languages
French (fr)
Korean (ko)
Other versions
WO2009131423A2 (en
Inventor
정인식
김경일
이종민
이현호
손동화
김원용
이희영
정호용
정하영
황보전
유기현
Original Assignee
경희대학교 산학협력단
메디칸(주)
김종범
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 경희대학교 산학협력단, 메디칸(주), 김종범 filed Critical 경희대학교 산학협력단
Publication of WO2009131423A2 publication Critical patent/WO2009131423A2/en
Publication of WO2009131423A3 publication Critical patent/WO2009131423A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to a novel hepatitis A virus antigen gene and transformed plants with the gene, more particularly to a novel hepatitis A virus antigen gene synthesized by optimization of a genetic code, a recombinant vector containing the gene and plants transformed with the recombinant vector.  According to the invention, the use of a synthesized antigen gene of hepatitis A virus makes it possible to prepare recombinant hepatitis A virus vaccine materials at a high efficiency, and transformed plants expressing a hepatitis A virus antigen are useful as functional food materials and orally administrated vaccine materials.
PCT/KR2009/002173 2008-04-25 2009-04-24 Novel hepatitis a virus antigen gene and transformed plants with the gene WO2009131423A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020080038483A KR101012830B1 (en) 2008-04-25 2008-04-25 Novel Gene Coding Antigen of Hepatitis A Virus and Plants Transformed by the Gene
KR10-2008-0038483 2008-04-25

Publications (2)

Publication Number Publication Date
WO2009131423A2 WO2009131423A2 (en) 2009-10-29
WO2009131423A3 true WO2009131423A3 (en) 2009-12-23

Family

ID=41217299

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/002173 WO2009131423A2 (en) 2008-04-25 2009-04-24 Novel hepatitis a virus antigen gene and transformed plants with the gene

Country Status (2)

Country Link
KR (1) KR101012830B1 (en)
WO (1) WO2009131423A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101635673B1 (en) 2014-05-28 2016-07-01 경희대학교 산학협력단 A vaccine material protein VP1-3N of hepatitis A virus and vaccine composition
KR101635672B1 (en) 2014-05-28 2016-07-01 경희대학교 산학협력단 A vaccine material 3D2 protein of hepatitis A virus and vaccine composition

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484719A (en) * 1991-08-26 1996-01-16 Edible Vaccines, Inc. Vaccines produced and administered through edible plants
KR20050100365A (en) * 2003-01-31 2005-10-18 센트로 데 인제니에리아 제네티카 와이 바이오테크놀로지아 Recombinant hepatitis a virus antigens obtained in plant cells
KR20060013000A (en) * 2004-08-05 2006-02-09 정인식 Plant expression vector containing bctv replicon

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100861923B1 (en) * 2006-12-07 2008-10-09 메디칸(주) Method for preparating Antigen of Hepatitis A Virus using Insect cells Tansformed with Recombinant Vector for Expressing an Antigen of Virus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484719A (en) * 1991-08-26 1996-01-16 Edible Vaccines, Inc. Vaccines produced and administered through edible plants
KR20050100365A (en) * 2003-01-31 2005-10-18 센트로 데 인제니에리아 제네티카 와이 바이오테크놀로지아 Recombinant hepatitis a virus antigens obtained in plant cells
KR20060013000A (en) * 2004-08-05 2006-02-09 정인식 Plant expression vector containing bctv replicon

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KIRSTEN B. J. SCHOLTEN ET AL.: "Codon modification of T cell receptors allows enhanced functional expression in transgenic human T cells.", CLINICAL IMMUNOLOGY, vol. 119, 2 February 2006 (2006-02-02), pages 135 - 145 *

Also Published As

Publication number Publication date
KR20090112784A (en) 2009-10-29
KR101012830B1 (en) 2011-02-10
WO2009131423A2 (en) 2009-10-29

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