WO2009072417A1 - プリオン病診断用組成物 - Google Patents

プリオン病診断用組成物 Download PDF

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Publication number
WO2009072417A1
WO2009072417A1 PCT/JP2008/071334 JP2008071334W WO2009072417A1 WO 2009072417 A1 WO2009072417 A1 WO 2009072417A1 JP 2008071334 W JP2008071334 W JP 2008071334W WO 2009072417 A1 WO2009072417 A1 WO 2009072417A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
diagnosis
prion disease
compound
prion
Prior art date
Application number
PCT/JP2008/071334
Other languages
English (en)
French (fr)
Inventor
Morio Nakayama
Mamoru Haratake
Masahiro Ono
Shigeru Katamine
Noriyuki Nishida
Original Assignee
Nagasaki University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nagasaki University filed Critical Nagasaki University
Publication of WO2009072417A1 publication Critical patent/WO2009072417A1/ja

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/0412—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K51/0419—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/0412—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K51/0421—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/0429—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K51/0431—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　　一般式（Ｉ） 【化１】 〔式中、Ｒ１、Ｒ２、Ｒ３、及びＲ４は水素原子などを示し、Ｒ５は４－ジメチルアミノフェニル基などを示す。〕 で表される化合物を含有する組成物を提供する。この化合物は、異常型プリオン蛋白質に対する高い結合特異性、及び脳への高い移行性を示すので、前記組成物は、プリオン病の診断に有用である。
PCT/JP2008/071334 2007-12-07 2008-11-25 プリオン病診断用組成物 WO2009072417A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007316987 2007-12-07
JP2007-316987 2007-12-07

Publications (1)

Publication Number Publication Date
WO2009072417A1 true WO2009072417A1 (ja) 2009-06-11

Family

ID=40717599

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/071334 WO2009072417A1 (ja) 2007-12-07 2008-11-25 プリオン病診断用組成物

Country Status (1)

Country Link
WO (1) WO2009072417A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011063574A (ja) * 2009-09-21 2011-03-31 Gifu Univ アイソトープ標識化合物及びアイソトープ標識化合物前駆体

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006057323A1 (ja) * 2004-11-26 2006-06-01 Nagasaki University アミロイド関連疾患診断用組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006057323A1 (ja) * 2004-11-26 2006-06-01 Nagasaki University アミロイド関連疾患診断用組成物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KAORI UBAGAI ET AL.: "Prion Tanpakushitsu Ketsugosei Kagobutsu no Tansaku to Bunshi Imaging eno Oyo", THE PHARMACEUTICAL SOCIETY OF JAPAN KYUSHU SHIBU TAIKAI KOEN YOSHISHU, vol. 24TH, 15 November 2007 (2007-11-15), pages 104 *
ONO,M. ET AL.: "Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains", J MED CHEM, vol. 49, no. 9, 2006, pages 2725 - 2730 *
ONO,M. ET AL.: "Structure-activity relationship of chalcones and related derivatives as ligands for detecting of beta-amyloid plaques in the brain", BIOORG MED CHEM, vol. 15, no. 19, 2007, pages 6388 - 6396 *
ONO,M. ET AL.: "Synthesis and characterization of styrylchromone derivatives as beta-amyloid imaging agents", BIOORG MED CHEM, vol. 15, no. 1, 2007, pages 444 - 450 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011063574A (ja) * 2009-09-21 2011-03-31 Gifu Univ アイソトープ標識化合物及びアイソトープ標識化合物前駆体

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