WO2009095701A1 - Dispositif d'injection - Google Patents

Dispositif d'injection Download PDF

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Publication number
WO2009095701A1
WO2009095701A1 PCT/GB2009/000299 GB2009000299W WO2009095701A1 WO 2009095701 A1 WO2009095701 A1 WO 2009095701A1 GB 2009000299 W GB2009000299 W GB 2009000299W WO 2009095701 A1 WO2009095701 A1 WO 2009095701A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
shield
injection device
release control
syringe
Prior art date
Application number
PCT/GB2009/000299
Other languages
English (en)
Inventor
Barry Peter Liversidge
Original Assignee
Barry Peter Liversidge
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Barry Peter Liversidge filed Critical Barry Peter Liversidge
Publication of WO2009095701A1 publication Critical patent/WO2009095701A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A61M2005/208—Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A61M5/3204—Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user

Definitions

  • This invention relates to an injection device for the administration of medicaments from a pre-filled syringe.
  • this invention relates to an injection device known as an "auto-injector" where a user may press the device on to an injection site and then simply operate a control in order for the device then to perform an injection, on a fully automatic basis.
  • forward and reversely refer to the end of the device which is presented to a body when an injection is to be performed (that is, the tip end of the needle) and the direction towards that end; and the terms “rearward” and “rearwardly” refer to the other end of the device (that is, the end of the device nearer a syringe with which the device may be used) and the direction towards that other end.
  • an injection device which is very easy to use and which can reliably deliver a set dose of a medicament, in order that the device may be used for self-injection or by other unskilled personnel, to deliver a medicament to a patient.
  • a patient susceptible to anaphylactic shock will normally carry an auto-injector device pre-charged with adrenalin to allow an emergency injection of that drug in the event that the patient is suffering from anaphylactic shock.
  • Speed is of the essence and it may be necessary for a completely unskilled person to use the injection device to administer that injection.
  • a similar situation where an emergency injection may have to be performed by an unskilled person is on a battlefield, where an antidote to a chemical agent may have to be administered very quickly and under extremely difficult conditions.
  • auto-injector devices have been developed which may be used merely by pressing the device on the skin of a patient and then working some kind of control to perform the injection.
  • Other devices are known which operate automatically when pressed against a surface, following release of a safety catch or shield for the needle. It is a common problem with an auto-injector that it is used the wrong way round and so with the operator pressing the wrong end of the device against the skin of a patient and then pressing the needle end of the device, in the hope of effecting the injection. This results in the injection being performed on the operator, rather than the patient. The consequence is that the patient may not be saved as these devices are intended for one-time operation only and the user of the device has wasted the injection on himself. It is a principal aim of the present invention to provide an injection device which addresses the above issues and seeks to prevent inadvertent operation even should an attempt be made to use the device the wrong way round and so present the wrong end of the injection device to the patient.
  • an injection device comprising an elongate housing containing a pre-filled syringe having a needle and a piston for expelling medicament out of the needle, a tubular shield for protecting the needle and movable rearwardly into the housing, a power unit for driving the piston, and a release control for the power unit which release control is initially at least partially concealed within the housing and emerges from the housing on rearward movement of the shield, to become exposed so as to be operable to release the energy of the power unit.
  • the injection device of this invention is configured to make it essentially impossible for the device to be operated until such time as the shield has been pressed on to a required injection site, so exposing the release control for operation, to allow release of the stored energy within the power unit.
  • the device will not operate since the release control cannot be operated to release the energy of the power unit with the same hand as is grasping the housing and is pressing the end of the shield.
  • a preferred form of the device has the release control disposed at the rear end of the housing, such that the release control emerges axially out of the housing when the shield moves rearwardly with respect to the housing, on being pressed into engagement with the required injection site.
  • the release control may be arranged for operation to release the stored energy of the power unit by being moved transversely of the length of the housing.
