WO2009082624A3 - Antagonists of il-17a, il-17f, and il-23 and methods of using the same - Google Patents

Antagonists of il-17a, il-17f, and il-23 and methods of using the same Download PDF

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Publication number
WO2009082624A3
WO2009082624A3 PCT/US2008/086292 US2008086292W WO2009082624A3 WO 2009082624 A3 WO2009082624 A3 WO 2009082624A3 US 2008086292 W US2008086292 W US 2008086292W WO 2009082624 A3 WO2009082624 A3 WO 2009082624A3
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WO
WIPO (PCT)
Prior art keywords
antagonists
methods
same
antibodies
superior
Prior art date
Application number
PCT/US2008/086292
Other languages
French (fr)
Other versions
WO2009082624A2 (en
Inventor
Katherine E. Lewis
Ty M. Brender
Eugene C. Yi
Penny J. Thompson
Brenda L. Stevens
George Robert Mabry Iii
Scott R. Presnell
Margaret D. Moore
Patricia I. Guerra-Lewis
Original Assignee
Zymogenetics, Inc.
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Publication date
Application filed by Zymogenetics, Inc. filed Critical Zymogenetics, Inc.
Publication of WO2009082624A2 publication Critical patent/WO2009082624A2/en
Publication of WO2009082624A3 publication Critical patent/WO2009082624A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23p19 or both IL-17 and IL-23p19. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease. In particular, antibodies and antibody fragments that have superior neutralizing potency for the IL-17A/F heterodimer, and bispecific molecules that combine this superior anti-IL-17A antibody with anti-IL-23A antibodies are disclosed.
PCT/US2008/086292 2007-12-10 2008-12-10 Antagonists of il-17a, il-17f, and il-23 and methods of using the same WO2009082624A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US1276707P 2007-12-10 2007-12-10
US61/012,767 2007-12-10
US1951808P 2008-01-07 2008-01-07
US61/019,518 2008-01-07
US3902208P 2008-03-24 2008-03-24
US61/039,022 2008-03-24

Publications (2)

Publication Number Publication Date
WO2009082624A2 WO2009082624A2 (en) 2009-07-02
WO2009082624A3 true WO2009082624A3 (en) 2009-10-29

Family

ID=40679588

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/086292 WO2009082624A2 (en) 2007-12-10 2008-12-10 Antagonists of il-17a, il-17f, and il-23 and methods of using the same

Country Status (1)

Country Link
WO (1) WO2009082624A2 (en)

