WO2009058929A1 - Lens delivery system - Google Patents
Lens delivery system Download PDFInfo
- Publication number
- WO2009058929A1 WO2009058929A1 PCT/US2008/081679 US2008081679W WO2009058929A1 WO 2009058929 A1 WO2009058929 A1 WO 2009058929A1 US 2008081679 W US2008081679 W US 2008081679W WO 2009058929 A1 WO2009058929 A1 WO 2009058929A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- handpiece
- plunger
- delivery system
- lock ring
- outer shaft
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1662—Instruments for inserting intraocular lenses into the eye
- A61F2/167—Instruments for inserting intraocular lenses into the eye with pushable plungers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1662—Instruments for inserting intraocular lenses into the eye
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1662—Instruments for inserting intraocular lenses into the eye
- A61F2/1667—Instruments for inserting intraocular lenses into the eye with rotatable plungers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0061—Devices for putting-in contact lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00736—Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
- A61M2005/31506—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit formed as a single piece, e.g. moulded
Definitions
- This invention relates to intraocular lenses (IOLs) and more particularly to devices used to inject IOLs into an eye.
- IOLs intraocular lenses
- the human eye in its simplest terms functions to provide vision by transmitting and refracting light through a clear outer portion called the cornea, and further focusing the image by way of the lens onto the retina at the back of the eye.
- the quality of the focused image depends on many factors including the size, shape and length of the eye, and the shape and transparency of the cornea and lens.
- cataract When trauma, age or disease cause the lens to become less transparent, vision deteriorates because of the diminished light which can be transmitted to the retina. This deficiency in the lens of the eye is medically known as a cataract.
- the treatment for this condition is surgical removal of the lens and implantation of an artificial lens or IOL.
- a need continues to exist for a lens delivery system handpiece having a plunger that can be advanced by pushing or by turning of a thumbscrew.
- the present invention improves upon prior art by providing a lens delivery system handpiece having a threaded plunger rod with a ball lock ring. Locking the ring causes the plunger to be advanced by turning a thumbscrew or knob. Unlocking the ring allows the plunger to be advanced by pushing on the thumbscrew or knob in a manner similar to a syringe.
- FIG. 1 is a side elevational view of the handpiece of the lens delivery system of the present invention.
- FIG. 2 is a cross-sectional view of the ball lock ring of the handpiece illustrated in
- FIG. 1 showing the lock ring in the locked position.
- FIG. 3 is a cross-sectional view of the ball lock ring of the handpiece illustrated in FIG. 1 showing the lock ring in the unlocked position.
- FIG. 4 is a perspective view of a cartridge that may be used with the lens delivery system of the present invention.
- FIG. 5 is a cross-section view of the handpiece of the lens delivery system of the present invention.
- lens delivery system 10 of the present invention generally includes cartridge 12 and handpiece 14.
- Handpiece 14 generally consists of barrel 16, ball lock ring 18 (shown in FIG. 1 in partial cross-section) and plunger rod 20.
- plunger rod 20 contains distal tip 22 and proximal end 23 which is rotationally journaled into grooved outer shaft 24 so that outer shaft 24 spins freely on proximal end 23 of plunger rod 20.
- Rigidly attached to outer shaft 24 is knob 26.
- Pin 35 fits against flat portion 37 of plunger rod 20 so that rotation of knob 26 and outer shaft 24 does not cause plunger rod 20 to rotate, but that plunger rod 20 may freely reciprocate within barrel 16.
- Barrel 16 contains notched portion 28 into which cartridge 12 is received so that tip 22 of plunger rod 20 reciprocates within bore 30 of cartridge 12.
- ball lock ring 18 contains a plurality of balls 34 sized to fit within groove 32 of outer shaft 24. Ring 18 also contains a plurality release angles 36 opposite groove 32 corresponding to the location of balls 34.
- rotating ball lock ring 18 counter-clockwise forces balls 34 into groove 32 and prevents plunger rod 20 from being advanced by pushing on knob 26. Instead, turning of knob 26 causes balls 34 to ride within groove 32 of grooved outer shaft 24, thereby threadedly pushing or pulling on proximal end 23 of plunger rod and causing corresponding reciprocation of tip 22 of plunger rod 20 within bore 30 of cartridge 12.
