WO2009070609A3 - Therapeutic targeting of il-6 using sirna in neutral liposomes - Google Patents

Therapeutic targeting of il-6 using sirna in neutral liposomes Download PDF

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Publication number
WO2009070609A3
WO2009070609A3 PCT/US2008/084742 US2008084742W WO2009070609A3 WO 2009070609 A3 WO2009070609 A3 WO 2009070609A3 US 2008084742 W US2008084742 W US 2008084742W WO 2009070609 A3 WO2009070609 A3 WO 2009070609A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
sirna
therapeutic targeting
neutral liposomes
component
Prior art date
Application number
PCT/US2008/084742
Other languages
French (fr)
Other versions
WO2009070609A2 (en
Inventor
Anil Sood
Gabriel Lopez-Berestein
Guillermo Armaiz-Pena
Original Assignee
The Board Of Regents Of The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Regents Of The University Of Texas System filed Critical The Board Of Regents Of The University Of Texas System
Publication of WO2009070609A2 publication Critical patent/WO2009070609A2/en
Publication of WO2009070609A3 publication Critical patent/WO2009070609A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Endocrinology (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Disclosed are compositions that include a nucleic acid component that include a nucleic acid that inhibits the expression of a gene that encodes interleukin-6 (IL-6), and a lipid component that includes one or more phospholipids. Also disclosed are methods of treating a subject with cancer that exhibits stress-related growth involve administering to the subject a pharmaceutically effective amount of a composition that includes a nucleic acid component that includes a nucleic acid that inhibits the expression of a gene that encodes IL- 6, and a lipid component comprising one or more phospholipids.
PCT/US2008/084742 2007-11-27 2008-11-25 Therapeutic targeting of il-6 using sirna in neutral liposomes WO2009070609A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99053807P 2007-11-27 2007-11-27
US60/990,538 2007-11-27

Publications (2)

Publication Number Publication Date
WO2009070609A2 WO2009070609A2 (en) 2009-06-04
WO2009070609A3 true WO2009070609A3 (en) 2010-09-10

Family

ID=40524697

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/084742 WO2009070609A2 (en) 2007-11-27 2008-11-25 Therapeutic targeting of il-6 using sirna in neutral liposomes

Country Status (1)

Country Link
WO (1) WO2009070609A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10214983A1 (en) 2002-04-04 2004-04-08 TransMIT Gesellschaft für Technologietransfer mbH Nebulisable liposomes and their use for pulmonary application of active substances
CN101579329B (en) * 2009-06-08 2011-11-09 沈阳亿灵医药科技有限公司 Bevantolol hydrochloride sustained release preparation
DE102009031274A1 (en) 2009-06-30 2011-01-13 Justus-Liebig-Universität Giessen Liposomes for pulmonary application
CL2011000273A1 (en) * 2011-02-08 2011-06-17 Univ Pontificia Catolica Chile Use of a phosphatidic acid phosphohydrolase enzyme (pap) inhibitor or combination of inhibitors, in which the inhibitor is d (+) propranolol, and the combination is racemic mixture of propranolol od (+) propranolol together with desipramine, to prepare a Useful medicine in the treatment of cancer.
WO2013059548A1 (en) 2011-10-19 2013-04-25 Sanofi Compositions and methods for treating cancer using jak2 inhibitor
CN103536594A (en) * 2013-10-21 2014-01-29 江苏亚虹医药科技有限公司 Application of G-protein-coupled receptor antagonist in preparing medicine for treating glutamate receptor high-expression tumor
CN114224875B (en) * 2021-11-04 2023-08-11 中南大学湘雅医院 New use of alcohol compound and antitumor drug

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006113679A2 (en) * 2005-04-15 2006-10-26 Board Of Regents, The University Of Texas System Delivery of sirna by neutral lipid compositions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006113679A2 (en) * 2005-04-15 2006-10-26 Board Of Regents, The University Of Texas System Delivery of sirna by neutral lipid compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LANDEN CHARLES N JR ET AL: "Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancer.", 1 November 2007, CANCER RESEARCH 1 NOV 2007, VOL. 67, NR. 21, PAGE(S) 10389 - 10396, ISSN: 1538-7445, XP002575012 *
NILSSON MONIQUE B ET AL: "Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism.", THE JOURNAL OF BIOLOGICAL CHEMISTRY IN PRESS, no. M611539200, 23 August 2007 (2007-08-23), pages 1 - 19, XP002574048, ISSN: 0021-9258, Retrieved from the Internet <URL:http://www.jbc.org/content/early/2007/08/23/jbc.M611539200> [retrieved on 20100318], DOI: 10.1074/jbc.M611539200 *

Also Published As

Publication number Publication date
WO2009070609A2 (en) 2009-06-04

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