WO2009120886A3 - Design and manufacturing of bioactive implanted surgical fixation devices using injection molding of gradient cellular strucures - Google Patents

Design and manufacturing of bioactive implanted surgical fixation devices using injection molding of gradient cellular strucures Download PDF

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Publication number
WO2009120886A3
WO2009120886A3 PCT/US2009/038436 US2009038436W WO2009120886A3 WO 2009120886 A3 WO2009120886 A3 WO 2009120886A3 US 2009038436 W US2009038436 W US 2009038436W WO 2009120886 A3 WO2009120886 A3 WO 2009120886A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioactive
strucures
manufacturing
design
injection molding
Prior art date
Application number
PCT/US2009/038436
Other languages
French (fr)
Other versions
WO2009120886A2 (en
Inventor
Gongyao Zhou
Peter I. Lelkes
Norman A. Johanson
Frederic A. Kleinbart
Donggang Yao
Original Assignee
Drexel University
Philadelphia Health & Education Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drexel University, Philadelphia Health & Education Corporation filed Critical Drexel University
Publication of WO2009120886A2 publication Critical patent/WO2009120886A2/en
Publication of WO2009120886A3 publication Critical patent/WO2009120886A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/8645—Headless screws, e.g. ligament interference screws
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/127—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing fillers of phosphorus-containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00893—Material properties pharmaceutically effective
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Medical Informatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention relates to compositions and methods for treating a bone defect. The present invention provides a multifunctional surgical fixation device having desirable mechanical integrity and bioactive utility. The device comprises a permeable medium containing porous materials having a gradient cellular structure.
PCT/US2009/038436 2008-03-28 2009-03-26 Design and manufacturing of bioactive implanted surgical fixation devices using injection molding of gradient cellular strucures WO2009120886A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7218008P 2008-03-28 2008-03-28
US61/072,180 2008-03-28

Publications (2)

Publication Number Publication Date
WO2009120886A2 WO2009120886A2 (en) 2009-10-01
WO2009120886A3 true WO2009120886A3 (en) 2010-01-07

Family

ID=41114728

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/038436 WO2009120886A2 (en) 2008-03-28 2009-03-26 Design and manufacturing of bioactive implanted surgical fixation devices using injection molding of gradient cellular strucures

Country Status (1)

Country Link
WO (1) WO2009120886A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110368522B (en) * 2018-04-13 2022-03-29 广州市阳铭新材料科技有限公司 Artificial bone and preparation method thereof

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101336780B1 (en) * 2012-03-22 2013-12-04 서울대학교산학협력단 Implant Mediated Drug Delivery device
FR2997623B1 (en) * 2012-11-05 2015-12-18 Lavigne Sainte Suzanne Christophe De INTRAOSSIBLE SCREW FOR ATTACHING TO A BONE A BONE FRAGMENT OR TRANSPLANT AND METHOD OF MAKING SUCH AN INTRAOSSEVER SCREW
CN104072705A (en) * 2014-07-08 2014-10-01 成都市绿科华通科技有限公司 Method for preparing acrylamide containing triblock copolymer serving as macromolecular drug carrier
EP3240584A1 (en) * 2014-12-29 2017-11-08 Hasirci, Vasif Nejat Craniofacial implants
JP7132619B2 (en) 2016-05-02 2022-09-07 マーケット ユニバーシティー Reinforced bone scaffold material
WO2019010485A1 (en) * 2017-07-07 2019-01-10 Symic Ip, Llc Treatment of fibrosis
CN110204778B (en) * 2019-06-17 2020-07-28 四川大学 Preparation method of polymer foam material with gradient pore structure
US11744711B2 (en) * 2021-03-22 2023-09-05 Orthofix Us Llc Spinal interbody devices with density gradients and associated methods

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US20060167147A1 (en) * 2005-01-24 2006-07-27 Blue Membranes Gmbh Metal-containing composite materials
US20070203584A1 (en) * 2006-02-14 2007-08-30 Amit Bandyopadhyay Bone replacement materials

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US20060167147A1 (en) * 2005-01-24 2006-07-27 Blue Membranes Gmbh Metal-containing composite materials
US20070203584A1 (en) * 2006-02-14 2007-08-30 Amit Bandyopadhyay Bone replacement materials

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110368522B (en) * 2018-04-13 2022-03-29 广州市阳铭新材料科技有限公司 Artificial bone and preparation method thereof

Also Published As

Publication number Publication date
WO2009120886A2 (en) 2009-10-01

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