WO2009128867A3 - Recombinant biologically contained filovirus - Google Patents

Recombinant biologically contained filovirus Download PDF

Info

Publication number
WO2009128867A3
WO2009128867A3 PCT/US2009/000056 US2009000056W WO2009128867A3 WO 2009128867 A3 WO2009128867 A3 WO 2009128867A3 US 2009000056 W US2009000056 W US 2009000056W WO 2009128867 A3 WO2009128867 A3 WO 2009128867A3
Authority
WO
WIPO (PCT)
Prior art keywords
filovirus
recombinant biologically
biologically contained
contained
recombinant
Prior art date
Application number
PCT/US2009/000056
Other languages
French (fr)
Other versions
WO2009128867A2 (en
Inventor
Yoshihiro Kawaoka
Peter J. Halfmann
Jin Hyun
Original Assignee
Warf - Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warf - Wisconsin Alumni Research Foundation filed Critical Warf - Wisconsin Alumni Research Foundation
Publication of WO2009128867A2 publication Critical patent/WO2009128867A2/en
Publication of WO2009128867A3 publication Critical patent/WO2009128867A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/14011—Filoviridae
    • C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
    • C12N2760/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/14011—Filoviridae
    • C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
    • C12N2760/14123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/14011—Filoviridae
    • C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
    • C12N2760/14134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/14011—Filoviridae
    • C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
    • C12N2760/14151—Methods of production or purification of viral material
    • C12N2760/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Abstract

The invention provides recombinant biologically contained filovirus and methods of making and using those viruses.
PCT/US2009/000056 2008-01-07 2009-01-07 Recombinant biologically contained filovirus WO2009128867A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1953208P 2008-01-07 2008-01-07
US61/019,532 2008-01-07

Publications (2)

Publication Number Publication Date
WO2009128867A2 WO2009128867A2 (en) 2009-10-22
WO2009128867A3 true WO2009128867A3 (en) 2010-03-25

Family

ID=41199612

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/000056 WO2009128867A2 (en) 2008-01-07 2009-01-07 Recombinant biologically contained filovirus

Country Status (1)

Country Link
WO (1) WO2009128867A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11851648B2 (en) 2019-02-08 2023-12-26 Wisconsin Alumni Research Foundation (Warf) Humanized cell line

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7211378B2 (en) * 2002-01-31 2007-05-01 Wisconsin Alumni Research Foundation Filovirus vectors and noninfectious filovirus-based particles
WO2010048615A2 (en) 2008-10-24 2010-04-29 The Government Of The United States Of America As Represented By The Secretary, Department Of Health & Human Services, Center For Disease Control And Prevention Human ebola virus species and compositions and methods thereof
WO2015196150A2 (en) 2014-06-20 2015-12-23 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
CN106636014A (en) * 2015-10-28 2017-05-10 中国科学院上海巴斯德研究所 Novel in-vitro and in-vivo infection model based on Ebola virus-like particles
EP3377096A4 (en) * 2015-11-16 2019-09-11 Georgia State University Research Foundation, Inc. Tunable vaccine platform against pathogens of the paramyxovirus family
JP2021533157A (en) * 2018-08-07 2021-12-02 ウィスコンシン アルムニ リサーチ ファンデイション Recombinant biologically contained filovirus vaccine
EP4022046A2 (en) 2019-08-27 2022-07-06 Wisconsin Alumni Research Foundation (WARF) Recombinant influenza viruses with stabilized ha for replication in eggs

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030215794A1 (en) * 2002-01-31 2003-11-20 Yoshihiro Kawaoka Filovirus vectors and noninfectious Filovirus-based particles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030215794A1 (en) * 2002-01-31 2003-11-20 Yoshihiro Kawaoka Filovirus vectors and noninfectious Filovirus-based particles

