WO2009060486A1 - Procede d'aspiration de produit liquide contenu dans une bouteille au moyen d'une seringue - Google Patents

Procede d'aspiration de produit liquide contenu dans une bouteille au moyen d'une seringue Download PDF

Info

Publication number
WO2009060486A1
WO2009060486A1 PCT/IT2007/000791 IT2007000791W WO2009060486A1 WO 2009060486 A1 WO2009060486 A1 WO 2009060486A1 IT 2007000791 W IT2007000791 W IT 2007000791W WO 2009060486 A1 WO2009060486 A1 WO 2009060486A1
Authority
WO
WIPO (PCT)
Prior art keywords
bottle
product
cannula
closing membrane
syringe
Prior art date
Application number
PCT/IT2007/000791
Other languages
English (en)
Inventor
Claudio Loccioni
Sandro Bartolucci
Original Assignee
Aea S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aea S.R.L. filed Critical Aea S.R.L.
Priority to PCT/IT2007/000791 priority Critical patent/WO2009060486A1/fr
Publication of WO2009060486A1 publication Critical patent/WO2009060486A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2072—Venting means for internal venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • A61M2005/1623—Details of air intake
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/1782—Devices aiding filling of syringes in situ
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft

Definitions

  • the present invention relates to a method for drawing in a liquid product from a bottle using a syringe.
  • the present invention finds particularly advantageous application in drawing in liquid pharmaceutical products, to • which the following description will make explicit reference, without loosing generality.
  • Figures 1-4 are schematic illustrations, in side elevation, of four different operating steps of a preferred embodiment of the method of the present invention.
  • the bottle 2 has a given longitudinal axis 4 ' and is closed, at an open end thereof, by a perforable elastic membrane 5, whilst the syringe 3 has a given longitudinal axis 6 and comprises a containment cylinder 7, a piston 8 slidably engaged in the cylinder 7, and a suction needle 9 engaged to the cylinder 7 itself.
  • the needle 9 comprises an engagement element 10, which is connected to the cylinder 7, and is provided with a- plurality of air-relief channels 11, which extend parallel to the axis 6, are uniformly distributed about the axis 6, and are made on an outer surface of the element 10 itself.
  • the needle 9 moreover comprises a suction cannula 12 fitted on the element 10 parallel to the axis 6.
  • drawing in the pharmaceutical product from the bottle 2 is performed by setting- the bottle 2 with the membrane 5 facing downwards, orienting the axis 4 of the bottle 2 parallel to a direction 13 set according to an angle different from 0° with respect to a substantially vertical direction 14, setting the syringe 3 with the needle 9 facing upwards, orienting the axis 6 of the syringe 3 according to an angle different from 0° with respect to the direction 14, in the case in point parallel to the direction 13, and displacing the bottle 2 and the syringe 3 with respect to one another in the direction 13 at a relatively high speed to enable the cannula 12 to perforate the membrane ' 5.
  • the speed of perforation of the membrane 5 is in any case higher than the average speed normally used for displacing the syringe 3 and for displacing the cylinder 7 and the piston 8 with respect to one another.
  • the inclination of the axes 4 and 6 with respect to the vertical direction 14 and the relatively high speed of perforation of the membrane 5 guarantee a relatively high seal between the cannula 12 and the membrane 5 itself and enable prevention of dripping and leakage of pharmaceutical product from the bottle 2.
  • the inclination of the axes 4 and 6 with respect to the vertical direction 14 moreover enables orientation of possible air bubbles present within the bottle 2 along a path substantially parallel to the direction 14 and . hence prevention of their suction into the needle 9 and the cylinder 7.
  • the piston 8 is displaced along the cylinder 7 so as to enable the needle 9 to draw in a first amount of pharmaceutical product from the bottle 2.
  • the pressure within the bottle 2 decreases so as to be, at the. end of the first suction step, lower than the pressure within the cylinder 7.
  • the bottle 2 and the syringe 3 are then displaced with respect to one another in the direction 13 so . as to enable the element 10 to traverse the membrane 5 and enable the channels 11 to connect the inside of the bottle 2 to the external environment .
  • drawing in the second amount of pharmaceutical product from the bottle 2 must be interrupted at the latest when the level of the pharmaceutical product in the bottle 2 substantially corresponds to an inlet hole (not illustrated) of the cannula 12 so as to prevent the needle 9 from sucking air into the cylinder 7.
  • the bottle 2 and the syringe 3 are displaced with respect to one another in the direction 13 for disengaging the element 10 again from the membrane 5, the cannula 12 is kept inside the bottle 2, the axis 4 of the bottle 2 is oriented parallel to the direction 14, and the axis 6 of the syringe 3 is kept parallel to the direction 13.
  • the piston 8 is displaced again along the cylinder 7 to enable the needle 9 to draw in a third amount of pharmaceutical product from the bottle 2.
  • the orientation of the axes 4 and 6 enables guaranteeing of a high seal between the membrane 5 and the cannula 12 and hence prevention of dripping and leakage of pharmaceutical product from the bottle 2.
  • drawing-in of the third amount of pharmaceutical product from the bottle 2 must be interrupted at the latest., when the level of the pharmaceutical product in the bottle 2 substantially corresponds to the aforesaid inlet hole (not illustrated) of the cannula 12 so as to prevent the needle 9 from sucking air into the cylinder 7.
  • the axis 4 of the bottle 2 is oriented again parallel to the direction 13 , the axis 6 of the syringe 3 is kept parallel to the direction 13 , and the bottle 2 and the syringe 3 are displaced with respect to one another in the direction 13 with a relatively low speed for disengaging the cannula 12 from the membrane 5 and from the bottle 2.
  • the relatively low speed of extraction of the cannula 12 from the membrane 5, which is in any case lower than the speed of perforation of the membrane 5 itself, enables the bottle 2 to be set in communication with the external environment so as to bring about ah increase in the pressure within the bottle 2 up to a value substantially equal to atmospheric pressure.
  • the piston 8 is displaced again along the cylinder 7 to draw the pharmaceutical product contained in the needle 9 into the cylinder 7, thus preventing any possible dripping of pharmaceutical product from the needle 9 itself.

