WO2009091645A3 - Compositions and methods for treating chondrosarcomas - Google Patents

Compositions and methods for treating chondrosarcomas Download PDF

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Publication number
WO2009091645A3
WO2009091645A3 PCT/US2009/030307 US2009030307W WO2009091645A3 WO 2009091645 A3 WO2009091645 A3 WO 2009091645A3 US 2009030307 W US2009030307 W US 2009030307W WO 2009091645 A3 WO2009091645 A3 WO 2009091645A3
Authority
WO
WIPO (PCT)
Prior art keywords
prp
chondrosarcoma cells
growth
cells
compositions
Prior art date
Application number
PCT/US2009/030307
Other languages
French (fr)
Other versions
WO2009091645A2 (en
Inventor
Karina Galoian
Sean Scully
Armen Galoyan
Original Assignee
University Of Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Miami filed Critical University Of Miami
Publication of WO2009091645A2 publication Critical patent/WO2009091645A2/en
Publication of WO2009091645A3 publication Critical patent/WO2009091645A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compositions, kits and methods for inhibiting growth of Chondrosarcoma cells involve compositions including PRP-I or PRP-I analogues in an amount effective to inhibit growth of the cells. A method of inhibiting growth of Chondrosarcoma cells includes providing a composition including PRP-I or a PRP-I analogue in an amount effective to inhibit growth of the Chondrosarcoma cells; and contacting the Chondrosarcoma cells with the composition, wherein contacting the Chondrosarcoma cells with the composition results in inhibition of growth of the Chondrosarcoma cells. A typical adjuvant composition includes PRP-I in an amount effective to inhibit growth of human Chondrosarcoma cells and a pharmaceutically acceptable carrier or diluent. Compositions and methods described herein are based on the discovery that contacting human Chondrosarcoma cells with PRP-l abolished MYC oncogene activity and inhibited growth of the Chondrosarcoma cells.
PCT/US2009/030307 2008-01-07 2009-01-07 Compositions and methods for treating chondrosarcomas WO2009091645A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1951008P 2008-01-07 2008-01-07
US61/019,510 2008-01-07

Publications (2)

Publication Number Publication Date
WO2009091645A2 WO2009091645A2 (en) 2009-07-23
WO2009091645A3 true WO2009091645A3 (en) 2009-09-11

Family

ID=40885865

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/030307 WO2009091645A2 (en) 2008-01-07 2009-01-07 Compositions and methods for treating chondrosarcomas

Country Status (1)

Country Link
WO (1) WO2009091645A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6267958B1 (en) * 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
WO2006135943A1 (en) * 2005-06-24 2006-12-28 Armen Galoyan Use of a proline-rich peptide derived from the hypothalamus for the manufacture of a medicament for the treatment and/or prophylaxis of cattle leucosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6267958B1 (en) * 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
WO2006135943A1 (en) * 2005-06-24 2006-12-28 Armen Galoyan Use of a proline-rich peptide derived from the hypothalamus for the manufacture of a medicament for the treatment and/or prophylaxis of cattle leucosis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LOH: "Atypical presentation of cutaneous T cell lymphosarcoma in a 19-month-old Holstein heifer", CAN. VET. J., vol. 48, no. 3, March 2007 (2007-03-01), pages 309 - 311 *
MORRISON ET AL.: "MYC amplification and polysomy 8 in chondrosarcoma: array comparative genomic hybridization, fluorescent in situ hybridization, and association with outcome", J. CLIN. ONCOL., vol. 23, no. 6, 20 December 2005 (2005-12-20), pages 9369 - 9376 *

Also Published As

Publication number Publication date
WO2009091645A2 (en) 2009-07-23

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