WO2009082624A3 - Antagonists of il-17a, il-17f, and il-23 and methods of using the same - Google Patents

Antagonists of il-17a, il-17f, and il-23 and methods of using the same Download PDF

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Publication number
WO2009082624A3
WO2009082624A3 PCT/US2008/086292 US2008086292W WO2009082624A3 WO 2009082624 A3 WO2009082624 A3 WO 2009082624A3 US 2008086292 W US2008086292 W US 2008086292W WO 2009082624 A3 WO2009082624 A3 WO 2009082624A3
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WO
WIPO (PCT)
Prior art keywords
antagonists
methods
same
antibodies
superior
Prior art date
Application number
PCT/US2008/086292
Other languages
French (fr)
Other versions
WO2009082624A2 (en
Inventor
Katherine E. Lewis
Ty M. Brender
Eugene C. Yi
Penny J. Thompson
Brenda L. Stevens
George Robert Mabry Iii
Scott R. Presnell
Margaret D. Moore
Patricia I. Guerra-Lewis
Original Assignee
Zymogenetics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Zymogenetics, Inc. filed Critical Zymogenetics, Inc.
Publication of WO2009082624A2 publication Critical patent/WO2009082624A2/en
Publication of WO2009082624A3 publication Critical patent/WO2009082624A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23p19 or both IL-17 and IL-23p19. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease. In particular, antibodies and antibody fragments that have superior neutralizing potency for the IL-17A/F heterodimer, and bispecific molecules that combine this superior anti-IL-17A antibody with anti-IL-23A antibodies are disclosed.
PCT/US2008/086292 2007-12-10 2008-12-10 Antagonists of il-17a, il-17f, and il-23 and methods of using the same WO2009082624A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US1276707P 2007-12-10 2007-12-10
US61/012,767 2007-12-10
US1951808P 2008-01-07 2008-01-07
US61/019,518 2008-01-07
US3902208P 2008-03-24 2008-03-24
US61/039,022 2008-03-24

Publications (2)

Publication Number Publication Date
WO2009082624A2 WO2009082624A2 (en) 2009-07-02
WO2009082624A3 true WO2009082624A3 (en) 2009-10-29

Family

ID=40679588

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/086292 WO2009082624A2 (en) 2007-12-10 2008-12-10 Antagonists of il-17a, il-17f, and il-23 and methods of using the same

Country Status (1)

Country Link
WO (1) WO2009082624A2 (en)

