WO2009077731A3 - Prolactin fusion proteins - Google Patents

Prolactin fusion proteins Download PDF

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Publication number
WO2009077731A3
WO2009077731A3 PCT/GB2008/004120 GB2008004120W WO2009077731A3 WO 2009077731 A3 WO2009077731 A3 WO 2009077731A3 GB 2008004120 W GB2008004120 W GB 2008004120W WO 2009077731 A3 WO2009077731 A3 WO 2009077731A3
Authority
WO
WIPO (PCT)
Prior art keywords
prolactin
fusion proteins
agonist
antagonist activity
disclose
Prior art date
Application number
PCT/GB2008/004120
Other languages
French (fr)
Other versions
WO2009077731A2 (en
Inventor
Peter Artymiuk
Richard Ross
Original Assignee
Asterion Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0724654A external-priority patent/GB0724654D0/en
Priority claimed from GB0724656A external-priority patent/GB0724656D0/en
Application filed by Asterion Limited filed Critical Asterion Limited
Publication of WO2009077731A2 publication Critical patent/WO2009077731A2/en
Publication of WO2009077731A3 publication Critical patent/WO2009077731A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57554—Prolactin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

We disclose prolactin fusion proteins that have agonist or antagonist activity and their use in the treatment of conditions that would benefit from prolactin agonist or antagonist activity.
PCT/GB2008/004120 2007-12-19 2008-12-16 Prolactin fusion proteins WO2009077731A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US60/015,424 1996-04-15
GB0724654.9 2007-12-19
GB0724654A GB0724654D0 (en) 2007-12-19 2007-12-19 Prolactin antagonist
GB0724656A GB0724656D0 (en) 2007-12-19 2007-12-19 Prolactin agonist
GB0724656.4 2007-12-19
US1541907P 2007-12-20 2007-12-20
US1542407P 2007-12-20 2007-12-20
US61/015,419 2007-12-20

Publications (2)

Publication Number Publication Date
WO2009077731A2 WO2009077731A2 (en) 2009-06-25
WO2009077731A3 true WO2009077731A3 (en) 2009-09-17

Family

ID=40430218

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/004120 WO2009077731A2 (en) 2007-12-19 2008-12-16 Prolactin fusion proteins

Country Status (1)

Country Link
WO (1) WO2009077731A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001096565A2 (en) * 2000-06-16 2001-12-20 Asterion Limited Binding agents: chimeric ligand/receptor proteins
WO2003070765A2 (en) * 2001-12-14 2003-08-28 Asterion Limited Growth hormone fusion protein
WO2006010891A2 (en) * 2004-07-26 2006-02-02 Asterion Limited Linkers
WO2007036033A1 (en) * 2005-09-27 2007-04-05 Stem Cell Therapeutics Corp. Oligodendrocyte precursor cell proliferation regulated by prolactin
WO2007128979A1 (en) * 2006-04-06 2007-11-15 Asterion Limited Polypeptide antagonist

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001096565A2 (en) * 2000-06-16 2001-12-20 Asterion Limited Binding agents: chimeric ligand/receptor proteins
WO2003070765A2 (en) * 2001-12-14 2003-08-28 Asterion Limited Growth hormone fusion protein
WO2006010891A2 (en) * 2004-07-26 2006-02-02 Asterion Limited Linkers
WO2007036033A1 (en) * 2005-09-27 2007-04-05 Stem Cell Therapeutics Corp. Oligodendrocyte precursor cell proliferation regulated by prolactin
WO2007128979A1 (en) * 2006-04-06 2007-11-15 Asterion Limited Polypeptide antagonist

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BERNICHTEIN SOPHIE ET AL: "Development of pure prolactin receptor antagonists", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM, US, vol. 278, no. 38, 19 September 2003 (2003-09-19), pages 35988 - 35999, XP002469191, ISSN: 0021-9258 *
DATABASE UniProt [online] 1 August 1990 (1990-08-01), "RecName: Full=Prolactin receptor; Short=PRL-R; Flags: Precursor;", XP002520261, retrieved from EBI accession no. UNIPROT:P16471 Database accession no. P16471 *
DATABASE UniProt [online] 21 July 1986 (1986-07-21), "RecName: Full=Prolactin; Short=PRL; Flags: Precursor;", XP002520260, retrieved from EBI accession no. UNIPROT:P01236 Database accession no. P01236 *
JOMAIN JEAN-BAPTISTE ET AL: "Structural and thermodynamic bases for the design of pure prolactin receptor antagonists", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 45, November 2007 (2007-11-01), pages 33118 - 33131, XP002520259, ISSN: 0021-9258 *
LABRIOLA ET AL: "Beneficial effects of prolactin and laminin on human pancreatic islet-cell cultures", MOLECULAR AND CELLULAR ENDOCRINOLOGY, ELSEVIER IRELAND LTD, IE, vol. 263, no. 1-2, 2 December 2006 (2006-12-02), pages 120 - 133, XP005792583, ISSN: 0303-7207 *
LANGENHEIM J F ET AL: "Two wrongs can make a right: Dimers of prolactin and growth hormone receptor antagonists behave as agonists", MOLECULAR ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 20, no. 3, 1 January 2006 (2006-01-01), pages 661 - 674, XP009089441, ISSN: 0888-8809 *
SPANGELO B L ET AL: "Stimulation of in vivo antibody production and concanavalin-A-induced mouse spleen cell mitogenesis by prolactin", IMMUNOPHARMACOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, XX, vol. 14, no. 1, 1 September 1987 (1987-09-01), pages 11 - 20, XP023816265, ISSN: 0162-3109, [retrieved on 19870901] *
WILKINSON IAN R ET AL: "A ligand-receptor fusion of growth hormone forms a dimer and is a potent long-acting agonist", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 13, no. 9, 1 September 2007 (2007-09-01), pages 1108 - 1113, XP009089546, ISSN: 1078-8956 *
YASUKAWA KIYOSHI ET AL: "Fusion protein of interleukin-6 and interleukin-6 receptor without a polypeptide linker.", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 96, no. 1, July 2003 (2003-07-01), pages 38 - 46, XP002520258, ISSN: 1389-1723 *

Also Published As

Publication number Publication date
WO2009077731A2 (en) 2009-06-25

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