  • an injection device comprising an elongate housing containing a pre-filled syringe having a needle and a piston for expelling medicament out of the needle, a power unit for driving the piston of the syringe, and a release control for the power unit which release control is operable transversely of the length of the housing to release the energy of the power unit.
  • the injection device of this second aspect may have a tubular shield for protecting the needle which shield is slidably mounted within the housing for rearward movement thereinto so as to expose the needle.
  • the release control is connected to a plunger for driving the piston by a frangible connection, the release control serving to hold the plunger against the action of the stored energy of the power unit until the release control has been broken away from the plunger.
  • the shield may have an initial position and a final position where the shield projects from the housing and an intermediate position where the shield is pressed back into the housing.
  • the syringe is mounted in a carrier which is slidable within the shield, the carrier being configured for supporting a conventional syringe though that syringe may have a modified plunger in order for co-operation with the power unit.
  • the syringe following operation of the release member to release the stored energy of the power unit, initially the syringe is driven forwardly with respect to the shield to project the needle beyond the end of the shield and then the syringe piston is driven forwardly with respect to the syringe body, to expel medicament out of the needle.
  • This action is possible in view of the hydraulic resistance to movement of the piston with respect to the syringe, in expelling medicament out of the syringe body, through the needle.
  • the injection device may have means for locking the shield in its final position, following the completion of an injection procedure and so when the shield is protecting a used needle.
  • This locking means may comprise a rearwardly projecting lock member on the shield which is arranged to engage behind an abutment on the housing when the shield is in its protecting position.
  • a wedging member may be associated with the syringe such that forward movement of the syringe with respect to the shield deforms the lock member outwardly, thereby allowing the lock member to move to its locking position on subsequent forward movement of the shield with respect to the syringe.
  • the housing of the injection device may be modified to include a guard which partially encloses the release control when projecting from the housing. Only limited access to the release control may then be gained, so reducing the likelihood of operation of the release control other than when the forward end of the device has been pressed on to the required injection site, so moving the shield fully rearwardly.
  • the syringe within the injection device may be pre-fitted with a needle, or it may be necessary to ready the device for use, by fitting a needle thereto when an injection is to be performed.
  • Figure 1 is an axial sectional view through the embodiment of injection device, in an initial setting
  • Figure 2 is an axial sectional view through the device of Figure 1 , but with a needle stripped, ready for use;
  • Figure 2A is a partly cut away isometric view of the device, in the setting of Figure 2;
  • Figure 3 is an axial sectional view through the device of Figure 1 but in a second setting, at the commencement of use;
  • Figure 3A is a partly cut away isometric view of the device, in the setting of Figure 3;
  • Figure 4 is an axial sectional view through the device of Figure 1 , but with a release control broken away;
  • Figure 4A is a partly cut away isometric view of the device, in the setting of Figure 4;
  • Figure 5 is an axial sectional view through the device of Figure 1 , but at the completion of an injection procedure;
  • Figure 5A is a partly cut away isometric view of the device, in the setting of Figure 5;
  • Figure 6 is an isometric view on the end region of a modified form of the device of Figure 1 , in an initial setting;
  • Figure 7 is similar to Figure 6, with the release control broken away;
  • Figure 8A to 8E are isometric drawings showing the sequence of operation of the injection device of Figures 1 to 7;
  • Figures 9A and 9B show a second embodiment of this invention where an operating button emerges axially into a window in the housing;
  • FIGS 10A and 10B show a third embodiment of this invention where an operating button emerges by rotation into a window in the housing;
  • Figure 11A shows a fourth embodiment where the operating button emerges through a window, for operation transversely of the housing;
  • Figure 11 B is a detail view on an enlarged scale of the encircled part of the fourth embodiment
  • Figure 12A shows a fifth embodiment where the operating button emerges through an opening at the end of the housing.
  • Figures 12B and 12C are detail views on an enlarged scale of the encircled part of the fifth embodiment, respectively with the operating button in its inoperable condition and subsequently for operation axially or transversely of the housing.
