WO2009069680A1 - Medicinal composition for treating gastrointestinal stromal tumor (gist) and kit and method for estimating the prognosis of patient suffering from gastrointestinal stromal tumor - Google Patents

Medicinal composition for treating gastrointestinal stromal tumor (gist) and kit and method for estimating the prognosis of patient suffering from gastrointestinal stromal tumor Download PDF

Info

Publication number
WO2009069680A1
WO2009069680A1 PCT/JP2008/071495 JP2008071495W WO2009069680A1 WO 2009069680 A1 WO2009069680 A1 WO 2009069680A1 JP 2008071495 W JP2008071495 W JP 2008071495W WO 2009069680 A1 WO2009069680 A1 WO 2009069680A1
Authority
WO
WIPO (PCT)
Prior art keywords
gastrointestinal stromal
stromal tumor
prognosis
estimating
kit
Prior art date
Application number
PCT/JP2008/071495
Other languages
French (fr)
Japanese (ja)
Inventor
Tadashi Kondo
Setsuo Hirohashi
Akira Kawai
Kazutaka Kikuta
Original Assignee
Japan Health Sciences Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Health Sciences Foundation filed Critical Japan Health Sciences Foundation
Publication of WO2009069680A1 publication Critical patent/WO2009069680A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

It is intended to provide a tumor marker by which poor prognosis cases can be distinguished from good prognosis cases at a high discrimination ratio among gastrointestinal stromal tumor cases. A medicinal composition for treating a gastrointestinal stromal tumor of a patient who is defined based on the expression of DDX39 from among patients suffering from gastrointestinal stromal tumor, which comprises as the active ingredient 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide represented by the following formula (I): [Chemical formula 1] (I) or a pharmaceutically acceptable salt thereof; and a kit and a method for estimating the prognosis of a patient suffering from gastrointestinal stromal tumor.
PCT/JP2008/071495 2007-11-29 2008-11-27 Medicinal composition for treating gastrointestinal stromal tumor (gist) and kit and method for estimating the prognosis of patient suffering from gastrointestinal stromal tumor WO2009069680A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-308856 2007-11-29
JP2007308856A JP5428004B2 (en) 2007-11-29 2007-11-29 Kit for predicting prognosis of patients with gastrointestinal stromal tumors

Publications (1)

Publication Number Publication Date
WO2009069680A1 true WO2009069680A1 (en) 2009-06-04

Family

ID=40678572

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/071495 WO2009069680A1 (en) 2007-11-29 2008-11-27 Medicinal composition for treating gastrointestinal stromal tumor (gist) and kit and method for estimating the prognosis of patient suffering from gastrointestinal stromal tumor

Country Status (2)

Country Link
JP (1) JP5428004B2 (en)
WO (1) WO2009069680A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014057045A1 (en) * 2012-10-10 2014-04-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of gastrointestinal stromal tumors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007043295A1 (en) * 2005-09-22 2007-04-19 Daiichi Pharmaceutical Co., Ltd. Method of identifying compounds inhibiting ddx39
JP2008100958A (en) * 2006-10-20 2008-05-01 Japan Health Science Foundation Pharmaceutical composition for treating gastrointestinal stromal tumor (gist), and kit and method for predicting prognosis of patient suffering from gist

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007043295A1 (en) * 2005-09-22 2007-04-19 Daiichi Pharmaceutical Co., Ltd. Method of identifying compounds inhibiting ddx39
JP2008100958A (en) * 2006-10-20 2008-05-01 Japan Health Science Foundation Pharmaceutical composition for treating gastrointestinal stromal tumor (gist), and kit and method for predicting prognosis of patient suffering from gist

