WO2009063376A1 - Capsule électronique pouvant être ingérée - Google Patents

Capsule électronique pouvant être ingérée Download PDF

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Publication number
WO2009063376A1
WO2009063376A1 PCT/IB2008/054673 IB2008054673W WO2009063376A1 WO 2009063376 A1 WO2009063376 A1 WO 2009063376A1 IB 2008054673 W IB2008054673 W IB 2008054673W WO 2009063376 A1 WO2009063376 A1 WO 2009063376A1
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WO
WIPO (PCT)
Prior art keywords
capsule
unfoldable
medicament
dispensing
capsule according
Prior art date
Application number
PCT/IB2008/054673
Other languages
English (en)
Inventor
Hans Zou
Original Assignee
Koninklijke Philips Electronics N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics N.V. filed Critical Koninklijke Philips Electronics N.V.
Publication of WO2009063376A1 publication Critical patent/WO2009063376A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A63—SPORTS; GAMES; AMUSEMENTS
    • A63B—APPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
    • A63B9/00—Climbing poles, frames, or stages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041—Capsule endoscopes for imaging
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B7/00—Connections of rods or tubes, e.g. of non-circular section, mutually, including resilient connections
    • F16B7/04—Clamping or clipping connections
    • F16B7/044—Clamping or clipping connections for rods or tubes being in angled relationship
    • F16B7/048—Clamping or clipping connections for rods or tubes being in angled relationship for rods or for tubes without using the innerside thereof
    • F16B7/0486—Clamping or clipping connections for rods or tubes being in angled relationship for rods or for tubes without using the innerside thereof forming an abutting connection of at least one tube