  • a single-use injection device intended primarily for self-injection or for the administration of an injection by persons other than skilled medical personnel.
  • the device is thus configured to ensure safety in operation as well as subsequent to the performance of an injection.
  • the device is arranged to ensure that the full dose of a required drug is delivered, in the course of the injection process.
  • the device uses a compact and reliable power unit which has been pre-charged with energy to allow the performance of the injection under the force derived from the power unit and which has been configured to ensure that the energy is released only when an operator positively requires that to occur.
  • the device comprises a cylindrical housing 10 having moulded plastics front and rear parts 11 and 12 snap-fitted together so as to be essentially inseparable once conjoined as shown. Contained within the housing is a conventional single-use syringe body 13 having a needle 14 secured to the front end of the syringe body and an outwardly projecting lip 15 at the rear end of the body.
  • the syringe is located within a tubular carrier 16 slidably mounted within a tubular shield 17, itself slidably mounted within the front part 11 of the housing 10.
  • a needle cover 18 is fitted to the forward end of the shield 17 and has a sheath 19 located therewithin, which sheath fits on to the needle hub 20 at the forward end of the syringe body 13 and also receives the sharp tip of the needle 14.
  • the shield 17 is tubular as best seen in Figure 2A.
  • Opposed windows 21 are formed through the tubular part of the shield 17, which windows align with corresponding openings 41 ( Figures 8A to 8E) in the front part 11 of the housing 10, when the housing and shield have the relative positions of Figures 1, 2 and 8A.
  • the shield Rearwardly of the window 21, the shield has an upstanding annular rib 22 from which a pair of opposed fingers 23 project rearwardly. Forwardly of the rib 22, there is a plurality of vanes 24, imparting stability on the rib.
  • the rear end of the carrier 16 has a flange 25 formed with a pair of opposed slots, the fingers 23 locating one in each slot, respectively. The carrier may thus slide within the shield 17 but not rotate relative thereto.
  • a wedging washer 27 having a generally conical forward face, is slidably mounted on the carrier 16 adjacent the flange 25 and is engageable with ramp surfaces formed on the fingers 23, on forward movement of the carrier with respect to the shield 17.
  • the syringe body 13 is furnished with a plunger 28 having a piston 29 fitted to the forward end thereof, for dispensing a liquid medicament contained within the syringe body out of the needle 14.
  • the piston 29 and forward end of the plunger 28 are essentially conventional but the rearward end portion of the plunger forms part of a power unit 30 contained within the housing 10, for delivering medicament from the syringe through the needle 14, when the needle has penetrated a required injection site.
  • the power unit 30 has a tubular first component 31 the forward end of which is located between the rearward ends of the fingers 23 of the shield 17, forward movement of that first component with respect to the shield 17 being limited by inwardly-directed projections 32 formed on the fingers.
  • the rearward end portion of the plunger 28 defines a second component 33 for the power unit and has an annular abutment 34 which is slidable within the first component 31.
  • a helical compression spring 35 is disposed around the second component 33 and acts between the annular abutment 34 thereof and in-turned lip 36 at the rearward end of the first component 31.
  • a neck 37 defining a weakened zone, that neck interconnecting the plunger 28 to a release control 38.
  • the release control Adjacent the neck 37, the release control has a generally part-spherical form 39 and projecting from that form is an operating button 40 having a part-conical profile, the button flaring outwardly towards its free end.
  • FIG. 1 and 8A show the injection device in its storage setting, with the power unit 30 pre-charged for delivering a medicament from a pre-filled syringe located within the device. In this setting, it is possible to view the medicament in the syringe, through the openings 41 in the housing 10 and the aligned windows 21 in shield 17.
  • the first stage of the procedure to use the injection device is to strip the sheath 19 from the needle 14 by pulling the needle cover 18 away from the forward end of the shield 17 and housing 10 ( Figure 8B).