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un procédé d'aspiration d'un produit liquide contenu dans une bouteille (2) au moyen d'une seringue (3). La seringue comprend une aiguille (9) définie par une canule d'aspiration (12) ajustée sur un élément de contact (10) comportant au moins un canal d'évacuation d'air (11), permettant la perforation d'une membrane (5) assurant la fermeture de la bouteille (2). Ce procédé consiste à maintenir la bouteille (2) et la seringue (3) inclinées par rapport à un sens de référence vertical (14) et à aspirer du produit liquide en respectant au moins trois étapes d'aspiration distinctes lors desquelles le canal d'évacuation d'air (11) est déplacé, respectivement, à l'extérieur, à l'intérieur et à nouveau à l'extérieur de la bouteille (2).
PCT/IT2007/000791 2007-11-08 2007-11-08 Procede d'aspiration de produit liquide contenu dans une bouteille au moyen d'une seringue WO2009060486A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IT2007/000791 WO2009060486A1 (fr) 2007-11-08 2007-11-08 Procede d'aspiration de produit liquide contenu dans une bouteille au moyen d'une seringue

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IT2007/000791 WO2009060486A1 (fr) 2007-11-08 2007-11-08 Procede d'aspiration de produit liquide contenu dans une bouteille au moyen d'une seringue

Publications (1)

Publication Number Publication Date
WO2009060486A1 true WO2009060486A1 (fr) 2009-05-14

Family

ID=39595615

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2007/000791 WO2009060486A1 (fr) 2007-11-08 2007-11-08 Procede d'aspiration de produit liquide contenu dans une bouteille au moyen d'une seringue

Country Status (1)

Country Link
WO (1) WO2009060486A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2409343A (en) * 1943-04-05 1946-10-15 Macalaster Bicknell Company Fluid inlet-outlet device, particularly for clinical purposes
US2541272A (en) * 1947-04-24 1951-02-13 John T Murphy Needle for filling or exhausting ampoules
US3063451A (en) * 1959-09-28 1962-11-13 Arthur J Kowalk Self-venting type needle
US6135172A (en) * 1997-08-20 2000-10-24 Junior Instruments Device for sampling and/or injecting inside a plugged sample tube
WO2002076374A1 (fr) * 2001-03-27 2002-10-03 Eli Lilly And Company Trousse incluant une aiguille de seringue a injection laterale pour preparer un medicament dans une cartouche de stylo injecteur
WO2004096114A1 (fr) * 2003-04-28 2004-11-11 Glaxosmithkline Biologicals S.A. Dispositif d'introduction d'un liquide dans un recipient pharmaceutique

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2409343A (en) * 1943-04-05 1946-10-15 Macalaster Bicknell Company Fluid inlet-outlet device, particularly for clinical purposes
US2541272A (en) * 1947-04-24 1951-02-13 John T Murphy Needle for filling or exhausting ampoules
US3063451A (en) * 1959-09-28 1962-11-13 Arthur J Kowalk Self-venting type needle
US6135172A (en) * 1997-08-20 2000-10-24 Junior Instruments Device for sampling and/or injecting inside a plugged sample tube
WO2002076374A1 (fr) * 2001-03-27 2002-10-03 Eli Lilly And Company Trousse incluant une aiguille de seringue a injection laterale pour preparer un medicament dans une cartouche de stylo injecteur
WO2004096114A1 (fr) * 2003-04-28 2004-11-11 Glaxosmithkline Biologicals S.A. Dispositif d'introduction d'un liquide dans un recipient pharmaceutique

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