WO2009130470A1 - Bimetallic catalytic complexes for the copolymerisation of carbon dioxide and an epoxide - Google Patents

Bimetallic catalytic complexes for the copolymerisation of carbon dioxide and an epoxide Download PDF

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Publication number
WO2009130470A1
WO2009130470A1 PCT/GB2009/001043 GB2009001043W WO2009130470A1 WO 2009130470 A1 WO2009130470 A1 WO 2009130470A1 GB 2009001043 W GB2009001043 W GB 2009001043W WO 2009130470 A1 WO2009130470 A1 WO 2009130470A1
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Prior art keywords
catalyst
group
oso
oac
dimeric
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PCT/GB2009/001043
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French (fr)
Inventor
Charlotte K Williams
Michael Kember
Paul Knight
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Imperial Innovations Limited
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Application filed by Imperial Innovations Limited filed Critical Imperial Innovations Limited
Priority to EP09735513.5A priority Critical patent/EP2285490B1/en
Priority to AU2009239767A priority patent/AU2009239767B2/en
Priority to JP2011505585A priority patent/JP5681096B2/en
Priority to US12/989,537 priority patent/US9453104B2/en
Priority to ES09735513.5T priority patent/ES2496180T3/en
Priority to PL09735513T priority patent/PL2285490T3/en
Publication of WO2009130470A1 publication Critical patent/WO2009130470A1/en
Priority to US14/526,017 priority patent/US9994675B2/en
Priority to US15/482,448 priority patent/US10308762B2/en

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/20—General preparatory processes
    • C08G64/32—General preparatory processes using carbon dioxide
    • C08G64/34—General preparatory processes using carbon dioxide and cyclic ethers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
    • B01J31/1805—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing nitrogen
    • B01J31/181—Cyclic ligands, including e.g. non-condensed polycyclic ligands, comprising at least one complexing nitrogen atom as ring member, e.g. pyridine
    • B01J31/1825—Ligands comprising condensed ring systems, e.g. acridine, carbazole
    • B01J31/183—Ligands comprising condensed ring systems, e.g. acridine, carbazole with more than one complexing nitrogen atom, e.g. phenanthroline
    • B01J31/1835—Ligands comprising condensed ring systems, e.g. acridine, carbazole with more than one complexing nitrogen atom, e.g. phenanthroline comprising aliphatic or saturated rings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2204—Organic complexes the ligands containing oxygen or sulfur as complexing atoms
    • B01J31/2208—Oxygen, e.g. acetylacetonates
    • B01J31/2226—Anionic ligands, i.e. the overall ligand carries at least one formal negative charge
    • B01J31/223—At least two oxygen atoms present in one at least bidentate or bridging ligand
    • B01J31/2239—Bridging ligands, e.g. OAc in Cr2(OAc)4, Pt4(OAc)8 or dicarboxylate ligands
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2204—Organic complexes the ligands containing oxygen or sulfur as complexing atoms
    • B01J31/2208—Oxygen, e.g. acetylacetonates
    • B01J31/2226—Anionic ligands, i.e. the overall ligand carries at least one formal negative charge
    • B01J31/2243—At least one oxygen and one nitrogen atom present as complexing atoms in an at least bidentate or bridging ligand
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2204—Organic complexes the ligands containing oxygen or sulfur as complexing atoms
    • B01J31/226—Sulfur, e.g. thiocarbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
    • B01J2531/0213—Complexes without C-metal linkages
    • B01J2531/0216—Bi- or polynuclear complexes, i.e. comprising two or more metal coordination centres, without metal-metal bonds, e.g. Cp(Lx)Zr-imidazole-Zr(Lx)Cp
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
    • B01J2531/0238—Complexes comprising multidentate ligands, i.e. more than 2 ionic or coordinative bonds from the central metal to the ligand, the latter having at least two donor atoms, e.g. N, O, S, P
    • B01J2531/0241—Rigid ligands, e.g. extended sp2-carbon frameworks or geminal di- or trisubstitution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/20—Complexes comprising metals of Group II (IIA or IIB) as the central metal
    • B01J2531/22—Magnesium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/20—Complexes comprising metals of Group II (IIA or IIB) as the central metal
    • B01J2531/26—Zinc
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/60—Complexes comprising metals of Group VI (VIA or VIB) as the central metal
    • B01J2531/62—Chromium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/70—Complexes comprising metals of Group VII (VIIB) as the central metal
    • B01J2531/72—Manganese
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/84—Metals of the iron group
    • B01J2531/842—Iron
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/84—Metals of the iron group
    • B01J2531/845—Cobalt
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/04—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing carboxylic acids or their salts

Definitions

  • the present invention provides a novel catalyst and its use in the co-polymerisation of carbon dioxide and an epoxide.
  • Carbon dioxide is an attractive reagent for synthetic chemistry as it is abundant, inexpensive, of low toxicity and the waste product of many chemical processes.
  • the copolymerization of carbon dioxide and epoxides known for several decades as illustrated in figure 1, is a particularly promising route to activate and use CO 2 as a renewable C-I source.
  • the copolymer has a high glass transition temperature and tensile strength, but is also degradable.
  • R 1 and R 2 are independently hydrogen, alkyl, haloalkyl, aryl, halide, amine, a nitro group, an ether group, a silyl ether group, a nitrile group or an acetylide group;
  • R 3 is alkylene, arylene or cycloalkylene
  • R 4 is H, alkyl, aryl or alkylaryl
  • Ei is C, E 2 is O, S or NH or Ei is N and E 2 is O;
  • X is OCOCH 3 , OCOCF 3 , OSO 2 C 7 H 7 , OSO(CH 3 ) 2 , alkyl, alkoxy, halide or amido;
  • M is Zn(II), Co(II), Mn(II), Mg (II), Fe(II), Cr(II), Cr (HI)-X, Co(III)-X, Mn(III)-X or Fe(III)-X.
  • an alkyl group is preferably a "Ci -6 alkyl group", that is an alkyl group that is a straight or branched chain with 1 to 6 carbons.
  • the alkyl group therefore has 1, 2, 3, 4, 5 or 6 carbon atoms.
  • Examples of "Ci -6 alkyl group” include methyl group, ethyl group, n-propyl group, iso-propyl group, n-butyl group, iso-butyl group, sec-butyl group, tert-butyl group, n-pentyl group, 1,1-dimethylpropyl group, 1,2-dimethylpropyl group, 2,2-dimethylpropyl group, 1-ethylpropyl group, n-hexyl group, l-ethyl-2-methylpropyl group, 1,1,2- trimethylpropyl group, 1-ethylbutyl group, 1-methylbutyl group, 2-methylbutyl group, 1,1-dimethylbutyl group, 1,2-dimethylbutyl group, 2,2-dimethylbutyl group, 1,3- dimethylbutyl group, 2,3-dimethylbutyl group, 2-ethylbutyl group, 2-methylpentyl group, 3
  • a cycloalkyl group is preferably a "C 3-8 cycloalkyl group” that is a cycloalkyl group with 3 to 8 carbon atoms.
  • the cycloalkyl group therefore has 3, 4, 5, 6, 7 or 8 carbon atoms.
  • examples of the C 3-8 cycloalkyl group include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl.
  • the cycloalkyl group may comprise a cycloalkyl ring bearing one or more linking or non-linking alkyl subsitutents, such as -CH 2 -cyclohexyl.
  • halide used herein means a fluorine atom, a chlorine atom, a bromine atom, an iodine atom and the like, preferably a fluorine atom or a chlorine atom, and more preferably a fluorine atom.
  • a haloalkyl group is prefereably a "Ci -6 haloalkyl group” and is a Q -6 alkyl group as described above substituted with 1, 2 or 3 halogen atom(s).
  • examples of "Ci- 6 haloalkyl group” include fluoromethyl group, difluoromethyl group, trifluoromethyl group, fluoroethyl group, difluroethyl group, trifluoroethyl group, chloromethyl group, bromomethyl group, iodomethyl group and the like.
  • An alkoxy group is preferably a "C 1-6 alkoxy group” and is an oxy group that is bonded to the previously defined "C 1-6 alkyl group".
  • examples of "Ci -6 alkoxy group” include methoxy group, ethoxy group, n-propoxy group, iso-propoxy group, n-butoxy group, iso-butoxy group, sec-butoxy group, tert-butoxy group, n- pentyloxy group, iso-pentyloxy group, sec-pentyloxy group, n-hexyloxy group, iso- hexyloxy group, 1,1-dimethylpropoxy group, 1,2- 1 dimethylpropoxy group, 2,2- dimethylpropoxy group, 2-methylbutoxy group, l-ethyl-2-methylpropoxy group, 1,1,2-trimethylpropoxy group, 1,1-dimethylbutoxy group, 1,2-dimethylbutoxy group, 2,2-dimethylbutoxy group, 2,3-dimethylbutoxy group,
  • An aryl group is preferably a "C 6 - I2 aryl group” and is an aryl group constituted by 6, 7, 8, 9, 10, 11 or 12 carbon atoms and includes condensed ring groups such as monocyclic ring group, or bicyclic ring group and the like.
  • examples of "C 6-1 Q aryl group” include phenyl group, biphenyl group, indenyl group, naphthyl group or azulenyl group and the like. It should be noted that condensed rings such as indan and tetrahydro naphthalene are also included in the aryl group.
  • alkylaryl group is preferably a "C 1-16 alkyl C 6-12 aryl group" and is an aryl group as defined above bonded at any position to an alkyl group as defined above.