  • the needle is then ready for use as shown in Figure 2 but still lies wholly within the shield 17 and so is still protected. Further, the shield 17 prevents sight of the needle and this facilitates the performance of a self-injection even by those suffering from needle-phobia (aprilophobia).
  • a small part of the operating button 40 projects beyond the end wall 42 of the housing 10.
  • the shield spring 43 urges the shield 17 forwardly, but the inter-engagement of that operating button with the end wall 42 prevents the shield 17 being moved forward under the action of the spring 43.
  • the interengagement of the part spherical form 39 of the release member 38 with the lip 36 at the rearward end of the first component 31 prevents the plunger 28 being driven forwardly with respect to the syringe under the action of spring 35, contained within the power unit.
  • An injection is performed by grasping the housing 10 like a dagger and pressing the forward end of the shield 17 against the skin at the required injection site. This moves the housing forwardly towards the skin and so the projecting part of the shield 17 moves rearwardly into the housing until the first component 31 abuts the end wall 42 as shown in Figure 3. In turn this causes the button 40 to emerge from the end wall 42 of the rear part 12, so bringing the part spherical form 39 into the opening in the end wall 42, as shown in
  • this causes the needle 14 to project beyond the forward end of the shield 17 and so into the tissues beneath the skin of the patient, before the plunger 28 and piston 29 is driven forwardly with respect to the syringe body 13, to expel the medicament through the needle and into those tissues.
  • the housing 10 is moved away from the injection site, so allowing shield 17 to move forwardly under the action of spring 43, thereby shielding once more the sharp tip of the needle (Figure 8E).
  • That washer 27 is also moved forwardly with the shield 17, sliding on the carrier 16.
  • the rear ends of the fingers 23 spring outwardly to engage behind an abutment surface 44 formed at the forward end of the rear part 12 of the housing, disposed within the front part thereof, to lock the shield against subsequent movement rearwardly with respect to the housing.
  • the injection device includes a further safety feature in that should the user place a thumb or finger over the operating button 40 on grasping the housing and before the forward end of the shield has been pressed on to the injection site, the shield cannot move rearwardly by virtue of the axial pressure on the operating button 40. It will thus be seen that the power unit cannot be released to dispense the medicament until the forward end of the shield 17 has been pressed on to the required injection site, since until then the operating button 40 cannot be manipulated to break the neck 37. The same will apply equally should the user hold the housing 10 the wrong way round and so present the operating button 40 to the injection site, and then attempt to press the forward end of the shield 17 to perform the injection. Again, no injection will occur since the button 40 cannot be moved laterally to allow the neck 37 to be broken.
  • FIG. 6 and 7 there is shown a modification to the rear part 12 of the housing 10 of the injection device, so as to reduce yet further the likelihood of inadvertent breaking of the neck 37, for example in either of the circumstances outlined immediately above.
  • a part-cylindrical guard 46 is carried by the rear part, so as to project rearwardly from the end wall 42. Even when the operating button 40 projects to its fullest extent from that end wall (as shown in Figure 7) the end of the button does not project beyond the guard 46. Consequently access to the button to effect breaking of the neck 37 can be gained only through the cut away part 47 of the guard 46, for example by way of the thumb of a user's hand grasping the housing 10.
  • FIGS 9A and 9B show a second embodiment which operates on a broadly similar manner to that described above with reference to Figures 8A to 8E, except that the operating button 50 does not emerge axially from the rearward end of the housing 51. Rather, the housing is provided with a window 52 in the side wall at the rear end thereof and the operating button 50 moves axially rearwardly to emerge into that window when the shield 53 at the forward end of the housing is pressed into engagement with the skin of a patient, as has been described above with reference to the first embodiment. Pressing the operating button 50 through the window causes operation of the device, as described previously.