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US7910703B2 (en) 2006-03-10 2011-03-22 Zymogenetics, Inc. Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use
WO2007147019A2 (en) 2006-06-13 2007-12-21 Zymogenetics, Inc. Il-17 and il-23 antagonists and methods of using the same
JP5087625B2 (en) 2006-09-01 2012-12-05 セラピューティック・ヒューマン・ポリクローナルズ・インコーポレーテッド Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals
PL2426144T3 (en) 2007-02-23 2019-05-31 Merck Sharp & Dohme Engineered anti-il-23p19 antibodies
EP2426145B1 (en) 2007-02-23 2017-01-18 Merck Sharp & Dohme Corp. Engineered anti-il-23p19 antibodies
MX2011011729A (en) * 2009-05-05 2012-04-10 Novimmune Sa Anti-il-17f antibodies and methods of use thereof.
AU2010291985B2 (en) 2009-09-14 2016-05-05 The Regents Of The University Of Colorado Modulation of yeast-based immunotherapy products and responses
JO3244B1 (en) 2009-10-26 2018-03-08 Amgen Inc Human il-23 antigen binding proteins
CN102905727B (en) 2009-10-30 2016-12-07 詹森生物科技公司 IL-17A Antagonist
US20130011406A1 (en) * 2010-03-26 2013-01-10 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies and uses thereof
CN103108886B (en) 2010-07-20 2016-08-24 赛法隆澳大利亚控股有限公司 Anti-il-23 heterodimer specific antibody
JP6126532B2 (en) 2010-11-04 2017-05-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Anti-IL-23 antibody
EP2668210B1 (en) 2011-01-26 2020-06-17 Celldex Therapeutics, Inc. Anti-kit antibodies and uses thereof
UA117218C2 (en) 2011-05-05 2018-07-10 Мерк Патент Гмбх Amino acid sequences directed against il-17a, il-17f and/or il17-a/f and polypeptides comprising the same
RU2018112861A (en) * 2011-10-20 2019-03-04 ИЭсБиЭйТЕК - Э НОВАРТИС КОМПАНИ ЭлЭлСи STABLE ANTIBODIES COMBINING WITH MULTIPLE ANTIGENS
US20130165638A1 (en) * 2011-12-27 2013-06-27 Development Center For Biotechnology Light chain-bridged bispecific antibody
WO2013116682A1 (en) 2012-02-02 2013-08-08 Ensemble Therapeutics Corporation Macrocyclic compounds for modulating il-17
CN109206516A (en) 2012-05-03 2019-01-15 勃林格殷格翰国际有限公司 Anti-il-23 p 19 antibodies
UY34815A (en) 2012-05-22 2013-11-29 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware BISPECIFIC ANTIBODIES AND THEIR METHODS OF USE
US9803010B2 (en) 2012-06-27 2017-10-31 Merck Sharp & Dohme Corp. Crystalline anti-human IL-23p19 antibodies
SG11201500489YA (en) 2012-07-25 2015-02-27 Kolltan Pharmaceuticals Inc Anti-kit antibodies and uses thereof
JOP20140049B1 (en) * 2013-03-08 2021-08-17 Lilly Co Eli Antibodies that bind il-23
JP2016517408A (en) 2013-03-15 2016-06-16 アムジェン インコーポレイテッド Method for treating psoriasis using anti-IL-23 antibody
CN105307675A (en) 2013-03-15 2016-02-03 美国安进公司 Methods for treating Crohn's disease using an anti-IL23 antibody
CA2929662C (en) * 2013-11-18 2023-05-02 Shanghai Hengrui Pharmaceutical Co., Ltd. Il-17a binding agent and uses thereof
CN113908269A (en) 2014-05-23 2022-01-11 塞尔德克斯医疗公司 Treatment of eosinophil or mast cell related disorders
EP3161001A2 (en) * 2014-06-25 2017-05-03 Novartis AG Antibodies specific for il-17a fused to hyaluronan binding peptide tags
US10507241B2 (en) 2014-07-24 2019-12-17 Boehringer Ingelheim International Gmbh Biomarkers useful in the treatment of IL-23A related diseases
TWI711629B (en) 2014-09-03 2020-12-01 德商包林格因蓋爾漢國際股份有限公司 Compound targeting il-23a and tnf-alpha and uses thereof
CA2998349A1 (en) 2015-09-17 2017-03-23 Amgen Inc. Prediction of clinical response to il23-antagonists using il23 pathway biomarkers
SG10202006332PA (en) * 2015-10-29 2020-08-28 Hoffmann La Roche Transgenic rabbit with common light chain
KR20180054851A (en) * 2015-10-30 2018-05-24 일라이 릴리 앤드 캄파니 Anti-CGRP / anti-IL-23 bispecific antibodies and uses thereof
JP2019508370A (en) 2015-12-22 2019-03-28 アムジェン インコーポレイテッド CCL20 as a Predictor of Clinical Response to IL23 Antagonists
PE20190209A1 (en) 2016-04-04 2019-02-07 Bioverativ Usa Inc COMPLEMENT ANTI-FACTOR BB ANTIBODIES AND USE OF THEM
WO2019075220A1 (en) 2017-10-11 2019-04-18 Bioverativ Usa Inc. Methods of inducing complement activity
US11970542B2 (en) 2017-11-08 2024-04-30 Fred Hutchinson Cancer Center Bispecific antibodies specific for treating hematological malignancies
EP3820897A2 (en) 2018-07-13 2021-05-19 Astrazeneca Collaboration Ventures, LLC Treating ulcerative colitis with brazikumab
WO2020024931A1 (en) * 2018-07-31 2020-02-06 Shen Weiqun Anti-il-17a antibodies and use thereof
CN114127108A (en) * 2019-07-30 2022-03-01 江苏恒瑞医药股份有限公司 Methods of treating autoimmune diseases with IL-17 antagonists
CN115135671A (en) 2019-12-20 2022-09-30 新石生物制药有限公司 Antibodies against interleukin-23P 19 and methods of use thereof
KR20210095781A (en) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 A multi-specific antibody comprising a fusion construct consisting of a Fab and a bioactive effector moiety
CA3173325A1 (en) 2020-04-20 2021-10-28 Graham Parry Humanized anti-complement factor bb antibodies and uses thereof
CN115735009A (en) * 2020-04-30 2023-03-03 詹森药业有限公司 Methods of identifying modulators of the IL-17 pathway
CN113769082A (en) * 2020-06-10 2021-12-10 上海君实生物医药科技股份有限公司 anti-IL-17A antibody pharmaceutical composition and application thereof

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