  • the alkylaryl group is -CH 2 -Ph or -CH 2 CH 2 -Ph.
  • An ether group is preferably a group OR 5 wherein R 5 can be an alkyl group or an aryl group as defined above.
  • R 5 is an alkyl group selected from methyl, ethyl or propyl.
  • a silyl ether group is preferably a group OSi(Ro) 3 wherein each R 6 can be independently an alkyl group or an aryl group as defined above.
  • each R 6 is an alkyl group selected from methyl, ethyl or propyl.
  • a nitrile group is preferably a group CN or a group CNR 7 wherein R 7 is an alkyl group or an aryl group as defined above.
  • R 7 is an alkyl group selected from methyl, ethyl or propyl.
  • R 8 can be an alkyl group or an aryl group as defined above.
  • the double bond can be present at any position along the alkyl chain.
  • R 8 is methyl, ethyl, propyl or phenyl.
  • An acetylide group contains a triple bond -C ⁇ C-Rg, wherein R 9 can be an alkyl group or an aryl group as defined above.
  • R 9 can be an alkyl group or an aryl group as defined above.
  • the triple bond can be present at any position along the alkyl chain.
  • R 9 is methyl, ethyl, propyl or phenyl.
  • An amino group is preferably NH 2 , NHR 1O or N(Rio) 2 wherein Rio can be an alkyl group, a silylalkyl group or an aryl group as defined above. It will be appreciated that when the amino group is N(R 10 ) 2 , each Ri 0 group can be independently selected from an alkyl group, a silylalkyl group or an aryl group as defined above.
  • R 10 is methyl, ethyl, propyl, SiMe 3 Or phenyl.
  • An amido group is -NR 11 C(O)- Or -C(O)-NRu- wherein R 11 can be hydrogen, an alkyl group or an aryl group as defined above.
  • R 11 is hydrogen, methyl, ethyl, propyl or phenyl.
  • R 1 and R 2 may be the same or different.
  • R 1 and R 2 are preferably independently selected from hydrogen, tBu, Me, CF 3 , phenyl, F, Cl, Br, I, NMe 2 , NEt 2 , NO 2 , OMe, OSiEt 3 , CNMe, CN or CCPh, more preferably hydrogen, OMe, Me or tBu (e.g. hydrogen or tBu).
  • R 2 is hydrogen and Ri is any one of the groups defined above, preferably tBu, OMe or Me.
  • R 3 is a disubstituted alkyl, aryl or cycloalkyl group which acts as a bridging group between two nitrogen centres in the catalyst of formula (I).
  • R 3 is a alkylene group, such as dimethylpropylene
  • the R 3 group has the structure -CH 2 -C(CH 3 ) 2 -CH 2 -.
  • the definitions of the alkyl, aryl and cycloalkyl groups set out above therefore also relate respectively to the alkylene, arylene and cycloalkylene groups set out for R 3 .
  • R 3 is ethylene, 2,2- dimethylpropylene, propylene, butylene, phenylene, cyclohexylene or biphenylene, more preferably 2,2-dimethylpropylene.
  • R 3 is cyclohexylene, it can be the racemic, RR- or SS- forms.
  • R 4 is H, Me, Et, Bn, iPr, tBu or Ph, more preferably hydrogen.
  • X is OCOCH 3 , OCOCF 3 , OSO 2 C 7 H 7 , OSO(CH 3 ) 2 , Et, Me, PhOEt, OMe, OiPr, OtBu, Cl, Br, I, F, N(iPr) 2 or N(SiMe 3 ) 2, , more preferably OCOCH 3 .
  • M is Zn(II), Cr(III), Cr(II), Co(III), Co(II), Mn(III), Mn(II), Mg (II), Fe(II) or Fe(III), more preferably Zn(II), Cr(III), Co(II), Mn(II), Mg(II), Fe(II) or Fe(III), and most preferably Zn(II) or Mg(II).
  • the catalyst of formula (I) will contain an additional X group co-ordinated to the metal centre, wherein X is as defined above.
  • a catalyst selected from:
  • a catalyst of formula (I) of the first aspect of the invention may be prepared by complexation of a ligand (for example H 2 L 1 , H 2 L 2 or H 2 L 3 , where L 1 , L 2 or L are as represented within the structures shown above) with a metal complex comprising the groups M and X. Carrying out this complexation in the presence of water where X is OCOCH 3 , OCOCF 3 , OSO 2 C 7 H 7 , OSO(CH 3 ) 2 or halide may lead, in addition to the formation of a catalyst of formula (I), to the formation of a dimeric catalyst species comprising two catalyst complexes of formula (I), linked by a bridging ligand X, with a bound water molecule.
  • a ligand for example H 2 L 1 , H 2 L 2 or H 2 L 3 , where L 1 , L 2 or L are as represented within the structures shown above
  • a metal complex comprising the groups M and X. Carrying out this complexation in the presence of
  • the invention provides a dimeric catalyst formed from two of the same monomelic subunits and a bound water molecule, wherein each monomelic subunit is a catalyst of formula (I) of the first aspect of the invention wherein X is OCOCH 3 , OCOCF 3 , OSO 2 C 7 H 7 , OSO(CH 3 ) 2 or halide, and wherein the two monomelic subunits are linked by a bridging ligand X.
  • the bridging group X may bridge between one M of each monomelic subunit, with a water molecule being bound to an M of one monomelic subunit.
  • Each monomelic subunit of formula (I) which forms the dimeric complex has the same structure (i.e. each subunit has the same group at the R 1 , R 2 , R 3 , R 4 , Ei, E 2 and M positions, respectively).
  • the dimeric catalyst of the second aspect can be illustrated by the formula (II):
  • X is OCOCH 3 , OCOCF 3 , OSO 2 C 7 H 7 , OSO(CH 3 ) 2 or halide.
  • X is OCOCH 3 , OCOCF 3 , OSO 2 C 7 H 7 or OSO(CH 3 ) 2 and more preferably OCOCH 3 .
  • M is preferably Zn(II) or Mg(II), more preferably Mg(II).
  • a ligand for example H 2 L 1 , H 2 L 2 or H 2 L 3
  • a metal complex comprising the groups M and X
  • the product formed may be a mixture of the catalyst of formula (I) of the first aspect and the dimeric catalyst of the second aspect of the invention, wherein X is OCOCH 3 , OCOCF 3 , OSO 2 C 7 H 7 , OSO(CH 3 ) 2 or halide.
  • a third aspect of the invention provides a mixture of the catalytic species of the first aspect and the second aspect of the invention.
  • the fourth aspect of the invention provides a process for the reaction of carbon dioxide with an epoxide in the presence of a catalyst of the first aspect, the second aspect or the third aspect of the invention.
  • the epoxide substrate is not limited.
  • the term epoxide therefore relates to any compound comprising an epoxide moiety.
  • Preferred examples of epoxides for the purposes of the present invention include cyclohexene oxide, propylene oxide, substituted cyclohexene oxides (such as limonene oxide, C 10 Hi 6 O or 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane,
  • alkylene oxides such as ethylene oxide and substituted ethylene oxides
  • substituted oxiranes such as epichlorohydrin, 1,2-epoxybutane, glycidyl ethers
  • the process of the fourth aspect of the invention is particularly provided for the reaction of carbon dioxide with an epoxide at low pressures.
  • the reaction can therefore be carried out at a pressure of 1 to 10 atmospheres, preferably at 1 or 2 atmospheres.
  • the process of the fourth aspect of the invention can be carried out at a temperature of 50°C to 100°C.
  • the duration of the process can be up to 48 hours preferably 20 to 24 hours.
  • the process of the fourth aspect of the invention can advantageously be carried out at low catalytic loading, for example, the catalytic loading for the process is preferably in the range of 1: 1000-10000 catalyst.epoxide, more preferably in the region of 1:1000 catalyst:epoxide, and most preferably in the region of 1:10000 catalyst:epoxide.
  • the present invention provides a bimetallic catalytic complex and allows the reaction of epoxides with carbon dioxide with high turn over numbers and turn over frequencies.
  • the catalysts of the present invention operate at remarkably low pressure, e.g. 1 atm of CO 2 . Indeed, the catalysts show comparable TON and TOF to literature catalysts but operate at 1/60 of the pressure of CO 2 .
  • the fifth aspect of the invention provides a product of the process of the fourth aspect of the invention.
  • the sixth aspect of the invention provides a process for the production of a catalyst of the first aspect of the invention, said process comprising reaction of a compound of formula (III)
  • the number of the groups X present in the metal complex will depend on the valency of the metal M.
  • M is Zn(II) and X is OAc
  • the metal complex will be Zn(OAc) 2 .
  • the metal complex may have the formula M-XH.
  • the reaction of the compound of formula (III) with a metal complex can be carried out in the presence or absence of a base.
  • the base can be selected from one or more of an amine base, such as Et 3 N or a hydride base, such as NaH, LiH or KH.
  • the reaction of the compound of formula (III) with a metal complex can be carried out in a solvent (for example THF, toluene, dichloromethane or methanol).
  • a solvent for example THF, toluene, dichloromethane or methanol.
  • the solvent is preferably anhydrous.
  • the process is carried out under anhydrous conditions and preferably the metal complex is anhydrous.
