WO2009057755A1 - Sugar chain array substrate and method for detection of sugar chain-binding molecule using the same - Google Patents

Sugar chain array substrate and method for detection of sugar chain-binding molecule using the same Download PDF

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Publication number
WO2009057755A1
WO2009057755A1 PCT/JP2008/069895 JP2008069895W WO2009057755A1 WO 2009057755 A1 WO2009057755 A1 WO 2009057755A1 JP 2008069895 W JP2008069895 W JP 2008069895W WO 2009057755 A1 WO2009057755 A1 WO 2009057755A1
Authority
WO
WIPO (PCT)
Prior art keywords
sugar chain
sugar
array substrate
binding molecule
detection
Prior art date
Application number
PCT/JP2008/069895
Other languages
French (fr)
Japanese (ja)
Inventor
Jun Hirabayashi
Hiroaki Tateno
Noboru Uchiyama
Atsushi Mori
Original Assignee
National Institute Of Advanced Industrial Science And Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institute Of Advanced Industrial Science And Technology filed Critical National Institute Of Advanced Industrial Science And Technology
Priority to JP2009539129A priority Critical patent/JP5454896B2/en
Publication of WO2009057755A1 publication Critical patent/WO2009057755A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4724—Lectins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates

Abstract

A sugar chain array substrate capable of presenting a sugar chain molecule in a polyvalent state by immobilizing a sugar chain-carrier complex in which a plurality of the same type of sugar chain molecules are bound to one carrier molecule on a substrate at a predetermined position is provided. Further, a sugar chain array substrate in which a purified or unpurified complex sugar is immobilized on the sugar chain array substrate at another predetermined position is provided. Further, the invention provides a method and a kit for detection or analysis of a sugar-binding molecule in a test sample, analysis of a sugar-binding activity of a test sugar-binding molecule, detection or analysis of a sugar chain in a complex sugar, search for a sugar-binding molecule having an unknown sugar-binding activity using the sugar chain array substrate.
PCT/JP2008/069895 2007-11-02 2008-10-31 Sugar chain array substrate and method for detection of sugar chain-binding molecule using the same WO2009057755A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009539129A JP5454896B2 (en) 2007-11-02 2008-10-31 Glycan array substrate and glycan binding molecule detection method using it

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-285877 2007-11-02
JP2007285877 2007-11-02

Publications (1)

Publication Number Publication Date
WO2009057755A1 true WO2009057755A1 (en) 2009-05-07

Family

ID=40591135

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/069895 WO2009057755A1 (en) 2007-11-02 2008-10-31 Sugar chain array substrate and method for detection of sugar chain-binding molecule using the same

Country Status (2)

Country Link
JP (1) JP5454896B2 (en)
WO (1) WO2009057755A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012091606A1 (en) 2010-12-30 2012-07-05 Obschestvo S Ogranichennoy Otvetstvennostyu "Synthaur" Improved glycan arrays and methods for their fabrication
WO2013065302A1 (en) * 2011-11-01 2013-05-10 独立行政法人産業技術総合研究所 Undifferentiated cell detection method and complex carbohydrate detection method
EP2600152A1 (en) * 2010-07-30 2013-06-05 Sumitomo Bakelite Co., Ltd. Sugar chain array
JP2013167614A (en) * 2012-02-17 2013-08-29 Sumitomo Bakelite Co Ltd Method of producing sugar chain array
JP2014003908A (en) * 2012-06-21 2014-01-16 National Institute Of Advanced Industrial & Technology Method for modifying protein function
WO2014069512A1 (en) * 2012-10-31 2014-05-08 住友ベークライト株式会社 Membrane support for detecting sugar chain recognition molecule
JP2015511706A (en) * 2012-03-16 2015-04-20 ダボス ダイアグノスティックス アーゲー Real-time diagnostic assay using evanescent biosensor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005064333A1 (en) * 2003-12-25 2005-07-14 National Institute Of Advanced Industrial Science And Technology Method of analyzing interaction between protein and sugar chain
WO2005077965A1 (en) * 2004-02-18 2005-08-25 Japan Science And Technology Agency Sugar chain ligand composite and method of analyzing protein with the ligand composite
JP2007510410A (en) * 2003-11-04 2007-04-26 アンスティテュ ナシオナル ドゥ ラ サントゥ エ ドゥ ラ ルシェルシェ メディカル（イーエヌエスエーエールエム） Use of hydrogels for chondrocyte culture

