WO2009069002A3 - Low dose colony stimulating factors to treat amyloidosis - Google Patents

Low dose colony stimulating factors to treat amyloidosis Download PDF

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Publication number
WO2009069002A3
WO2009069002A3 PCT/IB2008/003879 IB2008003879W WO2009069002A3 WO 2009069002 A3 WO2009069002 A3 WO 2009069002A3 IB 2008003879 W IB2008003879 W IB 2008003879W WO 2009069002 A3 WO2009069002 A3 WO 2009069002A3
Authority
WO
WIPO (PCT)
Prior art keywords
colony stimulating
low dose
stimulating factor
tissue
stimulating factors
Prior art date
Application number
PCT/IB2008/003879
Other languages
French (fr)
Other versions
WO2009069002A2 (en
Inventor
Serge Rivest
Original Assignee
Laval University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laval University filed Critical Laval University
Publication of WO2009069002A2 publication Critical patent/WO2009069002A2/en
Publication of WO2009069002A3 publication Critical patent/WO2009069002A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The invention relates a method of treating amyloidosis, diseases and disorders associated with amyloid plaque formation, e.g., Alzheimer's disease by increasing tissue resident macrophage activity in an organ or tissue of an animal requiring treatment by administration of a low dose of colony stimulating factor. For example, the activity of bone marrow-derived microglial cells in an organ or tissue can be increased by administration of a low dose of colony stimulating factor, particularly macrophage colony stimulating factor, either alone or in combination with additional colony stimulating factors, stem cell factors or other compounds capable of treating amyloidosis.
PCT/IB2008/003879 2007-11-29 2008-12-01 Low dose colony stimulating factors to treat amyloidosis WO2009069002A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99115907P 2007-11-29 2007-11-29
US60/991,159 2007-11-29

Publications (2)

Publication Number Publication Date
WO2009069002A2 WO2009069002A2 (en) 2009-06-04
WO2009069002A3 true WO2009069002A3 (en) 2011-04-28

Family

ID=40679070

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/003879 WO2009069002A2 (en) 2007-11-29 2008-12-01 Low dose colony stimulating factors to treat amyloidosis

Country Status (1)

Country Link
WO (1) WO2009069002A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022527532A (en) * 2019-04-03 2022-06-02 オンコペプティデス エービー Treatment of AL amyloidosis with melflufen

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008060610A2 (en) * 2006-11-17 2008-05-22 Biogen Idec Ma Inc. Systemic administration of colony stimulating factors to treat amyloid associated disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008060610A2 (en) * 2006-11-17 2008-05-22 Biogen Idec Ma Inc. Systemic administration of colony stimulating factors to treat amyloid associated disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAWATA, T. ET AL.: "Amyloid b Protein Deposition in Osteopetrotic (oplop) Mice is Reduced by Injections of Macrophage Colony Stimulating Factor.", THE JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol. 33, no. 6, 1 November 2005 (2005-11-01), pages 654 - 660 *
MITRASINOVIC, O. M. ET AL.: "Microglial Overexpression of the M-CSF receptor augments phagocytosis of opsonized Abeta", NEUROSCIENCE LETTERS, vol. 344, no. 6, 3 July 2003 (2003-07-03), pages 185 - 188 *

Also Published As

Publication number Publication date
WO2009069002A2 (en) 2009-06-04

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