  • a process as defined in the sixth aspect of the invention may be used to produce a catalyst of the second or third aspect of the invention, wherein X is OCOCH 3 , OCOCF 3 , OSO 2 C 7 H 7 , OSO(CH 3 ) 2 or halide, by the inclusion of water within the reaction, for example by providing a metal complex which is not completely anhydrous.
  • the seventh aspect of the invention provides a ligand as illustrated below:
  • the ligand of the seventh aspect of the invention is provided for use in the production of a catalyst of the first, second or third aspects of the invention.
  • the seventh aspect of the invention therefore further provides a process for the production of a catalyst of the first aspect of the invention, said process comprising reaction of the ligand of the seventh aspect of the invention with a metal complex comprising the groups M and X as defined in the first aspect of the invention.
  • the seventh aspect of the invention yet further provides a process for the production of a catalyst of the second or third aspects of the invention, said process comprising reaction of the ligand of the seventh aspect of the invention with a metal complex comprising the groups M and X, wherein X is OCOCH 3 , OCOCF 3 , OSO 2 C 7 H 7 , OSO(CH 3 ) 2 or halide, wherein the reaction is carried out in the presence of water, for example by providing a metal complex which is not completely anhydrous.
  • the process for the production of a catalyst of the first, second or third aspects of the invention is carried out in a solvent (for example THF, toluene, dichloromethane or methanol), preferably wherein the solvent is anhydrous.
  • a solvent for example THF, toluene, dichloromethane or methanol
  • the process for the production of a catalyst of the first, second or third aspects of the invention may be carried out in the presence of KH.
  • the metal complex is preferably Zn(OAc) 2 or Mg(OAc) 2 .
  • Figure 2 shows the synthesis of the dizinc complex [L 1 Zn 2 (OAc) 2 ].
  • Reagents and conditions i) KH, THF, -78 0 C ⁇ RT, 1 hour, ii) Zn(OAc) 2 , THF, RT, 16 hours.
  • Figure 3 shows a plot showing the M n of the polycarbonate, as determined by GPC, versus the percentage conversion, as determined by 1 H NMR.
  • the values in parentheses represent the polydispersity index
  • Figure 4 shows a 1 H NMR spectrum, at 110 0 C of the dizinc complex [L 1 Zn 2 (OAc) 2 ].
  • Figure 5 shows an X-ray crystallography structure for the dimeric catalyst complex [L 1 Z Mg 4 (OAc) 4 (H 2 O)]
  • the tert-butyl and acetate methyl groups resonate as singlets with integrals of 18H and 6H, respectively.
  • the methyl groups on the ligand backbone are also diastereotopic and are observed as two singlets, each with a relative integral of 6H. 0
  • the complex was tested, under very mild conditions, for the copolymerization of carbon dioxide and cyclohexene oxide as illustrated in figure 1. Results of the copolymerization are set out in table 1 below. Thus, at only 1 atm pressure of carbon dioxide and at 70 0 C, poly(cyclohexene carbonate) was produced with a TON of 300 and a TOF of 12 h "1 .
  • the catalyst is also selective, yielding a polymer with >99% polycarbonate linkages.
  • [L 1 Zn 2 (OAc) 2 ] is remarkably robust, it is still active after 24 h of reaction and at loadings of 0.01 mol%. It is also stable in air; indeed comparable TONs and TOFs are obtained for polymerizations when
  • H 2 L 1 (0.40 g, 0.72 mmol) was dissolved in dry THF (10 mL) and transferred into a Schlenk tube containing KH (0.04 g, 1.08 mmol), and cooled to -78 0 C, under nitrogen. This suspension was allowed to warm to room temperature and left to stir for 1 hour. The excess KH was filtered off and the solution transferred to a Schlenk tube containing Zn(OAc) 2 (0.27 g, 1.48 mmol). The reaction was left to stir for 16 hours overnight, after which the THF was removed in vacuo, and the product taken up in dry CH 2 Cl 2 (10 mL). This was then filtered and the CH 2 Cl 2 removed in vacuo to yield the title compound as a white powder (0.40 g, 69.5 %).
  • Cyclohexene oxide (5 mL, 49.4 mmol) and [L 1 Zn 2 (OAc) 2 ] (0.049 mmol) were added to a Schlenk tube.
  • the cyclohexene oxide was degassed, before being left stirring under 1 atm CO 2 , at a certain temperature, for 24 hours.
  • the crude reaction mixture was then taken up in CH 2 Cl 2 and evaporated in air, after which the product was dried in vacuo overnight.
  • the dimeric structure is formed due to the presence of an impurity of water during the complexation of the macrocyclic ligand H 2 L 1 with Mg(OAc) 2 .
  • Mg(OAc) 2 is not commercially available in anhydrous form.
  • Commercially available Mg(OAc) 2 '4H 2 O was dried under vacuum at 100°C, prior to use in the complexation reaction. It has been found that this drying was insufficient to remove all of the water, and therefore provides a source of water to allow the formation of a dimeric complex.
  • catalyst complexes of formula (I) of the present invention may form a dimeric structure or mixture of monomer and dimer where catalyst synthesis is carried out in the presence of water. Dimer formation is avoided when the synthesis is anhydrous.
  • Table 4 Comparison of [L Zn 2 (OAc) 2 ] and magnesium complex activities for copolymerization of cyclohexene oxide and CO 2 .
  • [L 1 Mg 2 (OAc) 2 ] represents a mixture of [L 1 Mg 2 (OAc) 2 ] and FlJ 2 Mg 4 (OAc) 3 (H 2 O)].
  • the molar catalyst loading is 1: 1000 (catalyst.epoxide) at 1 atm CO 2 and 1:10000 (catalyst:epoxide) at 10 atm CO 2 .
  • the magnesium catalyst mixture shows a TOF of almost 34 h 1 at 80 0 C and 1 atm CO 2 , this value increases to almost 97 h "1 when the temperature is increased to 100 °C (entries 2 and 4). If the pressure is increased to 10 atm, the activity is increased further still (entry 6). In addition, there is no evidence for the formation of any cyclic carbonate in the 1 H NMR spectra. This is observed for all copolymerisations using the magnesium catalyst and is very unusual, as the formation of cyclic carbonate is generally held to be under thermodynamic control, increasing with temperature.
  • the polymer properties are very similar to those produced by [L 1 Zn 2 (OAc) 2 ], with similar polydispersities, molecular weights and no observable ether linkages.
  • H 2 L 1 (0.40 g, 0.72 mmol) was dissolved in dry THF (10 mL) in a Schlenk tube The solution was transferred to another Schlenk tube containing Mg(OAc) 2 (0.21 g, 1.48 mmol). The reaction was left to stir for 16 hours overnight, after which the THF was removed in vacuo, and the product taken up in dry CH 2 Cl 2 (10 mL). The solution was then filtered, the solvent removed in vacuo and the white powdery product dried under vacuum overnight.

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Abstract

The present invention provides a novel catalyst of formula (I): wherein M is selected from Zn(H), Co(II), Mn(II), Mg(II), Fe(II), Cr(III)-X or Fe(III)- X, and the use thereof in polymerising carbon dioxide and an epoxide.

Description

BIMETALLIC CATALYTIC COMPLEXES FOR THE COPOLYMERISATION OF CARBON DIOXIDE AND AN EPOXIDE
The present invention provides a novel catalyst and its use in the co-polymerisation of carbon dioxide and an epoxide.
Carbon dioxide is an attractive reagent for synthetic chemistry as it is abundant, inexpensive, of low toxicity and the waste product of many chemical processes. The copolymerization of carbon dioxide and epoxides, known for several decades as illustrated in figure 1, is a particularly promising route to activate and use CO2 as a renewable C-I source. Furthermore, if cyclohexene oxide is used, the copolymer has a high glass transition temperature and tensile strength, but is also degradable.
The first report of the copolymerization of carbon dioxide and an epoxide was reported by Inoue et al, in 1969 using diethyl zinc and alcohols to produce poly(propylene carbonate), albeit with very low turn-over numbers (TON). Subsequently several research groups developed more active and controlled catalysts, including zinc phenoxide, zinc β-diiminate and chromium(III) or cobalt(III) salen complexes and various bimetallic zinc catalysts, including anilido aniline zinc catalysts. The zinc β-diiminate complexes show very high turn-over frequencies (TOF), as well as excellent control for the copolymerization of CO2 and cyclohexene oxide.
However, the copolymerization of carbon dioxide and an epoxide currently requires the use of high pressures in order to achieve the necessary turn over numbers and turn over frequencies. Furthermore, the use of such air sensitive catalysts requires the use of special handling techniques to avoid deactivation of the catalyst. There is therefore a need in the art for improved catalysts to allow use of carbon dioxide as a renewable C-I source.
There is therefore provided by the first aspect of the invention a catalyst of formula (I)
Figure imgf000003_0001
wherein R1 and R2 are independently hydrogen, alkyl, haloalkyl, aryl, halide, amine, a nitro group, an ether group, a silyl ether group, a nitrile group or an acetylide group;
R3 is alkylene, arylene or cycloalkylene;
R4 is H, alkyl, aryl or alkylaryl;
Ei is C, E2 is O, S or NH or Ei is N and E2 is O;
X is OCOCH3, OCOCF3, OSO2C7H7, OSO(CH3)2, alkyl, alkoxy, halide or amido;
M is Zn(II), Co(II), Mn(II), Mg (II), Fe(II), Cr(II), Cr (HI)-X, Co(III)-X, Mn(III)-X or Fe(III)-X.
