WO2009087568A3 - Compositions comprising antioxidant and mitoprotective flavonoids with neuroprotective properties - Google Patents

Compositions comprising antioxidant and mitoprotective flavonoids with neuroprotective properties Download PDF

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Publication number
WO2009087568A3
WO2009087568A3 PCT/IB2009/000035 IB2009000035W WO2009087568A3 WO 2009087568 A3 WO2009087568 A3 WO 2009087568A3 IB 2009000035 W IB2009000035 W IB 2009000035W WO 2009087568 A3 WO2009087568 A3 WO 2009087568A3
Authority
WO
WIPO (PCT)
Prior art keywords
mitochondrial
biapigenin
contributing
compositions
excitotoxicity
Prior art date
Application number
PCT/IB2009/000035
Other languages
French (fr)
Other versions
WO2009087568A2 (en
Inventor
Bruno Alexandre Cordeiro Silva
Paulo Jorge GOUVEIA SIMÕES DA SILVA OLIVEIRA
Joao José OLIVEIRA MALVA
Alberto Carlos Pires Dias
Original Assignee
Universidade De Coimbra
Universidade Do Minho
Centro De Neurociências E Biologia Celular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade De Coimbra, Universidade Do Minho, Centro De Neurociências E Biologia Celular filed Critical Universidade De Coimbra
Publication of WO2009087568A2 publication Critical patent/WO2009087568A2/en
Publication of WO2009087568A3 publication Critical patent/WO2009087568A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention discloses compositions comprising phenolic compounds present in plant extracts with therapeutic activity against neuronal excitotoxicity, oxidative stress and mitochondrial dysfunction. When used individually or in a formula composition quercetin, kaempferol and biapigenin significantly reduced neuronal death caused by excitotoxic insults or to exposure to amyloid-beta peptide. Moreover, it is also disclosed that biapigenin interferes with the ANT/mitochondrial transition pore complex contributing for enhanced mitochondrial calcium efflux, thereby reducing calcium burden and contributing for neuroprotection against excitotoxicity.
PCT/IB2009/000035 2008-01-10 2009-01-12 Compositions comprising antioxidant and mitoprotective flavonoids with neuroprotective properties WO2009087568A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2022608P 2008-01-10 2008-01-10
US61/020,226 2008-01-10

Publications (2)

Publication Number Publication Date
WO2009087568A2 WO2009087568A2 (en) 2009-07-16
WO2009087568A3 true WO2009087568A3 (en) 2009-10-29

Family

ID=40525396

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/000035 WO2009087568A2 (en) 2008-01-10 2009-01-12 Compositions comprising antioxidant and mitoprotective flavonoids with neuroprotective properties

Country Status (2)

Country Link
PT (1) PT104389A (en)
WO (1) WO2009087568A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201490050A1 (en) 2011-06-29 2014-07-30 Зе Дженерэл Хоспитэл Корпорейшн COMPOSITIONS AND METHODS OF INCREASING THE BIOENERGY CONDITION OF WOMEN'S EMERGENCY CELLS
JPWO2014171333A1 (en) * 2013-04-17 2017-02-23 株式会社フローラ Mitochondrial activator
EP2950102A1 (en) 2014-05-30 2015-12-02 Biocross, S.L. Method for the diagnosis of alzheimer s disease and mild cognitive impairment
EP3067699A1 (en) 2015-03-11 2016-09-14 Neuron Bio, S.A. Method for diagnosing alzheimer's disease
US10702571B2 (en) 2015-12-03 2020-07-07 The University Of North Carolina At Pembroke Materials for cathepsin B enhancement and methods of use
CN107753475A (en) * 2017-11-16 2018-03-06 黑龙江葆纳生物科技有限责任公司 Application of the Kaempferol in neurocyte protection
KR20200106988A (en) * 2018-04-13 2020-09-15 주식회사 그랜메드 Identification of granin as a pathogenic factor of Alzheimer's disease, inhibition of aggregation of granin, and composition and method for treating Alzheimer's disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000057707A1 (en) * 1999-03-15 2000-10-05 Proteotech, Inc. Methods of treating alzheimer's disease and other amyloidoses using hypericum perforatum and derivatives thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000057707A1 (en) * 1999-03-15 2000-10-05 Proteotech, Inc. Methods of treating alzheimer's disease and other amyloidoses using hypericum perforatum and derivatives thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
SILVA B A ET AL: "Phytochemical and antioxidant characterization of Hypericum perforatum alcoholic extracts", FOOD CHEMISTRY, ELSEVIER SCIENCE PUBLISHERS LTD, GB, vol. 90, no. 1-2, 1 March 2005 (2005-03-01), pages 157 - 167, XP025282796, ISSN: 0308-8146, [retrieved on 20050301] *
SILVA B ET AL: "Phenolic compounds from hypericum perforatum protect rat hippocampal neurons from excitotoxic and amyloid-beta toxicity: A role for mitochondria", BIOCHIMICA ET BIOPHYSICA ACTA, no. Suppl. S, 2006, & 14TH EUROPEAN BIOENERGETIC CONFERENCE; MOSCOW, RUSSIA; JULY 22 -27, 2006, pages 482 - 483, XP008110456, ISSN: 0005-2728 *
SILVA B ET AL: "Quercetin, kaempferol and biapigenin from hypericum perforatum are neuroprotective against excitotoxic insults", NEUROTOXICITY RESEARCH 2008 SPRINGER NEW YORK LLC USA, vol. 13, no. 3-4, 2008, pages 265 - 279, XP008110458, ISSN: 1029-8428 *
SILVA BRUNO A ET AL: "Mitochondria as targets for neuronal protection against excitotoxicity: A role for phenolic compounds?", CENTRAL NERVOUS SYSTEM AGENTS IN MEDICINAL CHEMISTRY, vol. 7, no. 3, September 2007 (2007-09-01), pages 205 - 222, XP008110447, ISSN: 1871-5249 *
SILVA BRUNO A ET AL: "Neuroprotective effect of H. perforatum extracts on beta-amyloid-induced neurotoxicity.", NEUROTOXICITY RESEARCH 2004, vol. 6, no. 2, 2004, pages 119 - 130, XP008110457, ISSN: 1029-8428 *
SILVA BRUNO A ET AL: "St. John's Wort (Hypericum perforatum) extracts and isolated phenolic compounds are effective antioxidants in several in vitro models of oxidative stress", FOOD CHEMISTRY, vol. 110, no. 3, October 2008 (2008-10-01), pages 611 - 619, XP022627515, ISSN: 0308-8146 *

Also Published As

Publication number Publication date
PT104389A (en) 2009-10-12
WO2009087568A2 (en) 2009-07-16

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