  • Figures 10A and 10B show a third embodiment similar to the second embodiment described with reference to Figures 9A and 9B, but in this third embodiment the operating button 50 emerges into the window 52 by rotation, rather than axial movement. The rotation is caused by a suitable camming mechanism within the housing, operated upon movement of the shield 53 into the housing.
  • the operating button may carry wording to indicate how the device should be operated. Instead of such wording, or perhaps in addition to that wording, the operating button may be coloured to show where pressure should be applied.
  • a panel (not shown) may lie circumferentially closely adjacent but not connected to the operating button, that panel also being coloured but with a different colour from that of the operating button. For example, the panel may be coloured green and the operating button red, such that when the shield is pressed against the skin of a patient, the red operating button comes into view showing that the device is then ready to operate.
  • FIG 11A shows a fourth embodiment where the operating button 55 emerges transversely through a window 56 in the housing 51 , as the shield 53 is pressed against a patient. Once emerged, as shown in Figure 11 B, transverse pressure on the operating button causes operation of the device, as a whole, again as described with reference to the first embodiment.
  • Figures 12A to 12C show a fifth embodiment where there is provided a window 58 in the generally spherical end portion 59 of the housing and the operating button 60 has a grooved outer surface 61 which emerges generally axially through that window 58.
  • operation of the device is possible by axial pressure or transverse pressure on the operating button 60, or by pressure on that button at an angle lying between the axial and transverse directions.
  • the grooved outer surface of the button may be coloured green and the side faces of the button red, such that the setting of the device ready to operate becomes apparent from the red becoming visible and the area for pressure is marked by the green colour.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un dispositif d'injection qui comporte un boîtier allongé (10) contenant une seringue préremplie (13) dotée d'une aiguille (14) et d'une protection tubulaire (17) destinée à protéger cette aiguille jusqu'à l'utilisation du dispositif. Lorsque l'extrémité avant de la protection (17) est pressée contre la peau d'un patient, la protection se rétracte dans le boîtier (10) et entraîne l'émergence d'un bouton de commande (40) soit de l'extrémité arrière (12) du boîtier (10) soit dans une fenêtre (52) à travers la paroi du boîtier. Le fait d'enfoncer le bouton de commande (40) libère l'énergie d'un bloc d'alimentation (30) situé à l'intérieur du boîtier pour déplacer le piston de seringue (29) vers l'avant et ainsi réaliser une injection.
PCT/GB2009/000299 2008-02-01 2009-02-02 Dispositif d'injection WO2009095701A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0801874.9 2008-02-01
GB0801874A GB0801874D0 (en) 2008-02-01 2008-02-01 Injection device

Publications (1)

Publication Number Publication Date
WO2009095701A1 true WO2009095701A1 (fr) 2009-08-06

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/000299 WO2009095701A1 (fr) 2008-02-01 2009-02-02 Dispositif d'injection

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GB (1) GB0801874D0 (fr)
WO (1) WO2009095701A1 (fr)

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2487188A (en) * 2011-01-07 2012-07-18 Owen Mumford Ltd Blood sampling device with trigger locking arrangement and method of assembly