For the purpose of the present invention, an alkyl group is preferably a "Ci-6 alkyl group", that is an alkyl group that is a straight or branched chain with 1 to 6 carbons. The alkyl group therefore has 1, 2, 3, 4, 5 or 6 carbon atoms. Specifically, examples of "Ci-6 alkyl group" include methyl group, ethyl group, n-propyl group, iso-propyl group, n-butyl group, iso-butyl group, sec-butyl group, tert-butyl group, n-pentyl group, 1,1-dimethylpropyl group, 1,2-dimethylpropyl group, 2,2-dimethylpropyl group, 1-ethylpropyl group, n-hexyl group, l-ethyl-2-methylpropyl group, 1,1,2- trimethylpropyl group, 1-ethylbutyl group, 1-methylbutyl group, 2-methylbutyl group, 1,1-dimethylbutyl group, 1,2-dimethylbutyl group, 2,2-dimethylbutyl group, 1,3- dimethylbutyl group, 2,3-dimethylbutyl group, 2-ethylbutyl group, 2-methylpentyl group, 3 -methyl pentyl group and the like. A cycloalkyl group is preferably a "C3-8 cycloalkyl group" that is a cycloalkyl group with 3 to 8 carbon atoms. The cycloalkyl group therefore has 3, 4, 5, 6, 7 or 8 carbon atoms. Specifically, examples of the C3-8 cycloalkyl group include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl. It will be appreciated that the cycloalkyl group may comprise a cycloalkyl ring bearing one or more linking or non-linking alkyl subsitutents, such as -CH2-cyclohexyl.
The term "halide" used herein means a fluorine atom, a chlorine atom, a bromine atom, an iodine atom and the like, preferably a fluorine atom or a chlorine atom, and more preferably a fluorine atom.
A haloalkyl group is prefereably a "Ci-6 haloalkyl group" and is a Q-6 alkyl group as described above substituted with 1, 2 or 3 halogen atom(s). Specifically, examples of "Ci-6 haloalkyl group" include fluoromethyl group, difluoromethyl group, trifluoromethyl group, fluoroethyl group, difluroethyl group, trifluoroethyl group, chloromethyl group, bromomethyl group, iodomethyl group and the like.
An alkoxy group is preferably a "C1-6 alkoxy group" and is an oxy group that is bonded to the previously defined "C1-6 alkyl group". Specifically, examples of "Ci-6 alkoxy group" include methoxy group, ethoxy group, n-propoxy group, iso-propoxy group, n-butoxy group, iso-butoxy group, sec-butoxy group, tert-butoxy group, n- pentyloxy group, iso-pentyloxy group, sec-pentyloxy group, n-hexyloxy group, iso- hexyloxy group, 1,1-dimethylpropoxy group, 1,2- 1 dimethylpropoxy group, 2,2- dimethylpropoxy group, 2-methylbutoxy group, l-ethyl-2-methylpropoxy group, 1,1,2-trimethylpropoxy group, 1,1-dimethylbutoxy group, 1,2-dimethylbutoxy group, 2,2-dimethylbutoxy group, 2,3-dimethylbutoxy group, 1,3-dimethylbutoxy group, 2- ethylbutoxy group, 2-methylpentyloxy group, 3-methylpentyloxy group and the like.
An aryl group is preferably a "C6-I2 aryl group" and is an aryl group constituted by 6, 7, 8, 9, 10, 11 or 12 carbon atoms and includes condensed ring groups such as monocyclic ring group, or bicyclic ring group and the like. Specifically, examples of "C6-1Q aryl group" include phenyl group, biphenyl group, indenyl group, naphthyl group or azulenyl group and the like. It should be noted that condensed rings such as indan and tetrahydro naphthalene are also included in the aryl group.
An alkylaryl group is preferably a "C1-16 alkyl C6-12 aryl group" and is an aryl group as defined above bonded at any position to an alkyl group as defined above. Preferably, the alkylaryl group is -CH2-Ph or -CH2CH2-Ph.
An ether group is preferably a group OR5 wherein R5 can be an alkyl group or an aryl group as defined above. Preferably, R5 is an alkyl group selected from methyl, ethyl or propyl.
A silyl ether group is preferably a group OSi(Ro)3 wherein each R6 can be independently an alkyl group or an aryl group as defined above. Preferably, each R6 is an alkyl group selected from methyl, ethyl or propyl.
A nitrile group is preferably a group CN or a group CNR7 wherein R7 is an alkyl group or an aryl group as defined above. Preferably R7 is an alkyl group selected from methyl, ethyl or propyl.
An alkenyl group contains a double bond -C=C-R8 wherein R8 can be an alkyl group or an aryl group as defined above. For the purposes of the invention when R8 is alkyl, the double bond can be present at any position along the alkyl chain. Preferably R8 is methyl, ethyl, propyl or phenyl.
An acetylide group contains a triple bond -C≡C-Rg, wherein R9 can be an alkyl group or an aryl group as defined above. For the purposes of the invention when R9 is alkyl, the triple bond can be present at any position along the alkyl chain. Preferably R9 is methyl, ethyl, propyl or phenyl.
An amino group is preferably NH2, NHR1O or N(Rio)2 wherein Rio can be an alkyl group, a silylalkyl group or an aryl group as defined above. It will be appreciated that when the amino group is N(R10)2, each Ri0 group can be independently selected from an alkyl group, a silylalkyl group or an aryl group as defined above. Preferably R10 is methyl, ethyl, propyl, SiMe3 Or phenyl. An amido group is -NR11C(O)- Or -C(O)-NRu- wherein R11 can be hydrogen, an alkyl group or an aryl group as defined above. Preferably R11 is hydrogen, methyl, ethyl, propyl or phenyl.
It will be appreciated that for the catalyst of the first aspect, the groups R1 and R2 may be the same or different. For the purposes of the present invention, R1 and R2 are preferably independently selected from hydrogen, tBu, Me, CF3, phenyl, F, Cl, Br, I, NMe2, NEt2, NO2, OMe, OSiEt3, CNMe, CN or CCPh, more preferably hydrogen, OMe, Me or tBu (e.g. hydrogen or tBu). In certain embodiments, R2 is hydrogen and Ri is any one of the groups defined above, preferably tBu, OMe or Me.
It will be appreciated that the group R3 is a disubstituted alkyl, aryl or cycloalkyl group which acts as a bridging group between two nitrogen centres in the catalyst of formula (I). Thus, where R3 is a alkylene group, such as dimethylpropylene, the R3 group has the structure -CH2-C(CH3)2-CH2-. The definitions of the alkyl, aryl and cycloalkyl groups set out above therefore also relate respectively to the alkylene, arylene and cycloalkylene groups set out for R3. Preferably R3 is ethylene, 2,2- dimethylpropylene, propylene, butylene, phenylene, cyclohexylene or biphenylene, more preferably 2,2-dimethylpropylene. When R3 is cyclohexylene, it can be the racemic, RR- or SS- forms.
Preferably R4 is H, Me, Et, Bn, iPr, tBu or Ph, more preferably hydrogen.
Preferably X is OCOCH3, OCOCF3, OSO2C7H7, OSO(CH3)2, Et, Me, PhOEt, OMe, OiPr, OtBu, Cl, Br, I, F, N(iPr)2 or N(SiMe3)2,, more preferably OCOCH3.
Preferably M is Zn(II), Cr(III), Cr(II), Co(III), Co(II), Mn(III), Mn(II), Mg (II), Fe(II) or Fe(III), more preferably Zn(II), Cr(III), Co(II), Mn(II), Mg(II), Fe(II) or Fe(III), and most preferably Zn(II) or Mg(II). It will be appreciated that when M is Cr(III), Co(III), Mn(III) or Fe (III), the catalyst of formula (I) will contain an additional X group co-ordinated to the metal centre, wherein X is as defined above.
In a particularly preferred aspect of the first aspect of the invention, there is provided a catalyst selected from:
Figure imgf000007_0001
[LiZn2(OAc)2] [L^Zn2(OAc)2]
Figure imgf000007_0002
A catalyst of formula (I) of the first aspect of the invention may be prepared by complexation of a ligand (for example H2L1, H2L2 or H2L3, where L1, L2 or L are as represented within the structures shown above) with a metal complex comprising the groups M and X. Carrying out this complexation in the presence of water where X is OCOCH3, OCOCF3, OSO2C7H7, OSO(CH3)2 or halide may lead, in addition to the formation of a catalyst of formula (I), to the formation of a dimeric catalyst species comprising two catalyst complexes of formula (I), linked by a bridging ligand X, with a bound water molecule. Accordingly, in a second aspect the invention provides a dimeric catalyst formed from two of the same monomelic subunits and a bound water molecule, wherein each monomelic subunit is a catalyst of formula (I) of the first aspect of the invention wherein X is OCOCH3, OCOCF3, OSO2C7H7, OSO(CH3)2 or halide, and wherein the two monomelic subunits are linked by a bridging ligand X. The bridging group X may bridge between one M of each monomelic subunit, with a water molecule being bound to an M of one monomelic subunit. Each monomelic subunit of formula (I) which forms the dimeric complex has the same structure (i.e. each subunit has the same group at the R1, R2, R3, R4, Ei, E2 and M positions, respectively).
