WO2009120192A3 - Processes for the preparation of benzo-fused dioxin derivatives - Google Patents

Processes for the preparation of benzo-fused dioxin derivatives Download PDF

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Publication number
WO2009120192A3
WO2009120192A3 PCT/US2008/058247 US2008058247W WO2009120192A3 WO 2009120192 A3 WO2009120192 A3 WO 2009120192A3 US 2008058247 W US2008058247 W US 2008058247W WO 2009120192 A3 WO2009120192 A3 WO 2009120192A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzo
processes
preparation
fused
dioxin derivatives
Prior art date
Application number
PCT/US2008/058247
Other languages
French (fr)
Other versions
WO2009120192A2 (en
Inventor
Scott A. Ballentine
Laura Reany
Original Assignee
Jassen Pharmaceutica, N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EA201071121A priority Critical patent/EA201071121A1/en
Priority to EP08732845A priority patent/EP2280951A2/en
Priority to AU2008353492A priority patent/AU2008353492A1/en
Priority to MX2010010597A priority patent/MX2010010597A/en
Application filed by Jassen Pharmaceutica, N.V. filed Critical Jassen Pharmaceutica, N.V.
Priority to BRPI0822396A priority patent/BRPI0822396A2/en
Priority to KR1020107023449A priority patent/KR20100126536A/en
Priority to PCT/US2008/058247 priority patent/WO2009120192A2/en
Priority to CA2719402A priority patent/CA2719402A1/en
Priority to CN2008801285523A priority patent/CN101981023A/en
Priority to JP2011501762A priority patent/JP2011517448A/en
Publication of WO2009120192A2 publication Critical patent/WO2009120192A2/en
Publication of WO2009120192A3 publication Critical patent/WO2009120192A3/en
Priority to IL208223A priority patent/IL208223A0/en
Priority to EC2010010498A priority patent/ECSP10010498A/en
Priority to ZA2010/07610A priority patent/ZA201007610B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention is directed to processes for the preparation of benzo-fused heteroaryl derivatives, useful for the treatment of epilepsy and related disorders. The present invention is further directed to processes for the preparation of intermediates in the synthesis of the benzo-fused heteroaryl derivatives.
PCT/US2008/058247 2008-03-26 2008-03-26 Process for the preparation of benzo-fused heteroaryl derivatives WO2009120192A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
KR1020107023449A KR20100126536A (en) 2008-03-26 2008-03-26 Processes for the preparation of benzo-fused dioxin derivatives
AU2008353492A AU2008353492A1 (en) 2008-03-26 2008-03-26 Processes for the preparation of benzo-fused dioxin derivatives
MX2010010597A MX2010010597A (en) 2008-03-26 2008-03-26 Processes for the preparation of benzo-fused dioxin derivatives.
CA2719402A CA2719402A1 (en) 2008-03-26 2008-03-26 Process for preparation of benzo-fused heteroaryl derivatives
BRPI0822396A BRPI0822396A2 (en) 2008-03-26 2008-03-26 process for preparing benzo fused dioxin derivatives
EP08732845A EP2280951A2 (en) 2008-03-26 2008-03-26 Processes for the preparation of benzo-fused dioxin derivatives
PCT/US2008/058247 WO2009120192A2 (en) 2008-03-26 2008-03-26 Process for the preparation of benzo-fused heteroaryl derivatives
EA201071121A EA201071121A1 (en) 2008-03-26 2008-03-26 METHOD OF OBTAINING PETROL DERIVATIVES OF DIOXIN
CN2008801285523A CN101981023A (en) 2008-03-26 2008-03-26 Process for the preparation of benzo-fused heteroaryl derivatives
JP2011501762A JP2011517448A (en) 2008-03-26 2008-03-26 Process for the preparation of benzo-fused dioxin derivatives
IL208223A IL208223A0 (en) 2008-03-26 2010-09-19 Processes for the preparation of benzo-fused dioxin derivatives
EC2010010498A ECSP10010498A (en) 2008-03-26 2010-09-24 PROCESSES FOR THE PREPARATION OF BENZOFUSED HETEROARILO DERIVATIVES
ZA2010/07610A ZA201007610B (en) 2008-03-26 2010-10-25 Processes for the preparation of benzo-fused dioxin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2008/058247 WO2009120192A2 (en) 2008-03-26 2008-03-26 Process for the preparation of benzo-fused heteroaryl derivatives

