WO2009121946A3 - Process for the preparation of optically enriched clopidogrel - Google Patents

Process for the preparation of optically enriched clopidogrel Download PDF

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Publication number
WO2009121946A3
WO2009121946A3 PCT/EP2009/053980 EP2009053980W WO2009121946A3 WO 2009121946 A3 WO2009121946 A3 WO 2009121946A3 EP 2009053980 W EP2009053980 W EP 2009053980W WO 2009121946 A3 WO2009121946 A3 WO 2009121946A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
clopidogrel
optically enriched
pharmaceutically acceptable
enriched clopidogrel
Prior art date
Application number
PCT/EP2009/053980
Other languages
French (fr)
Other versions
WO2009121946A2 (en
Inventor
Janez Smodis
Rok Zupet
Eva Veverkova
Miroslav Veverka
Igor Simonic
Original Assignee
Krka, Tovarna Zdravil, D.D., Novo Mesto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka, Tovarna Zdravil, D.D., Novo Mesto filed Critical Krka, Tovarna Zdravil, D.D., Novo Mesto
Priority to EP09727098A priority Critical patent/EP2276768A2/en
Publication of WO2009121946A2 publication Critical patent/WO2009121946A2/en
Publication of WO2009121946A3 publication Critical patent/WO2009121946A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a process for the preparation of substantially optically pure or optically enriched clopidogrel or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to a process for the preparation of a pharmaceutical formulation comprising substantially optically pure clopidogrel, or a pharmaceutically acceptable salt or solvate thereof, in combination with at least one pharmaceutically acceptable carrier.
PCT/EP2009/053980 2008-04-02 2009-04-02 Process for the preparation of optically enriched clopidogrel WO2009121946A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09727098A EP2276768A2 (en) 2008-04-02 2009-04-02 Process for the preparation of optically enriched clopidogrel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08153990A EP2107061A1 (en) 2008-04-02 2008-04-02 Process for the preparation of optically enriched clopidogrel
EP08153990.0 2008-04-02

Publications (2)

Publication Number Publication Date
WO2009121946A2 WO2009121946A2 (en) 2009-10-08
WO2009121946A3 true WO2009121946A3 (en) 2010-10-28

Family

ID=39712529

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/053980 WO2009121946A2 (en) 2008-04-02 2009-04-02 Process for the preparation of optically enriched clopidogrel

Country Status (2)

Country Link
EP (2) EP2107061A1 (en)
WO (1) WO2009121946A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010046852A1 (en) * 2008-10-20 2010-04-29 Ranbaxy Laboratories Limited Process for the preparation of clopidogrel hydrogen sulphate form 1
WO2012007019A1 (en) * 2010-07-13 2012-01-19 Pharmathen S.A. Process for the preparation of clopidogrel and salts thereof
CN102120745B (en) * 2011-01-31 2013-04-10 天津红日药业股份有限公司 Crystal form I of clopidogrel hydrochloride and preparation method and application thereof

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Patent Citations (7)

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Publication number Priority date Publication date Assignee Title
WO2004020443A1 (en) * 2002-08-27 2004-03-11 Zentiva, A.S. Method for manufacturing crystalline form i of clopidogrel hydrogen sulphate
WO2004074215A1 (en) * 2003-02-03 2004-09-02 Sunil Sadanand Nadkarni Process for preparation of clopidogrel, its salts and pharmaceutical compositions
US20050059696A1 (en) * 2003-05-08 2005-03-17 Dr. Reddy's Laboratories Limited Process for the recovery of S -(+)-methyl- (2-chlorophenyl)- (6,7-dihydro- 4H-thieno [3,2-c] pyrid-5-yl) acetate hydrogen sulfate (clopidogrel bisulfate) from its (R) and mixture of (R) and (S)- isomers
US20050176960A1 (en) * 2004-02-11 2005-08-11 Brantford Chemicals Inc. Resolution of racemates of methyl alpha-5-[4,5,6,7-tetrahydro[3,2-C]thienopyridyl]-(2-chlorophenyl) acetate
WO2005100364A1 (en) * 2004-04-19 2005-10-27 Krka, Tovarna Zdravil, D.D. Novo Mesto Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form i
WO2006094468A1 (en) * 2005-03-08 2006-09-14 Zentiva, A.S. METHOD OF RACEMIZATION OF THE R(-) ISOMER OF THE (2-CHLOROPHENYL)-6,7- DIHYDROTHIENO[3,2-c]PYRIDINE-5(4H)-ACETIC ACID METHYL ESTER
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Also Published As

Publication number Publication date
WO2009121946A2 (en) 2009-10-08
EP2107061A1 (en) 2009-10-07
EP2276768A2 (en) 2011-01-26

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