- rotating ball lock ring 18 clockwise forces balls 34 out of groove 32 and allows plunger rod 20 to be advanced by pushing on knob 26. Index pin 38 and slot 40 prevent over-rotation of ball lock ring 18.
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Prostheses (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2008318711A AU2008318711B2 (en) | 2007-10-30 | 2008-10-30 | Lens delivery system |
BRPI0818794 BRPI0818794A2 (en) | 2007-10-30 | 2008-10-30 | Lens Placement System |
CA2691551A CA2691551C (en) | 2007-10-30 | 2008-10-30 | Lens delivery system |
JP2010531333A JP5255064B2 (en) | 2007-10-30 | 2008-10-30 | Lens delivery device |
DE602008002748T DE602008002748D1 (en) | 2007-10-30 | 2008-10-30 | The lens |
AT08844603T ATE481948T1 (en) | 2007-10-30 | 2008-10-30 | LENS INTRODUCTION SYSTEM |
RU2010121933/14A RU2472468C2 (en) | 2007-10-30 | 2008-10-30 | System for lens delivery |
CN2008801003014A CN101815484B (en) | 2007-10-30 | 2008-10-30 | Lens delivery system |
EP08844603A EP2150204B1 (en) | 2007-10-30 | 2008-10-30 | Lens delivery system |
NZ582937A NZ582937A (en) | 2007-10-30 | 2008-10-30 | Intraoccular lens insertion device |
IL202868A IL202868A (en) | 2007-10-30 | 2009-12-21 | Lens delivery system |
ZA2010/00429A ZA201000429B (en) | 2007-10-30 | 2010-01-20 | Lens delivery system |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/928,554 | 2007-10-30 | ||
US11/928,554 US8105332B2 (en) | 2007-10-30 | 2007-10-30 | Lens delivery system |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009058929A1 true WO2009058929A1 (en) | 2009-05-07 |
Family
ID=40262200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/081679 WO2009058929A1 (en) | 2007-10-30 | 2008-10-30 | Lens delivery system |
Country Status (18)
Country | Link |
---|---|
US (1) | US8105332B2 (en) |
EP (1) | EP2150204B1 (en) |
JP (1) | JP5255064B2 (en) |
KR (1) | KR101471817B1 (en) |
CN (1) | CN101815484B (en) |
AR (1) | AR070664A1 (en) |
AT (1) | ATE481948T1 (en) |
AU (1) | AU2008318711B2 (en) |
BR (1) | BRPI0818794A2 (en) |
CA (1) | CA2691551C (en) |
DE (1) | DE602008002748D1 (en) |
ES (1) | ES2350818T3 (en) |
IL (1) | IL202868A (en) |
NZ (1) | NZ582937A (en) |
RU (1) | RU2472468C2 (en) |
TW (1) | TWI422363B (en) |
WO (1) | WO2009058929A1 (en) |
ZA (1) | ZA201000429B (en) |
Cited By (21)
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WO2011126144A1 (en) * | 2010-04-08 | 2011-10-13 | Hoya Corporation | Ocular implant insertion apparatus and methods |
US8382769B2 (en) | 2008-06-17 | 2013-02-26 | Hoya Corporation | Intraocular lens insertion device |
US8460311B2 (en) | 2004-12-27 | 2013-06-11 | Hoya Corporation | Intraocular lens implanting device |
US8470032B2 (en) | 2008-09-04 | 2013-06-25 | Hoya Corporation | Intraocular lens insertion device |
US8475528B2 (en) | 2007-05-30 | 2013-07-02 | Hoya Corporation | Intraocular lens insertion device |
US8523941B2 (en) | 2005-12-08 | 2013-09-03 | Hoya Corporation | Instrument for inserting intraocular lens |
US8523877B2 (en) | 2005-02-24 | 2013-09-03 | Hoya Corporation | Intraocular lens inserting instrument |
US8545512B2 (en) | 2005-01-26 | 2013-10-01 | Hoya Corporation | Intraocular lens insertion device |
US8574239B2 (en) | 2005-09-28 | 2013-11-05 | Hoya Corporation | Intraocular lens insertion device |
US8603103B2 (en) | 2009-01-07 | 2013-12-10 | Hoya Corporation | Intraocular lens insertion device |
US8647382B2 (en) | 2010-06-10 | 2014-02-11 | Hoya Corporation | Ocular implant insertion apparatus and methods |
