WO2009126866A3 - Delta-tocotrienol en tant qu'agent de contremesure radioprotecteur - Google Patents

Delta-tocotrienol en tant qu'agent de contremesure radioprotecteur Download PDF

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Publication number
WO2009126866A3
WO2009126866A3 PCT/US2009/040173 US2009040173W WO2009126866A3 WO 2009126866 A3 WO2009126866 A3 WO 2009126866A3 US 2009040173 W US2009040173 W US 2009040173W WO 2009126866 A3 WO2009126866 A3 WO 2009126866A3
Authority
WO
WIPO (PCT)
Prior art keywords
tocotrienol
delta
radioprotective
radiation
countermeasure agent
Prior art date
Application number
PCT/US2009/040173
Other languages
English (en)
Other versions
WO2009126866A2 (fr
Inventor
Venkataraman Srinivasan
John A. Hyatt
Andreas Papas
Original Assignee
Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.
Yasoo Health, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc., Yasoo Health, Inc. filed Critical Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.
Publication of WO2009126866A2 publication Critical patent/WO2009126866A2/fr
Publication of WO2009126866A3 publication Critical patent/WO2009126866A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention fournit des compositions comprenant du delta-tocotrienol, et des dérivés de celui-ci, qui sont efficaces pour une protection contre une blessure induite par un rayonnement et une mortalité induite par un rayonnement. L'invention concerne également des procédés d'utilisation de ces compositions pour protéger le corps d'une blessure induite par un rayonnement, et d'une mortalité induite par un rayonnement.
PCT/US2009/040173 2008-04-10 2009-04-10 Delta-tocotrienol en tant qu'agent de contremesure radioprotecteur WO2009126866A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4397208P 2008-04-10 2008-04-10
US61/043,972 2008-04-10

Publications (2)

Publication Number Publication Date
WO2009126866A2 WO2009126866A2 (fr) 2009-10-15
WO2009126866A3 true WO2009126866A3 (fr) 2010-01-14

Family

ID=41162635

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/040173 WO2009126866A2 (fr) 2008-04-10 2009-04-10 Delta-tocotrienol en tant qu'agent de contremesure radioprotecteur

Country Status (1)

Country Link
WO (1) WO2009126866A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2362726B1 (fr) 2008-10-14 2018-08-08 Bioelectron Technology Corporation Traitement d'affections liées au stress oxydatif, notamment de la néphropathie aux produits de contraste, des radiolésions et des perturbations de la fonction des globules rouges
PT2919777T (pt) 2012-11-13 2020-03-30 Invictus Biotechnology Pty Ltd Distribuição transmucosa de tocotrienol
EP3043807B1 (fr) 2013-09-13 2023-11-01 BioVentures, LLC Préparation et utilisation d'une composition pour la prévention et l'atténuation des effets de rayonnements
US20160324914A1 (en) 2015-05-05 2016-11-10 Tocol Pharmaceuticals, Llc Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation
CN113521030B (zh) * 2020-04-13 2023-03-28 中国医学科学院放射医学研究所 Ros敏感聚乙二醇-聚酯共聚物纳米给药系统及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0452507A1 (fr) * 1989-11-08 1991-10-23 Nippon Hypox Laboratories Incorporated Medicament contenant du glycoside de tocopheryle comme ingredient actif
US20060247306A1 (en) * 2003-02-14 2006-11-02 Kumar K S Radiation protection by gamma-tocotrienol

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0452507A1 (fr) * 1989-11-08 1991-10-23 Nippon Hypox Laboratories Incorporated Medicament contenant du glycoside de tocopheryle comme ingredient actif
US20060247306A1 (en) * 2003-02-14 2006-11-02 Kumar K S Radiation protection by gamma-tocotrienol

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AKAHO ET AL.: "Preparation and In Vivo Evaluation of a Water-Soluble Prodrug for 2R-gamma- Tocotrienol and as a Two-Step Prodrug for 2,7,8-Trimethyl-2S- (beta-carboxyethyl) -6- hydroxychroman (S-gamma-CEHC) in Rat.", DRUG METABOLISM AND DISPOSITION., vol. 35, no. 9, September 2007 (2007-09-01), pages 1503 *

Also Published As

Publication number Publication date
WO2009126866A2 (fr) 2009-10-15

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