WO2009108364A3 - Antagonistic analogues of ghrh - Google Patents

Antagonistic analogues of ghrh Download PDF

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Publication number
WO2009108364A3
WO2009108364A3 PCT/US2009/001279 US2009001279W WO2009108364A3 WO 2009108364 A3 WO2009108364 A3 WO 2009108364A3 US 2009001279 W US2009001279 W US 2009001279W WO 2009108364 A3 WO2009108364 A3 WO 2009108364A3
Authority
WO
WIPO (PCT)
Prior art keywords
analogues
hghrh
inhibit
ghrh
antagonistic
Prior art date
Application number
PCT/US2009/001279
Other languages
French (fr)
Other versions
WO2009108364A2 (en
Inventor
Zheng Xin Dong
Daniel B. Deoliveira
Original Assignee
Ipsen Pharma S.A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsen Pharma S.A.S. filed Critical Ipsen Pharma S.A.S.
Publication of WO2009108364A2 publication Critical patent/WO2009108364A2/en
Publication of WO2009108364A3 publication Critical patent/WO2009108364A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

There is provided a novel series of synthetic antagonistic analogues of hGHRH(l- 29)NH2 (SEQ E) NO: 1). These analogues inhibit the activity of endogenous hGHRH on the pituitary GHRH receptors, and therefore prevent the release of growth hormone. The analogues also inhibit the proliferation of human cancers through a direct effect on the cancer cells. The inhibitory potencies of the new analogues result from replacement of various amino acids.
PCT/US2009/001279 2008-02-27 2009-02-27 Antagonistic analogues of ghrh WO2009108364A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6731808P 2008-02-27 2008-02-27
US61/067,318 2008-02-27
US20736609P 2009-02-11 2009-02-11
US61/207,366 2009-02-11

Publications (2)

Publication Number Publication Date
WO2009108364A2 WO2009108364A2 (en) 2009-09-03
WO2009108364A3 true WO2009108364A3 (en) 2010-01-07

Family

ID=41016657

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/001279 WO2009108364A2 (en) 2008-02-27 2009-02-27 Antagonistic analogues of ghrh

Country Status (1)

Country Link
WO (1) WO2009108364A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111533800B (en) * 2020-03-18 2021-08-31 浙江湖州纳福生物医药有限公司 Novel somatotropin-releasing hormone analogous peptide modification and dimerization preparation and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689318A (en) * 1985-08-29 1987-08-25 The Salk Institute For Biological Studies GRF analogs
US20050148515A1 (en) * 2002-08-09 2005-07-07 Dong Zheng X. Growth hormone releasing peptides
US20070042950A1 (en) * 2003-08-05 2007-02-22 Administrators Of The Tulane Educational Fund, The Antagonistic analogs of gh rh (2003)

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689318A (en) * 1985-08-29 1987-08-25 The Salk Institute For Biological Studies GRF analogs
US20050148515A1 (en) * 2002-08-09 2005-07-07 Dong Zheng X. Growth hormone releasing peptides
US20070042950A1 (en) * 2003-08-05 2007-02-22 Administrators Of The Tulane Educational Fund, The Antagonistic analogs of gh rh (2003)

Also Published As

Publication number Publication date
WO2009108364A2 (en) 2009-09-03

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