US8702795B2 (en) | 2008-08-21 | 2014-04-22 | Hoya Corporation | Intraocular lens inserting device |
US8747465B2 (en) | 2007-05-30 | 2014-06-10 | Hoya Corporation | Intraocular lens insertion device |
US9114006B2 (en) | 2007-07-11 | 2015-08-25 | Hoya Corporation | Intraocular lens insertion device and method for controlling movement of the intraocular lens |
US9554894B2 (en) | 2008-06-05 | 2017-01-31 | Hoya Corporation | Intraocular lens insertion device and cartridge |
US9907697B2 (en) | 2012-04-24 | 2018-03-06 | Novartis Ag | Delivery system for ocular implant |
US10085633B2 (en) | 2012-04-19 | 2018-10-02 | Novartis Ag | Direct visualization system for glaucoma treatment |
US10531983B2 (en) | 2009-01-28 | 2020-01-14 | Novartis Ag | Ocular implant with stiffness qualities, methods of implantation and system |
US10799339B2 (en) | 2015-09-16 | 2020-10-13 | Hoya Corporation | Intraocular lens injector |
US10849738B2 (en) | 2015-09-16 | 2020-12-01 | Hoya Corporation | Intraocular lens injector |
US11033382B2 (en) | 2016-06-28 | 2021-06-15 | Hoya Corporation | Intraocular lens injector |
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US8460375B2 (en) * | 2006-08-14 | 2013-06-11 | Novartis Ag | Lens delivery system |
US9522061B2 (en) * | 2007-02-15 | 2016-12-20 | Novartis Ag | Lens delivery system |
US20080255577A1 (en) * | 2007-04-11 | 2008-10-16 | Downer David A | Lens Delivery System Cartridge and Method of Manufacture |
AU2009212211B2 (en) | 2008-02-07 | 2013-03-14 | Alcon Inc. | Lens delivery system cartridge |
US8801780B2 (en) | 2008-10-13 | 2014-08-12 | Alcon Research, Ltd. | Plunger tip coupling device for intraocular lens injector |
US8308736B2 (en) * | 2008-10-13 | 2012-11-13 | Alcon Research, Ltd. | Automated intraocular lens injector device |
US8808308B2 (en) | 2008-10-13 | 2014-08-19 | Alcon Research, Ltd. | Automated intraocular lens injector device |
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US8308799B2 (en) | 2010-04-20 | 2012-11-13 | Alcon Research, Ltd. | Modular intraocular lens injector device |
GB201011313D0 (en) | 2010-07-05 | 2010-08-18 | Ucl Business Plc | Implantation devices, methods and implants |
WO2012018547A1 (en) | 2010-07-25 | 2012-02-09 | Alcon Research, Ltd. | Dual mode automated intraocular lens injector device |
EP2567674B1 (en) * | 2011-09-07 | 2015-05-06 | SDI Surgical Device International GmbH | Modular intraocular lens injector |
US8690941B2 (en) | 2011-10-04 | 2014-04-08 | Novartis Ag | Intraocular lens surgical system and method |
US8657835B2 (en) | 2012-01-27 | 2014-02-25 | Alcon Research, Ltd. | Automated intraocular lens injector device |
GB2501109B (en) | 2012-04-12 | 2014-04-23 | Duckworth & Kent Ltd | Actuator for device for delivery of ophthalmic lenses |
JP6339065B2 (en) * | 2012-04-19 | 2018-06-06 | ノバルティス アーゲー | Delivery system for intraocular implants |
US9504561B2 (en) * | 2013-03-07 | 2016-11-29 | Novartis Ag | Systems and processes for inserting an intraocular lens |
GB2517921B (en) | 2013-09-04 | 2015-12-16 | Duckworth & Kent Ltd | Device for use in a delivery of ophthalmic lenses |
CN107427637A (en) * | 2014-04-17 | 2017-12-01 | 巴林医疗有限公司 | For preparing and using the instrument and method of blood constitutent |
US10722347B2 (en) * | 2015-12-17 | 2020-07-28 | Atrion Medical Products, Inc. | Intraocular lens delivery device and method of use |