WO2013175137A1 (fr) 2012-05-25 2013-11-28 Aptar France Sas Autoinjecteur
WO2013175136A1 (fr) 2012-05-25 2013-11-28 Aptar France Sas Autoinjecteur
WO2013175139A1 (fr) 2012-05-25 2013-11-28 Aptar France Sas Autoinjecteur avec un retardateur ayant un train épicycloidal pour retarder la retraction de l'aiguille
FR2990869A1 (fr) * 2012-05-25 2013-11-29 Aptar France Sas Autoinjecteur
US8657793B2 (en) 2011-09-30 2014-02-25 Becton Dickinson France, S.A.S Space saving plunger cap and rod assembly
WO2014049214A1 (fr) 2012-09-27 2014-04-03 Aptar France Sas Autoinjecteur
EP2675502B1 (fr) 2011-02-18 2015-04-08 Sanofi Auto-injecteur
JP2015520643A (ja) * 2012-05-25 2015-07-23 アプター フランス エスアーエス 自己注射器
US9526846B2 (en) 2009-08-19 2016-12-27 Safety Syringes, Inc. Patient-contact activated needle stick safety device
US9623181B2 (en) 2011-02-18 2017-04-18 Sanofi-Aventis Deutschland Gmbh Auto-injector
US9636459B2 (en) 2011-02-18 2017-05-02 Sanofi-Aventis Deutschland Gmbh Auto-injector
US9656021B2 (en) 2011-02-18 2017-05-23 Sanofi-Aventis Deutschland Gmbh Auto-injector
US9687607B2 (en) 2011-02-18 2017-06-27 Sanofi-Aventis Deutschland Gmbh Detent mechanism
US9717851B2 (en) 2012-05-25 2017-08-01 Aptar France Sas Autoinjector
US9925344B2 (en) 2011-02-18 2018-03-27 Sanofi-Aventis Deutschland Gmbh Auto-injector
US9931471B2 (en) 2010-06-28 2018-04-03 Sanofi-Aventis Deutschland Gmbh Auto-injector
US9950123B2 (en) 2011-02-18 2018-04-24 Sanofi-Aventis Deutschland Gmbh Detent mechanism
US10376642B2 (en) 2011-02-18 2019-08-13 Sanofi-Aventis Deutschland Gmbh Auto-injector
US10384016B2 (en) 2011-02-18 2019-08-20 Sanofi-Aventis Deutschland Gmbh Auto-injector
US10518041B2 (en) 2011-02-18 2019-12-31 Sanofi-Aventis Deutschland Gmbh Injection device
WO2020143991A1 (fr) * 2019-01-11 2020-07-16 Shl Medical Ag Dispositif d'administration de médicament
EP3641632A4 (fr) * 2017-06-19 2020-12-30 Dexcom, Inc. Applicateurs conçus pour appliquer des capteurs d'analytes transcutanés et procédés de fabrication associés
USD926326S1 (en) 2018-06-18 2021-07-27 Dexcom, Inc. Transcutaneous analyte sensor applicator
US11305906B2 (en) 2014-02-11 2022-04-19 Dexcom, Inc. Method of packaging analyte sensors

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021316A1 (fr) * 1993-03-24 1994-09-29 Owen Mumford Limited Amelioration concernant des dispositifs d'injection
US5779677A (en) * 1994-01-17 1998-07-14 Laboratoire Aguettant Automatic drug injector
US6077247A (en) * 1996-06-18 2000-06-20 Owen Mumford Limited Injection devices
EP1125593A1 (fr) * 2000-02-16 2001-08-22 Roche Diagnostics GmbH Système d'injection sous-cutanée sans aiguille
US20050222539A1 (en) * 2004-03-30 2005-10-06 Pediamed Pharmaceuticals, Inc. Automatic injection device
GB2414398A (en) * 2004-05-28 2005-11-30 Cilag Ag Int Injection Device.
US20060189938A1 (en) * 2005-02-18 2006-08-24 Edgar Hommann Automatic injector with a release lock
US20060264830A1 (en) * 2003-11-05 2006-11-23 Edgar Hommann Device for administering an injectable product

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021316A1 (fr) * 1993-03-24 1994-09-29 Owen Mumford Limited Amelioration concernant des dispositifs d'injection
US5779677A (en) * 1994-01-17 1998-07-14 Laboratoire Aguettant Automatic drug injector
US6077247A (en) * 1996-06-18 2000-06-20 Owen Mumford Limited Injection devices
EP1125593A1 (fr) * 2000-02-16 2001-08-22 Roche Diagnostics GmbH Système d'injection sous-cutanée sans aiguille
US20060264830A1 (en) * 2003-11-05 2006-11-23 Edgar Hommann Device for administering an injectable product
US20050222539A1 (en) * 2004-03-30 2005-10-06 Pediamed Pharmaceuticals, Inc. Automatic injection device
GB2414398A (en) * 2004-05-28 2005-11-30 Cilag Ag Int Injection Device.