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US7910703B2 (en) 2006-03-10 2011-03-22 Zymogenetics, Inc. Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use
WO2007147019A2 (en) 2006-06-13 2007-12-21 Zymogenetics, Inc. Il-17 and il-23 antagonists and methods of using the same
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HUE042172T2 (en) 2007-02-23 2019-06-28 Merck Sharp & Dohme Engineered anti-il-23p19 antibodies
CN103396489A (en) 2007-02-23 2013-11-20 默沙东公司 Engineered anti-IL-23p19 antibodies
JP6053517B2 (en) * 2009-05-05 2016-12-27 ノヴィミュンヌ エスア Anti-IL-17F antibodies and methods for their use
EP2477647B1 (en) 2009-09-14 2016-01-13 The Regents of the University of Colorado Modulation of yeast-based immunotherapy products and responses
JO3244B1 (en) * 2009-10-26 2018-03-08 Amgen Inc Human il-23 antigen binding proteins
BR112012010280B1 (en) * 2009-10-30 2020-09-24 Janssen Biotech, Inc. ISOLATED ANTIBODY OR FRAGMENT OF THE SAME THAT SPECIFICALLY LINKS TO HUMAN IL-17A, ITS USE, AND PHARMACEUTICAL COMPOSITION
EP2552956A1 (en) * 2010-03-26 2013-02-06 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies and uses thereof
US9127057B2 (en) 2010-07-20 2015-09-08 Teva Pharmaceuticals Ausralia Pty Ltd Anti-IL-23 heterodimer specific antibodies
CN103282382B (en) 2010-11-04 2017-11-03 勃林格殷格翰国际有限公司 The anti-antibody of IL 23
AR085091A1 (en) 2011-01-26 2013-09-11 Kolltan Pharmaceuticals Inc ANTI-KIT ANTIBODIES AND THEIR USES
UA117218C2 (en) 2011-05-05 2018-07-10 Мерк Патент Гмбх Amino acid sequences directed against il-17a, il-17f and/or il17-a/f and polypeptides comprising the same
UY34404A (en) * 2011-10-20 2013-05-31 Esbatech A Novartis Co Llc STABLE ANTIBODY UNITED TO MULTIPLE ANTIGENS
CN104185642A (en) * 2011-12-27 2014-12-03 财团法人生物技术开发中心 Light chain-bridged bispecific antibody
US9284283B2 (en) 2012-02-02 2016-03-15 Ensemble Therapeutics Corporation Macrocyclic compounds for modulating IL-17
KR102124758B1 (en) 2012-05-03 2020-06-19 베링거 인겔하임 인터내셔날 게엠베하 Anti-il-23p19 antibodies
TWI609882B (en) * 2012-05-22 2018-01-01 必治妥美雅史谷比公司 Bispecific antibodies and methods of using the same
EP2866833B1 (en) 2012-06-27 2019-05-15 Merck Sharp & Dohme Corp. Crystalline anti-human il-23 antibodies
EP4063391A1 (en) 2012-07-25 2022-09-28 Celldex Therapeutics, Inc. Anti-kit antibodies and uses thereof
TWI636063B (en) * 2013-03-08 2018-09-21 美國禮來大藥廠 Antibodies that bind il-23
JP2016517408A (en) 2013-03-15 2016-06-16 アムジェン インコーポレイテッド Method for treating psoriasis using anti-IL-23 antibody
CN105307675A (en) 2013-03-15 2016-02-03 美国安进公司 Methods for treating Crohn's disease using an anti-IL23 antibody
PT3072905T (en) * 2013-11-18 2020-09-17 Shanghai hengrui pharmaceutical co ltd Il-17a conjugate and uses thereof
JP6768639B2 (en) 2014-05-23 2020-10-21 セルデックス セラピューティクス，インコーポレーテッド Treatment of eosinophil or mast cell related disorders
US20170291939A1 (en) * 2014-06-25 2017-10-12 Novartis Ag Antibodies specific for il-17a fused to hyaluronan binding peptide tags
JP2017524359A (en) 2014-07-24 2017-08-31 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Biomarkers useful for the treatment of IL-23A related diseases
EA202193002A2 (en) 2014-09-03 2022-03-31 Бёрингер Ингельхайм Интернациональ Гмбх COMPOUND TARGETED TO IL-23A AND TNF-ALFA AND ITS APPLICATION
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EP3368066A1 (en) * 2015-10-30 2018-09-05 Eli Lilly and Company Anti-cgrp/anti-il-23 bispecific antibodies and uses thereof
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MX2018012176A (en) 2016-04-04 2019-02-07 Bioverativ Usa Inc Anti-complement factor bb antibodies and uses thereof.
EP3694874A1 (en) 2017-10-11 2020-08-19 Bioverativ USA Inc. Methods of inducing complement activity
WO2019094626A1 (en) * 2017-11-08 2019-05-16 Fred Hutchinson Cancer Research Center Bispecific antibody compositions and related methods for improved pretargeted radioimunotherapies
AU2019300491A1 (en) 2018-07-13 2021-03-04 Astrazeneca Collaboration Ventures, Llc Treating ulcerative colitis with brazikumab
US20210309735A1 (en) * 2018-07-31 2021-10-07 Weiqun SHEN Anti-il-17a antibodies and use thereof
EP4006053A4 (en) * 2019-07-30 2022-10-26 Jiangsu Hengrui Medicine Co., Ltd. Method for treating autoimmune disease by il-17 antagonist
JP2023509373A (en) 2019-12-20 2023-03-08 ノヴァロック バイオセラピューティクス， リミテッド ANTI-INTERLEUKIN-23 P19 ANTIBODY AND METHODS OF USE THEREOF
KR20210095781A (en) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 A multi-specific antibody comprising a fusion construct consisting of a Fab and a bioactive effector moiety
EP4139350A4 (en) 2020-04-20 2024-04-24 Genzyme Corp Humanized anti-complement factor bb antibodies and uses thereof
KR20230017211A (en) * 2020-04-30 2023-02-03 얀센 파마슈티카 엔.브이. Methods for Identifying Regulators of the IL-17 Pathway
CN113769082A (en) * 2020-06-10 2021-12-10 上海君实生物医药科技股份有限公司 anti-IL-17A antibody pharmaceutical composition and application thereof

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