WO2009071096A3 - Combination of medical and physical cooling treatment of ischemic effects - Google Patents

Combination of medical and physical cooling treatment of ischemic effects Download PDF

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Publication number
WO2009071096A3
WO2009071096A3 PCT/DK2008/050294 DK2008050294W WO2009071096A3 WO 2009071096 A3 WO2009071096 A3 WO 2009071096A3 DK 2008050294 W DK2008050294 W DK 2008050294W WO 2009071096 A3 WO2009071096 A3 WO 2009071096A3
Authority
WO
WIPO (PCT)
Prior art keywords
combination
agonists
hypothermia
receptor agonists
medical
Prior art date
Application number
PCT/DK2008/050294
Other languages
French (fr)
Other versions
WO2009071096A2 (en
Inventor
Jacob Gotfredsen
Uno Jakob Weber
Original Assignee
Neurokey A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurokey A/S filed Critical Neurokey A/S
Publication of WO2009071096A2 publication Critical patent/WO2009071096A2/en
Publication of WO2009071096A3 publication Critical patent/WO2009071096A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The present invention relates to the induction of hypothermia in humans in a predictable and dose responsive fashion by use of combination of physical /mechanical hypothermia therapy and a pharmaceutical composition comprising at least one compound selected among a (1) vanilloid receptor agonists, capsaicinoids or capsaicinoid-like agonists reaching and binding to vanilloid receptors, and (2) cannabinoids or cannabimimetic agonists reaching and binding to cannabinoid receptors, and (3) adenosine receptor agonists, and (4) neurotensin receptor agonists, and (5) thyroxine derivatives, and (6) cytochrome c oxidase inhibitors and (7) oxygen tension reducers thereby inducing hypothermia, thus benefiting patients suffering from illnesses characterized by tissue anoxia.
PCT/DK2008/050294 2007-12-05 2008-12-05 Combination of medical and physical cooling treatment of ischemic effects WO2009071096A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DKPA200701742 2007-12-05
DKPA200701744 2007-12-05
DKPA200701742 2007-12-05
DKPA200701744 2007-12-05
DKPA200801105 2008-08-15
DKPA200801104 2008-08-15
DKPA200801104 2008-08-15
DKPA200801105 2008-08-15

Publications (2)

Publication Number Publication Date
WO2009071096A2 WO2009071096A2 (en) 2009-06-11
WO2009071096A3 true WO2009071096A3 (en) 2010-01-07

Family

ID=40679505

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2008/050294 WO2009071096A2 (en) 2007-12-05 2008-12-05 Combination of medical and physical cooling treatment of ischemic effects

Country Status (1)

Country Link
WO (1) WO2009071096A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2155300A1 (en) 2007-04-05 2010-02-24 Velomedix, Inc Automated therapy system and method
EP2167000A1 (en) 2007-07-09 2010-03-31 Velomedix, Inc Hypothermia devices and methods
WO2012006625A2 (en) 2010-07-09 2012-01-12 Velomedix, Inc. Method and apparatus for pressure measurement
GB2504263B (en) * 2012-06-08 2015-09-16 Gw Pharma Ltd Synergistic therapies for neuroprotection
DK3466930T3 (en) 2013-02-08 2022-09-05 Gen Mills Inc FOOD PRODUCT WITH REDUCED SODIUM CONTENT
US10092591B2 (en) 2014-02-27 2018-10-09 University Of Alaska Fairbanks Methods and compositions for the treatment of ischemic injury to tissue using therapeutic hypothermia

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040102368A1 (en) * 2002-11-27 2004-05-27 Katz Laurence M. Methods of treating cerebral ischemia
WO2007140786A1 (en) * 2006-06-08 2007-12-13 Neurokey A/S Use of cannabinoid receptor agonists as hypothermia inducing drugs for the treatment of ischemia
WO2008040360A2 (en) * 2006-10-04 2008-04-10 Neurokey A/S Use of hypothermia inducing drugs to treat ischemia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040102368A1 (en) * 2002-11-27 2004-05-27 Katz Laurence M. Methods of treating cerebral ischemia
WO2007140786A1 (en) * 2006-06-08 2007-12-13 Neurokey A/S Use of cannabinoid receptor agonists as hypothermia inducing drugs for the treatment of ischemia
WO2008040360A2 (en) * 2006-10-04 2008-04-10 Neurokey A/S Use of hypothermia inducing drugs to treat ischemia

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
APPENDINO G ET AL: "TRPV1 (vanilloid receptor, capsaicin receptor) agonists and antagonists", EXPERT OPINION ON THERAPEUTIC PATENTS, INFORMA HEALTHCARE, GB, vol. 13, no. 12, 1 December 2003 (2003-12-01), pages 1825 - 1837, XP002487646, ISSN: 1354-3776 *
BONFILS P K ET AL: "Estimation of the hypothermic component in neuroprotection provided by cannabinoids following cerebral ischemia", NEUROCHEMISTRY INTERNATIONAL, PERGAMON PRESS, OXFORD, GB, vol. 49, no. 5, 1 October 2006 (2006-10-01), pages 508 - 518, XP025067906, ISSN: 0197-0186, [retrieved on 20061001] *
DING ET AL: "Capsaicin evokes hypothermia independent of cannabinoid CB1 and CB2 receptors", BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 1065, no. 1-2, 14 December 2005 (2005-12-14), pages 147 - 151, XP005206563, ISSN: 0006-8993 *
HAYAKAWA KAZUHIDE ET AL: "Delta(9)-tetrahydrocannabinol (Delta(9)-THC) Prevents cerebral infarction via hypothalamic-independent hypothermia", LIFE SCIENCES, vol. 80, no. 16, March 2007 (2007-03-01), pages 1466 - 1471, XP002551820, ISSN: 0024-3205 *
LEKER RONEN R ET AL: "Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210", STROKE, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 34, no. 8, 1 August 2003 (2003-08-01), pages 2000 - 2006, XP002451424, ISSN: 0039-2499 *
MAULER FRANK ET AL: "BAY 38-7271: a novel highly selective and highly potent cannabinoid receptor agonist for the treatment of traumatic brain injury", CNS DRUG REVIEWS, BRANFORD, CT, US, vol. 9, no. 4, 1 January 2003 (2003-01-01), pages 343 - 358, XP002451422, ISSN: 1080-563X *
OLSEN T S ET AL: "Therapeutic hypothermia for acute stroke", LANCET NEUROLOGY, LANCET PUBLISHING GROUP, LONDON, GB, vol. 2, no. 7, 1 July 2003 (2003-07-01), pages 410 - 416, XP004810147, ISSN: 1474-4422 *
PEGORINI S ET AL: "Capsaicin exhibits neuroprotective effects in a model of transient global cerebral ischemia in Mongolian gerbils", BRITISH JOURNAL OF PHARMACOLOGY, NATURE PUBLISHING GROUP, BASINGSTOKE, HANTS, vol. 144, 1 January 2005 (2005-01-01), pages 727 - 735, XP007904383, ISSN: 0007-1188 *
RAWLS S M ET AL: "CB1 receptors in the preoptic anterior hypothalamus regulate WIN 55212-2 [(4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalen yl-carbonyl) -6H-pyrrolo[3,2,1 ij]quinolin-6-one]-induced hypothermia", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 301, no. 3, 1 January 2002 (2002-01-01), pages 963 - 968, XP002451426, ISSN: 0022-3565 *

Also Published As

Publication number Publication date
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