Definitions

  • the present invention relates to an electronically controlled ingestible capsule, e.g., for release of a medicament or for diagnostic purposes.
  • Electronically controlled ingestible capsules can be used to provide therapeutic or diagnostic treatment during traversal of the gastrointestinal alimentary tract.
  • an ingestible capsule having a camera acquires diagnostic images as it traverses the gastrointestinal tract.
  • the capsule can be provided with an electronically controlled medicament delivery system. The capsule is moved by the peristaltic movement of the muscles along the gastrointestinal tract.
  • An electronically controlled capsule can be programmed or controlled to deliver or dispense a medicament according to a dispensing timing pattern while traversing through the gastrointestinal tract.
  • the electronically controlled capsule can include control and timing circuitry for controlling the opening and closing of a valve or hatch according to the desired dispensing timing pattern for dispensing a medicament stored within a medicament reservoir of the capsule.
  • the dispensing timing pattern can be preset and it can be fixed not being susceptible to a person's physiological processes and conditions, mood, age, gender, ailments, earlier-administered medicaments, etc.
  • the electronically controlled capsule allows a person to take all capsules substantially simultaneously, e.g. with breakfast, so that no more capsules are required for the day. Medication that does not fit into one electronically controlled capsule can be coordinated with other electronically controlled capsules for the full day's payload regimen. All of the medicaments required to be taken during a particular time period, for example, during a 24-hour period, can be provided within one or more electronically controlled capsules which can all be taken at the same time.
  • the electronically controlled capsules can have different dispensing timing patterns, so that a full day's coverage can be obtained.
  • the electronically controlled capsules present in the body may be programmed to stop dispensing medicament in the expectation that a new set of capsules will be taken. This prevents accidental overdose by having only the most recently taken capsules dispensing medicament in the body.
  • a program controlled medicament delivery system using such capsules avoids the need for a caregiver to wake up or otherwise disturb a patient or resident for the sole purpose of administering a medicament or to track down a patient or resident who may be in a different part of the hospital or nursing home for the sole purpose of administering a medicament. It also reduces the overload required for inventorying, ordering, tracking and logging the medicaments.
  • the word "medicament” refers to medicines, placebos, non- medicinal substances, contrast agents, gases, fluids, liquids, radiological agents, imaging or medical markers, sensors for monitoring the person's vital functions, etc.
  • a release capsule that can stay in the gastrointestinal tract for a longer period, e.g., for 10 hours or more.
  • a capsule comprising a balloon which is selectively inflatable and deflatable.
  • WO 2006077529 also discloses a treatment system which includes an ingestible capsule having a plurality of deflectable bristles biased to resume an original position. These are used to generate deflection signals for generating a topographical mapping of the alimentary tract traversed.
  • US 6719684 B2 discloses a micro capsule type robot for examining the internal organs of a human body with a stopping unit for stopping or delaying movement of the robot at a certain position.
  • the stopping units can include electroactive polymers. Such stopping units can cause friction with surrounding tissue of the gastrointestinal tract.
  • the object of the invention is to provide an ingestible capsule allowing prolonged retention time with reduced friction with surrounding tissue.
  • ingestible capsule comprising: at least one unfoldable member which can selectively be moved between a folded position and an unfolded position; control circuitry for controlling folding and unfolding of the unfoldable member; a pliant membrane covering the unfoldable member.
  • the pliant membrane substantially reduces friction with surrounding tissue.
  • Such membrane can for instance be made of a cloth or stretchable foil, stretchable under the action of the unfolded members.
  • Suitable materials for such a membrane are for example high-pressure, non-elastic plastics, which are formed of materials such as flexible polyvinyl chloride (PVC), cross linked polyethylene (PE), polyester polyethylene terephthalate (PDT), polyamide, or polyurethane; or the low-pressure elastomeric variety, which are formed of materials such as latex or silicone.
  • the pliant membrane can be fixed to at least one of the one or more unfoldable members, e.g., by a glue. Alternatively, it can be fixed to any other part of the capsule or be loose. In a further alternative, the pliant membrane can be part of one or more of the unfoldable members.
  • the pliant membrane can be permeable for medicament to be released by the capsule.
  • the membrane can have an opening in line with a medicament dispensing opening or nozzle.
  • the membrane may be provided with openings allowing a sensor in the capsule to interact with the environment to be examined.
  • Coatings may be provided on the membrane, such as lubricious coatings, hydrophilic or hydrophobic coatings, abrasion and puncture resistant coatings, tacky or high friction coatings, conductive coatings, anti-thrombogenic coatings, drug release coatings, reflective coatings and/or selective coatings.
  • At least one of the one or more unfoldable members can be a fin which is pivotable between the folded position, when it is at least partly sunk in the outer surface of the capsule, and the unfolded position.
  • the fins can, e.g., be made of a flexible material such as for instance biocompatible materials used to fabricate implantable medical devices. These materials include Pellethane® 2363 polyether urethane series of materials available from Dow Chemical Company and Elasthane polyether urethane available from the Polymer Technology Group, Inc. Other materials include PurSil® and CarboSil® also available from the Polymer Technology Group, Inc.
  • the expandable member can for example be a fin having a pivot pin and a slider pin wherein the pivot pin is pivotably mounted in a stationary first ring and the slider pin is slideably engaged in a lot in a second ring which is concentrically rotatable relative to the first ring.
  • the capsule can for instance have three or more of such pivotable fins equidistantially arranged over the perimeter of the capsule.
  • at least one of the one or more unfoldable members are formed by a strip of an electroactive polymer (EAP), such as an ionic polymer metal composite (IPMC), perfluorinated ion exchange membrane platinum composite (IEMP) or an electrorestrictive polymer (EP).
  • EAP electroactive polymer
  • IPMC ionic polymer metal composite
  • IEMP perfluorinated ion exchange membrane platinum composite
  • EP electrorestrictive polymer
