WO2009061131A3 - Novel tricyclic derivatives or pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical composition comprising the same - Google Patents
Novel tricyclic derivatives or pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical composition comprising the same Download PDFInfo
- Publication number
- WO2009061131A3 WO2009061131A3 PCT/KR2008/006527 KR2008006527W WO2009061131A3 WO 2009061131 A3 WO2009061131 A3 WO 2009061131A3 KR 2008006527 W KR2008006527 W KR 2008006527W WO 2009061131 A3 WO2009061131 A3 WO 2009061131A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preparation
- pharmaceutically acceptable
- pharmaceutical composition
- acceptable salts
- tricyclic derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4743—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having sulfur as a ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
The present invention relates to novel tricyclic derivatives having an excellent inhibitory activity on poly (ADP-ribose) polymerase, or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The tricyclic derivatives of the present invention inhibit the activity of poly (ADP-ribose) polymerase, thereby being used for the prevention or treatment of diseases that are caused by excessive activation of PARP, in particular, neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic neuropathic pain, inflammatory diseases, osteoporosis, and cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020070112573A KR101179753B1 (en) | 2007-11-06 | 2007-11-06 | Novel tricyclic derivatives or pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical composition comprising the same |
KR10-2007-0112573 | 2007-11-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009061131A2 WO2009061131A2 (en) | 2009-05-14 |
WO2009061131A3 true WO2009061131A3 (en) | 2009-06-25 |
Family
ID=40626341
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2008/006527 WO2009061131A2 (en) | 2007-11-06 | 2008-11-06 | Novel tricyclic derivatives or pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical composition comprising the same |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR101179753B1 (en) |
WO (1) | WO2009061131A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010056038A2 (en) * | 2008-11-11 | 2010-05-20 | 제일약품주식회사 | Novel tricyclic derivative or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same |
US8609672B2 (en) | 2010-08-27 | 2013-12-17 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
WO2013008217A1 (en) | 2011-07-13 | 2013-01-17 | Novartis Ag | 4 - piperidinyl compounds for use as tankyrase inhibitors |
CN103781776A (en) | 2011-07-13 | 2014-05-07 | 诺华股份有限公司 | Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors |
EP2731951B1 (en) * | 2011-07-13 | 2015-08-19 | Novartis AG | 4-oxo-3,5,7,8-tetrahydro-4h-pyrano {4,3-d} pyrminidinyl compounds for use as tankyrase inhibitors |
US10464919B2 (en) * | 2015-06-09 | 2019-11-05 | Je Il Pharmaceutical Co., Ltd. | Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same |
CN107602446B (en) * | 2016-07-12 | 2020-04-07 | 中国科学院上海药物研究所 | 1, 4-disubstituted-1, 2,3, 6-tetrahydropyridine compound, preparation method thereof, pharmaceutical composition and application thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0009386A1 (en) * | 1978-09-22 | 1980-04-02 | Pfizer Inc. | 2,10-Disubstituted dibenzo(b,d)pyrans and benzo(c)quinolines and pharmaceutical compositions thereof |
WO2002028183A1 (en) * | 2000-09-19 | 2002-04-11 | Syngenta Limited | Fungicides |
WO2003080581A1 (en) * | 2002-03-26 | 2003-10-02 | Fujisawa Pharmaceutical Co., Ltd. | Phenanthridinones as parp inhibitors |
-
2007
- 2007-11-06 KR KR1020070112573A patent/KR101179753B1/en not_active IP Right Cessation
-
2008
- 2008-11-06 WO PCT/KR2008/006527 patent/WO2009061131A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0009386A1 (en) * | 1978-09-22 | 1980-04-02 | Pfizer Inc. | 2,10-Disubstituted dibenzo(b,d)pyrans and benzo(c)quinolines and pharmaceutical compositions thereof |
WO2002028183A1 (en) * | 2000-09-19 | 2002-04-11 | Syngenta Limited | Fungicides |
WO2003080581A1 (en) * | 2002-03-26 | 2003-10-02 | Fujisawa Pharmaceutical Co., Ltd. | Phenanthridinones as parp inhibitors |
Also Published As
Publication number | Publication date |
---|---|
KR101179753B1 (en) | 2012-09-04 |
KR20090046431A (en) | 2009-05-11 |
WO2009061131A2 (en) | 2009-05-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2010056038A2 (en) | Novel tricyclic derivative or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same | |
WO2009061131A3 (en) | Novel tricyclic derivatives or pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical composition comprising the same | |
WO2008061720A3 (en) | Use of tricyclic diterpenes and their derivatives for the treatment, co-treatment or prevention of inflammatory disorders and/or joint disorders | |
WO2012019426A8 (en) | Phthalazinone derivative, and preparation method and pharmaceutical use thereof | |
WO2006102610A3 (en) | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof | |
WO2007109172A3 (en) | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof | |
WO2012019430A8 (en) | Phthalazinone derivative, and preparation method and pharmaceutical use thereof | |
WO2008070041A3 (en) | Inhibitors of akt activity | |
WO2007022225A3 (en) | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof | |
WO2007109160A3 (en) | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof | |
WO2009064460A3 (en) | Gastrointestinal delivery systems | |
WO2007109154A3 (en) | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof | |
WO2007149907A3 (en) | Pyrazoloquinazolinones as parp inhibitors | |
WO2006091395A3 (en) | Inhibitors of akt activity | |
WO2009043353A3 (en) | Micromirs | |
WO2012019427A8 (en) | Phthalazinone ketone derivative, preparation method thereof, and pharmaceutical use thereof | |
WO2006135627A3 (en) | Inhibitors of akt activity | |
WO2007127474A3 (en) | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors | |
WO2008118332A3 (en) | Hydrazido-peptides as inhibitors of hcv ns3-protease | |
WO2007109182A3 (en) | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof | |
WO2007109201A3 (en) | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof | |
WO2007131016A3 (en) | Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors | |
WO2008070268A3 (en) | Pharmaceutical compositions | |
WO2006110638A3 (en) | Inhibitors of akt activity | |
WO2007028022A3 (en) | Novel compounds as p2x7 modulators and uses thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 08846727 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 08846727 Country of ref document: EP Kind code of ref document: A2 |