WO2009059047A3 - Tricyclic compounds and methods for using the same - Google Patents

Tricyclic compounds and methods for using the same Download PDF

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Publication number
WO2009059047A3
WO2009059047A3 PCT/US2008/081858 US2008081858W WO2009059047A3 WO 2009059047 A3 WO2009059047 A3 WO 2009059047A3 US 2008081858 W US2008081858 W US 2008081858W WO 2009059047 A3 WO2009059047 A3 WO 2009059047A3
Authority
WO
WIPO (PCT)
Prior art keywords
same
methods
tricyclic compounds
provides
compounds
Prior art date
Application number
PCT/US2008/081858
Other languages
French (fr)
Other versions
WO2009059047A2 (en
Inventor
Linda May Rothblum Watkins
Mark Rowland Hutchinson
Original Assignee
The Regents Of The University Of Colorado
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of Colorado filed Critical The Regents Of The University Of Colorado
Publication of WO2009059047A2 publication Critical patent/WO2009059047A2/en
Publication of WO2009059047A3 publication Critical patent/WO2009059047A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention provides tricyclic compounds of the formula: or a pharmaceutically acceptable salt or a pro-drug thereof, where R1, R2, X, Y, n, A, and B are those defined herein. The invention also provides compositions comprising the same, and methods for using the same.
PCT/US2008/081858 2007-10-30 2008-10-30 Tricyclic compounds and methods for using the same WO2009059047A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98392907P 2007-10-30 2007-10-30
US60/983,929 2007-10-30

Publications (2)

Publication Number Publication Date
WO2009059047A2 WO2009059047A2 (en) 2009-05-07
WO2009059047A3 true WO2009059047A3 (en) 2009-10-15

Family

ID=40591758

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/081858 WO2009059047A2 (en) 2007-10-30 2008-10-30 Tricyclic compounds and methods for using the same

Country Status (1)

Country Link
WO (1) WO2009059047A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5977678B2 (en) 2010-03-12 2016-08-24 リサーチ コーポレーション テクノロジーズ インコーポレイテッド Viable Gram-negative bacteria lacking an outer membrane agonist of TLR4 / MD-2
EP3116509B1 (en) * 2014-03-12 2022-06-22 The Trustees of Columbia University in the City of New York A new class of mu-opioid receptor agonists
EP3349739A4 (en) 2015-09-16 2019-02-13 The Trustees of Columbia University in the City of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists
CN108055842B (en) * 2015-09-17 2021-06-29 豪夫迈·罗氏有限公司 Sulfinylphenyl or sulfonimidoylphenyl benzazepine idle

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BOTNEY, M. ET AL.: "Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system", ANNALS OF NEUROLOGY, vol. 13, no. 2, 2004, pages 160 - 164 *
LYNCH, M.E.: "Antidepressants as analgesics: a review of randomized controlled tirals", JOURNAL OF PSYCHIATRY & NEUROSCIENCE, vol. 26, no. 1, 2001, pages 30 - 36 *
MARTIN, L. E. ET AL.: "Neuropathic pain in cancer patients: mechanisms, syndromes, and clinical controversies", JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, vol. 14, no. 2, 1997, pages 99 - 117 *
SACERDOTE, P. ET AL.: "A role for serotonin and beta-endorphin in the analgesia induced by some tricyclic antidepressant drugs", PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol. 26, no. 1, 1987, pages 153 - 158 *
SAWYNOK, J. ET AL.: "Antidepressants as analgesics: an overview of central and peripheral mechanisms of action", JOURNAL OF PSYCHIATRY & NEUROSCIENCE, vol. 26, no. 1, 2001, pages 21 - 29 *
VALVERDE, O ET AL.: "Participation of opioid and monoaminergic mechanisms on the antinociceptive effect induced by tricyclic antidepressants in two behavioural pain tests in mice", PROGRESS IN NEUROPSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, vol. 18, no. 6, 1994, pages 1073 - 1092 *

Also Published As

Publication number Publication date
WO2009059047A2 (en) 2009-05-07

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