The dimeric catalyst of the second aspect can be illustrated by the formula (II):
Figure imgf000008_0001
(II)
wherein the groups Ri, R2, R3, R4, Ei, E2 and M are as defined for the first aspect of the invention and X is OCOCH3, OCOCF3, OSO2C7H7, OSO(CH3)2 or halide. Preferably X is OCOCH3, OCOCF3, OSO2C7H7 or OSO(CH3)2 and more preferably OCOCH3.
M is preferably Zn(II) or Mg(II), more preferably Mg(II).
In a particularly preferred aspect of the second aspect of the invention, there is provided a catalyst as illustrated below:
Figure imgf000009_0001
When a ligand (for example H2L1, H2L2 or H2L3 ) is combined with a metal complex comprising the groups M and X, in the presence of water, the product formed may be a mixture of the catalyst of formula (I) of the first aspect and the dimeric catalyst of the second aspect of the invention, wherein X is OCOCH3, OCOCF3, OSO2C7H7, OSO(CH3)2 or halide. Accordingly, a third aspect of the invention provides a mixture of the catalytic species of the first aspect and the second aspect of the invention.
The fourth aspect of the invention provides a process for the reaction of carbon dioxide with an epoxide in the presence of a catalyst of the first aspect, the second aspect or the third aspect of the invention. For the purposes of the present invention, the epoxide substrate is not limited. The term epoxide therefore relates to any compound comprising an epoxide moiety. Preferred examples of epoxides for the purposes of the present invention include cyclohexene oxide, propylene oxide, substituted cyclohexene oxides (such as limonene oxide, C10Hi6O or 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane,
CuH22O), alkylene oxides (such as ethylene oxide and substituted ethylene oxides) or substituted oxiranes (such as epichlorohydrin, 1,2-epoxybutane, glycidyl ethers).
The process of the fourth aspect of the invention is particularly provided for the reaction of carbon dioxide with an epoxide at low pressures. The reaction can therefore be carried out at a pressure of 1 to 10 atmospheres, preferably at 1 or 2 atmospheres.
The process of the fourth aspect of the invention can be carried out at a temperature of 50°C to 100°C. The duration of the process can be up to 48 hours preferably 20 to 24 hours.
The process of the fourth aspect of the invention can advantageously be carried out at low catalytic loading, for example, the catalytic loading for the process is preferably in the range of 1: 1000-10000 catalyst.epoxide, more preferably in the region of 1:1000 catalyst:epoxide, and most preferably in the region of 1:10000 catalyst:epoxide.
The present invention provides a bimetallic catalytic complex and allows the reaction of epoxides with carbon dioxide with high turn over numbers and turn over frequencies.
It should be noted that the catalysts of the present invention operate at remarkably low pressure, e.g. 1 atm of CO2. Indeed, the catalysts show comparable TON and TOF to literature catalysts but operate at 1/60 of the pressure of CO2.
In addition, unlike conventional catalysts, most of the catalysts of the present invention are air stable and do not require the special handling associated with the conventional air sensitive catalysts. The fifth aspect of the invention provides a product of the process of the fourth aspect of the invention.
The sixth aspect of the invention provides a process for the production of a catalyst of the first aspect of the invention, said process comprising reaction of a compound of formula (III)
Figure imgf000011_0001
with a metal complex comprising the groups M and X, wherein the groups Ri, R2, R3, R4, M, X, E) and E2 are as defined for the first aspect of the invention. It will be appreciated that when Ei is N and E2 is =0, the H atom is absent from the E2-H group illustrated for the compound of formula (III).
For the purposes of this invention the number of the groups X present in the metal complex will depend on the valency of the metal M. For example, wherein M is Zn(II) and X is OAc, the metal complex will be Zn(OAc)2. Alternatively, the metal complex may have the formula M-XH.
For the purposes of the sixth aspect of the invention, the reaction of the compound of formula (III) with a metal complex can be carried out in the presence or absence of a base. Where the reaction is carried out in the presence of a base, the base can be selected from one or more of an amine base, such as Et3N or a hydride base, such as NaH, LiH or KH.
The reaction of the compound of formula (III) with a metal complex can be carried out in a solvent (for example THF, toluene, dichloromethane or methanol). The solvent is preferably anhydrous. In certain embodiments, the process is carried out under anhydrous conditions and preferably the metal complex is anhydrous.
It will be appreciated that a process as defined in the sixth aspect of the invention may be used to produce a catalyst of the second or third aspect of the invention, wherein X is OCOCH3, OCOCF3, OSO2C7H7, OSO(CH3)2 or halide, by the inclusion of water within the reaction, for example by providing a metal complex which is not completely anhydrous.
The seventh aspect of the invention provides a ligand as illustrated below:
Figure imgf000012_0001
H2U H2L2 H2L3
The ligand of the seventh aspect of the invention is provided for use in the production of a catalyst of the first, second or third aspects of the invention. The seventh aspect of the invention therefore further provides a process for the production of a catalyst of the first aspect of the invention, said process comprising reaction of the ligand of the seventh aspect of the invention with a metal complex comprising the groups M and X as defined in the first aspect of the invention. The seventh aspect of the invention yet further provides a process for the production of a catalyst of the second or third aspects of the invention, said process comprising reaction of the ligand of the seventh aspect of the invention with a metal complex comprising the groups M and X, wherein X is OCOCH3, OCOCF3, OSO2C7H7, OSO(CH3)2 or halide, wherein the reaction is carried out in the presence of water, for example by providing a metal complex which is not completely anhydrous. In certain embodiments, the process for the production of a catalyst of the first, second or third aspects of the invention is carried out in a solvent (for example THF, toluene, dichloromethane or methanol), preferably wherein the solvent is anhydrous. The process for the production of a catalyst of the first, second or third aspects of the invention may be carried out in the presence of KH. For the purposes of the seventh aspect of the invention, the metal complex is preferably Zn(OAc)2 or Mg(OAc)2.
All preferred features of each of the aspects of the invention apply to all other aspects mutatis mutandis.
The invention may be put into practice in various ways and a number of specific embodiments will be described by way of example to illustrate the invention with reference to the accompanying drawings, in which:
Figure 1 shows the copolymerization of carbon dioxide and cyclohexene oxide, where [cat]= catalyst, frequently a Zn(II), Cr(III) or Co(III) complex;
Figure 2 shows the synthesis of the dizinc complex [L1Zn2(OAc)2]. Reagents and conditions: i) KH, THF, -78 0C → RT, 1 hour, ii) Zn(OAc)2, THF, RT, 16 hours.
Figure 3 shows a plot showing the Mn of the polycarbonate, as determined by GPC, versus the percentage conversion, as determined by 1H NMR. The values in parentheses represent the polydispersity index; and
Figure 4 shows a 1H NMR spectrum, at 1100C of the dizinc complex [L1Zn2(OAc)2].
Figure 5 shows an X-ray crystallography structure for the dimeric catalyst complex [L1 ZMg4(OAc)4(H2O)]
The present invention will now be illustrated by reference to one or more of the following non-limiting examples.
EXAMPLES Example 1
Reaction of a number of epoxides with carbon dioxide were carried out using a bimetallic zinc complex [L1Zn2(OAc)2] as illustrated in figure 2. The macrocyclic ligand, H2L1, was prepared two steps, in 84% overall yield, from commercial reagents 5 as described below. The bimetallic zinc complex, [L1Zn2(OAc)2], was prepared by the double deprotonation of the H2L1, using potassium hydride, and the subsequent reaction with zinc acetate. The complex was isolated, as a white solid, in 70% yield.
The complex stoichiometry was confirmed by the elemental analysis being in excellent agreement with the calculated values and a daughter peak in the FAB mass0 spectrum for the molecular ion less an acetate group. The 1H NMR spectrum, at 25 °C, shows several broadened resonances, consistent with the several diastereoisomers being present, which are fluxional on the NMR timescale. When the sample was heated to 110 °C, coalescence was observed as illustrated in Figure 4. A single resonance was observed for the aromatic protons and the NH groups showed a5 broadened resonance at 4.78 ppm. The methylene groups are di as tereo topic and so, four broadened resonances were observed from 3.32-2.46 ppm, each with an integral of 4H. The tert-butyl and acetate methyl groups resonate as singlets with integrals of 18H and 6H, respectively. The methyl groups on the ligand backbone are also diastereotopic and are observed as two singlets, each with a relative integral of 6H. 0 The complex was tested, under very mild conditions, for the copolymerization of carbon dioxide and cyclohexene oxide as illustrated in figure 1. Results of the copolymerization are set out in table 1 below. Thus, at only 1 atm pressure of carbon dioxide and at 70 0C, poly(cyclohexene carbonate) was produced with a TON of 300 and a TOF of 12 h"1. On increasing the temperature to 100 °C (Table 1, 1-4), the5 TON increased to 530 and the TOF to 26 h"1. There are very few catalysts which are effective at such low pressure, the most active of these is a dizinc complex with a TON of 20 and TOF of 3.3 h'1 (Table 1, entry 9 ). [L1Zn2(OAc)2] is also tolerant, it operates effectively at a loading of 0.01 mol% (Table 1, entries 5-9). The catalyst shows much enhanced activity at 1 atm compared to any previously reported @22i25vicatalysts; it has TONs which are up to 35 times greater and TOFs up to 10 times greater (entry 10). Indeed [L1Zn2(OAc)2] displays comparable TONs and TOFs to Darensbourg's bis(phenoxide)zinc catalysts (entry 12), but at 1/60 of the pressure of carbon dioxide. When the pressure of CO2 was increased (entries 7-9), the TONs and TOFs increased to a maximum of 3400 and 140 h"1, respectively. Indeed, under comparable conditions (70 °C, 7 atm), [L1Zn2OAc2] has a slightly higher TON (entry 7) than Coates β-diiminate catalysts (entry 11).