  • the capsule according to the present invention can for example be an electronic pill comprising: a sensor sensitive to environmental conditions in the gastrointestinal tract of a patient; - a medicine reservoir; a medicine dispenser.
  • the electronic pill can be controlled by an external control system, e.g. radiographical remote control, or the pill can comprise a processor programmed to release medicine from the reservoir via the medicine dispenser upon activation by the sensor.
  • the capsule according to the present invention can also be used for diagnostic purposes comprising a sensor for collecting desired information, e.g. a camera.
  • the capsule can also have one or more power sources, such as a battery, which provides power to control circuitry and/or other components of the capsule.
  • a battery is a thin film lithium battery (e.g., available from Frontedge Technologies TM, located in Baldwin Park, California, US), having a small footprint and a suitable shelf life (e.g., 1% discharge/year).
  • the battery may further be selected from other known batteries, such as photo lithium, silver oxide, lithium coin cells, zinc air cells, alkaline, etc..
  • the capsule may use passive power.
  • the power source includes a device configured for scavenging power from another device, which may employ electrostatic, micro fuel cells, micro-heat, temperature gradient, etc..
  • a capsule can be used comprising at least one expandable member which is expanded after entry into the stomach to a size preventing passage through the pylorus and which is re-contracted to a size allowing passage through the pylorus after release of an amount of one or more medicaments over a pre-determined period of time in accordance with a pre-set dispensing timing pattern.
  • a capsule can, e.g., be an electronic pill comprising a processor which is programmed to unfold one or more unfoldable members responsive to a signal issued by the sensor after detecting a condition typical for the stomach environment. The processor can also be programmed to fold back the one or more unfoldable members after release of a pre-determined amount of medicine and/or after a preset time period.
  • the capsule can contain particles of a medicament coated with a gastroresistant enteric coating.
  • Such coatings are resistant to the acidic stomach environment but soluble in the less acidic intestinal environment of the intestine, enabling controlled release of the therapeutic substance in the intestine.
  • the enteric coatings can for example be based on poly(meth)acrylates. Suitable examples of commercially available enteric coatings are for instance the Eudragit® coating materials of Degussa, and the Kollicoat® coating materials of BASF.
  • Figure IA shows a capsule according to the invention in longitudinal cross section
  • Figure IB shows the capsule of Figure IA with an unfolded fin
  • Figure 1C shows the capsule in cross section along line A-A' in Figure IA;
  • Figure ID shows the capsule with unfolded fin in cross section along line A- A' in Figure IA;
  • Figure 2A shows an alternative embodiment of a capsule according to the invention
  • Figure 2B shows the capsule of Figure 2 A with unfolded fins without the pliant membrane
  • Figure 2C shows the capsule of Figure 2 A with unfolded fins
  • Figure 2D shows the capsule of Figure 2A in longitudinal cross section with unfolded fins.
  • FIG. IA shows a first exemplary embodiment of an electronically controlled capsule according to the present invention. The same embodiment is shown with unfolded fin in Figure IB and in cross section in Figures 1C and ID.
  • the electronically controlled capsule 100 is a self-contained electronically controlled medicine delivery system.
  • the electronically controlled capsule 100 includes programmed electronics that control a release mechanism according to a dispensing pattern for dispensing a medicament.
  • the capsule 100 is made from bio-compatible materials such that the capsule 100 is bio-compatible for at least the amount of time it requires to traverse the gastrointestinal tract.
  • the bio-compatible materials are preferably stable in room temperature, such that the capsule has a long shelf life.
  • the electronically controlled capsule 100 includes an outer shell or housing 102; a medicament reservoir 104 for storing a medicament; an electronically controlled release valve or hatch 106 for dispensing the medicaments stored in the medicament reservoir 104; control and timing circuitry 108 for opening and closing the valve 106; and a battery 109.
  • the control and timing circuitry 108 opens and closes the valve 106 throughout a dispensing time period in accordance with a preset dispensing timing pattern as further described below.
  • the shell 102 can be manufactured from materials used to fabricate implantable devices.
  • the amount that the valve 106 is opened at each moment in time (e.g., each second) of the dispensing time period is dependent upon the preset dispensing timing pattern which is programmed within timing circuitry 110 of the control and timing circuitry 108.
  • the dispensing time period is defined as the time period from when the electronically controlled capsule 100 is placed in a person's mouth to the time all of the medicament stored within the medicament reservoir 104 has been dispensed, or the day (24-hour period) has expired. This 24-hour period may be shifted slightly to account for differences in absorption in the stomach versus the colon.
  • the control and timing circuitry 108 is programmed for closing the valve 106 and controlling the amount the valve 106 is opened for controlling the size of the valve opening.
  • the electronically controlled capsule 100 can precisely control the quantity of medicament released during each moment in time (e.g., each second) of the dispensing time period.
  • the control and timing circuitry 108 includes timing circuitry 110 programmed with the preset dispensing timing pattern, a start timer mechanism 112, a release controller 114 and a pressure mechanism 116.
  • the start timer mechanism 112 enables activation of the timing circuitry 110.
  • the battery 109 powers the control and timing circuitry 108 in order for each of the electromechanical components to operate during the dispensing time period.
  • the start timer mechanism 112 is a micro-electromechanical (MEM) mechanism having a sensor 118 (not shown in Fig. IA) for sensing the presence of a liquid, such as water, saliva, etc. When the capsule 100 is taken or administered, the sensor 118 senses the presence of a liquid, and transmits an electrical signal to the timing circuitry 110.
  • the start timer mechanism is a button which is pushed to transmit the electrical signal to the timing circuitry 110. The button is pushed just before the capsule 100 is administered to a person or animal.
  • this can be achieved by dissolving a thin, water soluble coating that separates two electrical contacts, enabling the switch to close the circuit.
  • the switch is manually triggered by the patient or caregiver.
  • the timing circuitry 110 Upon receiving the electrical signal, the timing circuitry 110 begins to clock the dispensing time period and to control the release controller 114 by transmitting a signal thereto.
