WO2009108384A3 - Compounds and compositions that cause non-apoptotic cell death and uses thereof - Google Patents

Compounds and compositions that cause non-apoptotic cell death and uses thereof Download PDF

Info

Publication number
WO2009108384A3
WO2009108384A3 PCT/US2009/001306 US2009001306W WO2009108384A3 WO 2009108384 A3 WO2009108384 A3 WO 2009108384A3 US 2009001306 W US2009001306 W US 2009001306W WO 2009108384 A3 WO2009108384 A3 WO 2009108384A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
compositions
cell death
apoptotic cell
cause non
Prior art date
Application number
PCT/US2009/001306
Other languages
French (fr)
Other versions
WO2009108384A2 (en
Inventor
Brent R. Stockwell
Original Assignee
Trustees Of Columbia University In The City Of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/072,866 external-priority patent/US20080299076A1/en
Application filed by Trustees Of Columbia University In The City Of New York filed Critical Trustees Of Columbia University In The City Of New York
Publication of WO2009108384A2 publication Critical patent/WO2009108384A2/en
Publication of WO2009108384A3 publication Critical patent/WO2009108384A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3

Abstract

The present invention relates to erastin analogs, particularly compounds of formulae I and II, including compounds 1-20, 22-24, 34, and 40. The invention also relates to pharmaceutical compositions containing such analogs and to methods of treating conditions in a mammal with such analogs and pharmaceutical compositions.
PCT/US2009/001306 2008-02-28 2009-02-27 Compounds and compositions that cause non-apoptotic cell death and uses thereof WO2009108384A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/072,866 2008-02-28
US12/072,866 US20080299076A1 (en) 2006-06-19 2008-02-28 Compunds and compositions that cause non-apoptotic cell death and uses thereof

Publications (2)

Publication Number Publication Date
WO2009108384A2 WO2009108384A2 (en) 2009-09-03
WO2009108384A3 true WO2009108384A3 (en) 2009-12-10

Family

ID=41037594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/001306 WO2009108384A2 (en) 2008-02-28 2009-02-27 Compounds and compositions that cause non-apoptotic cell death and uses thereof

Country Status (1)

Country Link
WO (1) WO2009108384A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070161644A1 (en) * 2005-01-25 2007-07-12 Stockwell Brent R Erastin analogs and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070161644A1 (en) * 2005-01-25 2007-07-12 Stockwell Brent R Erastin analogs and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YAGODA ET AL: "RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels", NATURE, vol. 447, no. 7146, 14 June 2007 (2007-06-14), pages 864 - 870 *

Also Published As

Publication number Publication date
WO2009108384A2 (en) 2009-09-03

Similar Documents

Publication Publication Date Title
WO2008013840A3 (en) Erastin analogs and uses thereof
MX2011012366A (en) Synergistic fungicidal mixtures.
NZ706739A (en) Substituted benzene compounds
WO2012080017A3 (en) Water-containing antiperspirant compositions with improved white mark protection
WO2008103470A3 (en) Oncogenic-ras-signal dependent lethal compounds
EA019744B9 (en) Isothiazolyloxyphenyl amidines and use thereof for combating fungi and seed material treated with isothiazolyloxyphenyl amidines
UA109122C2 (en) SYNERGIC HERBICIDIC COMPOSITION CONTAINING AMINOPIRALID AND 2,4-DICHLOROPHENOXYCIC ACID
WO2011107186A3 (en) Compounds for electronic devices
MX2010010508A (en) Sebum absorption compositions.
WO2009147205A3 (en) Synergistic fungicidal mixtures
WO2011084553A3 (en) Compositions and uses of cis-1,1,1,4,4,4-hexafluoro-2-butene
GEP20156266B (en) Spiroheterocyclic n-oxypiperidines as pesticides
EP3586631A3 (en) Plant health composition
PH12013500913A1 (en) Substituted-quinoxaline-type-piperidine compounds and the uses thereof
MX2010010135A (en) Fungicide hydroximoyl-tetrazole derivatives.
WO2008132021A3 (en) Fungicide mixtures
MX2010007677A (en) Fungicide hydroximoyl-tetrazole derivatives.
EP2557927A4 (en) Fungicidal mixtures i comprising quinazolines
DOP2010000329A (en) RENINE INHIBITORS
WO2012071520A3 (en) Fungicidal compositions and methods
EA201201623A1 (en) TREATMENT OF DIABETES TYPE 2
BR112015015515A2 (en) synergistic fungicidal compositions
SG158091A1 (en) Imidazoazepinone compounds
WO2008048680A3 (en) Notch 2 signaling as a breast cancer suppressor pathway
MX337380B (en) Pesticidal compositions.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09715848

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09715848

Country of ref document: EP

Kind code of ref document: A2