Entry # T (0C) P(CO2) TONa) TOFb) % % Mn e) PDIe) [atm] carbonatec) polyme [h 1] rd)
1 70 1 292 12.2 >99 >99.6 3518 1.22
2 80 1 439 18.3 >99 96 6193 1.19
3 90 1 567 23.6 >99 95 6519 1.21
4 100 1 527 25.1 >99 94 7358 1.21
5° 70 1 321 13.4 >99 >99 N/A N/A
6° 100 1 708 29.5 >99 89 1395 1.19
7o 70 7 728 30.3 >99 >99 1861 1.23
8° 70 10 760 31.6 >99 >99 2585 1.24
90 100 10 3347 139.5 >99 95 14100g) 1.03
10) 60 1 20 3.3 >99 N/A 19200 1.56
Comparative example
12) 50 7 494 247 90 N/A 31000 1.10
Comparative example
H) 80 60 774 32.2 >99 N/A 8900 1.2
Comparative example Table 1: The copolymerization of carbon dioxide and cyclohexene oxide, catalysed by [L1Zn2(OAc)2]. The copolymerizations were conducted in a Schlenk tube for 20 - 24 h, at a loading of [L1Zn2(OAc)2]:cyclohexene oxide of 1: 1000 (unless otherwise stated), or in a Parr reactor at 7-10 atm for 24 h (entries 7-9). a) the turn over number (TON) = number of moles of cyclohexene oxide consumed/ number of moles of
[L1Zn2(OAc)2]. b) the turn over frequency (TOF) = TON/reaction period, c) determined by integration of the signal at 3.45 ppm assigned to poly(cyclohexene ether) in the 1H NMR spectrum, d) assigned by integration of the signal at 4.65 ppm assigned to cyclohexene carbonate, e) determined by GPC in THF, using narrow Mw polystyrene standards, f) carried out at a loading of [L1Zn2(OAc)2]: cyclohexene oxide of 1: 10 000. g) a bimodal peak was observed with Mn of 14100 and 6600.
The catalyst is also selective, yielding a polymer with >99% polycarbonate linkages. In contrast to previous literature catalysts, [L1Zn2(OAc)2] is remarkably robust, it is still active after 24 h of reaction and at loadings of 0.01 mol%. It is also stable in air; indeed comparable TONs and TOFs are obtained for polymerizations when
[L1Zn2(OAc)2] is handled in air. The polymerization is well controlled, giving polycarbonate with a narrow polydispersity index (Table 1) and a linear relationship between the Mn and percentage conversion (as illustrated in Figure 3).
Materials and Methods
All reactions were conducted under a nitrogen atmosphere, using either standard anaerobic techniques or in a nitrogen filled glovebox. High-pressure reactions were carried out in a Parr 5513 100 mL bench reactor. 4-rert-butyl-2,6-diformylphenol was synthesised according to a literature procedure. All solvents and reagents were obtained from commercial sources (Aldrich and Merck). THF was distilled from sodium and stored under nitrogen. Cyclohexene oxide, methylene chloride and d2- TCE were distilled from CaH2 and stored under nitrogen. CP grade carbon dioxide was used for polymerisation studies.
1H and 13C{ 1H} NMR spectra were performed on a Bruker AV-400 instrument, unless otherwise stated. All mass spectrometry measurements were performed using a Fisons Analytical (VG) Autospec spectrometer. Elemental analyses were determined by Mr Stephen Boyer at London Metropolitan University, North Campus, Holloway Road, London, N7. SEC data were collected using a Polymer labs PL GPC-50 instrument with THF as the eluent, at a flow rate of imLmin"1. Two Polymer labs Mixed D columns were used in series. Narrow Mw polystyrene standards were used to calibrate the instrument.
Synthesis of [H4L1 ](C1O4)2
Figure imgf000017_0001
[H4L1 ](CIO4)2
To a round-bottomed flask was added 4-terr-butyl-2,6-diformylphenol (1.20 g, 5.80 mmol), NaClO4 (2.81 g, 23.2 mmol), acetic acid (0.66 mL, 11.6 mmol) and methanol (90 mL). This solution was heated to 70 °C whilst stirring, as the solution started to boil, 2,2-dimethyl-l,3-propanediamine (0.70 mL, 5.8 mmol) was added slowly in methanol (30 mL). The yellow reaction mixture was allowed to cool to room temperature, and left stirring for 72 hours, after which a bright orange precipitate was filtered and washed with cold (-78 °C) methanol (1.85 g, 95 %).
δH(400 MHz; ^-dmso) 13.61 (4 H, br s, NH/OH), 8.68 (4 Η, d, N=CH), 7.66 (4 Η, s, Ar-H), 3.87 (8 Η, s, CH2), 1.28 (12 Η, s, CH3), 1.15 (18 Η, s, CH3); δc(400 MHz; rf6- dmso) 176.5, 169.3, 142.5, 136.2, 116.6, 60.7, 35.2, 34.0, 31.2 and 23.6.
Synthesis of H2L1 [H4L1 KClO4^ (1.80 g, 2.69 mmol) was suspended in methanol (180 mL). The suspension was cooled to 0 °C and NaBH4 (2.65 g, 69.9 mmol) was added slowly. As NaBH4 was added, the red-orange suspension turned to a clear solution. Water was added slowly, and the solution turned cloudy. Once precipitate started to form, the mixture was left overnight and H2L1 was filtered off as a white solid (1.21 g, 88 %).
Mp 162 0C (from methanol); Anal. CaIc. for C34H56N4O2; C, 73.87; H, 10.21; N, 10.13. Found: C, 73.87; H, 10.26; N, 10.18; δH(400 MHz; CDCl3): 6.95 (s, 4H, Ar-H), 3.76 (s, 8Η, CH2), 2.53 (s, 8Η, CH2), 1.27 (s, 18Η, CH3), 1.02 (s, 12H, CHj); δc(400 MHz; CDCl3) 154.7, 140.7, 124.9, 124.3, 59.9, 53.4, 34.7, 34.1, 33.9, 31.7, and 25.2; m/z (ES) 553 (M+, 75 %), 277 (100), 216 (8), 175 (7).
Synthesis of [L1Zn2OAc2]
H2L1 (0.40 g, 0.72 mmol) was dissolved in dry THF (10 mL) and transferred into a Schlenk tube containing KH (0.04 g, 1.08 mmol), and cooled to -78 0C, under nitrogen. This suspension was allowed to warm to room temperature and left to stir for 1 hour. The excess KH was filtered off and the solution transferred to a Schlenk tube containing Zn(OAc)2 (0.27 g, 1.48 mmol). The reaction was left to stir for 16 hours overnight, after which the THF was removed in vacuo, and the product taken up in dry CH2Cl2 (10 mL). This was then filtered and the CH2Cl2 removed in vacuo to yield the title compound as a white powder (0.40 g, 69.5 %).
Anal. Calc.for C36H60N4O2Zn2: C, 57.07; H, 7.56; N, 7.01; Found: C, 56.91; H, 7.46; N, 6.92; δH (400 MHz, d2-tce, 383 K) 7.00 (4 H, s, Ar-H), 4.78 (4 H, br s, NH), 3.32 (4 H, br d, CH2), 2.95 (4 H, br s, CH2), 2.84 (4 H, br s, CH2) 2.46 (~ 4 H, br s, CH2), 2.08 (~ 6H, s, OAc), 1.35 (18 H, s, Ar-C-CH5), 1.29 (6 Η, s, CH2-C-CHj), 1.05 (6 Η, s, CH2-C-CH?); δc (400 MHz, d2-tce, 383 K) 174.7, 159.5 (br), 139.5 (br), 127.4, 124.4, 63.2, 56.3, 33.5, 31.4, 27.9, 21.1 and 20.7; m/z (FAB) 739 ([M-OAc]+, 100%).
Polymerization conditions
Cyclohexene oxide (5 mL, 49.4 mmol) and [L1Zn2(OAc)2] (0.049 mmol) were added to a Schlenk tube. The cyclohexene oxide was degassed, before being left stirring under 1 atm CO2, at a certain temperature, for 24 hours. The crude reaction mixture was then taken up in CH2Cl2 and evaporated in air, after which the product was dried in vacuo overnight.
For high-pressure reactions, [L1Zn2(OAc)2] (0.0198 mmol) was dissolved in cyclohexene oxide (20 mL, 197.6 mmol) in a Schlenk tube. This was transferred into the Parr reaction vessel, (which was dried in an oven at 140 0C overnight) under nitrogen. The reactor was brought up to temperature under 2 atm CO2 before being left at a certain pressure and temperature for 24 hours. Work-up as above.
Turn-over-number calculated as [(isolated yield - weight catalyst)/142.1]/moles catalyst.
Example 2
Complexes [L2Zn2(OAc)2] and [L3Zn2(OAc)2] were prepared in the same manner as [L1Zn2(OAc)2].
Figure imgf000019_0001
L2Zn2(OAc)2 L3Zn2(OAc)2
Both complexes were found to react with cyclohexene oxide in the same manner as [L1Zn2(OAc)2]. The nature of the complexes was confirmed by very similar features in the 1H and 13C NMR spectra, elemental analysis and FAB mass spectra to [L1Zn2(OAc)2].