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007510410A (en) * 2003-11-04 2007-04-26 アンスティテュ ナシオナル ドゥ ラ サントゥ エ ドゥ ラ ルシェルシェ メディカル（イーエヌエスエーエールエム） Use of hydrogels for chondrocyte culture
WO2005064333A1 (en) * 2003-12-25 2005-07-14 National Institute Of Advanced Industrial Science And Technology Method of analyzing interaction between protein and sugar chain
WO2005077965A1 (en) * 2004-02-18 2005-08-25 Japan Science And Technology Agency Sugar chain ligand composite and method of analyzing protein with the ligand composite

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DYUKOVA V.I. ET AL.: "Hydrogel glycan microarrays.", ANALYTICAL BIOCHEMISTRY, vol. 347, 2005, pages 94 - 105 *
EBE H. ET AL.: "Lectin Microarray no Kaihatsu Evanescent-ha Reikigata Keiko Scanner de Ko-throughput na Tosa Kaiseki", BIONICS, vol. 3, no. 5, 2006, pages 58 - 59 *
MANIMALA J.C. ET AL.: "High-throughput carbohydrate microarray analysis of 24 lectins.", ANGEWANDTE CHEMIE.INTERNATIONAL EDITION, vol. 45, no. 22, 2006, pages 3607 - 3610 *
TATENO H.: "Saibo Hyoso Real Glycom Profiling", DAI 27 KAI THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH NENKAI YOSHISHU, 10 July 2007 (2007-07-10), pages 35 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2600152A1 (en) * 2010-07-30 2013-06-05 Sumitomo Bakelite Co., Ltd. Sugar chain array
US9310358B2 (en) 2010-07-30 2016-04-12 Sumitomo Bakelite Co., Ltd. Sugar chain array
EP2600152A4 (en) * 2010-07-30 2015-02-25 Sumitomo Bakelite Co Sugar chain array
EP2686022A4 (en) * 2010-12-30 2014-10-15 Obschestvo S Ogranichennoy Otvetstvennostyu Semiotik Improved glycan arrays and methods for their fabrication
WO2012091606A1 (en) 2010-12-30 2012-07-05 Obschestvo S Ogranichennoy Otvetstvennostyu "Synthaur" Improved glycan arrays and methods for their fabrication
EP2686022A1 (en) * 2010-12-30 2014-01-22 Obschestvo s Ogranichennoy Otvetstvennostyu "Semiotik" Improved glycan arrays and methods for their fabrication
WO2013065302A1 (en) * 2011-11-01 2013-05-10 独立行政法人産業技術総合研究所 Undifferentiated cell detection method and complex carbohydrate detection method
US9500650B2 (en) 2011-11-01 2016-11-22 National Institute Of Advanced Industrial Science And Technology Undifferentiated cell detection method and complex carbohydrate detection method
CN103987855A (en) * 2011-11-01 2014-08-13 独立行政法人产业技术综合研究所 Undifferentiated cell detection method and complex carbohydrate detection method
JP2013167614A (en) * 2012-02-17 2013-08-29 Sumitomo Bakelite Co Ltd Method of producing sugar chain array
JP2015511706A (en) * 2012-03-16 2015-04-20 ダボス ダイアグノスティックス アーゲー Real-time diagnostic assay using evanescent biosensor
JP2014003908A (en) * 2012-06-21 2014-01-16 National Institute Of Advanced Industrial & Technology Method for modifying protein function
JP2014089149A (en) * 2012-10-31 2014-05-15 Sumitomo Bakelite Co Ltd Membrane carrier for detecting sugar chain recognition molecule
US20150253316A1 (en) * 2012-10-31 2015-09-10 Sumitomo Bakelite Co., Ltd. Membrane support for detecting sugar chain-recognizing molecule
WO2014069512A1 (en) * 2012-10-31 2014-05-08 住友ベークライト株式会社 Membrane support for detecting sugar chain recognition molecule

Also Published As

Publication number Publication date
JPWO2009057755A1 (en) 2011-03-10
JP5454896B2 (en) 2014-03-26

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