US11000410B2 (en) * | 2016-06-17 | 2021-05-11 | Gyroscope Therapeutics Limited | Guide apparatus for tangential entry into suprachoroidal space |
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CH714883A1 (en) * | 2018-04-12 | 2019-10-15 | Medicel Ag | Injector with two operating modes, in particular suitable for injecting an intraocular lens. |
TW202005618A (en) | 2018-07-10 | 2020-02-01 | 瑞士商愛爾康股份有限公司 | Intraocular lens injector |
EP3593838A1 (en) * | 2018-07-13 | 2020-01-15 | Zyno Medical, Llc | High precision syringe with removable pump unit |
EP4208126A1 (en) * | 2020-09-04 | 2023-07-12 | OPHTHALMO Pro GmbH | Injector for intraocular lenses |
BR112023004034A2 (en) * | 2020-09-04 | 2023-05-02 | Ophthalmo Pro Gmbh | INJECTOR FOR INTRAOCULAR LENSES |
DE102020126789A1 (en) * | 2020-10-13 | 2022-04-14 | OphthalmoPro GmbH | Injector for intraocular lenses |
DE102021112682B3 (en) | 2021-05-17 | 2022-09-15 | Iolution Gmbh | Injector with rotating element for an intraocular lens |
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-
2007
- 2007-10-30 US US11/928,554 patent/US8105332B2/en active Active
-
2008
- 2008-10-30 BR BRPI0818794 patent/BRPI0818794A2/en not_active IP Right Cessation
- 2008-10-30 JP JP2010531333A patent/JP5255064B2/en active Active
- 2008-10-30 AT AT08844603T patent/ATE481948T1/en not_active IP Right Cessation
- 2008-10-30 NZ NZ582937A patent/NZ582937A/en not_active IP Right Cessation
- 2008-10-30 AR ARP080104766A patent/AR070664A1/en not_active Application Discontinuation
- 2008-10-30 KR KR1020097027467A patent/KR101471817B1/en not_active IP Right Cessation
- 2008-10-30 ES ES08844603T patent/ES2350818T3/en active Active
- 2008-10-30 WO PCT/US2008/081679 patent/WO2009058929A1/en active Application Filing
- 2008-10-30 CA CA2691551A patent/CA2691551C/en not_active Expired - Fee Related
- 2008-10-30 CN CN2008801003014A patent/CN101815484B/en not_active Expired - Fee Related
- 2008-10-30 TW TW097141774A patent/TWI422363B/en not_active IP Right Cessation
- 2008-10-30 DE DE602008002748T patent/DE602008002748D1/en active Active
- 2008-10-30 EP EP08844603A patent/EP2150204B1/en active Active
- 2008-10-30 AU AU2008318711A patent/AU2008318711B2/en not_active Ceased
- 2008-10-30 RU RU2010121933/14A patent/RU2472468C2/en not_active IP Right Cessation
-
2009
- 2009-12-21 IL IL202868A patent/IL202868A/en not_active IP Right Cessation
-
2010
- 2010-01-20 ZA ZA2010/00429A patent/ZA201000429B/en unknown
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Also Published As
Publication number | Publication date |
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KR101471817B1 (en) | 2014-12-11 |
NZ582937A (en) | 2012-06-29 |
CN101815484B (en) | 2012-10-10 |
RU2472468C2 (en) | 2013-01-20 |
KR20100071947A (en) | 2010-06-29 |
RU2010121933A (en) | 2011-12-10 |
AU2008318711A1 (en) | 2009-05-07 |
DE602008002748D1 (en) | 2010-11-04 |
ATE481948T1 (en) | 2010-10-15 |
TW200930344A (en) | 2009-07-16 |
ZA201000429B (en) | 2011-03-30 |
CA2691551A1 (en) | 2009-05-07 |
TWI422363B (en) | 2014-01-11 |
AU2008318711B2 (en) | 2014-01-16 |
ES2350818T3 (en) | 2011-01-27 |
IL202868A (en) | 2015-03-31 |
AR070664A1 (en) | 2010-04-28 |
US8105332B2 (en) | 2012-01-31 |
EP2150204A1 (en) | 2010-02-10 |
CN101815484A (en) | 2010-08-25 |
EP2150204B1 (en) | 2010-09-22 |
JP5255064B2 (en) | 2013-08-07 |
US20090112223A1 (en) | 2009-04-30 |
JP2011502012A (en) | 2011-01-20 |
BRPI0818794A2 (en) | 2015-04-22 |
CA2691551C (en) | 2015-12-22 |
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