Both [L2Zn2(OAc)2] and [L3Zn2(OAc)2] were tested under mild conditions (80 °C, 1 atm CO2, 24 hours), for the copolymerisation of carbon dioxide and cyclohexene oxide. Results showed both complexes to have similar activity to [L1Zn2(OAc)2]. Results of the copolymerisation are set out in table 2.
Catalyst TON TOF [h 1] % carbonate % polymer Mn PDI % conversion
L1Zn2OAc2 439 18.4 >99 96 6200 1.20 45
L2Zn2OAc2 398 16.6 >99 96 5800 1.21 40
L3Zn2OAc2 288 12 >99 97 2800 1.21 29
Table 2: Comparison of catalytic activity between [L1 '23Zn2(OAc)2] at 80 0C, 1 atm CO2, 24 hours. Molar ratio of catalystrcyclohexene oxide - 1: 1000
[L Zn2(OAc)2] was also tested at a higher temperature and pressure (100 °C, 10 atm CO2, 24 hours) and was found to exhibit very similar activities to [L1Zn2(OAc)2] under these conditions. These results are outlined in table 3 below.
Catalyst TON TOF [h 1 ] % % Mn PDI carbonate polymer
L1Zn2(OAc)2 3347 140 >99 96 14100 1.03
L2Zn2(OAc)2 2839 118 >99 96 13000 1.04
Table 3: Comparison of catalytic activity between [L ' Zn2(OAc)2] at 100 °C, 10 atm CO2, 24 hours. Molar ratio of catalystxyclohexane oxide - 1:10000
General procedure for the synthesis of [HUL" KClO-O2
To a round-bottomed flask was added 4-R1-2,6-diformylphenol, wherein Ri is as defined for formula (I), (5.80 mmol), NaClO4 (2.81 g, 23.2 mmol), acetic acid (0.66 mL, 11.6 mmol) and methanol (90 mL). This solution was heated to 70 °C whilst stirring, as the solution started to boil, 2,2-dimethyl-l,3-propanedianiine (0.70 mL, 5.8 mmol) was added slowly in methanol (30 mL). The reaction mixture was allowed to cool to room temperature, and left stirring for 24 hours, after which a precipitate was filtered and washed with cold (-78 °C) methanol.
This procedure was carried out to produce [H4L2 ](C1O4)2 wherein R] is methyl, and to produce [H4L3 ](C1O4)2 wherein Ri is methoxy. [H4L2'](CIO4)2 (orange crystals; 1.72 g, 2.26 mmol, 76 %): 1H NMR (J6-DMSO): δ 8.63 (d, J = 13.5 Hz, 4H, N=CH), 7.34 (s, 4Η, Ar-H), 3.90 (d, 8Η, N-CH2-C), 2.13 (s, 6Η, Ar-CHO, 1.28 (s, 12Η, C-CH,). 13C( 1HJ NMR (J6-DMSO): δ 176.1, 168.1,
145.2, 122.5, 116.3, 60.2, 33.7, 30.4, 18.7. Anal. CaIc. for C28H38Cl2N4O10: C, 50.84; H, 5.79; N, 8.47. Found: C, 50.79; H, 5.77; N, 8.41.
[H4IZ](C-O-O2 (brick red powder; 0.63 g, 0.90 mmol, 31 %): 1H NMR (J6-DMSO): δ 13.83 (s, 4H, OH/NH), 8.67 (d, 4Η, N=CH), 7.22 (s, 4Η, Ar-H), 3.90 (s, 8Η, N-CH2- C), 3.69 (s, 6Η, Ar-O-CH5), 1.29 (s, 12Η, C-CH5). 13C{ 1H} NMR ((J6-DMSO): δ
174.3, 168.5, 147.3, 130.7, 116.9, 61.2, 56.4, 34.4, 23.5. Anal. CaIc. for C28H38Cl2N4Oi2: C, 48.49; H, 5.52; N, 8.08. Found: C, 48.47; H, 5.46; N, 8.12.
Synthesis of H2L2
[H4L2 ](C1O4)2 (2.7 mmol) was suspended in methanol (180 mL). The suspension was cooled to 0 0C and NaBH4 (2.65 g, 70 mmol) was added slowly. As NaBH4 was added, the red-orange suspension turned to a clear solution. The solution was allowed to stir at room temperature for 1 hour, after which water was added slowly, and the solution turned cloudy. Once precipitate started to form, the mixture was left overnight. The product was filtered, washed with water and dried under vacuum to yield white crystals of the title compound.
H2L2 (0.75 g, 1.6 mmol, 59 %): Mp 154 °C. 1H NMR (CDCl3): δ 6.74 (s, 4H, Ar-H), 3.74 (s, 8H, N-CH2-Ar), 2.51 (s, 8H, N-CH2-C), 2.22 (s, 6H, Ar-CH3), 1.03 (s, 12H,
C-CH3). 13C{1H} NMR (CDCl3): δ 154.6, 128.7, 127.2, 124.7, 59.7, 52.7, 34.7, 25.0, 20.4. m/z (ES): 469 ([M+H]+, 100 %), 235 (14 %). Anal. CaIc. for C28H44N4O2: C, 71.76; H, 9.46; N, 11.95. Found: C, 71.60; H, 9.52; N, 11.88.
Synthesis of H2L3
[H4L3'](C1O4)2 (1.40 g, 2.02 mmol) was suspended in MeOH (110 mL). The suspension was cooled to 0°C and NaBH4 (1.99 g, 52.6 mmol) was added slowly. As NaBH4 was added, the brick-red suspension turned to a light brown, clear solution. The solvent was removed in vacuo and the crude product taken up in a minimal 'amount of CHCl3. After an hour a brown precipitate was filtered off, and the solvent removed in vacuo. The product was recrystallised from MeOHZH2O and dried under vacuum.
H2L3 (White crystals, 0.340 g, 0.68 mmol, 34 % yield): Mp 74 °C (from CHCl3). 1H NMR (CDCl3): δ 6.52 (s, 4H, Ar-H), 3.74 (m, 14H, N-CH2-Ar and Ar-O-CH3), 2.50 (s, 8H, N-CH3-C), 1.02 (s, 12H, C-CH3). 13C( 1H) NMR (CDCl3): δ 151.7, 150.5,
125.6, 113.5, 59.4, 55.7, 52.6, 34.6, 24.9; m/z (ES): 501 (100 %, [M+H]+), 251 (25 %). Anal. Calc.for C28H44N4O4: C, 67.17; H, 8.86; N, 11.19. Found: C, 67.28; H, 8.98; N, 11.06.
General Procedure for the synthesis of [L11Zn2(OAc)2] H2L" (0.72 mmol) was dissolved in dry THF (10 mL) in a Schlenk tube. The solution was transferred to another Schlenk tube containing Zn(OAc)2 (0.27 g, 1.48 mmol). The reaction was left to stir for 16 hours overnight, after which the THF was removed in vacuo, and the product taken up in dry CH2Cl2 (10 mL). The solution was then filtered, the solvent removed in vacuo and the white powdery product dried under vacuum overnight.
[L2Zn2(OAc)2] (0.37 g, 0.52 mmol, 72 %): 1H NMR (J2-TCE, 383 K): δ 6.83 (s, 4H, Ar-H), 4.76 (br s, 4Η, NH), 3.26 (br s, 4Η, CH2), 2.96 (br s, 4Η, CH2), 2.79 (br s, 4Η, CH2), 2.44 (br s, 4Η, CH2), 2.27 (s, 6Η, Ar-CHj), 2.09 (s, 6Η, OAc), 1.26 (s, 6H, C- CHj), 1.04 (s, 6Η, C-CHj). 13C( 1HJ NMR (J2-TCE, 383 K): δ 175.1, 159.0 (br), 139.0 (br), 131.0, 124.7, 63.4, 56.1, 33.4, 27.9, 21.3, 19.7. m/z (FAB): 656 ([M -
OAc]+, 100 %). Anal. CaIc. for C32H48N4O6Zn2: C, 53.71; H, 6.76; N, 7.83. Found: C, 53.60; H, 6.74; N, 7.82.
[L3Zn2(OAc)2] (0.40 g, 0.54 mmol, 75 %): 1H NMR (J2-TCE, 383 K): δ 6.61 (s, 4H, Ar-H), 4.68 (s, br, 4Η, NH), 3.77 (s, 6Η, Ar-OCHj), 3.21 (s, br, 4Η, CH2), 2.98 (s, br, 4Η, CH2), 2.76 (s, br, 4Η, CH2), 2.49 (s, br, ~ 4Η, CH2), 2.01 (s, 6Η, OAc), 1.25 (s, 6H, C-CHj), 1.03 (s, 6Η, C-CH5). 13C(1H} NMR (J2-TCE, 383 K): δ 174.5, 155.2, 150.4, 125.5, 116.2, 63.2, 56.8, 33.4, 27.8, 21.4, 20.8. m/z (FAB): 687 ([M -OAc]+, 98 %). Anal. Calc.for C32H48N4O8Zn2: C, 51.42; H, 6.47; N, 7.49. Found: C, 51.36; H, 6.56; N, 7.49. Example 3
A complex of H2L1 and Mg(OAc)2 was prepared in the same manner as [L1Zn2(OAc)2]. X-ray crystallography, 1H and 13C NMR data suggest that the bimetallic magnesium complex produced is a mixture of two different structures, one containing two acetate groups ([L1Mg2(OAc)2]) and one being a dimeric structure containing two ligand moieties linked by a bridging acetate group, with one bound water molecule ([L^Mg4(OAc)3(H2O)]. The dimeric structure is shown in figure 5. The dimeric structure is formed due to the presence of an impurity of water during the complexation of the macrocyclic ligand H2L1 with Mg(OAc)2. Unlike Zn(OAc)2, Mg(OAc)2 is not commercially available in anhydrous form. Commercially available Mg(OAc)2'4H2O was dried under vacuum at 100°C, prior to use in the complexation reaction. It has been found that this drying was insufficient to remove all of the water, and therefore provides a source of water to allow the formation of a dimeric complex.
