WO2009060412A2 - Procédé et système d'analyse biologique utilisant un dispositif de communication mobile - Google Patents

Procédé et système d'analyse biologique utilisant un dispositif de communication mobile Download PDF

Info

Publication number
WO2009060412A2
WO2009060412A2 PCT/IB2008/054655 IB2008054655W WO2009060412A2 WO 2009060412 A2 WO2009060412 A2 WO 2009060412A2 IB 2008054655 W IB2008054655 W IB 2008054655W WO 2009060412 A2 WO2009060412 A2 WO 2009060412A2
Authority
WO
WIPO (PCT)
Prior art keywords
optical sensor
optical
sample
interface
luminescence
Prior art date
Application number
PCT/IB2008/054655
Other languages
English (en)
Other versions
WO2009060412A3 (fr
Inventor
Pablo Garcia Tello
Original Assignee
Nxp B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nxp B.V. filed Critical Nxp B.V.
Publication of WO2009060412A2 publication Critical patent/WO2009060412A2/fr
Publication of WO2009060412A3 publication Critical patent/WO2009060412A3/fr

Links

Classifications

    • G—PHYSICS
    • G08—SIGNALLING
    • G08C—TRANSMISSION SYSTEMS FOR MEASURED VALUES, CONTROL OR SIMILAR SIGNALS
    • G08C19/00—Electric signal transmission systems
    • G08C19/36—Electric signal transmission systems using optical means to covert the input signal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G01N21/763—Bioluminescence
    • G—PHYSICS
    • G08—SIGNALLING
    • G08C—TRANSMISSION SYSTEMS FOR MEASURED VALUES, CONTROL OR SIMILAR SIGNALS
    • G08C23/00—Non-electrical signal transmission systems, e.g. optical systems
    • G08C23/04—Non-electrical signal transmission systems, e.g. optical systems using light waves, e.g. infrared
    • G—PHYSICS
    • G08—SIGNALLING
    • G08C—TRANSMISSION SYSTEMS FOR MEASURED VALUES, CONTROL OR SIMILAR SIGNALS
    • G08C2201/00—Transmission systems of control signals via wireless link
    • G08C2201/90—Additional features
    • G08C2201/93—Remote control using other portable devices, e.g. mobile phone, PDA, laptop

