WO2009103862A3 - Methode de detection de cellules mitotiques - Google Patents

Methode de detection de cellules mitotiques Download PDF

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Publication number
WO2009103862A3
WO2009103862A3 PCT/FR2008/001537 FR2008001537W WO2009103862A3 WO 2009103862 A3 WO2009103862 A3 WO 2009103862A3 FR 2008001537 W FR2008001537 W FR 2008001537W WO 2009103862 A3 WO2009103862 A3 WO 2009103862A3
Authority
WO
WIPO (PCT)
Prior art keywords
mitotic cells
detecting
detecting mitotic
sequence
plalgr
Prior art date
Application number
PCT/FR2008/001537
Other languages
English (en)
Other versions
WO2009103862A2 (fr
Inventor
Bernard Ducommun
Martine Cazales
Muriel Valérie NICAISE-QUARANTA
Georges Delsol
Jeannine Boyes
Michel March
Talal Al Saati
Original Assignee
Centre National De La Recherche Scientifique
Inserm (Institut National De La Sante Et De La Recherche Medicale)
Chu De Toulouse
Universite Paul Sabatier Toulouse Iii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National De La Recherche Scientifique, Inserm (Institut National De La Sante Et De La Recherche Medicale), Chu De Toulouse, Universite Paul Sabatier Toulouse Iii filed Critical Centre National De La Recherche Scientifique
Publication of WO2009103862A2 publication Critical patent/WO2009103862A2/fr
Publication of WO2009103862A3 publication Critical patent/WO2009103862A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Méthode pour détecter des cellules mitotiques exprimant des protéines qui partagent au moins un des épitopes phosphorylés de la séquence peptidique comprenant ou constituée par un fragment contenant 2 à 13 acides aminés contigus issus de la séquence MEVEELSPPLALGR.
PCT/FR2008/001537 2007-11-02 2008-10-31 Methode de detection de cellules mitotiques WO2009103862A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0707703 2007-11-02
FR0707703A FR2923297A1 (fr) 2007-11-02 2007-11-02 Methode de detection de cellules mitotiques

Publications (2)

Publication Number Publication Date
WO2009103862A2 WO2009103862A2 (fr) 2009-08-27
WO2009103862A3 true WO2009103862A3 (fr) 2009-10-15

Family

ID=39166665

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/001537 WO2009103862A2 (fr) 2007-11-02 2008-10-31 Methode de detection de cellules mitotiques

Country Status (2)

Country Link
FR (1) FR2923297A1 (fr)
WO (1) WO2009103862A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006024796A1 (fr) * 2004-08-25 2006-03-09 Centre National De La Recherche Scientifique Nouvelles sequences phosphorylees de la phosphatase cdc25b, anticorps diriges contre ces sequences ainsi que leurs utilisations

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006024796A1 (fr) * 2004-08-25 2006-03-09 Centre National De La Recherche Scientifique Nouvelles sequences phosphorylees de la phosphatase cdc25b, anticorps diriges contre ces sequences ainsi que leurs utilisations

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BUTSCHAK G ET AL: "New monoclonal antibodies recognizing phosphorylated proteins in mitotic cells.", ACTA HISTOCHEMICA JAN 1995, vol. 97, no. 1, January 1995 (1995-01-01), pages 19 - 31, XP008089710, ISSN: 0065-1281 *
GABRIELLI BRIAN G ET AL: "Hyperphosphorylation of the N-terminal domain of Cdc25 regulates activity toward cyclin B1/Cdc2 but not cyclin A/Cdk2", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 272, no. 45, 7 November 1997 (1997-11-07), pages 28607 - 28614, XP002173983, ISSN: 0021-9258 *
HENDZEL M J ET AL: "MITOSIS-SPECIFIC PHOSPHORYLATION OF HISTONE H3 INITIATES PRIMARILY WITHIN PERICENTROMERIC HETEROCHROMATIN DURING G2 AND SPREADS IN AN ORDERED FASHION COINCIDENT WITH MITOTIC CHROMOSOME CONDENSATION", CHROMOSOMA, HEIDELBERG, DE, vol. 106, no. 6, November 1997 (1997-11-01), pages 348 - 360, XP000980606 *
TSAI I-CHEN ET AL: "Anti-phosphopeptide antibody, P-STM as a novel tool for detecting mitotic phosphoproteins: identification of lamins A and C as two major targets.", JOURNAL OF CELLULAR BIOCHEMISTRY 1 APR 2005, vol. 94, no. 5, 1 April 2005 (2005-04-01), pages 967 - 981, XP002474386, ISSN: 0730-2312 *

Also Published As

Publication number Publication date
WO2009103862A2 (fr) 2009-08-27
FR2923297A1 (fr) 2009-05-08

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