WO2009081283A3 - Aqueous formulations of acetaminophen for injection - Google Patents

Aqueous formulations of acetaminophen for injection Download PDF

Info

Publication number
WO2009081283A3
WO2009081283A3 PCT/IB2008/003925 IB2008003925W WO2009081283A3 WO 2009081283 A3 WO2009081283 A3 WO 2009081283A3 IB 2008003925 W IB2008003925 W IB 2008003925W WO 2009081283 A3 WO2009081283 A3 WO 2009081283A3
Authority
WO
WIPO (PCT)
Prior art keywords
acetaminophen
injection
aqueous formulations
formulations
preparing
Prior art date
Application number
PCT/IB2008/003925
Other languages
French (fr)
Other versions
WO2009081283A2 (en
Inventor
Perez Sergio Lloret
Pena Agnes Fernandez
Original Assignee
Combino Pharm Sl
Perez Sergio Lloret
Pena Agnes Fernandez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combino Pharm Sl, Perez Sergio Lloret, Pena Agnes Fernandez filed Critical Combino Pharm Sl
Publication of WO2009081283A2 publication Critical patent/WO2009081283A2/en
Publication of WO2009081283A3 publication Critical patent/WO2009081283A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to novel stable aqueous formulations of acetaminophen for injection as well as processes for preparing and using the same.
PCT/IB2008/003925 2007-06-18 2008-06-18 Aqueous formulations of acetaminophen for injection WO2009081283A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92919307P 2007-06-18 2007-06-18
US60/929,193 2007-06-18

Publications (2)

Publication Number Publication Date
WO2009081283A2 WO2009081283A2 (en) 2009-07-02
WO2009081283A3 true WO2009081283A3 (en) 2009-08-20

Family

ID=40785551

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/003925 WO2009081283A2 (en) 2007-06-18 2008-06-18 Aqueous formulations of acetaminophen for injection

Country Status (2)

Country Link
AR (1) AR067047A1 (en)
WO (1) WO2009081283A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2464332B1 (en) 2009-08-13 2016-03-02 Neogen N.V. Storage-stable formulation of paracetamol in aqueous solution
US8404748B2 (en) * 2009-08-13 2013-03-26 Neogen N.V. Storage-stable formulation of paracetamol in aqueous solution
US9089477B2 (en) 2011-02-10 2015-07-28 Neogen N.V. Storage-stable formulation of paracetamol in aqueous solution
ES2414557B1 (en) * 2012-01-16 2014-06-10 Novocat Farma, S.A. Aqueous composition of paracetamol for injection

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6028222A (en) * 1996-08-05 2000-02-22 Scr Pharmatop Stable liquid paracetamol compositions, and method for preparing same
WO2003051398A1 (en) * 2001-12-18 2003-06-26 Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. Parenteral composition of paracetamol
US20040054012A1 (en) * 2000-06-06 2004-03-18 Francois Dietlin Method for obtaining aqueous formulations of oxidation-sensitive active principles
US20060084703A1 (en) * 2003-02-14 2006-04-20 Tho Nguyen-Xuan Injectable liquid formulation of paracetamol
WO2008007150A1 (en) * 2006-07-13 2008-01-17 Unilever Plc Preparation of pharmaceutical compositions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6028222A (en) * 1996-08-05 2000-02-22 Scr Pharmatop Stable liquid paracetamol compositions, and method for preparing same
US20040054012A1 (en) * 2000-06-06 2004-03-18 Francois Dietlin Method for obtaining aqueous formulations of oxidation-sensitive active principles
WO2003051398A1 (en) * 2001-12-18 2003-06-26 Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. Parenteral composition of paracetamol
US20060084703A1 (en) * 2003-02-14 2006-04-20 Tho Nguyen-Xuan Injectable liquid formulation of paracetamol
WO2008007150A1 (en) * 2006-07-13 2008-01-17 Unilever Plc Preparation of pharmaceutical compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"PERFALGAN RTM CONSUMER MEDICINE INFORMATION", INTERNET CITATION, 1 January 2004 (2004-01-01), pages 1 - 3, XP002522560, Retrieved from the Internet <URL:http://www.bmsa.com.au/documents/Perfalgan_cmi.pdf> [retrieved on 20090409] *

Also Published As

Publication number Publication date
WO2009081283A2 (en) 2009-07-02
AR067047A1 (en) 2009-09-30

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