US20060189938A1 (en) * 2005-02-18 2006-08-24 Edgar Hommann Automatic injector with a release lock

Cited By (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9526846B2 (en) 2009-08-19 2016-12-27 Safety Syringes, Inc. Patient-contact activated needle stick safety device
US11400234B2 (en) 2009-08-19 2022-08-02 Safety Syringes, Inc. Patient-contact activated needle stick safety device
US10314985B2 (en) 2009-08-19 2019-06-11 Safety Syringes, Inc. Patient-contact activated needle stick safety device
US11813436B2 (en) 2010-06-28 2023-11-14 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11504475B2 (en) 2010-06-28 2022-11-22 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11311671B2 (en) 2010-06-28 2022-04-26 Sanofi-Aventis Deutschland Gmbh Auto-injector
US10603436B2 (en) 2010-06-28 2020-03-31 Sanofi-Aventis Deutschland Gmbh Auto-injector
US9931471B2 (en) 2010-06-28 2018-04-03 Sanofi-Aventis Deutschland Gmbh Auto-injector
US10835165B2 (en) 2011-01-07 2020-11-17 Owen Mumford Limited Blood sampling devices
GB2487188A (en) * 2011-01-07 2012-07-18 Owen Mumford Ltd Blood sampling device with trigger locking arrangement and method of assembly
US9795333B2 (en) 2011-01-07 2017-10-24 Owen Mumford Limited Blood sampling devices
US9950123B2 (en) 2011-02-18 2018-04-24 Sanofi-Aventis Deutschland Gmbh Detent mechanism
EP2675502B1 (fr) 2011-02-18 2015-04-08 Sanofi Auto-injecteur
US9604003B2 (en) 2011-02-18 2017-03-28 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11819670B2 (en) 2011-02-18 2023-11-21 Sanofi-Aventis Deutschland Gmbh Auto-injector
US9623181B2 (en) 2011-02-18 2017-04-18 Sanofi-Aventis Deutschland Gmbh Auto-injector
US9636459B2 (en) 2011-02-18 2017-05-02 Sanofi-Aventis Deutschland Gmbh Auto-injector
US9656021B2 (en) 2011-02-18 2017-05-23 Sanofi-Aventis Deutschland Gmbh Auto-injector
US9687607B2 (en) 2011-02-18 2017-06-27 Sanofi-Aventis Deutschland Gmbh Detent mechanism
US11559630B2 (en) 2011-02-18 2023-01-24 Sanofi-Aventis Deutschland Gmbh Auto-Injector
US11484655B2 (en) 2011-02-18 2022-11-01 Sanofi-Aventis Deutschland Gmbh Auto-injector
US10960142B2 (en) 2011-02-18 2021-03-30 Sanofi-Aventis Deutschland Gmbh Autoinjector
US10413668B2 (en) 2011-02-18 2019-09-17 Sanofi-Aventis Deutschland Gmbh Auto-injector
US10894132B2 (en) 2011-02-18 2021-01-19 Sanofi-Aventis Deutschland Gmbh Auto-injector
US9925344B2 (en) 2011-02-18 2018-03-27 Sanofi-Aventis Deutschland Gmbh Auto-injector
US10556064B2 (en) 2011-02-18 2020-02-11 Sanofi-Aventis Deutschland Gmbh Auto-injector
US10518041B2 (en) 2011-02-18 2019-12-31 Sanofi-Aventis Deutschland Gmbh Injection device
US10471210B2 (en) 2011-02-18 2019-11-12 Sanofi-Aventis Deutschland Gmbh Auto-injector
US10384016B2 (en) 2011-02-18 2019-08-20 Sanofi-Aventis Deutschland Gmbh Auto-injector
US10376642B2 (en) 2011-02-18 2019-08-13 Sanofi-Aventis Deutschland Gmbh Auto-injector
