WO2009125987A3 - 약제학적 제제 - Google Patents

약제학적 제제 Download PDF

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Publication number
WO2009125987A3
WO2009125987A3 PCT/KR2009/001833 KR2009001833W WO2009125987A3 WO 2009125987 A3 WO2009125987 A3 WO 2009125987A3 KR 2009001833 W KR2009001833 W KR 2009001833W WO 2009125987 A3 WO2009125987 A3 WO 2009125987A3
Authority
WO
WIPO (PCT)
Prior art keywords
drugs
pharmaceutical formulation
present
compartment
release
Prior art date
Application number
PCT/KR2009/001833
Other languages
English (en)
French (fr)
Other versions
WO2009125987A9 (ko
WO2009125987A2 (ko
Inventor
김성욱
전성수
조영관
구자성
선상욱
김정택
이아람
최진원
장석영
김병하
김진욱
남태영
이길호
Original Assignee
한올제약주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한올제약주식회사 filed Critical 한올제약주식회사
Publication of WO2009125987A2 publication Critical patent/WO2009125987A2/ko
Publication of WO2009125987A3 publication Critical patent/WO2009125987A3/ko
Publication of WO2009125987A9 publication Critical patent/WO2009125987A9/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 디히드로피리딘계 칼슘채널차단제를 함유하는 지연방출성 구획과 안지오텐신-2 수용체 차단제를 함유하는 선방출성 구획을 포함하는 약제학적 제제에 관한 것이다. 디히드로피리딘계 칼슘채널차단제와 안지오텐신-2 수용체 차단제가 별도의 구획에 포함된, 방출성이 제어된 약제학적 제제를 제공한다. 본 발명의 약제학적 제제는 제제 내 다른 구획내 포함된 상이한 약물이 시간차를 두고 방출됨으로써 약물 상호간 길항작용 및 부작용을 최소화하고, 약물 본래의 효과를 최대화한다. 본 발명의 두가지 약물의 특정 조합에 의한 약제학적 제제는, 각각의 단독 투여 및 단순 복합 투여에 비하여 현저히 우수한 질환의 치료 내지 예방 효과를 나타낸다.
PCT/KR2009/001833 2008-04-10 2009-04-09 약제학적 제제 WO2009125987A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20080033363 2008-04-10
KR10-2008-0033363 2008-04-10

Publications (3)

Publication Number Publication Date
WO2009125987A2 WO2009125987A2 (ko) 2009-10-15
WO2009125987A3 true WO2009125987A3 (ko) 2009-12-03
WO2009125987A9 WO2009125987A9 (ko) 2010-01-28

Family

ID=41162400

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/001833 WO2009125987A2 (ko) 2008-04-10 2009-04-09 약제학적 제제

Country Status (1)

Country Link
WO (1) WO2009125987A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111956624A (zh) * 2020-08-31 2020-11-20 珠海润都制药股份有限公司 一种奥美沙坦酯片及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010022385A (ko) * 1997-08-29 2001-03-15 실버스타인 아써 에이. 암로디핀 및 스타틴 화합물을 포함하는 복합 조성물
KR20070078625A (ko) * 2006-01-27 2007-08-01 씨제이 주식회사 멀티플 유닛 타입 서방성 경구 제제 및 그 제조방법
KR20080016801A (ko) * 2005-06-27 2008-02-22 다이이찌 산쿄 가부시키가이샤 안지오텐신 ⅱ 수용체 길항제 및 칼슘 채널 차단제를함유한 약학 제제
KR20080018841A (ko) * 2006-08-24 2008-02-28 한올제약주식회사 방출성이 제어된 디히드로피리딘계 칼슘길항제/스타틴계지질저하제의 복합제제

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010022385A (ko) * 1997-08-29 2001-03-15 실버스타인 아써 에이. 암로디핀 및 스타틴 화합물을 포함하는 복합 조성물
KR20080016801A (ko) * 2005-06-27 2008-02-22 다이이찌 산쿄 가부시키가이샤 안지오텐신 ⅱ 수용체 길항제 및 칼슘 채널 차단제를함유한 약학 제제
KR20070078625A (ko) * 2006-01-27 2007-08-01 씨제이 주식회사 멀티플 유닛 타입 서방성 경구 제제 및 그 제조방법
KR20080018841A (ko) * 2006-08-24 2008-02-28 한올제약주식회사 방출성이 제어된 디히드로피리딘계 칼슘길항제/스타틴계지질저하제의 복합제제

Also Published As

Publication number Publication date
WO2009125987A9 (ko) 2010-01-28
WO2009125987A2 (ko) 2009-10-15

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