Definitions

  • the present invention relates generally to bio-analysis and, more particularly, to pathogen detection using a mobile communication device.
  • test devices require purchase of relatively expensive testing equipment.
  • some testing procedures use optical sensors in combination with processing circuits to provide the test results.
  • the results from the testing devices are not easily communicated to a central site.
  • Various aspects of the present invention are directed to methods and arrangements for implementing processor power state transitions in a manner that addresses and overcomes the above-mentioned issues.
  • the present invention is directed to a wireless communication device that has a wireless transceiver and audio transducers for bi-directional audio communications using the wireless transceiver.
  • the device has an optical sensor that provides optical data in response to optical stimulus and an optical sensor interface for directing luminescence from the sample to the optical sensor.
  • a control circuit is also included for receiving the optical data from the optical sensor and interpreting the optical data to determine a level of luminescence received by the optical sensor and for providing the optical data to the wireless transceiver for transmission thereof.
  • the present invention is directed to an optical interface that directs light to an optical sensor.
  • the optical sensor is part of a wireless communication device.
  • the interface is for use in microbial analysis.
  • the microbial analysis is based upon readings obtained from the optical sensor.
  • the interface has a reservoir for mixing the sample with a reagent to generate luminescence indicative of the level of microbial matter present.
  • An adjustable securing mechanism secures the reservoir to the wireless communication device, and an optical arrangement directs light from the reservoir to the optical sensor.
  • FIG. 1 shows a block diagram of a mobile device implemented according to an example embodiment of the present invention
  • FIG. 2 shows a block diagram of a mobile device having a camera implemented according to an example embodiment of the present invention
  • FIG. 3 shows a block diagram showing the functionality of a sample holder implemented according to an embodiment of the present invention
  • FIG. 4 shows a block diagram showing the use of a calibration unit for use with an embodiment of the present invention
  • FIG. 5 shows a flow diagram of a method for use with an embodiment of the present invention.
  • FIG. 6 shows an adjustable sample holder for placement over a digital camera lens, according to an example embodiment of the present invention.
  • a mobile device such as a phone
  • an optical sensor is equipped with an optical sensor.
  • a biological sample is placed within an optical interface.
  • a luminescence agent is applied to the biological sample to generate luminescence in response to the presence of substances indicative of microorganisms (e.g., bacteria, protozoa, fungi or algae).
  • the optical interface allows the generated luminescence to be detected by the optical sensor.
  • a processing circuit processes resultant data by the optical sensor.
  • the processed data can then be used to determine the presence and/or amount of microorganisms present.
  • the processed data and/or the determined information can be sent using a wireless transceiver of the mobile phone.
  • a mobile phone has a digital camera.
  • a biological sample is placed within a digital camera interface.
  • a luminescence agent is applied to the biological sample to generate luminescence in response to the presence of substances indicative of microorganisms (e.g., bacteria, protozoa, fungi or algae).
  • the digital camera interface allows the generated luminescence to be detected by the digital camera.
  • a processor circuit is configured to determine the presence and/or amount of microorganisms present based upon the intensity/amount of detected luminescence.
  • the processed data and/or the determined information can be sent using a wireless transceiver of the mobile phone.
  • the use of the digital camera can be particularly useful for using existing or slightly modified mobile phone technology thereby allowing ease of implementation and reduction in costs.
  • Digital cameras can be implemented using an array of light sensors, such as charge-coupled devices (CCD) or CMOS sensors. Depending upon the necessary sensitivity, any number of pixel sensors can be used to determine the level of luminescence. Consistent with another example embodiment of the present invention, a mobile phone has an optical sensor, such as a photodiode, specifically designed for use in detecting luminescence from a biological sample.
  • CCD charge-coupled devices
  • CMOS sensors complementary metal-coupled devices
  • any number of pixel sensors can be used to determine the level of luminescence.
  • a mobile phone has an optical sensor, such as a photodiode, specifically designed for use in detecting luminescence from a biological sample.
  • FIG. 1 shows a block diagram of a mobile device implemented according to an example embodiment of the present invention.
  • Mobile device 100 includes a wireless transceiver 108 for communicating with a remote base- station (not shown).
  • mobile device 100 functions as a mobile communication device using, for example, audio transducers 110.
  • Mobile device 100 provides pathogen detection of a sample 102. The pathogen is detected using optical sensor 104.
  • Processing circuit 106 processes the signals from optical sensor 104, audio transducers 110 and wireless transceiver 108.
  • Processing circuit 106 receives signals from the optical sensor 104 that are indicative of the presence (or lack thereof) of various pathogens.
  • the received signals are processed for transmission using wireless transceiver 108.
  • the results of a pathogen test can be sent to a remote site for further processing, analysis or storage.
  • other relevant information can also be included.
  • possible additional information includes, but is not limited to, a time and date stamp, location indication, a mobile device identifier or input from the mobile device operator.
  • a graphical user interface (GUI) could be implemented to allow the user of the device to select from different options and add information to a transmission.
  • the test results can also be stored locally. This locally stored information can then be used as a backup of the information as well as for auditing of the information received and stored at the remote site.
  • the mobile device 100 can receive testing instructions from the remote site.
  • the remote site may request additional samples or instruct the user of the device in some manner.
  • the sample 102 is treated with a chemical reagent that reacts with pathogens to produce light.
  • Optical sensor 104 detects the presence and/or amount of pathogens in the sample 102 by detecting the amount of light produced.
  • a specific embodiment involves the detection of adenosine triphosphate (ATP).
  • the chemical reagent can include, for example, green fluorescent proteins (GFP) or liciferin/luciferase.
  • mobile device 100 is a cellular phone.
  • the cellular phone is communicates with remote devices by connecting to cellular towers. This can be particularly useful for using existing infrastructure to transmit the testing data.
  • the mobile device 100 is a satellite phone.
  • the satellite phone communicates with remote devices by connecting to satellites.
