WO2009120844A3 - Pharmaceutical compositions comprising insulin sensitizer and insulin secretagogue - Google Patents

Pharmaceutical compositions comprising insulin sensitizer and insulin secretagogue Download PDF

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Publication number
WO2009120844A3
WO2009120844A3 PCT/US2009/038365 US2009038365W WO2009120844A3 WO 2009120844 A3 WO2009120844 A3 WO 2009120844A3 US 2009038365 W US2009038365 W US 2009038365W WO 2009120844 A3 WO2009120844 A3 WO 2009120844A3
Authority
WO
WIPO (PCT)
Prior art keywords
insulin
pharmaceutical compositions
sensitizer
secretagogue
insulin sensitizer
Prior art date
Application number
PCT/US2009/038365
Other languages
French (fr)
Other versions
WO2009120844A2 (en
Inventor
Itamar Kanari
Minutza Liebovici
Michael Fox
Original Assignee
Teva Pharmaceutical Industries Ltd.
Teva Pharmaceuticals Usa, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd., Teva Pharmaceuticals Usa, Inc. filed Critical Teva Pharmaceutical Industries Ltd.
Priority to EP09725377A priority Critical patent/EP2190417A2/en
Publication of WO2009120844A2 publication Critical patent/WO2009120844A2/en
Publication of WO2009120844A3 publication Critical patent/WO2009120844A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Dosage forms containing an insulin sensitizer, such as pioglitazone, and an insulin secretogogue, such as glimepiride, are described. Including a cellulose derivative in the dosage form increased the dissolution rate of the insulin sensitizer and/or the insulin secretagogue.
PCT/US2009/038365 2008-03-26 2009-03-26 Pharmaceutical compositions comprising insulin sensitizer and insulin secretagogue WO2009120844A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09725377A EP2190417A2 (en) 2008-03-26 2009-03-26 Pharmaceutical compositions comprising insulin sensitizer and insulin secretagogue

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3969108P 2008-03-26 2008-03-26
US61/039,691 2008-03-26

Publications (2)

Publication Number Publication Date
WO2009120844A2 WO2009120844A2 (en) 2009-10-01
WO2009120844A3 true WO2009120844A3 (en) 2010-01-28

Family

ID=41051025

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/038365 WO2009120844A2 (en) 2008-03-26 2009-03-26 Pharmaceutical compositions comprising insulin sensitizer and insulin secretagogue

Country Status (2)

Country Link
EP (1) EP2190417A2 (en)
WO (1) WO2009120844A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101804056A (en) * 2010-04-16 2010-08-18 山东新华制药股份有限公司 Compound tablet of pioglitazone hydrochloride, glimepiride and preparation method thereof
WO2013034174A1 (en) 2011-09-06 2013-03-14 ZENTIVA Saglik Ürünleri Sanayi ve Ticaret A.S. Solid preparations of pioglitazone and glimepiride
BR112017028218A2 (en) * 2015-06-30 2018-08-28 Genentech Inc Immediate release tablets containing a drug and tableting processes.
CN112964810A (en) * 2020-11-26 2021-06-15 石药集团欧意药业有限公司 Method for measuring dissolution curve of glimepiride tablet in dissolution medium with pH1.2

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040147564A1 (en) * 2003-01-29 2004-07-29 Rao Vinay U. Combinations of glimepiride and the thiazolidinedione for treatment of diabetes
US20040266830A1 (en) * 1995-06-20 2004-12-30 Hitoshi Ikeda Pharmaceutical composition
WO2005009412A1 (en) * 2003-07-24 2005-02-03 Wockhardt Limited Oral compositions for treatment of diseases
WO2005041962A1 (en) * 2003-10-31 2005-05-12 Takeda Pharmaceutical Company Limited Solid preparation comprising an insulin sensitizer, an insulin secretagogue and a polyoxyethylene sorbitan fatty acid ester
EP1588708A1 (en) * 2003-01-29 2005-10-26 Takeda Pharmaceutical Company Limited Process for producing coated preparation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040266830A1 (en) * 1995-06-20 2004-12-30 Hitoshi Ikeda Pharmaceutical composition
US20040147564A1 (en) * 2003-01-29 2004-07-29 Rao Vinay U. Combinations of glimepiride and the thiazolidinedione for treatment of diabetes
EP1588708A1 (en) * 2003-01-29 2005-10-26 Takeda Pharmaceutical Company Limited Process for producing coated preparation
WO2005009412A1 (en) * 2003-07-24 2005-02-03 Wockhardt Limited Oral compositions for treatment of diseases
WO2005041962A1 (en) * 2003-10-31 2005-05-12 Takeda Pharmaceutical Company Limited Solid preparation comprising an insulin sensitizer, an insulin secretagogue and a polyoxyethylene sorbitan fatty acid ester

Also Published As

Publication number Publication date
EP2190417A2 (en) 2010-06-02
WO2009120844A2 (en) 2009-10-01

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