US10384015B2 (en) 2011-02-18 2019-08-20 Sanofi-Aventis Deutschland Gmbh Auto-injector
US8657793B2 (en) 2011-09-30 2014-02-25 Becton Dickinson France, S.A.S Space saving plunger cap and rod assembly
US9895492B2 (en) 2012-05-25 2018-02-20 Aptar France Sas Autoinjector
WO2013175137A1 (fr) 2012-05-25 2013-11-28 Aptar France Sas Autoinjecteur
WO2013175140A1 (fr) 2012-05-25 2013-11-28 Aptar France Sas Autoinjecteur
CN104394909A (zh) * 2012-05-25 2015-03-04 阿普塔尔法国简易股份公司 自动注射器
FR2990869A1 (fr) * 2012-05-25 2013-11-29 Aptar France Sas Autoinjecteur
US9616174B2 (en) 2012-05-25 2017-04-11 Aptar France Sas Autoinjector
WO2013175139A1 (fr) 2012-05-25 2013-11-28 Aptar France Sas Autoinjecteur avec un retardateur ayant un train épicycloidal pour retarder la retraction de l'aiguille
US9707343B2 (en) 2012-05-25 2017-07-18 Aptar France Sas Autoinjector comprising a time delay device having a planetary gear set for delaying the retraction of the needle
JP2015520643A (ja) * 2012-05-25 2015-07-23 アプター フランス エスアーエス 自己注射器
US9717851B2 (en) 2012-05-25 2017-08-01 Aptar France Sas Autoinjector
US9707357B2 (en) 2012-05-25 2017-07-18 Aptar France Sas Autoinjector
WO2013175142A1 (fr) 2012-05-25 2013-11-28 Aptar France Sas Autoinjecteur.
WO2013175136A1 (fr) 2012-05-25 2013-11-28 Aptar France Sas Autoinjecteur
WO2014049214A1 (fr) 2012-09-27 2014-04-03 Aptar France Sas Autoinjecteur
EP3308814A1 (fr) 2012-09-27 2018-04-18 APTAR France SAS Autoinjecteur
US11305906B2 (en) 2014-02-11 2022-04-19 Dexcom, Inc. Method of packaging analyte sensors
US11395607B2 (en) 2017-06-19 2022-07-26 Dexcom, Inc. Applicators for applying transcutaneous analyte sensors and associated methods of manufacture
US11452466B2 (en) 2017-06-19 2022-09-27 Dexcom, Inc. Applicators for applying transcutaneous analyte sensors and associated methods of manufacture
EP4154802A1 (fr) * 2017-06-19 2023-03-29 Dexcom, Inc. Applicateurs conçus pour appliquer des capteurs d'analytes transcutanés
US11653859B2 (en) 2017-06-19 2023-05-23 Dexcom, Inc. Applicators for applying transcutaneous analyte sensors and associated methods of manufacture
US11666252B2 (en) 2017-06-19 2023-06-06 Dexcom, Inc. Applicators for applying transcutaneous analyte sensors and associated methods of manufacture
EP3641632A4 (fr) * 2017-06-19 2020-12-30 Dexcom, Inc. Applicateurs conçus pour appliquer des capteurs d'analytes transcutanés et procédés de fabrication associés
EP4299081A3 (fr) * 2017-06-19 2024-02-28 DexCom, Inc. Applicateurs conçus pour appliquer des capteurs d'analytes transcutanés
US11963762B2 (en) 2017-06-19 2024-04-23 Dexcom, Inc. Applicators for applying transcutaneous analyte sensors and associated methods of manufacture
USD926326S1 (en) 2018-06-18 2021-07-27 Dexcom, Inc. Transcutaneous analyte sensor applicator
WO2020143991A1 (fr) * 2019-01-11 2020-07-16 Shl Medical Ag Dispositif d'administration de médicament

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