  • the timing circuitry 110 includes a microprocessor programmed with the preset dispensing timing pattern for relaying the signal to the release controller 114, such that the medicament is dispensed during the dispensing time period substantially according to the preset dispensing timing pattern.
  • the voltage level of the signal relays the size of the valve opening for controlling the quantity of the medicament dispensed at each moment of the dispensing time period substantially according to the preset dispensing timing pattern.
  • the signal transmitted by the timing circuitry 110 to the release controller 114 only relays the opening and closing of the valve 106 and not the size of the valve opening.
  • the release controller 114 can, e.g., be a micro-electromechanical mechanism capable of receiving the signal from the timing circuitry 110 and generating a signal having a variable voltage level to the electronically controlled valve 106 for closing the valve 106 and controlling the size of the valve opening or degree of opening of the valve 106 (in accordance with the voltage level of the received signal).
  • the release controller 114 is a transistor or D/ A circuit that provides voltages to the valve 106 causing it to open or close.
  • the electronically controlled valve 106 can, e.g., be a micro-electromechanical mechanism capable of being electrically controlled by a signal having a variable voltage level. Each voltage level corresponds to a different size of the valve opening and one voltage level (or no voltage at all, i.e., no signal) corresponds to the valve 106 being closed.
  • the valve 106 is similar in operation to valves used in ink-jet printers for dispensing ink in accordance with the amount that the valve is opened.
  • the valve 106 is characterized as a micro fluidic valve for controlling the movement of minute amount of liquids or gases in a miniaturized system.
  • the reservoir 104 is a micro-syringe, whereby pressure applied to a plunger of the syringe dispenses the medicament via a needle tip of the micro-syringe which is in fluid communication with an opening in the shell 102.
  • the opening replaces the valve 106.
  • a check valve is placed at the needle tip of the micro-syringe to avoid leakage of the medicament during time periods within the dispensing time period where there should be no dispensing according to the preset dispensing timing pattern, and/or for controlling the quantity of medicament dispensed during the dispensing time period.
  • the pressure mechanism 116 is located outside the medicament reservoir 104 ensuring that the medicament is directed toward the valve 106.
  • the pressure mechanism 116 is a biodegradable spring as shown by Figure 1.
  • the pressure mechanism 116 can also be another type of spring, a piston, or any mechanism for performing the function of the pressure mechanism 116. That is, for performing the function of applying pressure to a piston-type member 130 when the valve 106 is open to push the piston-type member 130 towards the valve 106. As the piston-type member 130 moves towards the valve 106 pressure within the reservoir 104 causes the medicament to be dispensed. In an alternative embodiment, the medicament reservoir 104 is kept under pressure to assure that a proper quantity of medicament is dispensed in accordance with the degree of openness of the valve 106, without the need for the pressure mechanism 116. The pressure can be monitored by a pressure sensor which relays the monitored pressure to the control and timing circuitry 108. If the pressure is outside a predetermined range, the circuitry 108 can then adjust the valve opening to increase or decrease the pressure. The pressure of the reservoir 104 can be different for each medicament and can depend on the medicament's viscosity.
  • a look-up table or other data structure can be assessed by the circuitry 108 which correlates pressure, degree of valve opening, and other parameters, such as period of time in the dispensing time period, for determining, for example, the degree of valve opening by knowing the pressure, and vice versa. Based on the information obtained by assessing the look-up table, the circuitry 108 can then adjust the pressure, the valve opening, etc. These adjustments can be made in order to substantially track the preset dispensing timing pattern programmed within the capsule 100.
  • capsule 100 further comprises a stationary ring 120 which is coaxial with the longitudinal axis of the capsule 100. Along its outer diameter the ring 120 is joined to the inner wall of the shell 102.
  • a second ring 121 is disposed having an outer diameter corresponding to the inner diameter of the first ring 120.
  • the inner ring 121 is coaxially rotatable within the stationary ring 120 under the action of an electric driving means 122 such as a magnet coil.
  • the capsule 100 further comprises a fin 123 with the shape of a circle segment (Figs. IB, 1C and ID).
  • the fin 123 has one end with two projections 124, 125, each provided with an opening.
  • a pivot pin 126 joins the fin 123 with the stationary ring 120.
  • the inner ring 121 is provided with a radial slot 127 provided with a slider pin 128 pivotably connected to the fin 123.
  • driving means 122 Fig. IB
  • the inner ring 121 rotates relative to the stationary ring 120.
  • This movement forces the slider pin 128 to slide to the other end of the slot 127.
  • the fin 123 turns outwardly to an unfolded position, as shown in figure ID.
  • the fin 123 is shaped as a C-shaped segment having an outer edge with a radius corresponding to the outer radius of the capsule 100. In the folded position, as shown in figure 1C, the fin 123 is sunk in the capsule 100 and the outer edge of the fin 123 is flush with the outer surface of the capsule 100.
  • the fin can be made of a flexible material, e.g., the same or a similar material as listed above for the outer shell 102.
  • a pliant membrane 129 envelopes the capsule 100.
  • the pliant membrane 129 is glued to the tip of fins 123.
  • the membrane 129 comprises an opening 140 in line with release valve 106.
  • the opening 140 is defined by a membrane edge 141 glued to the outer shell 102 around the release valve 106.
  • FIGS 2 A - 2D show a different capsule 500 according to the present invention.
  • the same reference numbers are used for the same components as used for the embodiment shown in figures IA-D.
  • figures 2 A and 2b show the capsule 500 without the pliant membrane envelope.
  • Sunk in the outer shell 102 are a number of strips 150 of an electroactive polymer. The strips stretch in the longitudinal direction of the capsule and are equidistantially and coaxially disposed in a circular array. One end of each strip is permanently attached to the outer shell 102.
  • the electroactive polymer strips 150 can be bended under an electric voltage to an unfolded position, as shown in figure 2B. In this position, it stretches the pliant membrane 129 as shown in figure 2C.
  • the capsule 500 is a remote controlled capsule with an antenna 502 (see figure 2D) for receiving control signals, such as RF control signals, for remotely communicating commands or instructions to the capsule 500.