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Index of GLRCE: documents from 2007", GREAT LAKES REGIONAL CENTER OF EXCELLENCE INDEX, 2007, XP002563469, Retrieved from the Internet <URL:http://www.rcebiodefense.org/glrce/docs/2007/> [retrieved on 20100114] *
ENTERLEIN , SVEN: "Untersuchungen zur Replikation und Transkription von Marburg- und Ebolavirus", 2005, PHILIPPS-UNIVERSITÄT MARBURG, XP002563470 *
HALFMANN PETER ET AL: "Generation of biologically contained Ebola viruses.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 29 JAN 2008, vol. 105, no. 4, 29 January 2008 (2008-01-29), pages 1129 - 1133, XP002563467, ISSN: 1091-6490 *
HALFMANN PETER ET AL: "Replication-deficient ebolavirus as a vaccine candidate.", JOURNAL OF VIROLOGY APR 2009, vol. 83, no. 8, April 2009 (2009-04-01), pages 3810 - 3815, XP002563468, ISSN: 1098-5514 *
KAWAOKA Y.: "Prevention and Control of Ebola Virus Infection (Ongoing Research Support)", 2007 GREAT LAKES REGIONAL CENTER OF EXCELLENCE (GLRCE) ANNUAL MEETING SCHEDULE, 29 November 2007 (2007-11-29), XP002563466, Retrieved from the Internet <URL:http://www.rcebiodefense.org/glrce/annualmeeting/2007Agenda.pdf> [retrieved on 20100114] *
KAWAOKA Y: "Identification by siRNA of host proteins involved in Ebolavirus replication", GREAT LAKES REGIONAL CENTER OF EXCELLENCE FOR BIODEFENSE AND EMERGING INFECTIOUS DISEASES RESEARCH, 2007, pages 1 - 19, XP002563465, Retrieved from the Internet <URL:http://www.rcebiodefense.org/glrce/docs/2007/Kawaoka.pdf> [retrieved on 20100113] *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11851648B2 (en) 2019-02-08 2023-12-26 Wisconsin Alumni Research Foundation (Warf) Humanized cell line

Also Published As

Publication number Publication date
WO2009128867A2 (en) 2009-10-22

Similar Documents

Publication Publication Date Title
WO2009058379A3 (en) Protein scaffolds
WO2009128867A3 (en) Recombinant biologically contained filovirus
WO2007130697A3 (en) Anti-ephb4 antibodies and methods using same
WO2011072099A3 (en) Compositions and methods comprising protease variants
WO2008100805A3 (en) Anti-robo4 antibodies and uses therefor
WO2008121767A3 (en) Stitched polypeptides
WO2008034013A3 (en) Medical devices and methods of making the same
UA104459C2 (en) Anti-fgfr3 antibodies and methods using same
WO2010083347A3 (en) Peptidomimetic macrocycles
WO2005097825A3 (en) Bmp-7 variants with improved properties
EP2178094A4 (en) Circuit connection material, and connection structure of circuit member and connection method of circuit member using the circuit connection material
WO2010065969A8 (en) Sparc binding scfcs
WO2007127834A3 (en) Compositions and methods of preparation thereof
TW200732349A (en) Anti-OX40L antibodies and methods using same
HK1257458A1 (en) Proteins from the webs of nephilengys cruentata, avicularia juruensis and parawixia bistriata spiders
WO2008124660A3 (en) Methods and compositions for the treatment of cancer
WO2008014008A3 (en) Compositions and methods for modulating angiogenesis
IL217124A0 (en) Enzymatic fusion proteins, compositions comprising the same and uses thereof
WO2005082020A8 (en) Flavivirus vaccines
WO2009130479A3 (en) Virus
WO2009033082A3 (en) Medical devices containing silicate and carbon particles
EP1948828A4 (en) Multimeric biosensors and methods of using the same
EP1909850A4 (en) Rnai modulation of the rho-a gene and uses thereof
GB0626021D0 (en) The stabilisation of proteins
WO2007127506A3 (en) Anti-ephrinb2 antibodies and methods using same

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09733570

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09733570

Country of ref document: EP

Kind code of ref document: A2