WO2009070380A3 - Water-soluble carbon nanotube compositions for drug delivery and medical applications - Google Patents

Water-soluble carbon nanotube compositions for drug delivery and medical applications Download PDF

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Publication number
WO2009070380A3
WO2009070380A3 PCT/US2008/078776 US2008078776W WO2009070380A3 WO 2009070380 A3 WO2009070380 A3 WO 2009070380A3 US 2008078776 W US2008078776 W US 2008078776W WO 2009070380 A3 WO2009070380 A3 WO 2009070380A3
Authority
WO
WIPO (PCT)
Prior art keywords
water
compositions
drug delivery
carbon nanotube
medical applications
Prior art date
Application number
PCT/US2008/078776
Other languages
French (fr)
Other versions
WO2009070380A2 (en
Inventor
James M. Tour
Rebecca Lucente-Schultz
Ashley Leonard
Dmitry V. Kosynkin
Brandi Katherine Price
Jared L. Hudson
Jodie L. Conyers
Valerie C. Moore
S. Ward Casscells
Jeffrey N. Myers
Zvonimir L. Milas
Kathy A. Mason
Luka Milas
Original Assignee
William Marsh Rice University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William Marsh Rice University filed Critical William Marsh Rice University
Publication of WO2009070380A2 publication Critical patent/WO2009070380A2/en
Publication of WO2009070380A3 publication Critical patent/WO2009070380A3/en

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle

Abstract

Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.
PCT/US2008/078776 2007-10-03 2008-10-03 Water-soluble carbon nanotube compositions for drug delivery and medical applications WO2009070380A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97731107P 2007-10-03 2007-10-03
US60/977,311 2007-10-03

Publications (2)

Publication Number Publication Date
WO2009070380A2 WO2009070380A2 (en) 2009-06-04
WO2009070380A3 true WO2009070380A3 (en) 2009-10-29

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/078776 WO2009070380A2 (en) 2007-10-03 2008-10-03 Water-soluble carbon nanotube compositions for drug delivery and medical applications

Country Status (1)

Country Link
WO (1) WO2009070380A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201012749A (en) 2008-08-19 2010-04-01 Univ Rice William M Methods for preparation of graphene nanoribbons from carbon nanotubes and compositions, thin films and devices derived therefrom
US9377449B2 (en) 2009-06-15 2016-06-28 William Marsh Rice University Nanocomposite oil sensors for downhole hydrocarbon detection
JP5972796B2 (en) * 2010-03-02 2016-08-17 キング アブドゥーラ ユニバーシティ オブ サイエンス アンド テクノロジー High surface area fibrous silica nanoparticles
CN102397256A (en) * 2010-09-13 2012-04-04 复旦大学 Hydrophilic drug and hydrophobic drug co-loaded target composite nano-drug preparation and preparation method thereof
US9572834B2 (en) 2011-04-26 2017-02-21 William Marsh Rice University Use of carbon nanomaterials with antioxidant properties to treat oxidative stress
RU2472796C1 (en) * 2011-06-21 2013-01-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет тонких химических технологий имени М.В. Ломоносова" (МИТХТ им. М.В.Ломоносова) Folate-polyethylene glycol-dihexadecyl-l-glutamate and method for production thereof
JP2015536319A (en) * 2012-10-16 2015-12-21 ウィリアム・マーシュ・ライス・ユニバーシティ Improved nanovector-based drug delivery system to overcome drug resistance
CN103172048A (en) * 2013-03-05 2013-06-26 电子科技大学 Preparation method of water-soluble carbon nanotube
CN103877580B (en) * 2013-11-11 2016-04-06 浙江大学 A kind of CNT complex gene carrier system and preparation method thereof
CN109077991A (en) * 2018-08-17 2018-12-25 河南工业大学 A kind of preparation method of functional carbon nanotubes drug carrier system

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5473055A (en) * 1992-06-19 1995-12-05 Farmitalia Carlo Erba S.R.L. Polymer-bound paclitaxel derivatives
US20050191680A1 (en) * 2004-02-27 2005-09-01 Otc Biotechnologies Lp Therapeutic nucleic acid-3' -conjugates
WO2005097672A2 (en) * 2004-04-07 2005-10-20 Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden Method for the production of carbon nanotubes that are ferromagnetically filled in part and carry biomolecules, and use thereof in diagnosis and therapy
EP0932399B1 (en) * 1996-03-12 2006-01-04 PG-TXL Company, L.P. Water soluble paclitaxel prodrugs
WO2007091663A1 (en) * 2006-02-06 2007-08-16 Nec Corporation Carbon nanohorn complex having substance encapsulated therein and method of producing the same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5473055A (en) * 1992-06-19 1995-12-05 Farmitalia Carlo Erba S.R.L. Polymer-bound paclitaxel derivatives
EP0932399B1 (en) * 1996-03-12 2006-01-04 PG-TXL Company, L.P. Water soluble paclitaxel prodrugs
US20050191680A1 (en) * 2004-02-27 2005-09-01 Otc Biotechnologies Lp Therapeutic nucleic acid-3' -conjugates
WO2005097672A2 (en) * 2004-04-07 2005-10-20 Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden Method for the production of carbon nanotubes that are ferromagnetically filled in part and carry biomolecules, and use thereof in diagnosis and therapy
WO2007091663A1 (en) * 2006-02-06 2007-08-16 Nec Corporation Carbon nanohorn complex having substance encapsulated therein and method of producing the same

Also Published As

Publication number Publication date
WO2009070380A2 (en) 2009-06-04

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