  • test-related information can be transmitted using any number of different protocols and methods including, but not limited to, text messaging, direct data transfer and packet-based communications.
  • packet-based communications could be implemented using e-mail or through a website.
  • a direct connection can be implemented using modem technology.
  • FIG. 2 shows a block diagram of a mobile device having a camera implemented according to an example embodiment of the present invention.
  • Mobile device 200 includes wireless transceiver 200, a processing circuit 206, audio transducers 210 and optical sensor 204.
  • optical sensor 204 is used as a digital camera for capturing images.
  • Processing circuit 206 processes data received from the optical sensor 204 to generated images that can be stored or transmitted by the mobile device.
  • Optical sensor 204 is also used to detect the presence of pathogens in sample 202.
  • Processing circuit 206 processes the data from optical sensor 204.
  • customized software is installed on the mobile device phone. The software controls the processing of data from optical sensor so as to allow for correct interpretation of data received during a pathogen detection test. Software can be used to determine the amount of luminescence received from the sample holder. This data can then be displayed and stored on the mobile device and/or transmitted using wireless transceiver 208.
  • Specialized software can be installed on the mobile phone to interface with the sample holder.
  • the software can be installed in any number of different manners including, but not limited to, during the manufacturing process, by a merchant or mobile service provider, downloading via the Internet or using a non-volatile memory device.
  • the sample holder includes a non- volatile memory with the specialized software.
  • the sample holder can be interfaced with the mobile device using any number of data transfer techniques including, but not limited to, Universal Serial Bus interfaces, Firewire interfaces, modem interfaces or infrared interfaces.
  • FIG. 3 shows a block diagram showing the functionality of a sample holder implemented according to an embodiment of the present invention. Swab 302 is used to collect the test sample from the desired location.
  • swab 302 is placed in container 304.
  • container 304 contains a solution that mixes with the test sample.
  • a luminescent/reagent 306 e.g., green fluorescent proteins (GFP) or liciferin/luciferase
  • GFP green fluorescent proteins
  • Detector 308 is used to determine the level of light given off from the mixture.
  • the sample holder produces a signal that is received by the processor of the mobile device.
  • the signal indicates that the luminescent 306 has been introduced to the solution.
  • the mobile device is then able to determine when the proper time for measuring the level of light given off from the mixture.
  • the combination of the reagent and sample may only produce significant levels of light during a certain window of time.
  • the indication of when the reagent was introduced can be used to collect readings from the optical sensor during the proper window of time.
  • the user of the device can manually press a button on the mobile phone to indicate when the reagent was activated.
  • FIG. 4 shows a block diagram showing the use of a calibration unit for use with an embodiment of the present invention.
  • Calibration unit 402 provides a known quantity of light.
  • the software 212 compares the detection level of the optical sensor 204 to the known quantity of light. The comparison can then be used as a baseline for subsequent (or previous) bio-analysis measurements.
  • This calibration is particularly useful for use with a large variety of optical sensors and configurations thereof.
  • calibration unit 402 can provide a number of different light intensities sequentially. This can be particularly useful for setting a plurality of threshold levels for bio-analysis of a sample.
  • software 212 can control the light intensity levels of the calibration unit through an acceptable communications interface.
  • FIG. 5 shows a flow diagram of a method for use with an embodiment of the present invention.
  • the mobile device is configured for bio-analysis. This can include software configuration, programmable logic configuration and/or discrete component configuration. The configuration can be accomplished during manufacture of the mobile device, after purchase by a user of the mobile device or anytime therebetween.
  • a sample holder or calibration unit is attached to the mobile device. This step may not be necessary where the sample holder/calibration unit is an integral part of the mobile device.
  • step 506 is another optical step during which the mobile device can be calibrated for future use.
  • the sample under test is placed in the sample holder.
  • the optical sensor detects luminescence originating in the sample holder due to the presence of the biological component being tested for (e.g., ATP).
  • the results of testing step 510 can be stored locally, displayed locally and/or wirelessly transmitted to a remote location.
  • FIG. 6 shows an adjustable sample holder for placement over a digital camera lens, according to an example embodiment of the present invention.
  • the sample holder can be a detachable holder that interfaces with the mobile device. This allows for the sample holder to be detached from the mobile device when the device is not being used for bio-analysis. This can also be particularly useful for use with a variety of off-the- shelf mobile devices/phones.
  • the sample holders can be specifically designed for use with one or more mobile phones.
  • the sample holders can be designed with a generic interface that works with a variety of different mobile phones.
  • Such a generic sample holder can include an adjustable attachment
  • the attachment mechanism can be implemented as a clip, strap, hook and loop fastener, snap, magnetic or any other suitable attachment mechanism.
  • the sample holder can also be implemented with an adjustable aperture 602.
  • Aperture 602 can be moved along both vertical and horizontal axes 604 and 602, respectively, thereby aligning the aperture with the optical sensor.
  • the size of aperture 602 can also be adjusted.
  • Such flexibility can be particularly useful for reducing the amount of ambient light from external sources, such as a display of the phone.
  • Various optical arrangements can be used to directed light from a reservoir of the sample holder to the optical sensor. For instance, a combination of one or more mirrors and lenses can be used to direct the light toward the optical sensor. In one instance, the light can be directed through a fiber optic cable to the optical sensor.
  • processing circuits may be implemented using a variety of approaches, including one or more of digital signal processors, general purposes processors, programmable logic devices, digital and/or analog circuitry and/or software-based approaches.
  • the above example embodiments and implementations may also be integrated with a variety of circuits, devices, systems and approaches including those for use in connection with cellular phones, laptop computers and handheld computing devices. These approaches are implemented in connection with various example embodiments of the present invention. Such modifications and changes do not depart from the true scope of the present invention that is set forth in the following claims.

