WO2009071301A3 - Method for finding effectors of the protease activity of cis/trans-isomerases - Google Patents

Method for finding effectors of the protease activity of cis/trans-isomerases Download PDF

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Publication number
WO2009071301A3
WO2009071301A3 PCT/EP2008/010303 EP2008010303W WO2009071301A3 WO 2009071301 A3 WO2009071301 A3 WO 2009071301A3 EP 2008010303 W EP2008010303 W EP 2008010303W WO 2009071301 A3 WO2009071301 A3 WO 2009071301A3
Authority
WO
WIPO (PCT)
Prior art keywords
cis
trans
effectors
finding
isomerases
Prior art date
Application number
PCT/EP2008/010303
Other languages
German (de)
French (fr)
Other versions
WO2009071301A2 (en
Inventor
Gunter Fischer
Cordula Schiene-Fischer
Tobias Aumueller
Guenther Jahreis
Gerhard Kuellertz
Original Assignee
Max Planck Gesellschaft
Gunter Fischer
Cordula Schiene-Fischer
Tobias Aumueller
Guenther Jahreis
Gerhard Kuellertz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft, Gunter Fischer, Cordula Schiene-Fischer, Tobias Aumueller, Guenther Jahreis, Gerhard Kuellertz filed Critical Max Planck Gesellschaft
Priority to CA2708021A priority Critical patent/CA2708021A1/en
Publication of WO2009071301A2 publication Critical patent/WO2009071301A2/en
Publication of WO2009071301A3 publication Critical patent/WO2009071301A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/533—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving isomerase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to a method for finding cis/trans-isomerase effectors and for quantifying the cis/trans isomerase inhibiting or activating effect of the respective effectors.
PCT/EP2008/010303 2007-12-04 2008-12-04 Method for finding effectors of the protease activity of cis/trans-isomerases WO2009071301A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2708021A CA2708021A1 (en) 2007-12-04 2008-12-04 Method for finding effectors of the protease activity of cis/trans isomerases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007058181 2007-12-04
DE102007058181.7 2007-12-04

Publications (2)

Publication Number Publication Date
WO2009071301A2 WO2009071301A2 (en) 2009-06-11
WO2009071301A3 true WO2009071301A3 (en) 2009-08-13

Family

ID=40626932

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/010303 WO2009071301A2 (en) 2007-12-04 2008-12-04 Method for finding effectors of the protease activity of cis/trans-isomerases

Country Status (2)

Country Link
CA (1) CA2708021A1 (en)
WO (1) WO2009071301A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002060436A2 (en) * 2000-12-22 2002-08-08 Pintex Pharmaceuticals, Inc. Use of fredericamycin a and its derivatives in the treatment of pin1-associated states

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002060436A2 (en) * 2000-12-22 2002-08-08 Pintex Pharmaceuticals, Inc. Use of fredericamycin a and its derivatives in the treatment of pin1-associated states

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COAKER GITTA ET AL: "Eukaryotic cyclophilin as a molecular switch for effector activation", MOLECULAR MICROBIOLOGY, vol. 61, no. 6, September 2006 (2006-09-01), pages 1485 - 1496, XP002528760, ISSN: 0950-382X *
LYON WILLIAM R ET AL: "Trigger factor-mediated prolyl isomerization influences maturation of the Streptococcus pyogenes cysteine protease.", JOURNAL OF BACTERIOLOGY JUN 2003, vol. 185, no. 12, June 2003 (2003-06-01), pages 3661 - 3667, XP002528759, ISSN: 0021-9193 *
MCCORNACK M A ET AL: "HIV protease substrate conformation: modulation by cyclophilin A.", FEBS LETTERS 1 SEP 1997, vol. 414, no. 1, 1 September 1997 (1997-09-01), pages 84 - 88, XP002528758, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
CA2708021A1 (en) 2009-06-11
WO2009071301A2 (en) 2009-06-11

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