Publications (2)

Publication Number Publication Date
WO2009120192A2 WO2009120192A2 (en) 2009-10-01
WO2009120192A3 true WO2009120192A3 (en) 2010-01-21

Family

ID=40351717

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/058247 WO2009120192A2 (en) 2008-03-26 2008-03-26 Process for the preparation of benzo-fused heteroaryl derivatives

Country Status (13)

Country Link
EP (1) EP2280951A2 (en)
JP (1) JP2011517448A (en)
KR (1) KR20100126536A (en)
CN (1) CN101981023A (en)
AU (1) AU2008353492A1 (en)
BR (1) BRPI0822396A2 (en)
CA (1) CA2719402A1 (en)
EA (1) EA201071121A1 (en)
EC (1) ECSP10010498A (en)
IL (1) IL208223A0 (en)
MX (1) MX2010010597A (en)
WO (1) WO2009120192A2 (en)
ZA (1) ZA201007610B (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8084490B2 (en) 2004-06-16 2011-12-27 Janssen Pharmaceutica N.V. Sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
US8283478B2 (en) 2005-05-20 2012-10-09 Janssen Pharmaceutica Nv Process for preparation of sulfamide derivatives
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8691867B2 (en) 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8809385B2 (en) 2008-06-23 2014-08-19 Janssen Pharmaceutica Nv Crystalline form of (2S)-(-)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide
US8815939B2 (en) 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
US8853263B2 (en) 2006-05-19 2014-10-07 Janssen Pharmaceutica Nv Co-therapy for the treatment of epilepsy and related disorders
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2760851A1 (en) * 2011-09-29 2014-08-06 Janssen Pharmaceutica, N.V. Process for the preparation of sulfamide derivatives
JP2014528399A (en) * 2011-09-29 2014-10-27 ヤンセン ファーマシューティカ エヌ．ベー． Improved preparation process for sulfamide derivatives

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0498770A1 (en) * 1991-02-08 1992-08-12 Ciba-Geigy Ag Certain benzodioxole, benzodioxane and benzodioxepin derivatives
WO2006007435A1 (en) * 2004-06-16 2006-01-19 Janssen Pharmaceutica, N.V. Sulfamate and sulfamide derivatives for the treatment of epilepsy and related disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0498770A1 (en) * 1991-02-08 1992-08-12 Ciba-Geigy Ag Certain benzodioxole, benzodioxane and benzodioxepin derivatives
WO2006007435A1 (en) * 2004-06-16 2006-01-19 Janssen Pharmaceutica, N.V. Sulfamate and sulfamide derivatives for the treatment of epilepsy and related disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CAIRA M R: "CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS", TOPICS IN CURRENT CHEMISTRY, SPRINGER, BERLIN, DE, vol. 198, 1 January 1998 (1998-01-01), pages 163 - 208, XP001156954 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8084490B2 (en) 2004-06-16 2011-12-27 Janssen Pharmaceutica N.V. Sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
US8283478B2 (en) 2005-05-20 2012-10-09 Janssen Pharmaceutica Nv Process for preparation of sulfamide derivatives
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8691867B2 (en) 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US8853263B2 (en) 2006-05-19 2014-10-07 Janssen Pharmaceutica Nv Co-therapy for the treatment of epilepsy and related disorders
US8809385B2 (en) 2008-06-23 2014-08-19 Janssen Pharmaceutica Nv Crystalline form of (2S)-(-)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide
US8815939B2 (en) 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives

Also Published As

Publication number Publication date
CN101981023A (en) 2011-02-23
KR20100126536A (en) 2010-12-01
IL208223A0 (en) 2010-12-30
ECSP10010498A (en) 2010-10-30
MX2010010597A (en) 2010-10-25
WO2009120192A2 (en) 2009-10-01
CA2719402A1 (en) 2009-10-01
EP2280951A2 (en) 2011-02-09
EA201071121A1 (en) 2011-04-29
JP2011517448A (en) 2011-06-09
BRPI0822396A2 (en) 2019-09-24
ZA201007610B (en) 2012-04-25
AU2008353492A1 (en) 2009-10-01

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