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Plasma & Fusion (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne une analyse microbienne d'un échantillon qui utilise divers dispositifs, systèmes, agencements et procédés. Un tel dispositif est un dispositif de communication sans fil équipé d'un émetteur-récepteur sans fil et de transducteurs audio pour communications audio bidirectionnelles utilisant l'émetteur-récepteur sans fil. Le dispositif est équipé d'un capteur optique qui fournit des données optiques en réponse à un stimulus optique et une interface de capteur optique pour orienter la luminescence à partir de l'échantillon vers le capteur optique. Un circuit de commande est également intégré pour recevoir les données optiques émanant du capteur optique et interpréter les données optiques pour déterminer un niveau de luminescence reçu par le capteur optique pour fournir les données optiques à l'émetteur-récepteur sans fil en vue de leur transmission.
PCT/IB2008/054655 2007-11-07 2008-11-07 Procédé et système d'analyse biologique utilisant un dispositif de communication mobile WO2009060412A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98608307P 2007-11-07 2007-11-07
US60/986,083 2007-11-07

Publications (2)

Publication Number Publication Date
WO2009060412A2 true WO2009060412A2 (fr) 2009-05-14
WO2009060412A3 WO2009060412A3 (fr) 2009-07-30

Family

ID=40626283

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/054655 WO2009060412A2 (fr) 2007-11-07 2008-11-07 Procédé et système d'analyse biologique utilisant un dispositif de communication mobile

Country Status (1)

Country Link
WO (1) WO2009060412A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012032171A1 (fr) * 2010-09-09 2012-03-15 Dublin City University Système d'analyse optique
EP2455745A1 (fr) * 2010-11-16 2012-05-23 Research In Motion Limited Appareil et procédé associé pour faciliter la détection de la contamination d'un objet

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0834848A2 (fr) * 1996-10-02 1998-04-08 Texas Instruments Incorporated Système de capteurs optiques fixes, et réseau de capteurs distribué
US20050157304A1 (en) * 2004-01-20 2005-07-21 General Electric Company Handheld device with a disposable element for chemical analysis of multiple analytes
AU2006203399A1 (en) * 1999-05-05 2006-09-07 Invitrogen Corporation Optical probes and assays
US20060263252A1 (en) * 2003-02-25 2006-11-23 Jorge Sanchez-Olea Apparatus and method for chemical and biological agent sensing
US20070084990A1 (en) * 2003-08-14 2007-04-19 Microspectral Sensing, Llc Integrated sensing system approach for handheld spectral measurements
US20070146703A1 (en) * 2005-09-19 2007-06-28 Jmar Technologies, Inc. Systems and Methods for Detection and Classification of Waterborne Particles Using a Multiple Angle Light Scattering (MALS) Instrument