  • the antenna 502 may also transmit information from the capsule 500 to the outside as further described below.
  • the antenna can be provided in a folded configuration.
  • the capsule 500 operates substantially in the same manner as the capsule 100, except for the operational differences described below with respect to the former capsule's remote-control capabilities.
  • the capsule 500 includes the same components as the capsule 100 where identical reference numbers in figures IA-D and 2A-D identify similar components.
  • the control signals received by the capsule 500 are transmitted to RF communication circuitry 504 within the timing circuitry 110 via wire leads 506.
  • the RF communication circuitry 504 includes a receiver and processing circuitry for processing and analyzing the received RF control signals and accordingly determining one or more particular actions indicative of the instructions or codes provided by the control signals.
  • the actions are determined by correlating the instructions or codes with one or more actions using a data structure, such as a look-up table, within the timing circuitry 110.
  • the instructions provided by the control signals can include overriding the preset dispensing timing pattern programmed within the timing circuitry 110 for one or more moments in time during the dispensing time period. This may be necessary to dynamically increase or decrease the amount of medicament being dispensed during a particular time during the dispensing time period due to the person's vital functions at a particular moment in time and other factors.
  • the person's vital functions can be monitored using conventional systems and sensors.
  • One or more of these sensors can be provided within the capsule 500 itself for sensing the person's vital functions as the capsule 500 traverses the gastrointestinal tract and for transmitting the information to the timing circuitry 110 which in turn dynamically adjusts the dosage based on the person's sensed vital functions.
  • the instructions provided by the control signals can further change the dispensing timing pattern by reprogramming the timing circuitry 110 with a different dispensing timing pattern.
  • the control signals can further provide instructions as to which moment in time of the new dispensing timing pattern the dispensing of the medicament should commence.
  • the new dispensing timing pattern can be transmitted via the control signals or be stored within a memory of the timing circuitry 110, where the memory includes a plurality of dispensing timing patterns and the control signals indicate which dispensing timing pattern is desired.
  • the control signals can also instruct the control and timing circuitry 108 to terminate the dispensing of the medicament within the body, in case the wrong medicament was administered, the wrong dose was prescribed, the person had an adverse reaction to the medicament, etc.
  • the control signals can further instruct the control and timing circuitry 108 to release a bowel slowing medication, such as Lomotil®, stored within a reservoir or micro- sac for temporarily halting the progress of the capsule 500 through the gastrointestinal tract.
  • the bowel slowing medication can be released in tandem with the medicament stored within the reservoir 104.
  • the bowel slowing medication can also be provided within a separate capsule.
  • the generation and transmission of the control signals can be synchronized with an external system, such as an MRI system, ultrasound imaging system, etc., for dispensing the medicament in accordance with the person's vital functions monitored by the external system, the mode of operation of the external system, etc.
  • the medicament can be an oral contrast agent used to enhance diagnostic images.
  • the control signals may for instance transmit unique identification information which is used by the timing circuitry 110 to ensure that the received control signals are for the respective capsule 500. This prevents control signals from initiating an action to a capsule 500 other than the intended capsule 500.
  • the identification information can be a unique serial number which is programmed within the timing circuitry 110. If the received serial number does not match the programmed serial number, the timing circuitry 110 does not respond to the received control signals. Accordingly, the timing circuitry 110 does not perform any action, such as the actions described above.
  • the communication circuitry 504 includes a transmitter for transmitting signals from the capsule 500.
  • the signals are generated by the communication circuitry 504 for providing information to a caregiver or the person.
  • Information that can be provided includes the particular moment in time of the dispensing time period; the cumulative quantity of medicament dispensed from the beginning of the dispensing time period to a particular moment in time of the dispensing time period; the average quantity of medicament dispensed during each moment in time of the dispensing time period (e.g., each second); etc.
  • the transmitter can provide a signal for alerting or notifying a caregiver or the person that the capsule 500 has been taken, in case the caregiver or the person do not remember if the capsule 500 was or was not taken.
  • the transmitter can also provide a signal if the capsule 500 after diagnostic tests are executed by the control and timing circuitry 108 and it is determined that the capsule 500 has malfunctioned, in cases such as if the capsule 500 is not dispensing the medicament, the medicament is not being dispensed according to the preset dispensing timing pattern, etc.
  • the capsule 500 includes an optional RFID tag 508 for tracking, identification, inventory and other purposes using an RFID reading system.
  • the RFID tag 508 can also be used to determine if the capsule 500 was administered by a caregiver or taken by the person, and if so, the RFID tag 508 can be used to determine the general location of the capsule 500 within the gastrointestinal tract.
  • the capsule 500 further includes a piezo-electric element and associated circuitry 510 for remotely transmitting commands via the communication circuitry 504 to the timing circuitry 110 for remotely controlling the capsule 500.
  • the element 510 is can be affixed to the housing 102 and is capable of being vibrated at one or more predetermined frequencies. The vibration is caused by placing an ultrasound probe, hydrophone or other vibration-causing device in proximity to the person.
  • the frequencies caused by the element 510 are converted to electrical signals by the associated circuitry.
  • the electrical signals are transmitted to the timing circuitry 110 via wire lead 512 where they are processed for determining an action to perform.
  • the action can be one of the actions described above with reference to the control signals provided to the timing circuitry 110 via the wire leads 506.
  • the action is can, e.g., be determined by correlating the vibration of the element 510 to an action using a data structure, such as a lookup table, stored within the control and timing circuitry 108 and accessible by the timing circuitry 110.