Other catalyst complexes of formula (I) of the present invention may form a dimeric structure or mixture of monomer and dimer where catalyst synthesis is carried out in the presence of water. Dimer formation is avoided when the synthesis is anhydrous.
The mixture of the [L1Mg2(OAc)2] complex and dimeric structure thereof was tested under mild conditions for the copolymerisation of carbon dioxide and cyclohexane oxide. Results of the copolymerisation are set out in table 4. Data shows that the magnesium complex mixture shows excellent activity under identical conditions as used for [L1Zn2(OAc)2].
Catalyst Time T P TON TOF % % Mn PDI (h) (°C) (atm) [h 1] carbonate polymer L1Zn2(OAc)2 24 80 1 439 18.3 >99 96 6200 1.19
L1Mg2(OAc)2 16 80 1 527 33.3 >99 >99 7200 1.23 L1Zn2(OAc)2 24 100 1 527 25.1 >99 94 7400 1.21
L1Mg2(OAc)2 5 100 1 482 96.4 >99 >99 6400 1.24 L1Zn2(OAc)2 24 100 10 3347 140 >99 96 14100 1.03
L1Mg2(OAc)2 5 100 10 3660 732 >99 >99 14300 1.05
Table 4: Comparison of [L Zn2(OAc)2] and magnesium complex activities for copolymerization of cyclohexene oxide and CO2. Where [L1Mg2(OAc)2] represents a mixture of [L1Mg2(OAc)2] and FlJ2Mg4(OAc)3(H2O)]. The molar catalyst loading is 1: 1000 (catalyst.epoxide) at 1 atm CO2 and 1:10000 (catalyst:epoxide) at 10 atm CO2.
As can be seen from table 4, the magnesium catalyst mixture shows a TOF of almost 34 h 1 at 80 0C and 1 atm CO2, this value increases to almost 97 h"1 when the temperature is increased to 100 °C (entries 2 and 4). If the pressure is increased to 10 atm, the activity is increased further still (entry 6). In addition, there is no evidence for the formation of any cyclic carbonate in the 1H NMR spectra. This is observed for all copolymerisations using the magnesium catalyst and is very unusual, as the formation of cyclic carbonate is generally held to be under thermodynamic control, increasing with temperature. The polymer properties are very similar to those produced by [L1Zn2(OAc)2], with similar polydispersities, molecular weights and no observable ether linkages.
Synthesis of the mixed magnesium complex
H2L1 (0.40 g, 0.72 mmol) was dissolved in dry THF (10 mL) in a Schlenk tube The solution was transferred to another Schlenk tube containing Mg(OAc)2 (0.21 g, 1.48 mmol). The reaction was left to stir for 16 hours overnight, after which the THF was removed in vacuo, and the product taken up in dry CH2Cl2 (10 mL). The solution was then filtered, the solvent removed in vacuo and the white powdery product dried under vacuum overnight.
1H NMR (CD3OD): δ Complex A (monomelic [L1Mg2(OAc)2]): 7.03 (s, 4H, Ar-H),
4.03 (d, J = 11.8 Hz, 4H, CH2), 3.22 (d, J = 11.8 Hz, 4H, CH2). 2.79 (d, J = 11.6 Hz, 4H, CH2), 2.65 (d, J = 11.5 Hz, 4H, CH2), 1.91 (s, ~6H, OAc), 1.28 (s, 18H, Ar-C- CH3), 1.26 (s, 6H, C-C-CH3), 1.03 (s, 6H, C-C-CH3). Complex B (dimeric complex [L^Mg4(OAc)4(H2O)]): 7.14 (s, 4H, Ar-H), 3.97 (s, 8H, Ar-CH2-N), 2.73 (s, 8H, N- CH2-C), 1.91 (s, ~6H, OAc), 1.29 (s, 18H, Ar-C-CH3), 1.26 (s, ~6H, C-C-CH3), 1.06
(s, 6H, C-C-CH3). m/z (FAB): 657 ([M -OAc]+, 100 %).

Claims

1. A catalyst of formula (I)
Figure imgf000025_0001
wherein Ri and R2 are independently hydrogen, alkyl, haloalkyl, aryl, halide, amine, a nitro group, an ether group, a silyl ether group, a nitrile group or an acetylide group;
R3 is alkylene, arylene or cycloalkylene;
R4 is H, alkyl, aryl or alkylaryl;
Ei is C, E2 is O, S or NH or Ei is N and E2 is O;
X is OCOCH3, OCOCF3, OSO2C7H7, OSO(CH3)2, alkyl, alkoxy, halide or amido; and
M is Zn(II), Cr(II), Co(II), Mn(II), Mg (II), Fe(II), Cr (HI)-X, Co (HI)-X, Mn (HI)-X Or Fe(III)-X.
2. A catalyst as claimed in claim 1 wherein Ri and R2 are independently selected from hydrogen, tBu, Me, CF3, phenyl, F, Cl, Br, I, NMe2, NEt2, NO2, OMe, OSiEt3, CNMe, CN or CCPh.
3. A catalyst as claimed in claim 1 or claim 2 wherein R3 is ethylene, 2,2- dimethylpropylene, propylene, butylene, phenylene, cyclohexylene or biphenylene.
4. A catalyst as claimed in any one of claims 1 to 3 wherein R4 is H, Me, Et, Bn, iPr, tBu or Ph.
5. A catalyst as claimed in any one of claims 1 to 4 wherein X is OCOCH3, OCOCF3, OSO2C7H7, OSO(CH3)2, Et, Me, PhOEt, OMe, OiPr, OtBu, Cl, Br, I, F,
N(iPr)2 or N(SiMe3)2,.
6. A catalyst as claimed in any one of claims 1 to 5 wherein said catalyst has a structure selected from:
Figure imgf000026_0001
[UZn2(OAc)2] [L2Zn2(OAc)2
Figure imgf000026_0002
7. A dimeric catalyst wherein said dimeric catalyst comprises two monomelic subunits and a bound water molecule, wherein each monomelic subunit is a catalyst of formula (I) of any of claims 1 to 6 , wherein X is OCOCH3, OCOCF3, OSO2C7H7, OSO(CH3)2 or halide, and wherein the two monomelic subunits are linked by a bridging ligand X.
8. A dimeric catalyst as claimed in claim 7 wherein said catalyst has the structure:
Figure imgf000027_0001
wherein:
R1, R2, R3, R4, M, Ei and E2 are as defined in any one of claims 1 to 5 and X is OCOCH3, OCOCF3, OSO2C7H7, OSO(CH3)2 or halide.
9. A dimeric catalyst as claimed in any one of claims 7 to 8 wherein said catalyst has the structure:
Figure imgf000028_0001
10. A mixture comprising a catalyst of formula (I) of any of claims 1 to 6 and a dimeric catalyst of any of claims 7 to 9, wherein the catalyst of formula (I) and the monomelic subunits forming the dimeric catalyst have the same structure and wherein X is OCOCH3, OCOCF3, OSO2C7H7, OSO(CH3)2 or halide.
11. A process for the reaction of carbon dioxide with an epoxide in the presence of a catalyst as claimed in any one of claims 1 to 10.
12. A process as claimed in claim 11 wherein the epoxide is selected from cyclohexene oxide, propylene oxide, a substituted cyclohexene oxide, an alkylene oxide or a substituted oxirane.
13. A process as claimed in claim 11 or claim 12 wherein said process is carried out at 1 atmosphere.
14. A product of the process of any one of claims 11 to 13.
15. A process for the production of a catalyst as claimed in any one of claims 1 to 6, said process comprising reaction of a compound of formula (III)
Figure imgf000029_0001
with a metal complex comprising the groups M and X, wherein the groups R1, R2, R3, R4, M, X, E1 and E2 are as defined in any one of claims 1 to 5.
16. A process for the production of a dimeric catalyst as claimed in any one of claims 7 to 9 or a mixture as claimed in claim 10, said process comprising reaction of a compound of formula (III)
Figure imgf000029_0002
with a metal complex comprising the groups M and X in the presence of water, wherein the groups R1, R2, R3, R4, M, E1 and E2 are as defined in any one of claims 1 to 5 and X is OCOCH3, OCOCF3, OSO2C7H7, OSO(CH3)2 or halide.
17. A process as claimed in claim 15 or 16 wherein said reaction occurs in the presence of base.
18. A process as claimed in claim 17 wherein the base is one or more selected from an amine base or a hydride base.
19. A ligand having the structure:
Figure imgf000030_0001
H2L1 H2L2 H2L3
20. A process for the production of a catalyst as claimed in claim 6, said process comprising reaction of a ligand as claimed in claim 19 with Zn(OAc)2 or Mg(OAc)2.
21. A catalyst, ligand, mixture or process substantially as hereinbefore defined with reference to one or more of the examples.
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