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0834848A2 (fr) * 1996-10-02 1998-04-08 Texas Instruments Incorporated Système de capteurs optiques fixes, et réseau de capteurs distribué
AU2006203399A1 (en) * 1999-05-05 2006-09-07 Invitrogen Corporation Optical probes and assays
US20060263252A1 (en) * 2003-02-25 2006-11-23 Jorge Sanchez-Olea Apparatus and method for chemical and biological agent sensing
US20070084990A1 (en) * 2003-08-14 2007-04-19 Microspectral Sensing, Llc Integrated sensing system approach for handheld spectral measurements
US20050157304A1 (en) * 2004-01-20 2005-07-21 General Electric Company Handheld device with a disposable element for chemical analysis of multiple analytes
US20070146703A1 (en) * 2005-09-19 2007-06-28 Jmar Technologies, Inc. Systems and Methods for Detection and Classification of Waterborne Particles Using a Multiple Angle Light Scattering (MALS) Instrument

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012032171A1 (fr) * 2010-09-09 2012-03-15 Dublin City University Système d'analyse optique
US9244066B2 (en) 2010-09-09 2016-01-26 Dublin City University Optical testing system
EP2455745A1 (fr) * 2010-11-16 2012-05-23 Research In Motion Limited Appareil et procédé associé pour faciliter la détection de la contamination d'un objet

Also Published As

Publication number Publication date
WO2009060412A3 (fr) 2009-07-30

Similar Documents

Publication Publication Date Title
US11385219B2 (en) Handheld diagnostic test device and method for use with an electronic device and a test cartridge in a rapid diagnostic test
WO2007044593A3 (fr) Procede et systeme destines a un estimateur de menace a imagerie chimique muni d'une sonde
US20110201382A1 (en) Portalbe sensor apparatus with detachable sensor units
US20050201898A1 (en) Universal optical imaging and processing system
DE602008006330D1 (de) Tragbares Endgerät, Informationsverarbeitungsvorrichtung und Inhaltsanzeigesystem
US20140335905A1 (en) Portable device for measuring blood alcohol level by using a mobile device susch as a phone, tablet or laptop
EP3651162B1 (fr) Procédés et dispositifs pour effectuer une mesure analytique
KR20170036755A (ko) 색조에 기초한 화학적 매개변수의 값을 결정하는 센서 장치 및 그 방법
US20180031482A1 (en) Spectrometric measuring device
RU2015105987A (ru) Устройство отображения изображения и способ отображения изображения, оконечное устройство передачи информации и способ передачи информации и система отображения изображения
JP2007143648A5 (fr)
EA200801809A1 (ru) Комбинация считывателя и термостата
Kwon et al. Applications of smartphone cameras in agriculture, environment, and food: A review
WO2009060412A2 (fr) Procédé et système d'analyse biologique utilisant un dispositif de communication mobile
US20150099306A1 (en) Test cassette reading device and reading method thereof
US20060092030A1 (en) Universal colorimetric imaging array device
JP2020508470A5 (fr)
US9140664B2 (en) Liquid characteristic analyzing apparatus
KR20180064705A (ko) 휴대폰을 이용한 휴대용 바이러스 검출 장치
US12108318B2 (en) Dynamic wireless information transmission
EP3354204A1 (fr) Dispositif de mesure biophotonique, programme de traitement d'informations et procédé de traitement d'informations
US20170356847A1 (en) Measuring device
EP3978909A1 (fr) Procédé de détermination de la concentration d'au moins un analyte dans un fluide corporel
EP3865862A1 (fr) Procédé pour améliorer la détermination d'une concentration d'analyte dans un fluide corporel
US9965872B2 (en) Display processing terminal device, photosensor-equipped unit, and photometric system

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08846834

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase in:

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08846834

Country of ref document: EP

Kind code of ref document: A2