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Abstract

La présente invention concerne une capsule (100, 500) pouvant être ingérée et comprenant au moins un élément (123, 150) qui peut être déplié et qui peut être déplacé de façon sélective entre une position pliée et une position dépliée, un circuit de commande conçu pour commander le pliage et le dépliage de l'élément pouvant être déplié, ainsi qu'une membrane souple (129) qui recouvre l'élément pouvant être déplié. Le dépliage des éléments pouvant être dépliés permet de prolonger le temps de séjour dans le tube digestif.
PCT/IB2008/054673 2007-11-13 2008-11-07 Capsule électronique pouvant être ingérée WO2009063376A1 (fr)

Applications Claiming Priority (2)

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US98747907P 2007-11-13 2007-11-13
US60/987,479 2007-11-13

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WO2009063376A1 true WO2009063376A1 (fr) 2009-05-22

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2460456A1 (fr) * 2010-12-02 2012-06-06 Chung-Shan Institute of Science and Technology, Armaments, Bureau, Ministry of National Defense Endoscope à capsule extensible
US11179341B2 (en) 2017-05-17 2021-11-23 Massachusetts Institute Of Technology Self-righting articles
US11202903B2 (en) 2018-05-17 2021-12-21 Massachusetts Institute Of Technology Systems for electrical stimulation
US11541016B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
US11771829B2 (en) 2019-02-01 2023-10-03 Massachusetts Institute Of Technology Systems and methods for liquid injection

Citations (4)

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Publication number Priority date Publication date Assignee Title
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