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
ARIMOTO Y.: "Jutsugo Imatinib Mesylate Toyo ga Yuko de atta Fukumaku Hanshu o Tomonatta Akusei I gastrointestinal stromal tumor no 1 Rei", JAPANESE JOURNAL OF GASTROENTEROLOGICAL SURGERY, vol. 38, no. 6, 2005, pages 614 - 619 *
CHENG, S.H.: "Genomic prediction of locoregional recurrence after mastectomy in breast cancer", J CLIN ONCOL, vol. 24, no. 28, 2006, pages 4594 - 4602 *
GASHAW, I.: "Gene signatures of testicular seminoma with emphasis on expression of ets variant gene 4", CELL MOL LIFE SCI, vol. 62, no. 19-20, 2005, pages 2359 - 2368 *
HIROTA S.: "Shokakan no Nenmakuka Shuyo 2004 Topics 2. Tyrosine Kinase Sogaizai ni yoru GIST no Chiryo Tekio", STOMACH AND INTESTINE, vol. 39, no. 4, 2004, pages 683 - 687 *
KIKUCHI, H.: "Immunohistochemical and genetic features of gastric and metastatic liver gastrointestinal stromal tumors: Sequential analyses", CANCER SCI, vol. 97, no. 2, 2006, pages 127 - 132 *
MIMURA T.: "Shitteokitaikoto A La Carte GIST", MED PRACT, vol. 24, no. 3, 1 March 2007 (2007-03-01), pages 574 - 576 *
OKAMOTO, K.: "A Treatment Using STI571 for Jejunal Gastrointestinal Stromal Tumor (GIST) Accompanied with Liver Metastasis and Peritoneal Dissemination", INTERN MED, vol. 43, no. 12, 2004, pages 1151 - 1156 *
PARK, J.T.: "Notch3 gene amplification in ovarian cancer", CANCER RES, vol. 66, no. 12, 2006, pages 6312 - 6318 *
SUDO H.: "Toin ni Okeru I GIST Shujutsu Shorei no Kento", JAPANESE JOURNAL OF GASTROENTEROLOGICAL SURGERY, vol. 38, no. 7, 2005, pages 985 *
SUGIURA, T.: "Intracellular characterization of DDX39, a novel growth-associated RNA helicase", EXP CELL RES, vol. 313, no. 4, February 2007 (2007-02-01), pages 782 - 790 *
TAKAHASHI, T.: "An enhanced risk-group stratification system for more practical prognostication of clinically malignant gastrointestinal stromal tumors", INT J CLIN ONCOL, vol. 12, no. 5, October 2007 (2007-10-01), pages 369 - 374 *
TAKENAKA H.: "Imatinib Mesylate Toyo ga Soko shita I GIST Dojisei Kan Tahatsu Ten'i no 1 Rei", YAMAGUCHI MEDICAL JOURNAL, vol. 55, no. 5, 2006, pages 173 - 178 *
TAKITA, J.: "Gene expression profiling and identification of novel prognostic marker genes in neuroblastoma", GENES CHROMOSOMES CANCER, vol. 40, no. 2, 2004, pages 120 - 132 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014057045A1 (en) * 2012-10-10 2014-04-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of gastrointestinal stromal tumors

Also Published As

Publication number Publication date
JP5428004B2 (en) 2014-02-26
JP2009132636A (en) 2009-06-18

Similar Documents

Publication Publication Date Title
MY148375A (en) Delta and epsilon crystal forms of imatinib mesylate
WO2002034727A3 (en) Treatment of gastrointestinal stromal tumors
WO2005075425A3 (en) Substituted bisarylurea derivatives as kinase inhibitors
NZ601483A (en) Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
MY148480A (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
MX2008016423A (en) Tetrazole-substituted arylamides.
MY143568A (en) 11b-hsd1 inhibitors for the treatment of diabetes
IL196543A (en) Pyridazinone derivatives and pharmaceutical compositions comprising them for use in the treatment of disorders
MX2009012390A (en) Use of 4-(pyrrolidin-1-yl)quinoline compounds to kill clinically latent microorganisms.
WO2006025070A3 (en) Nebivolol and its pharmaceutically acceptable salts, process for preparation and pharmaceutical compositions of nebivolol
MX2008002061A (en) Thiazolyl piperidine derivatives.
NO20071138L (en) Piperazine derivatives useful for the treatment of gastrointestinal disorders
MXPA06001838A (en) Succinate and malonate salt of trans-4-(ir, 3s)-6 -chloro- 3-phenylindan- 1-yl)-1, 2, 2- trimethylpiperazine and the use as a medicament.
NO20084853L (en) Compounds that are agonists of muscarinic receptors and which may be effective in the treatment of pain, Alzheimer's disease and / or schizophrenia
MY151295A (en) Pyrimidyl indoline compound
MX2010004501A (en) 5-lipoxygenase activating protein (flap) inhibitor.
MX2007006387A (en) 3-substituted pyridine derivatives as h3 antagonists.
NZ596154A (en) Cyclic compound having substituted phenyl group
IL205697A0 (en) 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazole-2-yl)benzenesulfon-amide derivatives, compositions comprising the same and uses thereof
MX2007004248A (en) Heterocyclic substituted bisarylurea derivatives as kinase inhibitors.
WO2008104473A3 (en) Pyrazolopyriidine derivatives and their use as kinase inhibitors
WO2007131907A3 (en) 1h-indol-5-yl-piperazin-1-yl-methanone derivatives
CY1112638T1 (en) USE OF INDOLIUM PRODUCERS AS NURR-1 ACTIVATORS FOR RARKINSON'S DISEASE TREATMENT
TW200700390A (en) Metabolites for nk-1 antagonists for emesis
WO2005118558A3 (en) Pyrimidine compounds and use thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08853644

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08853644

Country of ref document: EP

Kind code of ref document: A1