WO2009128088A3 - Preparation of 2-(2-alkoxy phenoxy) ethylamine, an intermediate of carvedilol and tamsulosin - Google Patents

Preparation of 2-(2-alkoxy phenoxy) ethylamine, an intermediate of carvedilol and tamsulosin Download PDF

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Publication number
WO2009128088A3
WO2009128088A3 PCT/IN2008/000725 IN2008000725W WO2009128088A3 WO 2009128088 A3 WO2009128088 A3 WO 2009128088A3 IN 2008000725 W IN2008000725 W IN 2008000725W WO 2009128088 A3 WO2009128088 A3 WO 2009128088A3
Authority
WO
WIPO (PCT)
Prior art keywords
ethylamine
preparation
tamsulosin
carvedilol
phenoxy
Prior art date
Application number
PCT/IN2008/000725
Other languages
French (fr)
Other versions
WO2009128088A2 (en
Inventor
Thota Giridhar
Gudipati Srinivasulu
Kotaru Srinivasa Rao
Original Assignee
Shodhana Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shodhana Laboratories Limited filed Critical Shodhana Laboratories Limited
Publication of WO2009128088A2 publication Critical patent/WO2009128088A2/en
Publication of WO2009128088A3 publication Critical patent/WO2009128088A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present patent application relates to a process for the preparation of 2-(2-Alkoxy phenoxy) ethylamine or a salt thereof, which is a useful intermediate in the preparation of several active pharmaceutical ingredients including Carvedilol and Tamsulosin. It also provides 2-(2-methoxy phenoxy) ethylamine in solid form.
PCT/IN2008/000725 2008-04-15 2008-11-03 Preparation of 2-(2-alkoxy phenoxy) ethylamine, an intermediate of carvedilol and tamsulosin WO2009128088A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN923/CHE/2008 2008-04-15
IN923CH2008 2008-04-15

Publications (2)

Publication Number Publication Date
WO2009128088A2 WO2009128088A2 (en) 2009-10-22
WO2009128088A3 true WO2009128088A3 (en) 2010-12-23

Family

ID=41199536

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000725 WO2009128088A2 (en) 2008-04-15 2008-11-03 Preparation of 2-(2-alkoxy phenoxy) ethylamine, an intermediate of carvedilol and tamsulosin

Country Status (1)

Country Link
WO (1) WO2009128088A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109206328A (en) * 2018-09-27 2019-01-15 铜仁学院 A kind of preparation method of 2- (2- methoxyphenoxy) ethamine
CN115232034B (en) * 2022-07-29 2024-02-20 上药康丽（常州）药业有限公司 Synthesis method of tamsulosin hydrochloride

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051576A1 (en) * 1998-04-08 1999-10-14 American Home Products Corporation N-aryloxyethylamine derivatives for the treatment of depression
US20010056211A1 (en) * 1997-07-31 2001-12-27 Ing-Jun Chen Guaiacoxypropanolamines with alpha/beta adrenergic blocking activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010056211A1 (en) * 1997-07-31 2001-12-27 Ing-Jun Chen Guaiacoxypropanolamines with alpha/beta adrenergic blocking activity
WO1999051576A1 (en) * 1998-04-08 1999-10-14 American Home Products Corporation N-aryloxyethylamine derivatives for the treatment of depression

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A.M. LIU ET AL, SYNTHESIS OF 2-(2-METHOXYPHENOXY)ETHYLAMINE, pages 794 - 796 *
CHEN, WEIMIN ET AL: "Synthesis of 2-(2- methoxyphenoxy)ethylamine by phase transfer catalysis and microwave radiation", HUAXUE SHIJIE, vol. 39, no. 2, 1998, pages 86 - 87 *
N.I. PEIZHOU ET AL, SYNTHESIS OF 2-(2-METHOXYPHENOXY)ETHYLAMINE, pages 321 *

Also Published As

Publication number Publication date
WO2009128088A2 (en) 2009-10-22

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