WO2009062136A3 - Controlled delivery of insulin from thermo-sensitive polymer solution - Google Patents

Controlled delivery of insulin from thermo-sensitive polymer solution Download PDF

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Publication number
WO2009062136A3
WO2009062136A3 PCT/US2008/082938 US2008082938W WO2009062136A3 WO 2009062136 A3 WO2009062136 A3 WO 2009062136A3 US 2008082938 W US2008082938 W US 2008082938W WO 2009062136 A3 WO2009062136 A3 WO 2009062136A3
Authority
WO
WIPO (PCT)
Prior art keywords
insulin
pla
thermo
polylactic acid
polymer solution
Prior art date
Application number
PCT/US2008/082938
Other languages
French (fr)
Other versions
WO2009062136A2 (en
Inventor
Jagdish Singh
Khaled Al-Tahami
Original Assignee
Ndsu Res Foundation
Jagdish Singh
Khaled Al-Tahami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ndsu Res Foundation, Jagdish Singh, Khaled Al-Tahami filed Critical Ndsu Res Foundation
Publication of WO2009062136A2 publication Critical patent/WO2009062136A2/en
Publication of WO2009062136A3 publication Critical patent/WO2009062136A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Biodegradable and temperature sensitive triblock copolymers are capable of releasing a drug over a sustained period of time. The polymers are polylactic acid-polyethylene glycol-polylactic acid (PLA-PEG-PLA) triblock polymers of varying molecular weight and chain lengths which are combined with insulin to provide a patient with zero order insulin release such that a constant delivery of insulin mimics basal insulin released from a healthy pancreas for a period of up to three months. The insulin provided is chemically and conformationally stable and biologically active. Methods for providing sustained-release drugs and a method for treating diabetes are disclosed.
PCT/US2008/082938 2007-11-08 2008-11-10 Controlled delivery of insulin from thermo-sensitive polymer solution WO2009062136A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98645107P 2007-11-08 2007-11-08
US60/986,451 2007-11-08

Publications (2)

Publication Number Publication Date
WO2009062136A2 WO2009062136A2 (en) 2009-05-14
WO2009062136A3 true WO2009062136A3 (en) 2009-07-30

Family

ID=40626465

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/082938 WO2009062136A2 (en) 2007-11-08 2008-11-10 Controlled delivery of insulin from thermo-sensitive polymer solution

Country Status (1)

Country Link
WO (1) WO2009062136A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140205671A1 (en) * 2013-01-18 2014-07-24 Nano And Advanced Materials Institute Limited Synthesis and use of polyhydroxyalkanoate (pha) nanocapsules as a protein carrier
WO2016175752A1 (en) 2015-04-27 2016-11-03 Halliburton Energy Services, Inc. Delayed-release additives in a degradable matrix
CN109054028B (en) * 2018-06-27 2021-01-29 湘潭大学 Temperature-controllable easily-degradable temperature-sensitive polymer and preparation method thereof
CN112870374B (en) * 2021-01-24 2023-08-08 南开大学 Preparation of sugar-responsive functionalized nano-composite micelle and application thereof in insulin delivery

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6592899B2 (en) * 2001-10-03 2003-07-15 Macromed Incorporated PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water
WO2006023388A2 (en) * 2004-08-16 2006-03-02 Macromed, Inc. Biodegradable diblock copolymers having reverse thermal gelation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6592899B2 (en) * 2001-10-03 2003-07-15 Macromed Incorporated PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water
WO2006023388A2 (en) * 2004-08-16 2006-03-02 Macromed, Inc. Biodegradable diblock copolymers having reverse thermal gelation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JEONG, B. ET AL.: "Thermogelling biodegradable polymers with hydrophilic backbones: PEG-g- PLGA.", MACROMOLECULES., vol. 33, 2000, pages 8317 - 8322 *
JO, S. ET AL.: "Reverse thermal gelation of aliphatically modified biodegradable triblock copolymer.", MACROMOLECULAR BIOSCIENCE., vol. 6, 2006, pages 923 - 928 *

Also Published As

Publication number Publication date
WO2009062136A2 (en) 2009-05-14

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